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Volumn 10, Issue 6, 2014, Pages 329-337

Genetic and epigenetic predictors of responsiveness to treatment in RA

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; CADHERIN; CD84 ANTIGEN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DNA; ETANERCEPT; GAMMA INTERFERON; HISTONE H3; INFLIXIMAB; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN; MESSENGER RNA; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PROTEIN TYROSINE PHOSPHATASE; REDUCED FOLATE CARRIER; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

EID: 84901928838     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.16     Document Type: Review
Times cited : (72)

References (86)
  • 1
    • 33845506003 scopus 로고    scopus 로고
    • Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: A meta-analysis
    • Finckh, A., Liang, M. H., van Herckenrode, C. M. & de Pablo, P. Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: a meta-analysis. Arthritis Rheum. 55, 864-872 (2006).
    • (2006) Arthritis Rheum , vol.55 , pp. 864-872
    • Finckh, A.1    Liang, M.H.2    Van Herckenrode, C.M.3    De Pablo, P.4
  • 2
    • 80051709582 scopus 로고    scopus 로고
    • Reduction of long-term disability in inflammatory polyarthritis by early and persistent suppression of joint inflammation: Results from the Norfolk Arthritis Register
    • Scirè, C. A. et al. Reduction of long-term disability in inflammatory polyarthritis by early and persistent suppression of joint inflammation: results from the Norfolk Arthritis Register. Arthritis Care Res. (Hoboken) 63, 945-952 (2011).
    • (2011) Arthritis Care Res. (Hoboken) , vol.63 , pp. 945-952
    • Scirè, C.A.1
  • 3
    • 84905158604 scopus 로고    scopus 로고
    • Early remission is associated with improved survival in patients with inflammatory polyarthritis: Results from the Norfolk Arthritis Register
    • Scirè, C. A., Lunt, M., Marshall, T., Symmons, D. P. & Verstappen, S. M. Early remission is associated with improved survival in patients with inflammatory polyarthritis: results from the Norfolk Arthritis Register. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-203339.
    • Ann. Rheum. Dis.
    • Scirè, C.A.1    Lunt, M.2    Marshall, T.3    Symmons, D.P.4    Verstappen, S.M.5
  • 4
    • 84901920490 scopus 로고    scopus 로고
    • Nice Pathways. Rheumatoid arthritis overview [online]
    • Nice Pathways. Rheumatoid arthritis overview [online], http://pathways.nice.org.uk/pathways/rheumatoid-arthritis (2013).
  • 5
    • 0036107631 scopus 로고    scopus 로고
    • Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-α antibody compared with methotrexate in long-standing rheumatoid arthritis
    • Barrera, P. et al. Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-α antibody compared with methotrexate in long-standing rheumatoid arthritis. Rheumatology (Oxford) 41, 430-439 (2002).
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 430-439
    • Barrera, P.1
  • 6
    • 33751416149 scopus 로고    scopus 로고
    • Predictors of response to anti-TNF-α therapy among patients with rheumatoid arthritis: Results from the British Society for Rheumatology Biologics Register
    • Hyrich, K. L., Watson, K. D., Silman, A. J. & Symmons, D. P. Predictors of response to anti-TNF-α therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford) 45, 1558-1565 (2006).
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1558-1565
    • Hyrich, K.L.1    Watson, K.D.2    Silman, A.J.3    Symmons, D.P.4
  • 7
    • 77950333600 scopus 로고    scopus 로고
    • Early treatment with, and time receiving, first disease-modifying antirheumatic drug predicts long-term function in patients with inflammatory polyarthritis
    • Farragher, T. M., Lunt, M., Fu, B., Bunn, D. & Symmons, D. P. Early treatment with, and time receiving, first disease-modifying antirheumatic drug predicts long-term function in patients with inflammatory polyarthritis. Ann. Rheum. Dis. 69, 689-695 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 689-695
    • Farragher, T.M.1    Lunt, M.2    Fu, B.3    Bunn, D.4    Symmons, D.P.5
  • 8
    • 58349103900 scopus 로고    scopus 로고
    • Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    • Potter, C. et al. Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann. Rheum. Dis. 68, 69-74 (2009).
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 69-74
    • Potter, C.1
  • 9
    • 58349088074 scopus 로고    scopus 로고
    • Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis?
    • Hider, S. L. et al. Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis? Ann. Rheum. Dis. 68, 57-62 (2009).
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 57-62
    • Hider, S.L.1
  • 10
    • 33744502855 scopus 로고    scopus 로고
    • Cancer biomarkers-an invitation to the table
    • Dalton, W. S. & Friend, S. H. Cancer biomarkers-an invitation to the table. Science 312, 1165-1168 (2006).
    • (2006) Science , vol.312 , pp. 1165-1168
    • Dalton, W.S.1    Friend, S.H.2
  • 11
    • 22044433685 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
    • Bodin, L. et al. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood 106, 135-140 (2005).
    • (2005) Blood , vol.106 , pp. 135-140
    • Bodin, L.1
  • 12
    • 51649110496 scopus 로고    scopus 로고
    • A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
    • Cooper, G. M. et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 112, 1022-1027 (2008).
    • (2008) Blood , vol.112 , pp. 1022-1027
    • Cooper, G.M.1
  • 13
    • 33750352061 scopus 로고    scopus 로고
    • And metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis
    • Dervieux, T., Greenstein, N. & Kremer, J. Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum. 54, 3095-3103 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 3095-3103
    • Dervieux, T.1    Greenstein, N.2    Pharmacogenomic, K.J.3
  • 14
    • 0036263469 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses
