In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin

Journal of Controlled Release

Volumn 189, Issue , 2014, Pages 19-24

  Nielsen, Ebbe Juel Bech ^a,b   Yoshida, Shinya ^c   Kamei, Noriyasu ^a   Iwamae, Ruisha ^a   Khafagy, El Sayed ^a,d   Olsen, Jørgen ^b   Rahbek, Ulrik Lytt ^b   Pedersen, Betty Lomstein ^b   Takayama, Kozo ^c   Takeda Morishita, Mariko ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NOVO NORDISK A S   (Denmark)

^c HOSHI UNIVERSITY   (Japan)

^d Suez Canal University   (Egypt)

Author keywords

Cell penetrating peptides; Insulin; Oral absorption; Penetratin; Pharmacological availability

Indexed keywords

CELL MEMBRANES; DYES; MAMMALS; PEPTIDES;

BLOOD GLUCOSE CONCENTRATION; CELL-PENETRATING PEPTIDE; GASTROINTESTINAL TRACT; HYDROPHILIC MACROMOLECULES; INTERMOLECULAR INTERACTIONS; ORAL ABSORPTION; PENETRATIN; PHARMACOLOGICAL ACTIVITY;

INSULIN;

GLUCOSE; PENETRATIN; RECOMBINANT HUMAN INSULIN; ANTIDIABETIC AGENT; CARRIER PROTEIN; CELL PENETRATING PEPTIDE; GLUCOSE BLOOD LEVEL; INSULIN;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG MEGADOSE; FIRST PASS EFFECT; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN TREATMENT; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ANALYSIS; ANIMAL; CHEMISTRY; INTESTINAL SECRETIONS; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CELL-PENETRATING PEPTIDES; DRUG DELIVERY SYSTEMS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL SECRETIONS; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84904003181     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.022     Document Type: Article

References (36)

