-
1
-
-
0034116273
-
Oral delivery of proteins: effect of chicken and duck ovomucoid on the stability of insulin in the presence of a-chymotrypsin and trypsin
-
Agarwal V, Reddy IK, Khan MA. Oral delivery of proteins: effect of chicken and duck ovomucoid on the stability of insulin in the presence of a-chymotrypsin and trypsin. Pharm Pharmacol Commun 2000;6:223-7.
-
(2000)
Pharm Pharmacol Commun
, vol.6
, pp. 223-227
-
-
Agarwal, V.1
Reddy, I.K.2
Khan, M.A.3
-
2
-
-
84955189506
-
Functionalized nanoparticles for targeting the gastrointestinal apical membrane receptors
-
Vooght-Johnson RD, editor. Future Science Group
-
Araújo F, Pereira C, Granja PL, Santos HA, Sarmento B. Functionalized nanoparticles for targeting the gastrointestinal apical membrane receptors. In: Vooght-Johnson RD, editor. Advances and Challenges in Oral Delivery of Macromolecules. Future Science Group; 2014a.
-
(2014)
Advances and Challenges in Oral Delivery of Macromolecules
-
-
Araújo, F.1
Pereira, C.2
Granja, P.L.3
Santos, H.A.4
Sarmento, B.5
-
3
-
-
84906788144
-
The impact of nanoparticles on themucosal translocation and transport of GLP-1 across the intestinal epithelium
-
Araújo F, Shrestha N, Shahbazi M-A, Fonte P, Mäkilä EM, Salonen JJ, et al. The impact of nanoparticles on themucosal translocation and transport of GLP-1 across the intestinal epithelium. Biomaterials 2014b;35:9199-207.
-
(2014)
Biomaterials
, vol.35
, pp. 9199-9207
-
-
Araújo, F.1
Shrestha, N.2
Shahbazi, M.-A.3
Fonte, P.4
Mäkilä, E.M.5
Salonen, J.J.6
-
4
-
-
15044364588
-
Diethyl methyl chitosan as an intestinal paracellular enhancer: ex vivo and in vivo studies
-
Avadi MR, Jalali A, Sadeghi AM, Shamimi K, Bayati KH, Nahid E, et al. Diethyl methyl chitosan as an intestinal paracellular enhancer: ex vivo and in vivo studies. Int J Pharm 2005;293:83-9.
-
(2005)
Int J Pharm
, vol.293
, pp. 83-89
-
-
Avadi, M.R.1
Jalali, A.2
Sadeghi, A.M.3
Shamimi, K.4
Bayati, K.H.5
Nahid, E.6
-
5
-
-
75149163234
-
Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method
-
Avadi MR, Sadeghi AM, Mohammadpour N, Abedin S, Atyabi F, Dinarvand R, et al. Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomedicine 2010;6:58-63.
-
(2010)
Nanomedicine
, vol.6
, pp. 58-63
-
-
Avadi, M.R.1
Sadeghi, A.M.2
Mohammadpour, N.3
Abedin, S.4
Atyabi, F.5
Dinarvand, R.6
-
6
-
-
84898832108
-
Ex vivo evaluation of insulin nanoparticles using chitosan and Arabic gum
-
Avadi MR, Sadeghi AM, Mohamadpour Dounighi N, Dinarvand R, Atyabi F, Rafiee-Tehrani M. Ex vivo evaluation of insulin nanoparticles using chitosan and Arabic gum. ISRN Pharm 2011;2011:860109.
-
(2011)
ISRN Pharm
, vol.2011
-
-
Avadi, M.R.1
Sadeghi, A.M.2
Mohamadpour Dounighi, N.3
Dinarvand, R.4
Atyabi, F.5
Rafiee-Tehrani, M.6
-
7
-
-
50749118593
-
The internal secretion of the pancreas
-
Banting FG, Best CH. The internal secretion of the pancreas. J Lab Clin Med 1922;7:251-66.
-
(1922)
J Lab Clin Med
, vol.7
, pp. 251-266
-
-
Banting, F.G.1
Best, C.H.2
-
8
-
-
42649142580
-
Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies
-
Bayat A, Dorkoosh FA, Dehpour AR, Moezi L, Larijani B, Junginger HE, et al. Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies. Int J Pharm 2008a;356:259-66.
-
(2008)
Int J Pharm
, vol.356
, pp. 259-266
-
-
Bayat, A.1
Dorkoosh, F.A.2
Dehpour, A.R.3
Moezi, L.4
Larijani, B.5
Junginger, H.E.6
-
9
-
-
44449154695
-
Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives
-
Bayat A, Larijani B, Ahmadian S, Junginger HE, Rafiee-Tehrani M. Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives. Nanomedicine 2008b;4:115-20.
-
(2008)
Nanomedicine
, vol.4
, pp. 115-120
-
-
Bayat, A.1
Larijani, B.2
Ahmadian, S.3
Junginger, H.E.4
Rafiee-Tehrani, M.5
-
11
-
-
34447577190
-
Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
-
Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 2007a;122:141-50.
-
(2007)
J Control Release
, vol.122
, pp. 141-150
-
-
Chalasani, K.B.1
Russell-Jones, G.J.2
Jain, A.K.3
Diwan, P.V.4
Jain, S.K.5
-
12
-
-
33846940490
-
A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin
-
Chalasani KB, Russell-Jones GJ, Yandrapu SK, Diwan PV, Jain SK. A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin. J Control Release 2007b;117:421-9.
-
(2007)
J Control Release
, vol.117
, pp. 421-429
-
-
Chalasani, K.B.1
Russell-Jones, G.J.2
Yandrapu, S.K.3
Diwan, P.V.4
Jain, S.K.5
-
14
-
-
79954420700
-
Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents
-
Chaudhury A, Das S. Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents. AAPS PharmSciTech 2011; 12:10-20.
-
(2011)
AAPS PharmSciTech
, vol.12
, pp. 10-20
-
-
Chaudhury, A.1
Das, S.2
-
15
-
-
1842739438
-
A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery
-
Chen SC, Wu YC, Mi FL, Lin YH, Yu LC, Sung HW. A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J Control Release 2004;96:285-300.
