14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-aα-Induced time course-dependent NF-κb activity

Journal of Proteome Research

Volumn 9, Issue 7, 2010, Pages 3465-3478

  Zuo, Shuai ^a   Xue, Yan ^a,b,c   Tang, Siwei ^a   Yao, Jun ^a   Du, Ruyun ^a   Yang, Pengyuan ^a   Chen, Xian ^a,b  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

14 3 3 ; Amino acid coded mass tagging; immune response; LC MS MS; nuclear factor kappa B; PPM1B; TAK1; tumor necrosis factor R

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE 2C BETA; PROTEIN 14 3 3; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARRIER PROTEIN; DNA HELICASE; FLAG PEPTIDE; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; OLIGOPEPTIDE; PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE 2C; RUVBL2 PROTEIN, HUMAN; YWHAE PROTEIN, HUMAN;

ARTICLE; BIOINFORMATICS; CELL CYCLE REGULATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA REPAIR; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; BIOLOGY; CELL LINE; CONFOCAL MICROSCOPY; GENETICS; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

14-3-3 PROTEINS; CARRIER PROTEINS; CELL LINE; COMPUTATIONAL BIOLOGY; DNA HELICASES; HUMANS; IMMUNOBLOTTING; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, CONFOCAL; NF-KAPPA B; OLIGOPEPTIDES; PEPTIDES; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN INTERACTION MAPPING; REPRODUCIBILITY OF RESULTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954374360     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr9011377     Document Type: Article

References (91)

1. Baud, V.; Karin, M. Signal transduction by tumor necrosis factor and its relatives Trends Cell Biol. 2001, 11 (9) 372-377
2. Tracey, K. J.; Cerami, A. Tumor-necrosis-factor-a pleiotropic cytokine and therapeutic target Ann. Rev. Med. 1994, 45, 491-503
3. Dolcet, X.; Llobet, D.; Pallares, J.; Matias-Guiu, X. NF-kB in development and progression of human cancer Virchows Arch. 2005, 446 (5) 475-82
4. Giuliani, C.; Napolitano, G.; Bucci, I.; Montani, V.; Monaco, F. [Nf-kB transcription factor: role in the pathogenesis of inflammatory, autoimmune, and neoplastic diseases and therapy implications] La Clin. Ter. 2001, 152 (4) 249-53
5. Magnani, M.; Crinelli, R.; Bianchi, M.; Antonelli, A. The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB) Curr. Drug Targets 2000, 1 (4) 387-99
6. Salminen, A.; Huuskonen, J.; Ojala, J.; Kauppinen, A.; Kaarniranta, K.; Suuronen, T. Activation of innate immunity system during aging: NF-kappa B signaling is the molecular culprit of inflamm-aging Ageing Res. Rev. 2008, 7 (2) 83-105
7. Aguilera, C.; Fernandez-Majada, V.; Ingles-Esteve, J.; Rodilla, V.; Bigas, A.; Espinosa, L. Efficient nuclear export of p65-I kappa B alpha complexes requires 14-3-3 proteins J. Cell Sci. 2006, 119 (17) 3695-3704
8. Wajant, H.; Pfizenmaier, K.; Scheurich, P. Tumor necrosis factor signaling Cell Death Differ. 2003, 10 (1) 45-65
9. Varfolomeev, E. E.; Ashkenazi, A. Tumor necrosis factor: An apoptosis JuNKie Cell 2004, 116 (4) 491-497
10. Bouwmeester, T.; Bauch, A.; Ruffner, H.; Angrand, P. O.; Bergamini, G.; Croughton, K.; Cruciat, C.; Eberhard, D.; Gagneur, J.; Ghidelli, S.; Hopf, C.; Huhse, B.; Mangano, R.; Michon, A. M.; Schirle, M.; Schlegl, J.; Schwab, M.; Stein, M. A.; Bauer, A.; Casari, G.; Drewes, G.; Gavin, A. C.; Jackson, D. B.; Joberty, G.; Neubauer, G.; Rick, J.; Kuster, B.; Superti-Furga, G. A physical and functional map of the human TNF-alpha NF-kappa B signal transduction pathway Nat. Cell Biol. 2004, 6 (2) 97-105
