The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis

Journal of Molecular and Cellular Cardiology

Volumn 47, Issue 2, 2009, Pages 188-195

  Espira, Leon ^a   Lamoureux, Lise ^a   Jones, Stephen C ^a   Gerard, Robert D ^b   Dixon, Ian M C ^a   Czubryt, Michael P ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cardiac fibroblasts; Cardiac myofibroblasts; Extracellular matrix; Fibrosis; Gene expression

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA2; SCLERAXIS; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RAT; SCAR FORMATION; TRANSACTIVATION; UPREGULATION;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; COLLAGEN; FIBROBLASTS; MALE; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIAL INFARCTION; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTIONAL ACTIVATION;

RATTUS;

EID: 67649130137     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.03.024     Document Type: Article

References (30)

1. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol. Rev. 79 (1999) 215-262
2. Powell D.W., Mifflin R.C., Valentich J.D., Crowe S.E., Saada J.I., and West A.B. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am. J. Physiol. 277 (1999) C183-C201
3. Petrov V.V., Fagard R.H., and Lijnen P.J. Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension 39 (2002) 258-263
4. Zeisberg E.M., Tarnavski O., Zeisberg M., Dorfman A.L., McMullen J.R., Gustafsson E., et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13 (2007) 952-961
5. Campbell S.E., and Katwa L.C. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J. Mol. Cell. Cardiol. 29 (1997) 1947-1958
6. Evans R.A., Tian Y.C., Steadman R., and Phillips A.O. TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp. Cell. Res. 282 (2003) 90-100
7. Czubryt M.P., McAnally J., Fishman G.I., and Olson E.N. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1711-1716
8. Cserjesi P., Brown D., Ligon K.L., Lyons G.E., Copeland N.G., Gilbert D.J., et al. Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 121 (1995) 1099-1110
9. Liu Y., Watanabe H., Nifuji A., Yamada Y., Olson E.N., and Noda M. Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J. Biol. Chem. 272 (1997) 29880-29885
10. Carlberg A.L., Tuan R.S., and Hall D.J. Regulation of scleraxis function by interaction with the bHLH protein E47. Mol. Cell. Biol. Res. Commun. 3 (2000) 82-86
11. Raizman J.E., Komljenovic J., Chang R., Deng C., Bedosky K.M., Rattan S.G., et al. The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation. J. Cell. Physiol. 213 (2007) 540-551
12. Ju H., Hao J., Zhao S., and Dixon I.M. Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts. Biochim. Biophys. Acta 1448 (1998) 51-60
13. Aoki K., Barker C., Danthinne X., Imperiale M.J., and Nabel G.J. Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro. Mol. Med. 5 (1999) 224-231
14. Gerard R.D., and Meidell R.S. Adenovirus vectors. In: Hames B.D., and Glover D. (Eds). DNA cloning - a practical approach: mammalian systems (1995), Oxford University Press, Oxford 285-307
15. Waser M., Mesaeli N., Spencer C., and Michalak M. Regulation of calreticulin gene expression by calcium. J. Cell. Biol. 138 (1997) 547-557
16. Wang B., Omar A., Angelovska T., Drobic V., Rattan S.G., Jones S.C., et al. Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H1282-H1290
17. Wang B., Hao J., Jones S.C., Yee M.S., Roth J.C., and Dixon I.M. Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H1685-H1696
18. Ju H., Zhao S., Jassal D.S., and Dixon I.M. Effect of AT1 receptor blockade on cardiac collagen remodeling after myocardial infarction. Cardiovasc. Res. 35 (1997) 223-232
19. Freed D.H., Cunnington R.H., Dangerfield A.L., Sutton J.S., and Dixon I.M. Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc. Res. 65 (2005) 782-792
20. Lejard V., Brideau G., Blais F., Salingcarnboriboon R., Wagner G., Roehrl M.H., et al. Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J. Biol. Chem. 282 (2007) 17665-17675
21. Ramirez F., Tanaka S., and Bou-Gharios G. Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases. Matrix Biol. 25 (2006) 365-372
22. Langlands K., Yin X., Anand G., and Prochownik E.V. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 272 (1997) 19785-19793
23. Sun Y., and Weber K.T. Infarct scar: a dynamic tissue. Cardiovasc. Res. 46 (2000) 250-256
24. Stefanovic B., Hellerbrand C., Holcik M., Briendl M., Aliebhaber S., and Brenner D.A. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol. Cell. Biol. 17 (1997) 5201-5209
25. Anthwal N., Chai Y., and Tucker A.S. The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev. Dyn. 237 (2008) 1604-1613
26. Khan R., and Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118 (2006) 10-24
27. Murchison N.D., Price B.A., Conner D.A., Keene D.R., Olson E.N., Tabin C.J., et al. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 134 (2007) 2697-2708
28. Feng X.H., and Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu. Rev. Cell. Dev. Biol. 21 (2005) 659-693
29. Levay A.K., Peacock J.D., Lu Y., Koch M., Hinton Jr. R.B., Kadler K.E., et al. Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ. Res. 103 (2008) 948-956
30. Muir T., Sadler-Riggleman I., and Skinner M.K. Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation. Mol. Endocrinol. 19 (2005) 2164-2174