-
(2004)
J Control Release
, vol.96
, pp. 285-300
-
-
Chen, S.C.1
Wu, Y.C.2
Mi, F.L.3
Lin, Y.H.4
Yu, L.C.5
Sung, H.W.6
-
16
-
-
80054061227
-
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
-
Chen MC, Sonaje K, Chen KJ, Sung HW. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011;32:9826-38.
-
(2011)
Biomaterials
, vol.32
, pp. 9826-9838
-
-
Chen, M.C.1
Sonaje, K.2
Chen, K.J.3
Sung, H.W.4
-
17
-
-
84878862620
-
Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules
-
Chen MC, Mi FL, Liao ZX, Hsiao CW, Sonaje K, Chung MF, et al. Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv Drug Deliv Rev 2013;65:865-79.
-
(2013)
Adv Drug Deliv Rev
, vol.65
, pp. 865-879
-
-
Chen, M.C.1
Mi, F.L.2
Liao, Z.X.3
Hsiao, C.W.4
Sonaje, K.5
Chung, M.F.6
-
18
-
-
84922064951
-
A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
-
Choonara BF, Choonara YE, Kumar P, Bijukumar D, du Toit LC, Pillay V. A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules. Biotechnol Adv 2014;32:1269-82.
-
(2014)
Biotechnol Adv
, vol.32
, pp. 1269-1282
-
-
Choonara, B.F.1
Choonara, Y.E.2
Kumar, P.3
Bijukumar, D.4
du Toit, L.C.5
Pillay, V.6
-
19
-
-
0037422066
-
Regulated portals of entry into the cell
-
Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003;422:37-44.
-
(2003)
Nature
, vol.422
, pp. 37-44
-
-
Conner, S.D.1
Schmid, S.L.2
-
21
-
-
33747884001
-
Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation
-
Cui F, Shi K, Zhang L, Tao A, Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J Control Release 2006;114:242-50.
-
(2006)
J Control Release
, vol.114
, pp. 242-250
-
-
Cui, F.1
Shi, K.2
Zhang, L.3
Tao, A.4
Kawashima, Y.5
-
22
-
-
33847666114
-
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery
-
Cui F, Tao A, Cun D, Zhang L, Shi K. Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci 2007;96:421-7.
-
(2007)
J Pharm Sci
, vol.96
, pp. 421-427
-
-
Cui, F.1
Tao, A.2
Cun, D.3
Zhang, L.4
Shi, K.5
-
23
-
-
33846543799
-
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
-
Damgé C, Maincent P, Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 2007;117:163-70.
-
(2007)
J Control Release
, vol.117
, pp. 163-170
-
-
Damgé, C.1
Maincent, P.2
Ubrich, N.3
-
24
-
-
74049130927
-
Poly(e-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes
-
Damgé C, Socha M, Ubrich N, Maincent P. Poly(e-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes. J Pharm Sci 2010;99: 879-89.
-
(2010)
J Pharm Sci
, vol.99
, pp. 879-889
-
-
Damgé, C.1
Socha, M.2
Ubrich, N.3
Maincent, P.4
-
25
-
-
38749146888
-
Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery
-
Davaran S, Omidi Y, Rashidi MR, Anzabi M, Shayanfar A, Ghyasvand S, et al. Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery. J Bioact Compat Polym 2008;23:115-31.
-
(2008)
J Bioact Compat Polym
, vol.23
, pp. 115-131
-
-
Davaran, S.1
Omidi, Y.2
Rashidi, M.R.3
Anzabi, M.4
Shayanfar, A.5
Ghyasvand, S.6
-
26
-
-
33751253462
-
Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
-
des Rieux A, Fievez V, Garinot M, Schneider YJ, Preat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116:1-27.
-
(2006)
J Control Release
, vol.116
, pp. 1-27
-
-
des Rieux, A.1
Fievez, V.2
Garinot, M.3
Schneider, Y.J.4
Preat, V.5
-
27
-
-
84878835640
-
Targeted nanoparticles with novel non-peptidic ligands for oral delivery
-
des Rieux A, Pourcelle V, Cani PD, Marchand-Brynaert J, Preat V. Targeted nanoparticles with novel non-peptidic ligands for oral delivery. Adv Drug Deliv Rev 2013;65: 833-44.
-
(2013)
Adv Drug Deliv Rev
, vol.65
, pp. 833-844
-
-
des Rieux, A.1
Pourcelle, V.2
Cani, P.D.3
Marchand-Brynaert, J.4
Preat, V.5
-
28
-
-
38849181571
-
Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delivery system
-
Deutel B, GreindlM, Thaurer M, Bernkop-Schnurch A. Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delivery system. Biomacromolecules 2008;9:278-85.
-
(2008)
Biomacromolecules
, vol.9
, pp. 278-285
-
-
Deutel, B.1
Greindl, M.2
Thaurer, M.3
Bernkop-Schnurch, A.4
-
29
-
-
84901857109
-
Decanoic acid grafted oligochitosan nanoparticles as a carrier for insulin transport in the gastrointestinal tract
-
Du X, Zhang J, Zhang Y, Li S, Lin X, Tang X, et al. Decanoic acid grafted oligochitosan nanoparticles as a carrier for insulin transport in the gastrointestinal tract. Carbohydr Polym 2014;111:433-41.
-
(2014)
Carbohydr Polym
, vol.111
, pp. 433-441
-
-
Du, X.1
Zhang, J.2
Zhang, Y.3
Li, S.4
Lin, X.5
Tang, X.6
-
30
-
-
80052599281
-
Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin
-
Elsayed A, Al-Remawi M, Qinna N, Farouk A, Al-Sou'od KA, Badwan AA. Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin. AAPS PharmSciTech 2011;12:958-64.
-
(2011)
AAPS PharmSciTech
, vol.12
, pp. 958-964
-
-
Elsayed, A.1
Al-Remawi, M.2
Qinna, N.3
Farouk, A.4
Al-Sou'od, K.A.5
Badwan, A.A.6
-
31
-
-
0030938926
-
Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
-
Fasano A, Uzzau S. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest 1997;99:1158-64.
