메뉴 건너뛰기




Volumn 12, Issue 1, 2016, Pages 49-62

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGONISTIC TUMOR NECROSIS FACTOR RECEPTOR 1 SPECIFIC ANTIBODY; COMPLEX IIA PROTEIN; COMPLEX IIB PROTEIN; COMPLEX IIC PROTEIN; MDS 5541; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 1 ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR 1 SILENCER; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; XENP 345; XPRO 1595;

EID: 84954197918     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2015.169     Document Type: Article
Times cited : (972)

References (147)
  • 1
    • 84862962823 scopus 로고    scopus 로고
    • Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
    • Aggarwal, B. B., Gupta, S. C. & Kim, J. H. Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey. Blood 119, 651-665 (2012).
    • (2012) Blood , vol.119 , pp. 651-665
    • Aggarwal, B.B.1    Gupta, S.C.2    Kim, J.H.3
  • 2
    • 67650766977 scopus 로고    scopus 로고
    • Translating molecular insights in autoimmunity into effective therapy
    • Feldmann, M. Translating molecular insights in autoimmunity into effective therapy. Annu. Rev. Immunol. 27, 1-27 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 1-27
    • Feldmann, M.1
  • 3
    • 78650185999 scopus 로고    scopus 로고
    • The value of failure: The discovery of TNF and its natural inhibitor erythropoietin
    • Cerami, A. The value of failure: the discovery of TNF and its natural inhibitor erythropoietin. J. Intern. Med. 269, 8-15 (2011).
    • (2011) J. Intern. Med. , vol.269 , pp. 8-15
    • Cerami, A.1
  • 5
    • 84944076771 scopus 로고    scopus 로고
    • Treatment of hidradenitis suppurativa with biologic medications
    • Lee, R. A. & Eisen, D. B. Treatment of hidradenitis suppurativa with biologic medications. J. Am. Acad. Dermatol. 73, S82-88 (2015).
    • (2015) J. Am. Acad. Dermatol. , vol.73 , pp. S82-88
    • Lee, R.A.1    Eisen, D.B.2
  • 6
    • 84948714780 scopus 로고    scopus 로고
    • Biosimilars in rheumatology: Current perspectives and lessons learnt
    • Dorner, T. & Kay, J. Biosimilars in rheumatology: current perspectives and lessons learnt. Nat. Rev. Rheumatol. http://dx.doi.org/10.1038/nrrheum.2015.110 (2015).
    • (2015) Nat. Rev. Rheumatol.
    • Dorner, T.1    Kay, J.2
  • 7
    • 78649477259 scopus 로고    scopus 로고
    • TNF-antagonists beyond approved indications: Stories of success and prospects for the future
    • Karampetsou, M. P., Liossis, S. N. & Sfikakis, P. P. TNF-antagonists beyond approved indications: stories of success and prospects for the future. QJM 103, 917-928 (2010).
    • (2010) QJM , vol.103 , pp. 917-928
    • Karampetsou, M.P.1    Liossis, S.N.2    Sfikakis, P.P.3
  • 8
    • 84873349403 scopus 로고    scopus 로고
    • IRHOM2 is a critical pathogenic mediator of inflammatory arthritis
    • Issuree, P. D. et al. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J. Clin. Invest. 123, 928-932 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 928-932
    • Issuree, P.D.1
  • 9
    • 38449086094 scopus 로고    scopus 로고
    • Cutting edge: TNF-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    • Horiuchi, K. et al. Cutting edge: TNF-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179, 2686-2689 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 2686-2689
    • Horiuchi, K.1
  • 10
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley, R. M., Killeen, N. & Lenardo, M. J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501 (2001).
    • (2001) Cell , vol.104 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 11
    • 0028866022 scopus 로고
    • The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
    • Grell, M. et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83, 793-802 (1995).
    • (1995) Cell , vol.83 , pp. 793-802
    • Grell, M.1
  • 12
    • 84938285609 scopus 로고    scopus 로고
    • TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects
    • Probert, L. TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects. Neuroscience 302, 2-22 (2015).
    • (2015) Neuroscience , vol.302 , pp. 2-22
    • Probert, L.1
  • 13
    • 84922602504 scopus 로고    scopus 로고
    • Necroptosis and its role in inflammation
    • Pasparakis, M. & Vandenabeele, P. Necroptosis and its role in inflammation. Nature 517, 311-320 (2015).
    • (2015) Nature , vol.517 , pp. 311-320
    • Pasparakis, M.1    Vandenabeele, P.2
  • 14
    • 84929875491 scopus 로고    scopus 로고
    • Regulation of tumour necrosis factor signalling: Live or let die
    • Brenner, D., Blaser, H. & Mak, T. W. Regulation of tumour necrosis factor signalling: live or let die. Nat. Rev. Immunol. 15, 362-374 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 362-374
    • Brenner, D.1    Blaser, H.2    Mak, T.W.3
  • 15
    • 71149119391 scopus 로고    scopus 로고
    • A tangled web of ubiquitin chains: Breaking news in TNF-R1 signaling
    • Bianchi, K. & Meier, P. A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36, 736-742 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 736-742
    • Bianchi, K.1    Meier, P.2
  • 16
    • 71149105333 scopus 로고    scopus 로고
    • Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    • Haas, T. L. et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol. Cell 36, 831-844 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 831-844
    • Haas, T.L.1
  • 17
    • 62549155321 scopus 로고    scopus 로고
    • Specific recognition of linear ubiquitin chains by NEMO is important for NF-B activation
    • Rahighi, S. et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-B activation. Cell 136, 1098-1109 (2009).
    • (2009) Cell , vol.136 , pp. 1098-1109
    • Rahighi, S.1
  • 18
    • 78650300883 scopus 로고    scopus 로고
    • C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
    • Dynek, J. N. et al. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 29, 4198-4209 (2010).
