A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery

Journal of Controlled Release

Volumn 96, Issue 2, 2004, Pages 285-300

  Chen, Sung Ching ^a   Wu, Yung Chih ^a   Mi, Fwu Long ^b   Lin, Yu Hsin ^a   Yu, Lin Chien ^a   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b Chinese Naval Academy Kaohsiung   (Taiwan)

Author keywords

Drug delivery system; Genipin; pH sensitive hydrogel; Semi IPN

Indexed keywords

BIOASSAY; BODY FLUIDS; CROSSLINKING; HYDROGELS; HYDROGEN BONDS; PROTEINS; SCANNING ELECTRON MICROSCOPY;

ELECTROSTATIC REPULSION; HYDROGEL SYSTEMS;

CONTROLLED DRUG DELIVERY;

ALGINIC ACID; AMINO ACID; BOVINE SERUM ALBUMIN; CHITOSAN DERIVATIVE; DRUG CARRIER; GENIPIN; GENIPOSIDE; N,O CARBOXYMETHYLCHITOSAN; NINHYDRIN; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CROSS LINKING; DENSITY; DRUG DELIVERY SYSTEM; ELECTRICITY; GASTROINTESTINAL TRACT; HYDROGEL; HYDROGEN BOND; HYDROPHILICITY; IONIZATION; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SIMULATION; X RAY SPECTROMETRY;

ALGINATES; CHITOSAN; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGELS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; IRIDOIDS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, SCANNING; PROTEINS; PYRANS; SERUM ALBUMIN, BOVINE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS;

EID: 1842739438     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.02.002     Document Type: Article

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