-
(1997)
J Clin Invest
, vol.99
, pp. 1158-1164
-
-
Fasano, A.1
Uzzau, S.2
-
32
-
-
2942702257
-
Issues in oral nanoparticle drug carrier uptake and targeting
-
Florence AT. Issues in oral nanoparticle drug carrier uptake and targeting. J Drug Target 2004;12:65-70.
-
(2004)
J Drug Target
, vol.12
, pp. 65-70
-
-
Florence, A.T.1
-
33
-
-
84886728300
-
Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying
-
Fonte P, Soares S, Costa A, Andrade J, Seabra V, Reis S, et al. Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying. Biomatter 2012;2:329-39.
-
(2012)
Biomatter
, vol.2
, pp. 329-339
-
-
Fonte, P.1
Soares, S.2
Costa, A.3
Andrade, J.4
Seabra, V.5
Reis, S.6
-
36
-
-
34347324085
-
Chitosan nanoparticle as protein delivery carrier-systematic examination of fabrication conditions for efficient loading and release
-
Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier-systematic examination of fabrication conditions for efficient loading and release. Colloids Surf B Biointerfaces 2007;59:24-34.
-
(2007)
Colloids Surf B Biointerfaces
, vol.59
, pp. 24-34
-
-
Gan, Q.1
Wang, T.2
-
37
-
-
0037393955
-
Challenges for the oral delivery of macromolecules
-
Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov 2003;2:289-95.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 289-295
-
-
Goldberg, M.1
Gomez-Orellana, I.2
-
38
-
-
33344469955
-
Oral insulin: fact or fiction? Possibilities of achieving oral delivery for insulin
-
Gowthamarajan K, Kulkarni G. Oral insulin: fact or fiction? Possibilities of achieving oral delivery for insulin. Resonance 2003;8:38-46.
-
(2003)
Resonance
, vol.8
, pp. 38-46
-
-
Gowthamarajan, K.1
Kulkarni, G.2
-
39
-
-
84866077717
-
Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery
-
HanL, ZhaoY, YinL, LiR, LiangY, HuangH, et al. Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery. AAPS PharmSciTech 2012;13:836-45.
-
(2012)
AAPS PharmSciTech
, vol.13
, pp. 836-845
-
-
Han, L.1
Zhao, Y.2
Yin, L.3
Li, R.4
Liang, Y.5
Huang, H.6
-
40
-
-
0037472115
-
Chitosan-based gastrointestinal delivery systems
-
Hejazi R, Amiji M. Chitosan-based gastrointestinal delivery systems. J Control Release 2003;89:151-65.
-
(2003)
J Control Release
, vol.89
, pp. 151-165
-
-
Hejazi, R.1
Amiji, M.2
-
42
-
-
68949208465
-
Nanocarriers' entry into the cell: relevance to drug delivery
-
Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009;66:2873-96.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2873-2896
-
-
Hillaireau, H.1
Couvreur, P.2
-
43
-
-
0028321502
-
Mechanisms of absorption enhancement and tight junction regulation
-
Hochman J, Artursson P. Mechanisms of absorption enhancement and tight junction regulation. J Control Release 1994;29:253-67.
-
(1994)
J Control Release
, vol.29
, pp. 253-267
-
-
Hochman, J.1
Artursson, P.2
-
44
-
-
79954501836
-
Nanoparticles and toxicity in therapeutic delivery: the ongoing debate
-
Hossain S, Chowdhury EH, Akaike T. Nanoparticles and toxicity in therapeutic delivery: the ongoing debate. Ther Deliv 2011;2:125-32.
-
(2011)
Ther Deliv
, vol.2
, pp. 125-132
-
-
Hossain, S.1
Chowdhury, E.H.2
Akaike, T.3
-
45
-
-
84905913947
-
Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery
-
Hosseininasab S, Pashaei-Asl R, Khandaghi AA, Nasrabadi HT, Nejati-Koshki K, Akbarzadeh A, et al. Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery. Chem Biol Drug Des 2014;84:307-15.
-
(2014)
Chem Biol Drug Des
, vol.84
, pp. 307-315
-
-
Hosseininasab, S.1
Pashaei-Asl, R.2
Khandaghi, A.A.3
Nasrabadi, H.T.4
Nejati-Koshki, K.5
Akbarzadeh, A.6
-
46
-
-
84955208521
-
-
[Access Pharmaceuticals web page]
-
http://www.accesspharma.com, 2014. [Access Pharmaceuticals web page].
-
(2014)
-
-
-
47
-
-
85031860576
-
-
[NanoMega Medical Corporation web page]
-
http://www.nanomegamedical.com, 2014. [NanoMega Medical Corporation web page].
-
(2014)
-
-
-
48
-
-
85031860086
-
-
NOD Pharmaceuticals, Inc. web page
-
http://www.nodpharm.com, 2014. NOD Pharmaceuticals, Inc. web page.
-
(2014)
-
-
-
49
-
-
73849132523
-
A novel insulin oral delivery system assisted by cationic ß-cyclodextrin polymers
-
Huang L, Xin J, Guo Y, Li J. A novel insulin oral delivery system assisted by cationic ß-cyclodextrin polymers. J Appl Polym Sci 2010;115:1371-9.
-
(2010)
J Appl Polym Sci
, vol.115
, pp. 1371-1379
-
-
Huang, L.1
Xin, J.2
Guo, Y.3
Li, J.4
-
50
-
-
84865606140
-
Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective
-
Hunter AC, Elsom J, Wibroe PP, Moghimi SM. Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective. Nanomedicine 2012; 8(Suppl. 1):S5-S20.
-
(2012)
Nanomedicine
, vol.8
, pp. S5-S20
-
-
Hunter, A.C.1
Elsom, J.2
Wibroe, P.P.3
Moghimi, S.M.4
-
51
-
-
84866688083
-
Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin
-
Jain S, Rathi VV, Jain AK, Das M, Godugu C. Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin. Nanomedicine (Lond) 2012;7:1311-37.
-
(2012)
Nanomedicine (Lond)
, vol.7
, pp. 1311-1337
-
-
Jain, S.1
Rathi, V.V.2
Jain, A.K.3
Das, M.4
Godugu, C.5
-
52
-
-
0035937593
-
Polysaccharide colloidal particles as delivery systems for macromolecules
-
Janes KA, Calvo P, Alonso MJ. Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Deliv Rev 2001;47:83-97.