    • (2010) EMBO J. , vol.29 , pp. 4198-4209
    • Dynek, J.N.1
  • 20
    • 84927671957 scopus 로고    scopus 로고
    • Programmed necrosis in the cross talk of cell death and inflammation
    • Chan, F. K., Luz, N. F. & Moriwaki, K. Programmed necrosis in the cross talk of cell death and inflammation. Annu. Rev. Immunol. 33, 79-106 (2015).
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 79-106
    • Chan, F.K.1    Luz, N.F.2    Moriwaki, K.3
  • 21
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190 (2003).
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 22
    • 43049152912 scopus 로고    scopus 로고
    • TNF-induces two distinct caspase-8 activation pathways
    • Wang, L., Du, F. & Wang, X. TNF-induces two distinct caspase-8 activation pathways. Cell 133, 693-703 (2008).
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 23
    • 84862907788 scopus 로고    scopus 로고
    • Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
    • Sun, L. et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227 (2012).
    • (2012) Cell , vol.148 , pp. 213-227
    • Sun, L.1
  • 24
    • 85017409091 scopus 로고    scopus 로고
    • Epithelial cell death and inflammation in skin
    • Kumari, S. & Pasparakis, M. Epithelial cell death and inflammation in skin. Curr. Top. Microbiol. Immunol. http://dx.doi.org/10.1007/82-2015-466 (2015).
    • (2015) Curr. Top. Microbiol. Immunol.
    • Kumari, S.1    Pasparakis, M.2
  • 25
    • 84907210946 scopus 로고    scopus 로고
    • RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
    • Dannappel, M. et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513, 90-94 (2014).
    • (2014) Nature , vol.513 , pp. 90-94
    • Dannappel, M.1
  • 26
    • 84907197966 scopus 로고    scopus 로고
    • RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
    • Takahashi, N. et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 513, 95-99 (2014).
    • (2014) Nature , vol.513 , pp. 95-99
    • Takahashi, N.1
  • 27
    • 84931377023 scopus 로고    scopus 로고
    • The diverse role of RIP kinases in necroptosis and inflammation
    • Silke, J., Rickard, J. A. & Gerlic, M. The diverse role of RIP kinases in necroptosis and inflammation. Nat. Immunol. 16, 689-697 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 689-697
    • Silke, J.1    Rickard, J.A.2    Gerlic, M.3
  • 28
    • 84858725584 scopus 로고    scopus 로고
    • Regulation of NF. ÈB by deubiquitinases
    • Harhaj, E. W. & Dixit, V. M. Regulation of NF. ÈB by deubiquitinases. Immunol. Rev. 246, 107-124 (2012).
    • (2012) Immunol. Rev. , vol.246 , pp. 107-124
    • Harhaj, E.W.1    Dixit, V.M.2
  • 29
    • 77952419246 scopus 로고    scopus 로고
    • Mutations of optineurin in amyotrophic lateral sclerosis
    • Maruyama, H. et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465, 223-226 (2010).
    • (2010) Nature , vol.465 , pp. 223-226
    • Maruyama, H.1
  • 30
    • 34547924464 scopus 로고    scopus 로고
    • Optineurin negatively regulates TNF ¿-induced NF. ÈB activation by competing with NEMO for ubiquitinated RIP
    • Zhu, G., Wu, C. J., Zhao, Y. & Ashwell, J. D. Optineurin negatively regulates TNF ¿-induced NF. ÈB activation by competing with NEMO for ubiquitinated RIP. Curr. Biol. 17, 1438-1443 (2007).
    • (2007) Curr. Biol. , vol.17 , pp. 1438-1443
    • Zhu, G.1    Wu, C.J.2    Zhao, Y.3    Ashwell, J.D.4
  • 31
    • 84867032420 scopus 로고    scopus 로고
    • P47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO
    • Shibata, Y. et al. p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat. Commun. 3, 1061 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 1061
    • Shibata, Y.1
  • 32
    • 84867062977 scopus 로고    scopus 로고
    • A20 inhibits LUBAC-mediated NF. ÈB activation by binding linear polyubiquitin chains via its zinc finger 7
    • Verhelst, K. et al. A20 inhibits LUBAC-mediated NF. ÈB activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 31, 3845-3855 (2012).
    • (2012) EMBO J. , vol.31 , pp. 3845-3855
    • Verhelst, K.1
  • 33
    • 84867043680 scopus 로고    scopus 로고
    • Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF. ÈB regulation
    • Tokunaga, F. et al. Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF. ÈB regulation. EMBO J. 31, 3856-3870 (2012).
    • (2012) EMBO J , vol.31 , pp. 3856-3870
    • Tokunaga, F.1
  • 34
    • 84878862687 scopus 로고    scopus 로고
    • OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1.linked polyubiquitin
    • Keusekotten, K. et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1.linked polyubiquitin. Cell 153, 1312-1326 (2013).
    • (2013) Cell , vol.153 , pp. 1312-1326
    • Keusekotten, K.1
  • 35
    • 81255177676 scopus 로고    scopus 로고
    • The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
    • Ahmed, N. et al. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat. Immunol. 12, 1176-1183 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 1176-1183
    • Ahmed, N.1
  • 36
    • 39449083378 scopus 로고    scopus 로고
    • The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    • Shembade, N. et al. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat. Immunol. 9, 254-262 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 254-262
    • Shembade, N.1
  • 37
    • 43549094447 scopus 로고    scopus 로고
    • Localization of A20 to a lysosomeassociated compartment and its role in NFÈB signaling
    • Li, L. et al. Localization of A20 to a lysosomeassociated compartment and its role in NF ÈB signaling. Biochim. Biophys. Acta 1783, 1140-1149 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 1140-1149
    • Li, L.1
  • 38
    • 37349111560 scopus 로고    scopus 로고
    • RNAi screen in mouse astrocytes identifies phosphatases that regulate NF. ÈB signaling
    • Li, S., Wang, L., Berman, M. A., Zhang, Y. & Dorf, M. E. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF. ÈB signaling. Mol. Cell 24, 497-509 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 497-509
    • Li, S.1    Wang, L.2    Berman, M.A.3    Zhang, Y.4    Dorf, M.E.5
  • 39
    • 42449137850 scopus 로고    scopus 로고
    • Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1
    • Li, H. Y. et al. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat. Immunol. 9, 533-541 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 533-541
    • Li, H.Y.1
  • 40
    • 77954374360 scopus 로고    scopus 로고
    • 14.3.3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF- ¿-induced time course-dependent NF. ÈB activity
    • Zuo, S. et al. 14.3.3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-¿-induced time course-dependent NF. ÈB activity. J. Proteome Res. 9, 3465-3478 (2010).