1. H.-C. Yeh, T.T. Brown, N. Maruthur, P. Ranasinghe, Z. Berger, Y.D. Suh, L.M. Wilson, E.B. Haberl, J. Brick, E.B. Bass, and S.H. Golden Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: a systematic review and meta-analysis Ann. Intern. Med. 157 5 2012 336 347
2. S. Soares, A. Costa, and B. Sarmento Novel non-invasive methods of insulin delivery Expert Opin. Drug Deliv. 9 12 2012 1539 1558
3. E. Arbit, and M. Kidron Oral insulin: the rationale for this approach and current developments J. Diabetes Sci. Technol. 3 3 2009 562 567
4. Y. Aoki, M. Morishita, K. Asai, B. Akikusa, S. Hosoda, and K. Takayama Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane Pharm. Res. 22 11 2005 1854 1862 (Pubitemid 41504338)
5. R.A. Cone Barrier properties of mucus Adv. Drug Deliv. Rev. 61 2 2009 75 85
6. J. Blanchette, N. Kavimandan, and N.A. Peppas Principles of transmucosal delivery of therapeutic agents Biomed. Pharmacother. 58 3 2004 142 151 (Pubitemid 38479918)
7. S. Aijaz, M.S. Balda, and K. Matter Tight junctions: molecular architecture and function Int. Rev. Cytol. 248 2006 261 298 (Pubitemid 43238173)
8. T.A. Sonia, and C.P. Sharma An overview of natural polymers for oral insulin delivery Drug Discov. Today 17 13-14 2012 784 792
9. M.-C. Chen, K. Sonaje, K.-J. Chen, and H.-W. Sung A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery Biomaterials 32 36 2011 9826 9838
10. M.R. Rekha, and C.P. Sharma Oral delivery of therapeutic protein/peptide for diabetes - future perspectives Int. J. Pharm. 440 1 2013 48 62
11. H. Liu, R. Tang, W.-S. Pan, Y. Zhang, and H. Liu Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats J. Pharm. Pharmacol. 55 11 2003 1523 1529 (Pubitemid 37441358)
12. M. Morishita, and N.A. Peppas Is the oral route possible for peptide and protein drug delivery? Drug Discov. Today 11 19-20 2006 905 910 (Pubitemid 44403178)
13. N. Kamei, M. Morishita, Y. Eda, N. Ida, R. Nishio, and K. Takayama Usefulness of cell-penetrating peptides to improve intestinal insulin absorption J. Control. Release 132 1 2008 21 25
14. E.-S. Khafagy, M. Morishita, K. Isowa, J. Imai, and K. Takayama Effect of cell-penetrating peptides on the nasal absorption of insulin J. Control. Release 133 2 2009 103 108
15. E.-S. Khafagy, and M. Morishita Oral biodrug delivery using cell-penetrating peptide Adv. Drug Deliv. Rev. 64 6 2012 531 539
16. F. Milletti Cell-penetrating peptides: classes, origin, and current landscape Drug Discov. Today 17 15-16 2012 850 860
17. M. Lindgren, and U. Langel Classes and prediction of cell-penetrating peptides Methods Mol. Biol. 683 2011 3 19
18. N. Kamei, S. Kikuchi, M. Takeda-Morishita, Y. Terasawa, A. Yasuda, S. Yamamoto, N. Ida, R. Nishio, and K. Takayama Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps J. Pharm. Sci. 102 2 2013 469 479
19. N. Kamei, M. Morishita, and K. Takayama Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides J. Control. Release 136 3 2009 179 186
20. M. Morishita, N. Kamei, J. Ehara, K. Isowa, and K. Takayama A novel approach using functional peptides for efficient intestinal absorption of insulin J. Control. Release 118 2 2007 177 184 (Pubitemid 46329737)
21. E.-S. Khafagy, N. Kamei, E.J.B. Nielsen, R. Nishio, and M. Takeda-Morishita One-month subchronic toxicity study of cell-penetrating peptides for insulin nasal delivery in rats Eur. J. Pharm. Biopharm. 85 3 Pt A 2013 736 743
22. H. Asada, T. Douen, Y. Mizokoshi, T. Fujita, M. Murakami, A. Yamamoto, and S. Muranishi Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution Pharm. Res. 11 8 1994 1115 1120 (Pubitemid 24259850)
23. E. Koren, and V.P. Torchilin Cell-penetrating peptides: breaking through to the other side Trends Mol. Med. 18 7 2012 385 393
24. C. Foged, and H.M. Nielsen Cell-penetrating peptides for drug delivery across membrane barriers Expert Opin. Drug Deliv. 5 1 2008 105 117 (Pubitemid 351234112)
25. E.-S. Khafagy, M. Morishita, N. Kamei, Y. Eda, Y. Ikeno, and K. Takayama Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins Int. J. Pharm. 381 1 2009 49 55
26. J. Renukuntla, A.D. Vadlapudi, A. Patel, S.H.S. Boddu, and A.K. Mitra Approaches for enhancing oral bioavailability of peptides and proteins Int. J. Pharm. 447 1-2 2013 75 93
27. F. Cárdenas-Bailón, G. Osorio-Revilla, and T. Gallardo-Velázquez Microencapsulation techniques to develop formulations of insulin for oral delivery: a review J. Microencapsul. 30 5 2013 409 424
28. F. Cui, F. Qian, Z. Zhao, L. Yin, C. Tang, and C. Yin Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles Biomacromolecules 10 5 2009 1253 1258
29. K. Sonaje, Y.-J. Chen, H.-L. Chen, S.-P. Wey, J.-H. Juang, H.-N. Nguyen, C.-W. Hsu, K.-J. Lin, and H.-W. Sung Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery Biomaterials 31 12 2010 3384 3394
30. F.-Y. Su, K.-J. Lin, K. Sonaje, S.-P. Wey, T.-C. Yen, Y.-C. Ho, N. Panda, E.-Y. Chuang, B. Maiti, and H.-W. Sung Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery Biomaterials 33 9 2012 2801 2811
31. E.-Y. Chuang, K.-J. Lin, F.-Y. Su, H.-L. Chen, B. Maiti, Y.-C. Ho, T.-C. Yen, N. Panda, and H.-W. Sung Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an egta-conjugated carrier for oral insulin delivery J. Control. Release 169 3 2013 296 305
32. S. Jain, V.V. Rathi, A.K. Jain, M. Das, and C. Godugu Folate-decorated plga nanoparticles as a rationally designed vehicle for the oral delivery of insulin Nanomedicine (London) 7 9 2012 1311 1337
33. Y. Zhang, X. Wu, L. Meng, Y. Zhang, R. Ai, N. Qi, H. He, H. Xu, and X. Tang Thiolated eudragit nanoparticles for oral insulin delivery: preparation, characterization and in vivo evaluation Int. J. Pharm. 436 1-2 2012 341 350
34. J.R. Pappenheimer, C.E. Dahl, M.L. Karnovsky, and J.E. Maggio Intestinal absorption and excretion of octapeptides composed of d amino acids Proc. Natl. Acad. Sci. U. S. A. 91 5 1994 1942 1945 (Pubitemid 24080322)
35. N. Kamei, Y. Onuki, K. Takayama, and M. Takeda-Morishita Mechanistic study of the uptake/permeation of cell-penetrating peptides across a caco-2 monolayer and their stimulatory effect on epithelial insulin transport J. Pharm. Sci. 102 11 2013 3998 4008
36. A. Walrant, C. Bechara, I.D. Alves, and S. Sagan Molecular partners for interaction and cell internalization of cell-penetrating peptides: how identical are they? Nanomedicine (London) 7 1 2012 133 143