Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery

AAPS PharmSciTech

Volumn 13, Issue 3, 2012, Pages 836-845

  Han, Lina ^a,b   Zhao, Yuefang ^a,b   Yin, Lifang ^a,b   Li, Ruiming ^a   Liang, Yang ^a,b   Huang, Huan ^a,b   Pan, Shirong ^a   Wu, Chuanbin ^a,b   Feng, Min ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b Research and Development Center of Pharmaceutics of Guangdong Province   (China)

Author keywords

high entrapment efficiency; hyaluronic acid nanoparticles; insulin; pH sensitive; transcellular delivery

Indexed keywords

HYALURONIC ACID; NANOPARTICLE; RECOMBINANT HUMAN INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; DUODENUM; EMULSION; EPITHELIUM CELL; FREEZE DRYING; HUMAN; HUMAN CELL; ILEUM; MALE; MEMBRANE PERMEABILITY; MONOLAYER CULTURE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; SMALL INTESTINE; STOMACH ACID SECRETION; STREPTOZOCIN DIABETES; TRANSCYTOSIS;

ANIMALS; CACO-2 CELLS; DRUG DELIVERY SYSTEMS; HUMANS; HYALURONIC ACID; HYDROGEN-ION CONCENTRATION; INSULIN; NANOPARTICLES; ORGAN CULTURE TECHNIQUES; RATS; TRANSCYTOSIS;

EID: 84866077717     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9807-2     Document Type: Article

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