    • (2010) J. Proteome Res. , vol.9 , pp. 3465-3478
    • Zuo, S.1
  • 41
    • 67349245931 scopus 로고    scopus 로고
    • WIP1 phosphatase is a negative regulator of NF. ÈB signalling
    • Chew, J. et al. WIP1 phosphatase is a negative regulator of NF. ÈB signalling. Nat. Cell Biol. 11, 659-666 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 659-666
    • Chew, J.1
  • 42
    • 0037044575 scopus 로고    scopus 로고
    • The I ÈB.NF. ÈB signaling module: Temporal control and selective gene activation
    • Hoffmann, A., Levchenko, A., Scott, M. L. & Baltimore, D. The I ÈB.NF. ÈB signaling module: temporal control and selective gene activation. Science 298, 1241-1245 (2002).
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 43
    • 66449092314 scopus 로고    scopus 로고
    • Kinetic control of negative feedback regulators of NF. ÈB/RelA determines their pathogenand cytokine-receptor signaling specificity
    • Shih, V. F. et al. Kinetic control of negative feedback regulators of NF. ÈB/RelA determines their pathogenand cytokine-receptor signaling specificity. Proc. Natl Acad. Sci. USA 106, 9619-9624 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9619-9624
    • Shih, V.F.1
  • 44
    • 33747388013 scopus 로고    scopus 로고
    • I ÈB Ã provides negative feedback to control NF. ÈB oscillations, signaling dynamics, and inflammatory gene expression
    • Kearns, J. D., Basak, S., Werner, S. L., Huang, C. S. & Hoffmann, A. I ÈB Ã provides negative feedback to control NF. ÈB oscillations, signaling dynamics, and inflammatory gene expression. J. Cell Biol. 173, 659-664 (2006).
    • (2006) J. Cell Biol. , vol.173 , pp. 659-664
    • Kearns, J.D.1    Basak, S.2    Werner, S.L.3    Huang, C.S.4    Hoffmann, A.5
  • 45
    • 7444254365 scopus 로고    scopus 로고
    • Oscillations in NF. ÈB signaling control the dynamics of gene expression
    • Nelson, D. E. et al. Oscillations in NF. ÈB signaling control the dynamics of gene expression. Science 306, 704-708 (2004).
    • (2004) Science , vol.306 , pp. 704-708
    • Nelson, D.E.1
  • 46
    • 64849104716 scopus 로고    scopus 로고
    • Pulsatile stimulation determines timing and specificity of NF. ÈB-dependent transcription
    • Ashall, L. et al. Pulsatile stimulation determines timing and specificity of NF. ÈB-dependent transcription. Science 324, 242-246 (2009).
    • (2009) Science , vol.324 , pp. 242-246
    • Ashall, L.1
  • 47
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF. ÈB dynamics reveal digital activation and analogue information processing
    • Tay, S. et al. Single-cell NF. ÈB dynamics reveal digital activation and analogue information processing. Nature 466, 267-271 (2010).
    • (2010) Nature , vol.466 , pp. 267-271
    • Tay, S.1
  • 48
    • 84875721405 scopus 로고    scopus 로고
    • Tumor necrosis factor ¿ induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts
    • Lee, A. et al. Tumor necrosis factor ¿ induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 65, 928-938 (2013).
    • (2013) Arthritis Rheum , vol.65 , pp. 928-938
    • Lee, A.1
  • 49
    • 84931044499 scopus 로고    scopus 로고
    • Cloaked in ubiquitin, a killer hides in plain sight: The molecular regulation of RIPK1
    • Justus, S. J. & Ting, A. T. Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1. Immunol. Rev. 266, 145-160 (2015).
    • (2015) Immunol. Rev. , vol.266 , pp. 145-160
    • Justus, S.J.1    Ting, A.T.2
  • 50
    • 79953237668 scopus 로고    scopus 로고
    • SHARPIN is a component of the NF. ÈB-activating linear ubiquitin chain assembly complex
    • Tokunaga, F. et al. SHARPIN is a component of the NF. ÈB-activating linear ubiquitin chain assembly complex. Nature 471, 633-636 (2011).
    • (2011) Nature , vol.471 , pp. 633-636
    • Tokunaga, F.1
  • 51
    • 79953239980 scopus 로고    scopus 로고
    • SHARPIN forms a linear ubiquitin ligase complex regulating NF. ÈB activity and apoptosis
    • Ikeda, F. et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF. ÈB activity and apoptosis. Nature 471, 637-641 (2011).
    • (2011) Nature , vol.471 , pp. 637-641
    • Ikeda, F.1
  • 52
    • 79953240109 scopus 로고    scopus 로고
    • Linear ubiquitination prevents inflammation and regulates immune signalling
    • Gerlach, B. et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471, 591-596 (2011).
    • (2011) Nature , vol.471 , pp. 591-596
    • Gerlach, B.1
  • 53
    • 84924401688 scopus 로고    scopus 로고
    • Sharpin prevents skin inflammation by inhibiting TNFR1.induced keratinocyte apoptosis
    • Kumari, S. et al. Sharpin prevents skin inflammation by inhibiting TNFR1.induced keratinocyte apoptosis. eLIFE 3, e03422 (2014).
    • (2014) ELIFE , vol.3 , pp. e03422
    • Kumari, S.1
  • 54
    • 84925358056 scopus 로고    scopus 로고
    • TNFR1.dependent cell death drives inflammation in Sharpin-deficient mice
    • Rickard, J. A. et al. TNFR1.dependent cell death drives inflammation in Sharpin-deficient mice. eLIFE 3, e03464 (2014).