11. Choi, E. Y.; Orlova, V. V.; Fagerholm, S. C.; Nurmi, S. M.; Zhang, L.; Ballantyne, C. M.; Gahmberg, C. G.; Chavakis, T. Regulation of LFA-1-dependent inflammatory cell recruitment by Cb1-b and 14-3-3 proteins Blood 2008, 111 (7) 3607-3614
12. Tzivion, G.; Gupta, V. S.; Kaplun, L.; Balan, V. 14-3-3 proteins as potential oncogenes Semin. Cancer Biol. 2006, 16 (3) 203-213
13. Winter, S.; Simboeck, E.; Fischle, W.; Zupkovitz, G.; Dohnal, I.; Mechtler, K.; Ammerer, G.; Seiser, C. 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation EMBO J. 2008, 27 (1) 88-99
14. Zannis-Hadjopoulos, M.; Yahyaoui, W.; Callejo, M. 14-3-3 Cruciform-binding proteins as regulators of eukaryotic DNA replication Trends in Biochem. Sci. 2008, 33 (1) 44-50
15. Usui, T.; Petrini, J. H. The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53 Proc. Natl. Acad. Sci. U. S. A. 2007, 104 (8) 2797-2802
16. Milton, A. H.; Khaire, N.; Ingram, L.; O'Donnell, A. J.; La Thangue, N. B. 14-3-3 proteins integrate E2F activity with the DNA damage response EMBO J. 2006, 25 (5) 1046-57
17. Lee, J. A.; Park, J. E.; Lee, D. H.; Park, S. G.; Myung, P. K.; Park, B. C.; Cho, S. G(1) to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1 Oncogene 2008, 27 (9) 1297-1305
18. Porter, G. W.; Khuri, F. R.; Fu, H. Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways Semin. Cancer Biol. 2006, 16 (3) 193-202
19. Rubio, M. P.; Geraghty, K. M.; Wong, B. H. C.; Wood, N. T.; Campbell, D. G.; Morrice, N.; Mackintosh, C. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking Biochem. J. 2004, 379, 395-408
20. Meek, S. E. M.; Lane, W. S.; Piwnica-Worms, H. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins J. Biol. Chem. 2004, 279 (31) 32046-32054
21. Jin, J.; Smith, F. D.; Stark, C.; Wells, C. D.; Fawcett, J. P.; Kulkarni, S.; Metalnikov, P.; O'Donnell, P.; Taylor, P.; Taylor, L.; Zougman, A.; Woodgett, J. R.; Langeberg, L. K.; Scott, J. D.; Pawson, T. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization Curr. Biol. 2004, 14 (16) 1436-1450
22. Angrand, P. O.; Segura, I.; Volkel, P.; Ghidelli, S.; Terry, R.; Brajenovic, M.; Vintersten, K.; Klein, R.; Superti-Furga, G.; Drewes, G.; Kuster, B.; Bouwmeester, T.; Acker-Palmer, A. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling Mol. Cell. Proteomics 2006, 5 (12) 2211-2227
23. Satoh, J.; Nanri, Y.; Yamamura, T. Rapid identification of 14-3-3-binding proteins by protein microarray analysis J. Neurosci. Methods 2006, 152 (1-2) 278-288
24. Benzinger, A.; Muster, N.; Koch, H. B.; Yates, J. R.; Hermeking, H. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer Mol. Cell. Proteomics 2005, 4 (6) 785-795
25. Pereira-Faca, S. R.; Kuick, R.; Puravs, E.; Zhang, Q.; Krasnoselsky, A. L.; Phanstiel, D.; Qiu, J.; Misek, D. E.; Hinderer, R.; Tammemagi, M.; Landi, M. T.; Caporaso, N.; Pfeiffer, R.; Edelstein, C.; Goodman, G.; Barnett, M.; Thornquist, M.; Brenner, D.; Hanash, S. M. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer Cancer Res. 2007, 67 (24) 12000-12006
26. Lv, J.; Zhu, X.; Dong, K.; Lin, Y.; Hu, Y.; Zhu, C., Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics. Fertil. Steril. 2008, 1892 - 1898.