-
(2001)
Adv Drug Deliv Rev
, vol.47
, pp. 83-97
-
-
Janes, K.A.1
Calvo, P.2
Alonso, M.J.3
-
53
-
-
11144358593
-
Intestinal villous M cells: an antigen entry site in the mucosal epithelium
-
Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A 2004;101:6110-5.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 6110-6115
-
-
Jang, M.H.1
Kweon, M.N.2
Iwatani, K.3
Yamamoto, M.4
Terahara, K.5
Sasakawa, C.6
-
54
-
-
78649906926
-
Development of pH-sensitive insulin nanoparticles using Eudragit L100-55 and chitosan with different molecular weights
-
JelvehgariM, Zakeri-Milani P, Siahi-ShadbadMR, Loveymi BD, Nokhodchi A, Azari Z, et al. Development of pH-sensitive insulin nanoparticles using Eudragit L100-55 and chitosan with different molecular weights. AAPS PharmSciTech 2010;11:1237-42.
-
(2010)
AAPS PharmSciTech
, vol.11
, pp. 1237-1242
-
-
Jelvehgari, M.1
Zakeri-Milani, P.2
Siahi-Shadbad, M.R.3
Loveymi, B.D.4
Nokhodchi, A.5
Azari, Z.6
-
55
-
-
83355173904
-
Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
-
Jin Y, Song Y, Zhu X, Zhou D, Chen C, Zhang Z, et al. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials 2012;33:1573-82.
-
(2012)
Biomaterials
, vol.33
, pp. 1573-1582
-
-
Jin, Y.1
Song, Y.2
Zhu, X.3
Zhou, D.4
Chen, C.5
Zhang, Z.6
-
56
-
-
67349268446
-
Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cellpenetrating peptides
-
Kamei N, Morishita M, Takayama K. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cellpenetrating peptides. J Control Release 2009;136:179-86.
-
(2009)
J Control Release
, vol.136
, pp. 179-186
-
-
Kamei, N.1
Morishita, M.2
Takayama, K.3
-
57
-
-
12344312013
-
Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model
-
Lane ME, O'Driscoll CM, Corrigan OI. Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. J Pharm Pharmacol 2005;57:169-75.
-
(2005)
J Pharm Pharmacol
, vol.57
, pp. 169-175
-
-
Lane, M.E.1
O'Driscoll, C.M.2
Corrigan, O.I.3
-
58
-
-
4444222974
-
Oil-based formulations for oral delivery of insulin
-
Li CL, Deng YJ. Oil-based formulations for oral delivery of insulin. J Pharm Pharmacol 2004;56:1101-7.
-
(2004)
J Pharm Pharmacol
, vol.56
, pp. 1101-1107
-
-
Li, C.L.1
Deng, Y.J.2
-
59
-
-
33845579346
-
Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats
-
Li MG, LuWL, Wang JC, Zhang X, Wang XQ, Zheng AP, et al. Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats. Int J Pharm 2007; 329:182-91.
-
(2007)
Int J Pharm
, vol.329
, pp. 182-191
-
-
Li, M.G.1
Lu, W.L.2
Wang, J.C.3
Zhang, X.4
Wang, X.Q.5
Zheng, A.P.6
-
60
-
-
33846410236
-
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery
-
Lin YH, Mi FL, Chen CT, ChangWC, Peng SF, Liang HF, et al. Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 2007;8:146-52.
-
(2007)
Biomacromolecules
, vol.8
, pp. 146-152
-
-
Lin, Y.H.1
Mi, F.L.2
Chen, C.T.3
Chang, W.C.4
Peng, S.F.5
Liang, H.F.6
-
61
-
-
56649089693
-
Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs
-
Lin YH, Sonaje K, Lin KM, Juang JH, Mi FL, Yang HW, et al. Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release 2008;132:141-9.
-
(2008)
J Control Release
, vol.132
, pp. 141-149
-
-
Lin, Y.H.1
Sonaje, K.2
Lin, K.M.3
Juang, J.H.4
Mi, F.L.5
Yang, H.W.6
-
62
-
-
0344876583
-
Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats
-
Liu H, Tang R, Pan WS, Zhang Y, Liu H. Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats. J Pharm Pharmacol 2003;55: 1523-9.
-
(2003)
J Pharm Pharmacol
, vol.55
, pp. 1523-1529
-
-
Liu, H.1
Tang, R.2
Pan, W.S.3
Zhang, Y.4
Liu, H.5
-
63
-
-
84875913755
-
Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin
-
Liu X, Liu C, ZhangW, Xie C, Wei G, LuW. Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin. Int J Pharm 2013;448:159-67.
-
(2013)
Int J Pharm
, vol.448
, pp. 159-167
-
-
Liu, X.1
Liu, C.2
Zhang, W.3
Xie, C.4
Wei, G.5
Lu, W.6
-
64
-
-
0036282756
-
Formulation pHmodulates the interaction of insulinwith chitosan nanoparticles
-
Ma Z, Yeoh HH, LimLY. Formulation pHmodulates the interaction of insulinwith chitosan nanoparticles. J Pharm Sci 2002;91:1396-404.
-
(2002)
J Pharm Sci
, vol.91
, pp. 1396-1404
-
-
Ma, Z.1
Yeoh, H.H.2
Lim, L.Y.3
-
65
-
-
15044355133
-
Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats
-
Ma Z, Lim TM, Lim LY. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm 2005;293:271-80.
-
(2005)
Int J Pharm
, vol.293
, pp. 271-280
-
-
Ma, Z.1
Lim, T.M.2
Lim, L.Y.3
-
66
-
-
79954628593
-
Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery
-
Makhlof A, Tozuka Y, Takeuchi H. Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci 2011;42:445-51.
-
(2011)
Eur J Pharm Sci
, vol.42
, pp. 445-451
-
-
Makhlof, A.1
Tozuka, Y.2
Takeuchi, H.3
-
67
-
-
11144279341
-
Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles
-
Mesiha MS, Sidhom MB, Fasipe B. Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles. Int J Pharm 2005;288:289-93.