    • (2014) ELIFE , vol.3 , pp. e03464
    • Rickard, J.A.1
  • 55
    • 84929899399 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
    • Onizawa, M. et al. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat. Immunol. 16, 618-627 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 618-627
    • Onizawa, M.1
  • 56
    • 84897088275 scopus 로고    scopus 로고
    • Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
    • Newton, K. et al. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science 343, 1357-1360 (2014).
    • (2014) Science , vol.343 , pp. 1357-1360
    • Newton, K.1
  • 57
    • 84901386193 scopus 로고    scopus 로고
    • RIPK1 blocks early postnatal lethality mediated by caspase.8 and RIPK3
    • Dillon, C. P. et al. RIPK1 blocks early postnatal lethality mediated by caspase.8 and RIPK3. Cell 157, 1189-1202 (2014).
    • (2014) Cell , vol.157 , pp. 1189-1202
    • Dillon, C.P.1
  • 58
    • 84901422731 scopus 로고    scopus 로고
    • RIPK1 regulates RIPK3.MLKLdriven systemic inflammation and emergency hematopoiesis
    • Rickard, J. A. et al. RIPK1 regulates RIPK3.MLKLdriven systemic inflammation and emergency hematopoiesis. Cell 157, 1175-1188 (2014).
    • (2014) Cell , vol.157 , pp. 1175-1188
    • Rickard, J.A.1
  • 59
    • 84923108417 scopus 로고    scopus 로고
    • Chromatin remodelling and autocrine TNF ¿ are required for optimal interleukin.6 expression in activated human neutrophils
    • Zimmermann, M. et al. Chromatin remodelling and autocrine TNF ¿ are required for optimal interleukin.6 expression in activated human neutrophils. Nat. Commun. 6, 6061 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6061
    • Zimmermann, M.1
  • 60
    • 84896919030 scopus 로고    scopus 로고
    • Chromatin contributions to the regulation of innate immunity
    • Smale, S. T., Tarakhovsky, A. & Natoli, G. Chromatin contributions to the regulation of innate immunity. Annu. Rev. Immunol. 32, 489-511 (2014).
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 489-511
    • Smale, S.T.1    Tarakhovsky, A.2    Natoli, G.3
  • 61
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • Ostuni, R. et al. Latent enhancers activated by stimulation in differentiated cells. Cell 152, 157-171 (2013).
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1
  • 63
    • 84933060018 scopus 로고    scopus 로고
    • DNA methylome signature in synoviocytes from patients with early rheumatoid arthritis compared to synoviocytes from patients with longstanding rheumatoid arthritis
    • Ai, R. et al. DNA methylome signature in synoviocytes from patients with early rheumatoid arthritis compared to synoviocytes from patients with longstanding rheumatoid arthritis. Arthritis Rheumatol. 67, 1978-1980 (2015).
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1978-1980
    • Ai, R.1
  • 64
    • 84872713887 scopus 로고    scopus 로고
    • Regulation of DNA methylation in rheumatoid arthritis synoviocytes
    • Nakano, K., Boyle, D. L. & Firestein, G. S. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J. Immunol. 190, 1297-1303 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1297-1303
    • Nakano, K.1    Boyle, D.L.2    Firestein, G.S.3
  • 65
    • 84896760044 scopus 로고    scopus 로고
    • Modulation of ten-eleven translocation 1 (TET1) isocitrate dehydrogenase (IDH) expression, ¿-ketoglutarate ( ¿.KG), and DNA hydroxymethylation levels by interleukin.1 À in primary human chondrocytes
    • Haseeb, A., Makki, M. S. & Haqqi, T. M. Modulation of ten-eleven translocation 1 (TET1), isocitrate dehydrogenase (IDH) expression, ¿-ketoglutarate ( ¿.KG), and DNA hydroxymethylation levels by interleukin.1 À in primary human chondrocytes. J. Biol. Chem. 289, 6877-6885 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 6877-6885
    • Haseeb, A.1    Makki, M.S.2    Haqqi, T.M.3
  • 66
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue, J. et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288 (2014).
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1
  • 68
    • 40949123747 scopus 로고    scopus 로고
    • TNF activates an IRF1.dependent autocrine loop leading to sustained expression of chemokines and STAT1.dependent type i interferonresponse genes
    • Yarilina, A., Park-Min, K. H., Antoniv, T., Hu, X. & Ivashkiv, L. B. TNF activates an IRF1.dependent autocrine loop leading to sustained expression of chemokines and STAT1.dependent type I interferonresponse genes. Nat. Immunol. 9, 378-387 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 378-387
    • Yarilina, A.1    Park-Min, K.H.2    Antoniv, T.3    Hu, X.4    Ivashkiv, L.B.5
  • 69
    • 60749124122 scopus 로고    scopus 로고
    • The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
    • Hao, S. & Baltimore, D. The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 10, 281-288 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 281-288
    • Hao, S.1    Baltimore, D.2
  • 70
    • 79952159585 scopus 로고    scopus 로고
    • TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages
    • Yarilina, A., Xu, K., Chen, J. & Ivashkiv, L. B. TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proc. Natl Acad. Sci. USA 108, 1573-1578 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 1573-1578
    • Yarilina, A.1    Xu, K.2    Chen, J.3    Ivashkiv, L.B.4
  • 71
    • 84857239335 scopus 로고    scopus 로고
    • The JAK inhibitor CP.690 550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type i interferon
    • Rosengren, S., Corr, M., Firestein, G. S. & Boyle, D. L. The JAK inhibitor CP.690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann. Rheum. Dis. 71, 440-447 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 440-447
    • Rosengren, S.1    Corr, M.2    Firestein, G.S.3    Boyle, D.L.4
  • 72
    • 63049122784 scopus 로고    scopus 로고
    • Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    • Ghisletti, S. et al. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 23, 681-693 (2009).
    • (2009) Genes Dev , vol.23 , pp. 681-693
    • Ghisletti, S.1
  • 73
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • Hargreaves, D. C., Horng, T. & Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138, 129-145 (2009).