27. Bhawal, U. K.; Tsukinoki, K.; Sasahira, T.; Sato, F.; Mori, Y.; Muto, N.; Sugiyama, M.; Kuniyasu, H. Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer Oncol. Rep. 2007, 18 (4) 817-824
28. Chen, J.; Lee, C. T.; Errico, S. L.; Becker, K. G.; Freed, W. J. Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells J. Neurosci. Res. 2007, 85 (8) 1724-33
29. Kilani, R. T.; Maksymowych, W. P.; Aitken, A.; Boire, G.; St-Pierre, Y.; Li, Y.; Ghahary, A. Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation J. Rheumatol. 2007, 34 (8) 1650-7
30. Wang, W.; Shakes, D. C. Molecular evolution of the 14-3-3 protein family J. Mol. Evol. 1996, 43 (4) 384-98
31. Di Fede, G.; Giaccone, G.; Limido, L.; Mangieri, M.; Suardi, S.; Puoti, G.; Morbin, M.; Mazzoleni, G.; Ghetti, B.; Tagliavini, F. The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Straussler-Scheinker disease J. Neuropathol. Exp. Neurol. 2007, 66 (2) 124-130
32. Liou, J. Y.; Ghelani, D.; Yeh, S.; Wu, K. K. Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon Cancer Res. 2007, 67 (7) 3185-3191
33. Qi, W.; Liu, X.; Qiao, D.; Martinez, J. D. Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues Int. J. Cancer 2005, 113 (3) 359-363
34. Chuthapisith, S.; Layfield, R.; Kerr, I. D.; Hughes, C.; Eremin, O. Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs Int. J. Oncol. 2007, 30 (6) 1545-51
35. Seow, T. K.; Ong, S. E.; Liang, R.; Ren, E. C.; Chan, L.; Ou, K.; Chung, M. C. M. Two-dimensional electrophoresis map of the human hepatocellular carcinoma cell line, HCC-M, and identification of the separated proteins by mass spectrometry Electrophoresis 2000, 21 (9) 1787-1813
36. Lee, S. K.; Park, S. O.; Joe, C. O.; Kim, Y. S. Interaction of HCV core protein with 14-3-3 epsilon protein releases Bax to activate apoptosis Biochem. Biophys. Res. Commun. 2007, 352 (3) 756-762
37. Chong, S. S.; Tanigami, A.; Roschke, A. V.; Ledbetter, D. H. 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region Genome Res. 1996, 6 (8) 735-741
38. Liou, J. Y.; Ghelani, D.; Yeh, S.; Wu, K. K. Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3 epsilon Cancer Res. 2007, 67 (7) 3185-3191
39. Wang, T. Y.; Gu, S.; Ronni, T.; Du, Y. C.; Chen, M. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response J. Proteome Res. 2005, 4 (3) 941-949
40. Du, Y. C.; Gu, S.; Zhou, J. H.; Wang, T. Y.; Cai, H.; MacInnes, M. A.; Bradbury, E. M.; Chen, X. The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca2+/calmodulin in the ionizing radiation-induced cell cycle arrest Mol. Cell. Proteomics 2006, 5 (6) 1033-1044
41. Liang, S.; Yu, Y.; Yang, P.; Gu, S.; Xue, Y.; Chen, X. Analysis of the protein complex associated with 14-3-3 epsilon by a deuterated-leucine labeling quantitative proteomics strategy J. Chromatogr., B 2009, 877 (7) 627-634
42. Cantin, G. T.; Venable, J. D.; Cociorva, D.; Yates, J. R. Quantitative phosphoproteomic analysis of the tumor necrosis factor pathway J. Proteome Res. 2006, 5 (1) 127-134
43. Mercurio, F.; Murray, B. W.; Shevchenko, A.; Bennett, B. L.; Young, D. B.; Li, J. W.; Pascual, G.; Motiwala, A.; Zhu, H.; Mann, M.; Manning, A. M. Ikappa B kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex Mol. Cell. Biol. 1999, 19 (2) 1526-1538