-
(2005)
Int J Pharm
, vol.288
, pp. 289-293
-
-
Mesiha, M.S.1
Sidhom, M.B.2
Fasipe, B.3
-
68
-
-
33748752402
-
Is the oral route possible for peptide and protein drug delivery?
-
Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov Today 2006;11:905-10.
-
(2006)
Drug Discov Today
, vol.11
, pp. 905-910
-
-
Morishita, M.1
Peppas, N.A.2
-
69
-
-
84867262237
-
Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review
-
Mukhopadhyay P, Mishra R, Rana D, Kundu PP. Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review. Prog Polym Sci 2012;37:1457-75.
-
(2012)
Prog Polym Sci
, vol.37
, pp. 1457-1475
-
-
Mukhopadhyay, P.1
Mishra, R.2
Rana, D.3
Kundu, P.P.4
-
70
-
-
84869087095
-
Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model
-
Mukhopadhyay P, Sarkar K, Chakraborty M, Bhattacharya S, Mishra R, Kundu PP. Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model. Mater Sci Eng C 2013;33:376-82.
-
(2013)
Mater Sci Eng C
, vol.33
, pp. 376-382
-
-
Mukhopadhyay, P.1
Sarkar, K.2
Chakraborty, M.3
Bhattacharya, S.4
Mishra, R.5
Kundu, P.P.6
-
71
-
-
84885551237
-
Chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals
-
Sarmento B, das Neves J, editors. John Wiley & Sons, Ltd
-
Muzzarelli R. Chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals. In: Sarmento B, das Neves J, editors. Chitosanbased systems for biopharmaceuticals: delivery, targeting and polymer therapeutics. John Wiley & Sons, Ltd; 2012. p. 3-21.
-
(2012)
Chitosanbased systems for biopharmaceuticals: delivery, targeting and polymer therapeutics
, pp. 3-21
-
-
Muzzarelli, R.1
-
72
-
-
84904003181
-
In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cellpenetrating peptide penetratin
-
Nielsen EJB, Yoshida S, Kamei N, Iwamae R, Khafagy E-S, Olsen J, et al. In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cellpenetrating peptide penetratin. J Control Release 2014;189:19-24.
-
(2014)
J Control Release
, vol.189
, pp. 19-24
-
-
Nielsen, E.J.B.1
Yoshida, S.2
Kamei, N.3
Iwamae, R.4
Khafagy, E.-S.5
Olsen, J.6
-
73
-
-
0037027876
-
Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo
-
Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, Wei G, et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 2002;249:139-47.
-
(2002)
Int J Pharm
, vol.249
, pp. 139-147
-
-
Pan, Y.1
Li, Y.J.2
Zhao, H.Y.3
Zheng, J.M.4
Xu, H.5
Wei, G.6
-
74
-
-
70349329277
-
Insulin-loaded poly(acrylic acid)-cysteine nanoparticles: stability studies towards digestive enzymes of the intestine
-
Perera G, Greindl M, Palmberger TF, Bernkop-Schnürch A. Insulin-loaded poly(acrylic acid)-cysteine nanoparticles: stability studies towards digestive enzymes of the intestine. Drug Deliv 2009;16:254-60.
-
(2009)
Drug Deliv
, vol.16
, pp. 254-260
-
-
Perera, G.1
Greindl, M.2
Palmberger, T.F.3
Bernkop-Schnürch, A.4
-
77
-
-
47049129381
-
Toxicological in vivo studies of an oral insulin nanosystem
-
Reis CP, Veiga F, Nunes P, Soares AF, Laranjeira T, Carvalho R, et al. Toxicological in vivo studies of an oral insulin nanosystem. Toxicol Lett 2007;172:S90-S.
-
(2007)
Toxicol Lett
, vol.172
, pp. S90-S90
-
-
Reis, C.P.1
Veiga, F.2
Nunes, P.3
Soares, A.F.4
Laranjeira, T.5
Carvalho, R.6
-
78
-
-
57349099275
-
Toxicological assessment of orally delivered nanoparticulate insulin
-
Reis CP, Figueiredo IV, Carvalho RA, Jones J, Nunes P, Soares AF, et al. Toxicological assessment of orally delivered nanoparticulate insulin. Nanotoxicology 2008;2: 205-17.
-
(2008)
Nanotoxicology
, vol.2
, pp. 205-217
-
-
Reis, C.P.1
Figueiredo, I.V.2
Carvalho, R.A.3
Jones, J.4
Nunes, P.5
Soares, A.F.6
-
79
-
-
84866734897
-
In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles
-
Reix N, Parat A, Seyfritz E, Van Der Werf R, Epure V, Ebel N, et al. In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles. Int J Pharm 2012;437:213-20.
-
(2012)
Int J Pharm
, vol.437
, pp. 213-220
-
-
Reix, N.1
Parat, A.2
Seyfritz, E.3
Van Der Werf, R.4
Epure, V.5
Ebel, N.6
-
80
-
-
62849083225
-
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption
-
Rekha MR, Sharma CP. Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J Control Release 2009;135:144-51.
-
(2009)
J Control Release
, vol.135
, pp. 144-151
-
-
Rekha, M.R.1
Sharma, C.P.2
-
81
-
-
84871617217
-
Oral delivery of therapeutic protein/peptide for diabetes-future perspectives
-
Rekha MR, Sharma CP. Oral delivery of therapeutic protein/peptide for diabetes-future perspectives. Int J Pharm 2013;440:48-62.
-
(2013)
Int J Pharm
, vol.440
, pp. 48-62
-
-
Rekha, M.R.1
Sharma, C.P.2
-
82
-
-
41349110165
-
Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods
-
Sadeghi AM, Dorkoosh FA, Avadi MR, Saadat P, Rafiee-Tehrani M, Junginger HE. Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods. Int J Pharm 2008a;355:299-306.
-
(2008)
Int J Pharm
, vol.355
, pp. 299-306
-
-
Sadeghi, A.M.1
Dorkoosh, F.A.2
Avadi, M.R.3
Saadat, P.4
Rafiee-Tehrani, M.5
Junginger, H.E.6
-
83
-
-
50249129610
-
Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells
-
Sadeghi AM, Dorkoosh FA, Avadi MR, Weinhold M, Bayat A, Delie F, et al. Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur J Pharm Biopharm 2008b;70:270-8.