    • (2009) Cell , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 74
    • 84928175766 scopus 로고    scopus 로고
    • Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli
    • Cronk, J. C. et al. Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli. Immunity 42, 679-691 (2015).
    • (2015) Immunity , vol.42 , pp. 679-691
    • Cronk, J.C.1
  • 75
    • 84919940967 scopus 로고    scopus 로고
    • Prolonged tumor necrosis factor ¿ primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin
    • Sohn, C. et al. Prolonged tumor necrosis factor ¿ primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis Rheumatol. 67, 86-95 (2015).
    • (2015) Arthritis Rheumatol , vol.67 , pp. 86-95
    • Sohn, C.1
  • 76
    • 79959373435 scopus 로고    scopus 로고
    • Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
    • Park, S. H., Park-Min, K. H., Chen, J., Hu, X. & Ivashkiv, L. B. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat. Immunol. 12, 607-615 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 607-615
    • Park, S.H.1    Park-Min, K.H.2    Chen, J.3    Hu, X.4    Ivashkiv, L.B.5
  • 77
    • 84880815366 scopus 로고    scopus 로고
    • Short-term memory of danger signals and environmental stimuli in immune cells
    • Monticelli, S. & Natoli, G. Short-term memory of danger signals and environmental stimuli in immune cells. Nat. Immunol. 14, 777-784 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 777-784
    • Monticelli, S.1    Natoli, G.2
  • 78
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF ¿-deficient mice: A critical requirement for TNF ¿ in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. Immune and inflammatory responses in TNF ¿-deficient mice: a critical requirement for TNF ¿ in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397.1411 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1397-1411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 79
    • 0345609037 scopus 로고    scopus 로고
    • Characterization of tumor necrosis factor-deficient mice
    • Marino, M. W. et al. Characterization of tumor necrosis factor-deficient mice. Proc. Natl Acad. Sci. USA 94, 8093-8098 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8093-8098
    • Marino, M.W.1
  • 80
    • 0031916192 scopus 로고    scopus 로고
    • TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
    • Liu, J. et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat. Med. 4, 78-83 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 78-83
    • Liu, J.1
  • 81
    • 0022382737 scopus 로고
    • Recombinant human tumor necrosis factor-alpha: Effects on proliferation of normal and transformed cells in vitro
    • Sugarman, B. J. et al. Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 230, 943-945 (1985).
    • (1985) Science , vol.230 , pp. 943-945
    • Sugarman, B.J.1
  • 82
    • 84874192617 scopus 로고    scopus 로고
    • T.helper-1.cell cytokines drive cancer into senescence
    • Braumuller, H. et al. T.helper-1.cell cytokines drive cancer into senescence. Nature 494, 361-365 (2013).
    • (2013) Nature , vol.494 , pp. 361-365
    • Braumuller, H.1
  • 83
    • 0035705454 scopus 로고    scopus 로고
    • TNF ¿ promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett, H. A. et al. TNF ¿ promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4, 1116-1122 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1116-1122
    • Arnett, H.A.1
  • 84
    • 84941022388 scopus 로고    scopus 로고
    • Tumor necrosis factor- ¿ confers cardioprotection through ectopic expression of keratins K8 and K18
    • Papathanasiou, S. et al. Tumor necrosis factor- ¿ confers cardioprotection through ectopic expression of keratins K8 and K18. Nat. Med. 21, 1076-1084 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1076-1084
    • Papathanasiou, S.1
  • 85
    • 84954224471 scopus 로고    scopus 로고
    • Progranulin protects against osteoarthritis through interacting with TNF- ¿ and À-catenin signalling
    • Zhao, Y. P. et al. Progranulin protects against osteoarthritis through interacting with TNF- ¿ and À-catenin signalling. Ann. Rheum. Dis. 74, 2244-2253 (2014).
    • (2014) Ann. Rheum. Dis. , vol.74 , pp. 2244-2253
    • Zhao, Y.P.1
  • 86
    • 77952924538 scopus 로고    scopus 로고
    • Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis
    • Bluml, S. et al. Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum. 62, 1608-1619 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1608-1619
    • Bluml, S.1
  • 87
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53, 457-465 (1999).
    • (1999) Neurology , vol.53 , pp. 457-465
  • 88
    • 0035464263 scopus 로고    scopus 로고
    • Demyelinating and neurologic events reported in association with tumor necrosis factor ¿ antagonism: By what mechanisms could tumor necrosis factor ¿ antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis
    • Robinson, W. H., Genovese, M. C. & Moreland, L. W. Demyelinating and neurologic events reported in association with tumor necrosis factor ¿ antagonism: by what mechanisms could tumor necrosis factor ¿ antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis Arthritis Rheum. 44, 1977-1983 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 1977-1983
    • Robinson, W.H.1    Genovese, M.C.2    Moreland, L.W.3
  • 89
    • 37149037678 scopus 로고    scopus 로고
    • Collagen-induced arthritis as a model of hyperalgesia: Functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    • Inglis, J. J. et al. Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade. Arthritis Rheum. 56, 4015-4023 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 4015-4023
    • Inglis, J.J.1
  • 90
    • 49449108807 scopus 로고    scopus 로고
    • Antinociceptive effects of tumor necrosis factor ¿ neutralization in a rat model of antigen-induced arthritis: Evidence of a neuronal target
    • Boettger, M. K. et al. Antinociceptive effects of tumor necrosis factor ¿ neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target. Arthritis Rheum. 58, 2368-2378 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 2368-2378
    • Boettger, M.K.1
  • 91
    • 78649866369 scopus 로고    scopus 로고
    • Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats
    • Richter, F. et al. Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats. Arthritis Rheum. 62, 3806-3814 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 3806-3814
    • Richter, F.1
  • 92
    • 77951719845 scopus 로고    scopus 로고
    • Spinal tumor necrosis factor alpha neutralization reduces peripheral inflammation and hyperalgesia and suppresses autonomic responses in experimental arthritis: A role for spinal tumor necrosis factor alpha during induction and maintenance of peripheral inflammation
    • Boettger, M. K. et al. Spinal tumor necrosis factor alpha neutralization reduces peripheral inflammation and hyperalgesia and suppresses autonomic responses in experimental arthritis: a role for spinal tumor necrosis factor alpha during induction and maintenance of peripheral inflammation. Arthritis Rheum. 62, 1308-1318 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1308-1318
    • Boettger, M.K.1
  • 93
    • 84896287865 scopus 로고    scopus 로고
    • Involvement of peripheral and spinal tumor necrosis factor alpha in spinal cord hyperexcitability during knee joint inflammation in rats
    • Konig, C., Zharsky, M., Moller, C., Schaible, H. G. & Ebersberger, A. Involvement of peripheral and spinal tumor necrosis factor alpha in spinal cord hyperexcitability during knee joint inflammation in rats. Arthritis Rheumatol. 66, 599-609 (2014).
