Oil-based formulations for oral delivery of insulin

Journal of Pharmacy and Pharmacology

Volumn 56, Issue 9, 2004, Pages 1101-1107

  Li, Chun Lei ^a   Deng, Ying Jie ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EDETIC ACID; GLUCOSE; INSULIN; LIPOSOME; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EMULSION; ENZYME INHIBITION; FREEZE DRYING; HYPOGLYCEMIA; IN VIVO STUDY; INTESTINE MOTILITY; MALE; MICELLE; NONHUMAN; RABBIT; RAT; RAT STRAIN; ROOM TEMPERATURE; SOLUBILIZATION;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; INSULIN; MALE; OILS; RABBITS; RATS; RATS, WISTAR;

EID: 4444222974     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357044175     Document Type: Article

References (25)

1. Bernkop-Schnurch, A. (1998) The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release 52: 1-16,
2. Bernkop-Schnurch, A., Krajicek, M. E. (1998) Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J. Control. Release 50: 215-223
3. Cournarie, F., Auchere, D., Chevenne, D., Lacour, B., Seiller, M., Vauthier, C. (2002) Absorption and efficiency of insulin after oral administration of insulin-loaded nanocapsules in diabetic rats. Int. J. Pharm. 242: 325-328
4. Damge, C., Vranckx, H., Balschmidt, P., Couvreur, P. (1997) Poly(alkyl cyanoacrylate) nanospheres for oral administration of insulin. J. Pharm. Sci. 86: 1403-1409
5. Fix, J. A. (1996) Strategies for delivery of peptides utilizing absorption-enhancing agents. J. Pharm. Sci. 85: 1282-1285
6. Hansen, M. B. (2003) Neurolmmoral control of gastrointestinal motility. Physiol. Res. 52: 1-30
7. Hosny, E. A., Ghilzai, N. M. K., Elmazar, M. M. (1997) Promotion of oral insulin absorption in diabetic rabbits using pH-dependent coated capsules containing sodium cholate. Pharm. Acta Helv. 72: 203-207
8. Hosny, E. A., Al-Shora, H. I., Elmazar, M. M. A. (2002) Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs. Int. J. Pharm. 237:71-76
9. Kisel, M. A., Kulik, L. N., Tsybovsky, I. S., Vlasov, A. P., Vorob'yov, M. S., Kholodova, E. A., Zabarovskaya, Z. V. (2001) Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat. Int. J. Pharm. 216: 105-114
10. Lowman, A. M., Morishita, M., Kajita, M., Nagai, T., Peppas, N. A. (1999) Oral delivery of insulin using pH-responsive complexation gel. J. Pharm. Sci. 88: 933-937
11. Luisi, P. L., Giomini, M., Pileni, M. P., Robinson, B. H. (1988) Reverse micelles as hosts for proteins and small molecules. Biochim. Biophys. Acta 947: 209-246
12. 2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol. Pharm. Bull. 16: 68-72
13. Muramatsu, K., Maitani, Y., Nagai, T. (1996) DPPC liposomes with soybean-derived sterols and cholesterol as a carrier for the oral administration of insulin in rats. Biol. Pharm. Bull. 19: 1055-1058
14. New, R. R. C., Kirby, C. J. (1997) Solubilization of hydropohilic drugs in oily formulations. Adv. Drug Deliv. Rev. 25: 59-69
15. Nordskog, B. K., Phan, C. T., Nutting, D. F., Tso, P. (2001) An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv. Drug Deliv. Rev. 50: 21-44
16. Olsson, C., Holmgren, S. (2001) The control of gut motility. Comp. Biochem. Phys. A. 128: 481-503
17. Pillai, O., Panchagnula, R. (2001) Insulin therapies - past, present and future. Drug Discov. Today 6: 1056-1061
18. Pouton, C. W. (2000) Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur. J. Pharm. Sci. 11 (Suppl. 2): S93-S98
19. Radwan, M. A. (2001) Enhancement of absorption of insulin-loaded polyisobutylcyanoacrylate nanospheres by sodium cholate after oral and subcutaneous administration in diabetic rats. Drug Dev. Ind. Pharm. 27: 981-989
20. Shimoda, J., Onishi, H., Machida, Y. (2001) Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine. Drug Dev. Ind. Pharm. 27: 567-576
21. Tomita, M., Hayashi, NT., Awazu, S. (1994) Comparison of absorption-enhancing effect between sodium caprate and disodium ethylenediaminetetraacetate in Caco-2 cells. Biol. Pharm. Bull. 17: 753-755
22. Tomita, M., Hayashi, M., Awazu, S. (1996) Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells. J. Pharm. Sci. 85: 608-611
23. Tozaki, H., Nishioka, J., Komoike, J., Okada, N., Fujita, T., Muranishi, S., Kim, S., Terashima, H., Yamamoto, A. (2001) Enhanced absorption of insulin and (Asu 1,7) eel-calcitionin using novel azopolymer-coated pellets for colon-specific drug delivery. J. Pharm. Sci. 90: 89-97
24. Trehan, A., Ali, A. (1998) Recent approaches in insulin delivery. Drug Dev. Ind. Pharm. 90: 589-597
25. Watnasirichaikul, S., Rades, T., Taker, I. G., Davies, N. M. (2002) In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion. J. Pharm. Pharmacol. 54: 473-480