-
(2008)
Eur J Pharm Biopharm
, vol.70
, pp. 270-278
-
-
Sadeghi, A.M.1
Dorkoosh, F.A.2
Avadi, M.R.3
Weinhold, M.4
Bayat, A.5
Delie, F.6
-
84
-
-
33750008879
-
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery
-
Sajeesh S, Sharma CP. Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm 2006;325:147-54.
-
(2006)
Int J Pharm
, vol.325
, pp. 147-154
-
-
Sajeesh, S.1
Sharma, C.P.2
-
85
-
-
77950916224
-
Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties
-
Sandri G, Bonferoni MC, Rossi S, Ferrari F, Boselli C, Caramella C. Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties. AAPS PharmSciTech 2010;11:362-71.
-
(2010)
AAPS PharmSciTech
, vol.11
, pp. 362-371
-
-
Sandri, G.1
Bonferoni, M.C.2
Rossi, S.3
Ferrari, F.4
Boselli, C.5
Caramella, C.6
-
87
-
-
33751348253
-
Development and characterization of new insulin containing polysaccharide nanoparticles
-
Sarmento B, Ribeiro A, Veiga F, Ferreira D. Development and characterization of new insulin containing polysaccharide nanoparticles. Colloids Surf B Biointerfaces 2006; 53:193-202.
-
(2006)
Colloids Surf B Biointerfaces
, vol.53
, pp. 193-202
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
Ferreira, D.4
-
88
-
-
34948841373
-
Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles
-
Sarmento B, Ferreira DC, Jorgensen L, van deWeert M. Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles. Eur J Pharm Biopharm 2007a;65:10-7.
-
(2007)
Eur J Pharm Biopharm
, vol.65
, pp. 10-17
-
-
Sarmento, B.1
Ferreira, D.C.2
Jorgensen, L.3
van deWeert, M.4
-
89
-
-
35549012407
-
Oral bioavailability of insulin contained in polysaccharide nanoparticles
-
Sarmento B, Ribeiro A, Veiga F, Ferreira D, Neufeld R. Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules 2007b;8:3054-60.
-
(2007)
Biomacromolecules
, vol.8
, pp. 3054-3060
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
Ferreira, D.4
Neufeld, R.5
-
90
-
-
35848959714
-
Alginate/chitosan nanoparticles are effective for oral insulin delivery
-
Sarmento B, Ribeiro A, Veiga F, Sampaio P, Neufeld R, Ferreira D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res 2007c;24:2198-206.
-
(2007)
Pharm Res
, vol.24
, pp. 2198-2206
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
Sampaio, P.4
Neufeld, R.5
Ferreira, D.6
-
91
-
-
35348917098
-
Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation
-
Sarmento B, Ribeiro AJ, Veiga F, Ferreira DC, Neufeld RJ. Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation. J Nanosci Nanotechnol 2007d;7:2833-41.
-
(2007)
J Nanosci Nanotechnol
, vol.7
, pp. 2833-2841
-
-
Sarmento, B.1
Ribeiro, A.J.2
Veiga, F.3
Ferreira, D.C.4
Neufeld, R.J.5
-
92
-
-
84871615592
-
Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: development, pharmacokinetics, biodistribution and pharmacodynamics
-
Sharma G, van der Walle CF, Ravi Kumar MNV. Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: development, pharmacokinetics, biodistribution and pharmacodynamics. Int J Pharm 2013;440:99-110.
-
(2013)
Int J Pharm
, vol.440
, pp. 99-110
-
-
Sharma, G.1
van der Walle, C.F.2
Ravi Kumar, M.N.V.3
-
93
-
-
67349179610
-
Nanoparticle-based targeted drug delivery
-
Singh R, Lillard Jr J. Nanoparticle-based targeted drug delivery. Exp Mol Pathol 2009;86: 215-23.
-
(2009)
Exp Mol Pathol
, vol.86
, pp. 215-223
-
-
Singh, R.1
Lillard, J.2
-
94
-
-
10644263255
-
Involvement of protein kinase C in chitosan glutamatemediated tight junction disruption
-
Smith JM, Dornish M, Wood EJ. Involvement of protein kinase C in chitosan glutamatemediated tight junction disruption. Biomaterials 2005;26:3269-76.
-
(2005)
Biomaterials
, vol.26
, pp. 3269-3276
-
-
Smith, J.M.1
Dornish, M.2
Wood, E.J.3
-
95
-
-
70350322768
-
Influence of polymers ratio on insulin-loaded nanoparticles based on poly-e-caprolactone and Eudragit® RS for oral administration
-
Socha M, Sapin A, Damgé C, Maincent P. Influence of polymers ratio on insulin-loaded nanoparticles based on poly-e-caprolactone and Eudragit® RS for oral administration. Drug Deliv 2009;16:430-6.
-
(2009)
Drug Deliv
, vol.16
, pp. 430-436
-
-
Socha, M.1
Sapin, A.2
Damgé, C.3
Maincent, P.4
-
96
-
-
60849130683
-
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
-
Sonaje K, Lin YH, Juang JH, Wey SP, Chen CT, Sung HW. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009; 30:2329-39.
-
(2009)
Biomaterials
, vol.30
, pp. 2329-2339
-
-
Sonaje, K.1
Lin, Y.H.2
Juang, J.H.3
Wey, S.P.4
Chen, C.T.5
Sung, H.W.6
-
97
-
-
76749103819
-
Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery
-
Sonaje K, Chen YJ, Chen HL, Wey SP, Juang JH, Nguyen HN, et al. Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010;31:3384-94.
-
(2010)
Biomaterials
, vol.31
, pp. 3384-3394
-
-
Sonaje, K.1
Chen, Y.J.2
Chen, H.L.3
Wey, S.P.4
Juang, J.H.5
Nguyen, H.N.6
-
98
-
-
84860726458
-
Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultrastructural, and computed-tomographic observations
-
Sonaje K, Chuang EY, Lin KJ, Yen TC, Su FY, TsengMT, et al. Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultrastructural, and computed-tomographic observations. Mol Pharm 2012;9:1271-9.
