Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: Development, pharmacokinetics, biodistribution and pharmacodynamics

International Journal of Pharmaceutics

Volumn 440, Issue 1, 2013, Pages 99-110

  Sharma, G ^a   Van Der Walle, C F ^a   Ravi Kumar, M N V ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Biodegradable; Hyperglycemia; Inflammation; Nanoparticles; Oral delivery

Indexed keywords

ANTACID AGENT; C REACTIVE PROTEIN; CHOLESTEROL; DIDODECYLDIMETHYLAMMONIUM BROMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; INTERLEUKIN 6; MAGNESIUM HYDROXIDE; NANOPARTICLE; POLYESTER; POLYGLACTIN; POLYMER; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ZINC CARBONATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG FORMULATION; DRUG QUALITY; DRUG STRUCTURE; FLUORESCENCE; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN DEGRADATION; MALE; NANOENCAPSULATION; NONHUMAN; OUTCOME ASSESSMENT; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TREATMENT RESPONSE;

ADMINISTRATION, ORAL; ANIMALS; ANTACIDS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; MALE; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84871615592     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.12.038     Document Type: Article

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