    • (2014) Arthritis Rheumatol , vol.66 , pp. 599-609
    • Konig, C.1    Zharsky, M.2    Moller, C.3    Schaible, H.G.4    Ebersberger, A.5
  • 94
    • 79952748060 scopus 로고    scopus 로고
    • Blockade of TNF- ¿ rapidly inhibits pain responses in the central nervous system
    • Hess, A. et al. Blockade of TNF- ¿ rapidly inhibits pain responses in the central nervous system. Proc. Natl Acad. Sci. USA 108, 3731-3736 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 3731-3736
    • Hess, A.1
  • 95
    • 0016723594 scopus 로고
    • An endotoxin-induced serum factor that causes necrosis of tumors
    • Carswell, E. A. et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl Acad. Sci. USA 72, 3666-3670 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 3666-3670
    • Carswell, E.A.1
  • 96
    • 0022485610 scopus 로고
    • Cachectin and tumour necrosis factor as two sides of the same biological coin
    • Beutler, B. & Cerami, A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320, 584-588 (1986).
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 97
    • 84888633713 scopus 로고    scopus 로고
    • Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
    • Elinav, E. et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat. Rev. Cancer 13, 759-771 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 759-771
    • Elinav, E.1
  • 98
    • 84868629269 scopus 로고    scopus 로고
    • TNF signaling drives myeloid-derived suppressor cell accumulation
    • Zhao, X. et al. TNF signaling drives myeloid-derived suppressor cell accumulation. J. Clin. Invest. 122, 4094-4104 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 4094-4104
    • Zhao, X.1
  • 99
    • 84893381289 scopus 로고    scopus 로고
    • Transmembrane TNF- ¿ promotes suppressive activities of myeloid-derived suppressor cells via TNFR2
    • Hu, X. et al. Transmembrane TNF- ¿ promotes suppressive activities of myeloid-derived suppressor cells via TNFR2. J. Immunol. 192, 1320-1331 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 1320-1331
    • Hu, X.1
  • 100
    • 34848920368 scopus 로고    scopus 로고
    • TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
    • Haudek, S. B., Taffet, G. E., Schneider, M. D. & Mann, D. L. TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. J. Clin. Invest. 117, 2692-2701 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2692-2701
    • Haudek, S.B.1    Taffet, G.E.2    Schneider, M.D.3    Mann, D.L.4
  • 101
    • 84933678127 scopus 로고    scopus 로고
    • Atherosclerosis in rheumatoid arthritis: Is it all about inflammation
    • Skeoch, S. & Bruce, I. N. Atherosclerosis in rheumatoid arthritis: is it all about inflammation Nat. Rev. Rheumatol. 11, 390-400 (2015).
    • (2015) Nat. Rev. Rheumatol. , vol.11 , pp. 390-400
    • Skeoch, S.1    Bruce, I.N.2
  • 102
    • 84874635531 scopus 로고    scopus 로고
    • Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target
    • Verjee, L. S. et al. Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Proc. Natl Acad. Sci. USA 110, E928-E937 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E928-E937
    • Verjee, L.S.1
  • 104
    • 67749093214 scopus 로고    scopus 로고
    • Endemic fungal infections in patients receiving tumour necrosis factor-inhibitor therapy
    • Smith, J. A. & Kauffman, C. A. Endemic fungal infections in patients receiving tumour necrosis factor-inhibitor therapy. Drugs 69, 1403-1415 (2009).
    • (2009) Drugs , vol.69 , pp. 1403-1415
    • Smith, J.A.1    Kauffman, C.A.2
  • 106
    • 84919904195 scopus 로고    scopus 로고
    • Combined inhibition of tumor necrosis factor and interleukin17 as a therapeutic opportunity in rheumatoid arthritis: Development and characterization of a novel bispecific antibody
    • Fischer, J. A. et al. Combined inhibition of tumor necrosis factor and interleukin17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody. Arthritis Rheumatol. 67, 51-62 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 51-62
    • Fischer, J.A.1
  • 107
    • 2342551979 scopus 로고    scopus 로고
    • Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
    • Genovese, M. C. et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum. 50, 1412-1419 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 1412-1419
    • Genovese, M.C.1
  • 109
    • 84883238929 scopus 로고    scopus 로고
    • Selective blockade of tumor necrosis factor receptor i inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures
    • Schmidt, E. M. et al. Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures. Arthritis Rheum. 65, 2262-2273 (2013).
    • (2013) Arthritis Rheum , vol.65 , pp. 2262-2273
    • Schmidt, E.M.1
  • 110
    • 78649640090 scopus 로고    scopus 로고
    • ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor onespecific antibody
    • Zettlitz, K. A. et al. ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor onespecific antibody. MAbs 2, 639-647 (2010).
