Thiolated Eudragit nanoparticles for oral insulin delivery: Preparation, characterization and in vivo evaluation

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 341-350

  Zhang, Yan ^a   Wu, Xiaorong ^a   Meng, Lingkuo ^a   Zhang, Yu ^a   Ai, Ruiting ^b   Qi, Na ^a   He, Haibing ^a   Xu, Hui ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b National Center for Biotechnology Development   (China)

Author keywords

Eudragit L100; Insulin nanoparticles; Mucoadhesion; Oral administration; pH responsive; Thiomer

Indexed keywords

CARBOXYLIC ACID; CYSTEINE; EUDRAGIT; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINES; MALE; NANOPARTICLES; POLYMETHACRYLIC ACIDS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

EID: 84865299530     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.06.054     Document Type: Article

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