Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation

Journal of Controlled Release

Volumn 114, Issue 2, 2006, Pages 242-250

  Cui, Fude ^a   Shi, Kai ^a   Zhang, Liqiang ^a   Tao, Anjin ^a   Kawashima, Yoshiaki ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Complex; Insulin; Nanoparticles; Oral delivery; Reverse micelles

Indexed keywords

BIODEGRADATION; COMPLEXATION; DRUG PRODUCTS; EVAPORATION; INSULIN; LIPIDS; MICELLES; X RAY DIFFRACTION;

NANOPARTICLES; ORAL DELIVERY; REVERSE MICELLES; SOLUBILIZATION;

NANOSTRUCTURED MATERIALS;

GLUCOSE; INSULIN; NANOPARTICLE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POLYMER; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BIODEGRADABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DIABETES MELLITUS; DIET RESTRICTION; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; EVAPORATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INFRARED RADIATION; MALE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; REVERSE MICELLE; SOLUBILIZATION; ULTRACENTRIFUGATION; ULTRAFILTRATION; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ALGORITHMS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; BLOOD GLUCOSE; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, EXPERIMENTAL; EXCIPIENTS; FREEZE DRYING; HALF-LIFE; HYPOGLYCEMIC AGENTS; INDICATORS AND REAGENTS; INSULIN; LACTIC ACID; MALE; MICELLES; NANOSTRUCTURES; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; POLYGLYCOLIC ACID; POLYMERS; RATS; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED;

EID: 33747884001     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.05.013     Document Type: Article

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