    • (2010) MAbs , vol.2 , pp. 639-647
    • Zettlitz, K.A.1
  • 111
    • 84886095507 scopus 로고    scopus 로고
    • Antagonistic TNF receptor one-specific antibody (ATROSAB): Receptor binding and in vitro bioactivity
    • Richter, F. et al. Antagonistic TNF receptor one-specific antibody (ATROSAB): receptor binding and in vitro bioactivity. PLoS ONE 8, e72156 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e72156
    • Richter, F.1
  • 112
    • 84908365717 scopus 로고    scopus 로고
    • Selective tumor necrosis factor receptor i blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis
    • McCann, F. E. et al. Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis. Arthritis Rheumatol. 66, 2728-2738 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 2728-2738
    • McCann, F.E.1
  • 113
    • 84922775279 scopus 로고    scopus 로고
    • Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1
    • Steeland, S. et al. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J. Biol. Chem. 290, 4022-4037 (2015).
    • (2015) J. Biol. Chem. , vol.290 , pp. 4022-4037
    • Steeland, S.1
  • 114
    • 0141757326 scopus 로고    scopus 로고
    • Inactivation of TNF signaling by rationally designed dominant-negative TNF variants
    • Steed, P. M. et al. Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science 301, 1895-1898 (2003).
    • (2003) Science , vol.301 , pp. 1895-1898
    • Steed, P.M.1
  • 115
    • 34548657310 scopus 로고    scopus 로고
    • Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
    • Zalevsky, J. et al. Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J. Immunol. 179, 1872-1883 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 1872-1883
    • Zalevsky, J.1
  • 116
    • 38149000306 scopus 로고    scopus 로고
    • Creation and Xray structure analysis f the tumor necrosis factor receptor-1selective mutant of a tumor necrosis factor-antagonist
    • Shibata, H. et al. Creation and Xray structure analysis f the tumor necrosis factor receptor-1selective mutant of a tumor necrosis factor-antagonist. J. Biol. Chem. 283, 998-1007 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 998-1007
    • Shibata, H.1
  • 117
    • 84863011699 scopus 로고    scopus 로고
    • Novel TNF-receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice
    • Kitagaki, M. et al. Novel TNF-receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice. J. Atheroscler. Thromb. 19, 36-46 (2012).
    • (2012) J. Atheroscler. Thromb. , vol.19 , pp. 36-46
    • Kitagaki, M.1
  • 118
    • 81055124816 scopus 로고    scopus 로고
    • A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death
    • Fischer, R. et al. A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. PLoS ONE 6, e27621 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e27621
    • Fischer, R.1
  • 119
    • 79955477738 scopus 로고    scopus 로고
    • The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    • Tang, W. et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332, 478-484 (2011).
    • (2011) Science , vol.332 , pp. 478-484
    • Tang, W.1
  • 120
    • 84919467063 scopus 로고    scopus 로고
    • Therapeutic vaccination with TNFKinoid in TNF antagonist-resistant rheumatoid arthritis: A Phase II randomized, controlled clinical trial
    • Durez, P. et al. Therapeutic vaccination with TNFKinoid in TNF antagonist-resistant rheumatoid arthritis: a Phase II randomized, controlled clinical trial. PLoS ONE 9, e113465 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e113465
    • Durez, P.1
  • 121
    • 77956137185 scopus 로고    scopus 로고
    • IB acts to inhibit and activate gene expression during the inflammatory response
    • Rao, P. et al. IB acts to inhibit and activate gene expression during the inflammatory response. Nature 466, 1115-1119 (2010).
    • (2010) Nature , vol.466 , pp. 1115-1119
    • Rao, P.1
  • 122
    • 84908602740 scopus 로고    scopus 로고
    • NFB directs dynamic super enhancer formation in inflammation and atherogenesis
    • Brown, J. D. et al. NFB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol. Cell 56, 219-231 (2014).
    • (2014) Mol. Cell , vol.56 , pp. 219-231
    • Brown, J.D.1
  • 123
    • 84870325487 scopus 로고    scopus 로고
    • Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors
    • Yarilina, A., Xu, K., Chan, C. & Ivashkiv, L. B. Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 64, 3856-3866 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 3856-3866
    • Yarilina, A.1    Xu, K.2    Chan, C.3    Ivashkiv, L.B.4
  • 124
    • 84954338878 scopus 로고    scopus 로고
    • The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
    • Klein, K., Kabala, P. A. & Grabiec, A. M. The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2014-205809 (2014).
    • (2014) Ann. Rheum. Dis.
    • Klein, K.1    Kabala, P.A.2    Grabiec, A.M.3
  • 125
    • 84857233842 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL6 production by accelerating mRNA decay
    • Grabiec, A. M., Korchynskyi, O., Tak, P. P. & Reedquist, K. A. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL6 production by accelerating mRNA decay. Ann. Rheum. Dis. 71, 424-431 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 424-431
    • Grabiec, A.M.1    Korchynskyi, O.2    Tak, P.P.3    Reedquist, K.A.4
  • 126
    • 84866111542 scopus 로고    scopus 로고
    • Identification of microRNA221/222 and microRNA3233p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model
    • Pandis, I. et al. Identification of microRNA221/222 and microRNA3233p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann. Rheum. Dis. 71, 1716-1723 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1716-1723
    • Pandis, I.1
  • 127
    • 84875721809 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced microRNA18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NFB signaling
    • Trenkmann, M. et al. Tumor necrosis factor-induced microRNA18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NFB signaling. Arthritis Rheum. 65, 916-927 (2013).
    • (2013) Arthritis Rheum , vol.65 , pp. 916-927
    • Trenkmann, M.1
  • 128
    • 84880748598 scopus 로고    scopus 로고
    • A mammalian pseudogene lncRNA at the interface of inflammation and antiinflammatory therapeutics
    • Rapicavoli, N. A. et al. A mammalian pseudogene lncRNA at the interface of inflammation and antiinflammatory therapeutics. eLIFE 2, e00762 (2013).
    • (2013) ELIFE , vol.2 , pp. e00762
    • Rapicavoli, N.A.1
  • 130
    • 84901928838 scopus 로고    scopus 로고
    • Genetic and epigenetic predictors of responsiveness to treatment in RA
    • Plant, D., Wilson, A. G. & Barton, A. Genetic and epigenetic predictors of responsiveness to treatment in RA. Nat. Rev. Rheumatol. 10, 329-337 (2014).