-
(2012)
Mol Pharm
, vol.9
, pp. 1271-1279
-
-
Sonaje, K.1
Chuang, E.Y.2
Lin, K.J.3
Yen, T.C.4
Su, F.Y.5
Tseng, M.T.6
-
99
-
-
84910640276
-
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review
-
Sosnik A, das Neves J, Sarmento B. Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci 2014;39:2030-75.
-
(2014)
Prog Polym Sci
, vol.39
, pp. 2030-2075
-
-
Sosnik, A.1
das Neves, J.2
Sarmento, B.3
-
100
-
-
0036105205
-
Development of oral insulin: progress and current status
-
Still JG. Development of oral insulin: progress and current status. Diabetes Metab Res Rev 2002;18(Suppl. 1):S29-37.
-
(2002)
Diabetes Metab Res Rev
, vol.18
, pp. S29-S37
-
-
Still, J.G.1
-
101
-
-
84855967689
-
Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery
-
Su FY, Lin KJ, Sonaje K, Wey SP, Yen TC, Ho YC, et al. Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery. Biomaterials 2012;33:2801-11.
-
(2012)
Biomaterials
, vol.33
, pp. 2801-2811
-
-
Su, F.Y.1
Lin, K.J.2
Sonaje, K.3
Wey, S.P.4
Yen, T.C.5
Ho, Y.C.6
-
102
-
-
77955451745
-
Insulin-S.O. (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation
-
Sun S, Liang N, Piao H, Yamamoto H, Kawashima Y, Cui F. Insulin-S.O. (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation. J Microencapsul 2010;27:471-8.
-
(2010)
J Microencapsul
, vol.27
, pp. 471-478
-
-
Sun, S.1
Liang, N.2
Piao, H.3
Yamamoto, H.4
Kawashima, Y.5
Cui, F.6
-
103
-
-
84859891864
-
pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications
-
Sung HW, Sonaje K, Liao ZX, Hsu LW, Chuang EY. pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc Chem Res 2012;45:619-29.
-
(2012)
Acc Chem Res
, vol.45
, pp. 619-629
-
-
Sung, H.W.1
Sonaje, K.2
Liao, Z.X.3
Hsu, L.W.4
Chuang, E.Y.5
-
104
-
-
67349139863
-
The complexation between novel comb shaped amphiphilic polyallylamine and insulin-towards oral insulin delivery
-
Thompson CJ, Tetley L, Uchegbu IF, Cheng WP. The complexation between novel comb shaped amphiphilic polyallylamine and insulin-towards oral insulin delivery. Int J Pharm 2009;376:46-55.
-
(2009)
Int J Pharm
, vol.376
, pp. 46-55
-
-
Thompson, C.J.1
Tetley, L.2
Uchegbu, I.F.3
Cheng, W.P.4
-
105
-
-
70449532115
-
The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin-towards oral insulin delivery
-
Thompson CJ, Tetley L, ChengWP. The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin-towards oral insulin delivery. Int J Pharm 2010;383:216-27.
-
(2010)
Int J Pharm
, vol.383
, pp. 216-227
-
-
Thompson, C.J.1
Tetley, L.2
Cheng, W.P.3
-
106
-
-
79955619433
-
Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by Caco-2 cells-towards oral insulin
-
Thompson CJ, ChengW, Gadad P, Skene K, Smith M, Smith G, et al. Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by Caco-2 cells-towards oral insulin. Pharm Res 2011;28:886-96.
-
(2011)
Pharm Res
, vol.28
, pp. 886-896
-
-
Thompson, C.J.1
Cheng, W.2
Gadad, P.3
Skene, K.4
Smith, M.5
Smith, G.6
-
107
-
-
85055435802
-
pH responsive polymeric nanoparticles for oral insulin delivery
-
Tyagi C, Tomar L, Kumar P, Choonara YE, Toit LD, Singh H, et al. pH responsive polymeric nanoparticles for oral insulin delivery. Int J Pharm Pharmacol Tech 2012:1.
-
(2012)
Int J Pharm Pharmacol Tech
, pp. 1
-
-
Tyagi, C.1
Tomar, L.2
Kumar, P.3
Choonara, Y.E.4
Toit, L.D.5
Singh, H.6
-
108
-
-
3843146208
-
Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs
-
van der Merwe SM, Verhoef JC, Verheijden JH, Kotze AF, Junginger HE. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm 2004;58:225-35.
-
(2004)
Eur J Pharm Biopharm
, vol.58
, pp. 225-235
-
-
van der Merwe, S.M.1
Verhoef, J.C.2
Verheijden, J.H.3
Kotze, A.F.4
Junginger, H.E.5
-
109
-
-
46749090384
-
Synthesis, characterization and in vitro biological properties of O-methyl free N, N, N-trimethylated chitosan
-
Verheul RJ, Amidi M, van der Wal S, van Riet E, Jiskoot W, Hennink WE. Synthesis, characterization and in vitro biological properties of O-methyl free N, N, N-trimethylated chitosan. Biomaterials 2008;29:3642-9.
-
(2008)
Biomaterials
, vol.29
, pp. 3642-3649
-
-
Verheul, R.J.1
Amidi, M.2
van der Wal, S.3
van Riet, E.4
Jiskoot, W.5
Hennink, W.E.6
-
111
-
-
82955247909
-
IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030
-
Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21.
-
(2011)
Diabetes Res Clin Pract
, vol.94
, pp. 311-321
-
-
Whiting, D.R.1
Guariguata, L.2
Weil, C.3
Shaw, J.4
-
112
-
-
2342466734
-
Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
-
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
-
(2004)
Diabetes Care
, vol.27
, pp. 1047-1053
-
-
Wild, S.1
Roglic, G.2
Green, A.3
Sicree, R.4
King, H.5
-
113
-
-
77957264181
-
Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles
-
Woitiski CB, Neufeld RJ, Veiga F, Carvalho RA, Figueiredo IV. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur J Pharm Sci 2010;41:556-63.