44. Andrews, N. C.; Faller, D. V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian-cells Nucleic Acids Res. 1991, 19 (9) 2499-2499
45. Dubois, T.; Rommel, C.; Howell, S.; Steinhussen, U.; Soneji, Y.; Morrice, N.; Moelling, K.; Aitken, A. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction J. Biol. Chem. 1997, 272 (46) 28882-28888
46. Spooncer, E.; Brouard, N.; Nilsson, S. K.; Williams, B.; Liu, M. C.; Unwin, R. D.; Blinco, D.; Jaworska, E.; Simmons, P. J.; Whetton, A. D. Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting Mol. Cell Proteomics 2008, 7 (3) 573-581
47. Adhikari, A.; Xu, M.; Chen, Z. J. Ubiquitin-mediated activation of TAK1 and IKK Oncogene 2007, 26 (22) 3214-3226
48. Takaesu, G.; Surabhi, R. M.; Park, K. J.; Ninomiya-Tsuji, J.; Matsumoto, K.; Gaynor, R. B. TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway J. Mol. Biol. 2003, 326 (1) 105-115
49. Vidal, S.; Khush, R. S.; Leulier, F.; Tzou, P.; Nakamura, M.; Lemaitre, B. Mutations in the Drosophila dTAK1 gene reveal a conserved function or MAPKKKs in the control of rel/NF-kappa B-dependent innate immune responses Genes Dev. 2001, 15 (15) 1900-1912
50. Shim, J. H.; Xiao, C. C.; Paschal, A. E.; Bailey, S. T.; Rao, P.; Hayden, M. S.; Lee, K. Y.; Bussey, C.; Steckel, M.; Tanaka, N.; Yamada, G.; Akira, S.; Matsumoto, K.; Ghosh, S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo Genes Dev. 2005, 19 (22) 2668-2681
51. Sato, S.; Sanjo, H.; Takeda, K.; Ninomiya-Tsuji, J.; Yamamoto, M.; Kawai, T.; Matsumoto, K.; Takeuchi, O.; Akira, S. Essential function for the kinase TAK1 in innate and adaptive immune responses Nat. Immunol. 2005, 6 (11) 1087-1095
52. King, C. G.; Kobayashi, T.; Cejas, P. J.; Kim, T.; Yoon, K.; Kim, G. K.; Chiffoleau, E.; Hickman, S. P.; Walsh, P. T.; Turka, L. A.; Choi, Y. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis Nat. Med. 2006, 12 (9) 1088-1092
53. Sun, L. J.; Deng, L.; Ea, C. K.; Xia, Z. P.; Chen, Z. J. J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes Mol. Cell 2004, 14 (3) 289-301
54. Hanada, M.; Ninomiya-Tsuji, J.; Komaki, K.; Ohnishi, M.; Katsura, K.; Kanamaru, R.; Matsumoto, K.; Tamura, S. Regulation of the TAK1 signaling pathway by protein phosphatase 2C J. Biol. Chem. 2001, 276 (8) 5753-5759 (Pubitemid 37385728)
55. Tamura, S.; Toriumi, S.; Saito, J.; Awano, K.; Kudo, T.; Kobayashi, T. PP2C family members play key roles in regulation of cell survival and apoptosis Cancer Sci. 2006, 97 (7) 563-567
56. Heideker, J.; Lis, E. T.; Romesberg, F. E. Phosphatases, DNA damage checkpoints and checkpoint deactivation Cell Cycle 2007, 6 (24) 3058-3064
57. Klumpp, S.; Thissen, M. C.; Krieglstein, J. Protein phosphatases types 2Calpha and 2Cbeta in apoptosis Biochem. Soc. Trans. 2006, 34 (Pt 6) 1370-1375
58. Schweighofer, A.; Hirt, H.; Meskiene, I. Plant PP2C phosphatases: emerging functions in stress signaling Trends Plant Sci. 2004, 9 (5) 236-243
59. Steinberg, G. R. Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance Cell Cycle 2007, 6 (8) 888-894