    • (2014) Nat. Rev. Rheumatol. , vol.10 , pp. 329-337
    • Plant, D.1    Wilson, A.G.2    Barton, A.3
  • 131
    • 80051986818 scopus 로고    scopus 로고
    • The kinase IKK inhibits activation of the transcription factor NFB by phosphorylating the regulatory molecule TAX1BP1
    • Shembade, N., Pujari, R., Harhaj, N. S., Abbott, D. W. & Harhaj, E. W. The kinase IKK inhibits activation of the transcription factor NFB by phosphorylating the regulatory molecule TAX1BP1. Nat. Immunol. 12, 834-843 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 834-843
    • Shembade, N.1    Pujari, R.2    Harhaj, N.S.3    Abbott, D.W.4    Harhaj, E.W.5
  • 132
    • 61949220270 scopus 로고    scopus 로고
    • The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NFB signalling
    • Shembade, N., Parvatiyar, K., Harhaj, N. S. & Harhaj, E. W. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NFB signalling. EMBO J. 28, 513-522 (2009).
    • (2009) EMBO J. , vol.28 , pp. 513-522
    • Shembade, N.1    Parvatiyar, K.2    Harhaj, N.S.3    Harhaj, E.W.4
  • 133
    • 41949100650 scopus 로고    scopus 로고
    • Involvement of Ymer in suppression of NFB activation by regulated interaction with lysine-63linked polyubiquitin chain
    • Bohgaki, M. et al. Involvement of Ymer in suppression of NFB activation by regulated interaction with lysine-63linked polyubiquitin chain. Biochim. Biophys. Acta 1783, 826-837 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 826-837
    • Bohgaki, M.1
  • 134
    • 84867898782 scopus 로고    scopus 로고
    • A20: Linking a complex regulator of ubiquitylation to immunity and human disease
    • Ma, A. & Malynn, B. A. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat. Rev. Immunol. 12, 774-785 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 774-785
    • Ma, A.1    Malynn, B.A.2
  • 135
    • 3943054838 scopus 로고    scopus 로고
    • Deubiquitination and ubiquitin ligase domains of A20 downregulate NFB signalling
    • Wertz, I. E. et al. Deubiquitination and ubiquitin ligase domains of A20 downregulate NFB signalling. Nature 430, 694-699 (2004).
    • (2004) Nature , vol.430 , pp. 694-699
    • Wertz, I.E.1
  • 136
    • 77955417276 scopus 로고    scopus 로고
    • Lys11linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
    • Bremm, A., Freund, S. M. & Komander, D. Lys11linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat. Struct. Mol. Biol. 17, 939-947 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 939-947
    • Bremm, A.1    Freund, S.M.2    Komander, D.3
  • 137
    • 84880851215 scopus 로고    scopus 로고
    • OTULIN restricts Met1linked ubiquitination to control innate immune signaling
    • Fiil, B. K. et al. OTULIN restricts Met1linked ubiquitination to control innate immune signaling. Mol. Cell 50, 818-830 (2013).
    • (2013) Mol. Cell , vol.50 , pp. 818-830
    • Fiil, B.K.1
  • 138
    • 84899911195 scopus 로고    scopus 로고
    • Molecular basis and regulation of OTULIN-LUBAC interaction
    • Elliott, P. R. et al. Molecular basis and regulation of OTULIN-LUBAC interaction. Mol. Cell 54, 335-348 (2014).
    • (2014) Mol. Cell , vol.54 , pp. 335-348
    • Elliott, P.R.1
  • 139
    • 84899982792 scopus 로고    scopus 로고
    • Binding of OTULIN to the PUB domain of HOIP controls NFB signaling
    • Schaeffer, V. et al. Binding of OTULIN to the PUB domain of HOIP controls NFB signaling. Mol. Cell 54, 349-361 (2014).
    • (2014) Mol. Cell , vol.54 , pp. 349-361
    • Schaeffer, V.1
  • 140
    • 18844464056 scopus 로고    scopus 로고
    • Identification of the familial cylindromatosis tumour-suppressor gene
    • Bignell, G. R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat. Genet. 25, 160-165 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 160-165
    • Bignell, G.R.1
  • 141
    • 84924269252 scopus 로고    scopus 로고
    • Structures of CYLD USP with Met1-or Lys63linked diubiquitin reveal mechanisms for dual specificity
    • Sato, Y. et al. Structures of CYLD USP with Met1-or Lys63linked diubiquitin reveal mechanisms for dual specificity. Nat. Struct. Mol. Biol. 22, 222-229 (2015).
    • (2015) Nat. Struct. Mol. Biol. , vol.22 , pp. 222-229
    • Sato, Y.1
  • 142
    • 84862907678 scopus 로고    scopus 로고
    • Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF-induced cancer cell migration
    • Xiao, N. et al. Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF-induced cancer cell migration. Biochem. J. 441, 979-986 (2012).
    • (2012) Biochem. J. , vol.441 , pp. 979-986
    • Xiao, N.1
  • 143
    • 78650371990 scopus 로고    scopus 로고
    • MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NFB signaling
    • Liang, J. et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NFB signaling. J. Exp. Med. 207, 2959-2973 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2959-2973
    • Liang, J.1
  • 144
    • 67349167059 scopus 로고    scopus 로고
    • Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay
    • Matsushita, K. et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458, 1185-1190 (2009).
    • (2009) Nature , vol.458 , pp. 1185-1190
    • Matsushita, K.1
  • 145
    • 33748702290 scopus 로고    scopus 로고
    • Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    • McCoy, M. K. et al. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. 26, 9365-9375 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 9365-9375
    • McCoy, M.K.1
  • 146
    • 62249094525 scopus 로고    scopus 로고
    • Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    • McAlpine, F. E. et al. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol. Dis. 34, 163-177 (2009).
    • (2009) Neurobiol. Dis. , vol.34 , pp. 163-177
    • McAlpine, F.E.1
  • 147
    • 84861556594 scopus 로고    scopus 로고
    • Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
    • Sama, D. M. et al. Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. PLoS ONE 7, e38170 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e38170
    • Sama, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.