-
(2010)
Eur J Pharm Sci
, vol.41
, pp. 556-563
-
-
Woitiski, C.B.1
Neufeld, R.J.2
Veiga, F.3
Carvalho, R.A.4
Figueiredo, I.V.5
-
114
-
-
79957529691
-
Facilitated nanoscale delivery of insulin across intestinal membrane models
-
Woitiski CB, Sarmento B, Carvalho RA, Neufeld RJ, Veiga F. Facilitated nanoscale delivery of insulin across intestinal membrane models. Int J Pharm 2011;412:123-31.
-
(2011)
Int J Pharm
, vol.412
, pp. 123-131
-
-
Woitiski, C.B.1
Sarmento, B.2
Carvalho, R.A.3
Neufeld, R.J.4
Veiga, F.5
-
115
-
-
84868371710
-
Evaluation of hepatic glucose metabolismvia gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles
-
Woitiski CB, Neufeld RJ, Soares AF, Figueiredo IV, Veiga FJ, Carvalho RA. Evaluation of hepatic glucose metabolismvia gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles. Drug Dev Ind Pharm 2012;38:1441-50.
-
(2012)
Drug Dev Ind Pharm
, vol.38
, pp. 1441-1450
-
-
Woitiski, C.B.1
Neufeld, R.J.2
Soares, A.F.3
Figueiredo, I.V.4
Veiga, F.J.5
Carvalho, R.A.6
-
116
-
-
84864023319
-
Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery
-
Wu ZM, Ling L, Zhou LY, Guo XD, Jiang W, Qian Y, et al. Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery. Nanoscale Res Lett 2012a;7:299.
-
(2012)
Nanoscale Res Lett
, vol.7
, pp. 299
-
-
Wu, Z.M.1
Ling, L.2
Zhou, L.Y.3
Guo, X.D.4
Jiang, W.5
Qian, Y.6
-
117
-
-
84862777724
-
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin
-
Wu ZM, Zhou L, Guo XD, Jiang W, Ling L, Qian Y, et al. HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. Int J Pharm 2012b;425:1-8.
-
(2012)
Int J Pharm
, vol.425
, pp. 1-8
-
-
Wu, Z.M.1
Zhou, L.2
Guo, X.D.3
Jiang, W.4
Ling, L.5
Qian, Y.6
-
118
-
-
34249904641
-
Vesicles from pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery
-
Xiong XY, Li YP, Li ZL, Zhou CL, Tam KC, Liu ZY, et al. Vesicles from pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. J Control Release 2007;120:11-7.
-
(2007)
J Control Release
, vol.120
, pp. 11-17
-
-
Xiong, X.Y.1
Li, Y.P.2
Li, Z.L.3
Zhou, C.L.4
Tam, K.C.5
Liu, Z.Y.6
-
119
-
-
84880392606
-
Pluronic P85/poly(lactic acid) vesicles as novel carrier for oral insulin delivery
-
Xiong XY, Li QH, Li YP, Guo L, Li ZL, Gong YC. Pluronic P85/poly(lactic acid) vesicles as novel carrier for oral insulin delivery. Colloids Surf B Biointerfaces 2013;111:282-8.
-
(2013)
Colloids Surf B Biointerfaces
, vol.111
, pp. 282-288
-
-
Xiong, X.Y.1
Li, Q.H.2
Li, Y.P.3
Guo, L.4
Li, Z.L.5
Gong, Y.C.6
-
120
-
-
84862777284
-
Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles
-
Yang J, Sun H, Song C. Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles. Diabetes Obes Metab 2012;14:358-64.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 358-364
-
-
Yang, J.1
Sun, H.2
Song, C.3
-
121
-
-
79959876473
-
Mechanismand consequence of chitosan-mediated reversible epithelial tight junction opening
-
Yeh TH, Hsu LW, Tseng MT, Lee PL, Sonjae K, Ho YC, et al. Mechanismand consequence of chitosan-mediated reversible epithelial tight junction opening. Biomaterials 2011;32: 6164-73.
-
(2011)
Biomaterials
, vol.32
, pp. 6164-6173
-
-
Yeh, T.H.1
Hsu, L.W.2
Tseng, M.T.3
Lee, P.L.4
Sonjae, K.5
Ho, Y.C.6
-
122
-
-
68549122512
-
Drug permeability andmucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
-
Yin L, Ding J, He C, Cui L, Tang C, Yin C. Drug permeability andmucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 2009; 30:5691-700.
-
(2009)
Biomaterials
, vol.30
, pp. 5691-5700
-
-
Yin, L.1
Ding, J.2
He, C.3
Cui, L.4
Tang, C.5
Yin, C.6
-
123
-
-
77953364193
-
Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles
-
Zhang N, Li J, Jiang W, Ren C, Xin J, Li K. Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles. Int J Pharm 2010;393:212-8.
-
(2010)
Int J Pharm
, vol.393
, pp. 212-218
-
-
Zhang, N.1
Li, J.2
Jiang, W.3
Ren, C.4
Xin, J.5
Li, K.6
-
124
-
-
84862828348
-
Preparation and characterization of insulinloaded bioadhesive PLGA nanoparticles for oral administration
-
Zhang X, Sun M, Zheng A, Cao D, Bi Y, Sun J. Preparation and characterization of insulinloaded bioadhesive PLGA nanoparticles for oral administration. Eur J PharmSci 2012; 45:632-8.
-
(2012)
Eur J PharmSci
, vol.45
, pp. 632-638
-
-
Zhang, X.1
Sun, M.2
Zheng, A.3
Cao, D.4
Bi, Y.5
Sun, J.6
-
125
-
-
84865299530
-
Thiolated Eudragit nanoparticles for oral insulin delivery: preparation, characterization and in vivo evaluation
-
Zhang Y, Wu X, Meng L, Zhang Y, Ai R, Qi N, et al. Thiolated Eudragit nanoparticles for oral insulin delivery: preparation, characterization and in vivo evaluation. Int J Pharm 2012;436:341-50.
-
(2012)
Int J Pharm
, vol.436
, pp. 341-350
-
-
Zhang, Y.1
Wu, X.2
Meng, L.3
Zhang, Y.4
Ai, R.5
Qi, N.6
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