60. Tamura, S.; Toriumi, S.; Saito, J.; Awano, K.; Kudo, T. A.; Kobayashi, T. PP2C family members play key roles in regulation of cell survival and apoptosis Cancer Sci. 2006, 97 (7) 563-7
61. Prajapati, S.; Verma, U.; Yamamoto, Y.; Kwak, Y. T.; Gaynor, R. B. Protein phosphatase 2C beta association with the I kappa B kinase complex is involved in regulating NF-kappa B activity J. Biol. Chem. 2004, 279 (3) 1739-1746
62. Bao, H. M.; Song, P. M.; Liu, Q. P.; Liu, Y. K.; Yun, D.; Saiyin, H.; Du, R. Y.; Zhang, Y.; Fan, H. Z.; Yang, P. Y.; Chen, X. Quantitative proteomic analysis of a paired human liver healthy versus carcinoma cell lines with the same genetic background to identify potential hepatocellular carcinoma markers Proteomics Clin. Appl. 2009, 3 (6) 705-719
63. Aggarwal, B. B. Signalling pathways of the TNF superfamily: A double-edged sword Nat. Rev. Immunol. 2003, 3 (9) 745-756
64. Yoshida, K.; Yamaguchi, T.; Natsume, T.; Kufe, D.; Miki, Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage Nat. Cell Biol. 2005, 7 (3) 278-85
65. Van Der Hoeven, P. C.; Van Der Wal, J. C.; Ruurs, P.; Van Dijk, M. C.; Van Blitterswijk, J. 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation Biochem. J. 2000, 345 (2) 297-306
66. Aitken, A. 14-3-3 proteins: a historic overview Semin. Cancer Biol. 2006, 16 (3) 162-72
67. Roberts, M. R. 14-3-3 Proteins find new partners in plant cell signalling Trends Plant Sci. 2003, 8 (5) 218-223
68. Shishodia, S.;; Aggarwal, B. B. Nuclear factor-[kappa]B: a friend or a foe in cancer? Biochem. Pharmacol. 2004, 68 (6) 1071-1080
69. Choo, M. K.; Sakurai, H.; Koizumi, K.; Saiki, I. TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells Int. J. Cancer 2006, 118 (11) 2758-64
70. Jackson-Bernitsas, D. G.; Ichikawa, H.; Takada, Y.; Myers, J. N.; Lin, X. L.; Darnay, B. G.; Chaturvedi, M. M.; Aggarwal, B. B. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma Oncogene 2007, 26 (10) 1385-1397
71. Lammers, T.; Peschke, P.; Ehemann, V.; Debus, J.; Slobodin, B.; Lavi, S.; Huber, P. Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity Mol. Cancer 2007, 6, 65
72. Prajapati, S.; Verma, U.; Yamamoto, Y.; Kwak, Y. T.; Gaynor, R. B. Protein phosphatase 2C{beta} association with the I{kappa}B kinase complex is involved in regulating NF-{kappa}B activity J. Biol. Chem. 2004, 279 (3) 1739-1746
73. Chen, G. Q.; Cao, P.; Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90 Mol. Cell 2002, 9 (2) 401-410
74. Parfait, B.; Giovangrandi, Y.; Asheuer, M.; Laurendeau, I.; Olivi, M.; Vodovar, N.; Vidaud, D.; Vidaud, M.; Bieche, I. Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3 Ann. Genet. 2000, 43 (2) 69-74
75. Ikura, T.; Ogryzko, V. V.; Grigoriev, M.; Groisman, R.; Wang, J.; Horikoshi, M.; Scully, R.; Qin, J.; Nakatani, Y. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis Cell 2000, 102 (4) 463-473
76. Shen, X. T.; Mizuguchi, G.; Hamiche, A.; Wu, C. A chromatin remodelling complex involved in transcription and DNA processing Nature 2000, 406 (6795) 541-544
