In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles

International Journal of Pharmaceutics

Volumn 437, Issue 1-2, 2012, Pages 213-220

  Reix, Nathalie ^a   Parat, Audrey ^b   Seyfritz, Elodie ^a   Van Der Werf, Remmelt ^a,c   Epure, Virginia ^a,b   Ebel, Nicolas ^b   Danicher, Louis ^a,b   Marchioni, Eric ^c   Jeandidier, Nathalie ^a,c   Pinget, Michel ^a,c   Frère, Yves ^b   Sigrist, Séverine ^a  

^a Centre Europeen d'Etude du Diabete   (France)

^b INSTITUT CHARLES SADRON   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Caco 2 cells; Endocytosis; Exocytosis; Insulin; Nanoparticles; PLGA

Indexed keywords

CLATHRIN; INSULIN; NANOPARTICLE; POLYGLACTIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BASOLATERAL MEMBRANE; CELL FATE; CELL MIGRATION; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TRANSPORT; EMULSION; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTRACELLULAR SPACE; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; ENDOCYTOSIS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; INTESTINES; LACTIC ACID; MALE; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, WISTAR;

EID: 84866734897     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.024     Document Type: Article

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