77. Kanemaki, M.; Kurokawa, Y.; Matsu-ura, T.; Makino, Y.; Masani, A.; Okazaki, K.; Morishita, T.; Tamura, T. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a J. Biol. Chem. 1999, 274 (32) 22437-22444
78. Bauer, A.; Chauvet, S.; Huber, O.; Usseglio, F.; Rothbacher, U.; Aragnol, D.; Kemler, R.; Pradel, J. Pontin52 and Reptin52 function as antagonistic regulators of beta-catenin signalling activity EMBO J. 2000, 19 (22) 6121-6130
79. Cho, S. G.; Bhoumik, A.; Broday, L.; Ivanov, V.; Rosenstein, B.; Ronai, Z. TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage Mol. Cell. Biol. 2001, 21 (24) 8398-8413
80. Wood, M. A.; McMahon, S. B.; Cole, M. D. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc Mol. Cell 2000, 5 (2) 321-330
81. Rousseau, B.; Menard, L.; Haurie, V.; Taras, D.; Blanc, J. F.; Moreau-Gaudry, F.; Metzler, P.; Hugues, M.; Boyault, S.; Lemiere, S.; Canron, Z.; Costet, P.; Cole, M.; Balabaud, C.; Bioulac-Sage, P.; Zucman-Rossi, J.; Rosenbaum, J. Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma Hepatology 2007, 46, 1108-1118
82. Fitzgerald, K. A.; McWhirter, S. M.; Faia, K. L.; Rowe, D. C.; Latz, E.; Golenbock, D. T.; Coyle, A. J.; Liao, S. M.; Maniatis, T. IKK epsilon and TBK1 are essential components of the IRF3 signaling pathway Nat. Immunol. 2003, 4 (5) 491-496
83. Pomerantz, J. L.; Baltimore, D. NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase EMBO J. 1999, 18 (23) 6694-6704
84. Ikeda, F.; Hecker, C. M.; Rozenknop, A.; Nordmeier, R. D.; Rogov, V.; Hofmann, K.; Akira, S.; Dotsch, V.; Dikic, I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes EMBO J. 2007, 26 (14) 3451-3462
85. Karin, M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation J. Biol. Chem. 1999, 274 (39) 27339-42
86. Tojima, Y.; Fujimoto, A.; Delhase, M.; Chen, Y.; Hatakeyama, S.; Nakayama, K.; Kaneko, Y.; Nimura, Y.; Motoyama, N.; Ikeda, K.; Karin, M.; Nakanishi, M. NAK is an IkappaB kinase-activating kinase Nature 2000, 404 (6779) 778-82
87. Westermarck, J.; Weiss, C.; Saffrich, R.; Kast, J.; Musti, A. M.; Wessely, M.; Ansorge, W.; Seraphin, B.; Wilm, M.; Valdez, B. C.; Bohmann, D. The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription EMBO J. 2002, 21 (3) 451-460
88. Yang, H. S.; Zhou, J. H.; Ochs, R. L.; Henning, D.; Jin, R. Y.; Valdez, B. C. Down-regulation of RNA helicase II/Gu results in the depletion of 18 and 28 S rRNAs in Xenopus oocyte J. Biol. Chem. 2003, 278 (40) 38847-38859
89. Henning, D.; So, R. B.; Jin, R. Y.; Lau, L. F.; Valdez, B. C. Silencing of RNA helicase II/Gu alpha inhibits mammalian ribosomal RNA production J. Biol. Chem. 2003, 278 (52) 52307-52314
90. Dhar, S. K.; Lynn, B. C.; Daosukho, C.; St. Clair, D. K. Identification of nucleophosmin as an NF-{kappa}B Co-activator for the induction of the human SOD2 gene J. Biol. Chem. 2004, 279 (27) 28209-28219
91. Matsuda, A.; Suzuki, Y.; Honda, G.; Muramatsu, S.; Matsuzaki, O.; Nagano, Y.; Doi, T.; Shimotohno, K.; Harada, T.; Nishida, E.; Hayashi, H.; Sugano, S. Large-scale identification and characterization of human genes that activate NF-[kappa]B and MAPK signaling pathways. Oncogene 22, (21), 3307 - 3318.