    • Urano, W. et al. Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. Pharmacogenetics 12, 183-190 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 183-190
    • Urano, W.1
  • 15
    • 84884211861 scopus 로고    scopus 로고
    • MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: Analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms
    • Owen, S. A. et al. MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms. Pharmacogenomics J. 13, 137-147 (2013).
    • (2013) Pharmacogenomics J , vol.13 , pp. 137-147
    • Owen, S.A.1
  • 16
    • 70649086092 scopus 로고    scopus 로고
    • Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    • Raychaudhuri, S. et al. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat. Genet. 41, 1313-1318 (2009).
    • (2009) Nat. Genet , vol.41 , pp. 1313-1318
    • Raychaudhuri, S.1
  • 17
    • 77954241353 scopus 로고    scopus 로고
    • Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy
    • Cui, J. et al. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy. Arthritis Rheum. 62, 1849-1861 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1849-1861
    • Cui, J.1
  • 18
    • 84857721973 scopus 로고    scopus 로고
    • Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort
    • Plant, D. et al. Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum. 64, 665-670 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 665-670
    • Plant, D.1
  • 19
    • 84879502298 scopus 로고    scopus 로고
    • Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: Results from the CORRONA registry and meta-analysis
    • Pappas, D. A., Oh, C., Plenge, R. M., Kremer, J. M. & Greenberg, J. D. Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis. Inflammation 36, 279-284 (2013).
    • (2013) Inflammation , vol.36 , pp. 279-284
    • Pappas, D.A.1    Oh, C.2    Plenge, R.M.3    Kremer, J.M.4    Greenberg, J.D.5
  • 20
    • 84875993860 scopus 로고    scopus 로고
    • Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    • Cui, J. et al. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet. 9, e1003394 (2013).
    • (2013) PLoS Genet , vol.9
    • Cui, J.1
  • 21
    • 84877648835 scopus 로고    scopus 로고
    • GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis
    • Acosta-Colman, I. et al. GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics 14, 727-734 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 727-734
    • Acosta-Colman, I.1
  • 22
    • 84878404904 scopus 로고    scopus 로고
    • The potential use of expression profiling: Implications for predicting treatment response in rheumatoid arthritis
    • Smith, S. L., Plant, D., Eyre, S. & Barton, A. The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis. Ann. Rheum. Dis. 72, 1118-1124 (2013).
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 1118-1124
    • Smith, S.L.1    Plant, D.2    Eyre, S.3    Barton, A.4
  • 23
    • 79953706343 scopus 로고    scopus 로고
    • Tobacco-smoking-related differential DNA methylation: 27K discovery and replication
    • Breitling, L. P., Yang, R., Korn, B., Burwinkel, B. & Brenner, H. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am. J. Hum. Genet. 88, 450-457 (2011).
    • (2011) Am. J. Hum. Genet , vol.88 , pp. 450-457
    • Breitling, L.P.1    Yang, R.2    Korn, B.3    Burwinkel, B.4    Brenner, H.5
  • 24
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga, M. F. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102, 10604-10609 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10604-10609
    • Fraga, M.F.1
  • 25
    • 84882884517 scopus 로고    scopus 로고
    • Charting a dynamic DNA methylation landscape of the human genome
    • Ziller, M. J. et al. Charting a dynamic DNA methylation landscape of the human genome. Nature 500, 477-481 (2013).
    • (2013) Nature , vol.500 , pp. 477-481
    • Ziller, M.J.1
  • 26
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T. Chromatin modifications and their function. Cell 128, 693-705 (2007).
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 27
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • Nile, C. J., Read, R. C., Akil, M., Duff, G. W. & Wilson, A. G. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum. 58, 2686-2693 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 2686-2693
    • Nile, C.J.1    Read, R.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 28
    • 0034121235 scopus 로고    scopus 로고
    • Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
    • MacGregor, A. J. et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 43, 30-37 (2000).
    • (2000) Arthritis Rheum , vol.43 , pp. 30-37
    • MacGregor, A.J.1
  • 30
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen, B. C. et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 5, e1000602 (2009).
    • (2009) PLoS Genet , vol.5
    • Christensen, B.C.1
  • 31
    • 79960121131 scopus 로고    scopus 로고
    • The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood
    • Langevin, S. M. et al. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 6, 908-919 (2011).
    • (2011) Epigenetics , vol.6 , pp. 908-919
    • Langevin, S.M.1
  • 32
    • 84872607594 scopus 로고    scopus 로고
    • Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa
    • Tapp, H. S. et al. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell 12, 148-155 (2013).
    • (2013) Aging Cell , vol.12 , pp. 148-155
    • Tapp, H.S.1
  • 33
    • 73249146755 scopus 로고    scopus 로고
    • DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    • Karouzakis, E., Gay, R. E., Michel, B. A., Gay, S. & Neidhart, M. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 60, 3613-3622 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 3613-3622
    • Karouzakis, E.1    Gay, R.E.2    Michel, B.A.3    Gay, S.4    Neidhart, M.5
  • 34
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson, B. et al. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 33, 1665-1673 (1990).
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1
  • 35
    • 84875943253 scopus 로고    scopus 로고
    • Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression
    • de la Rica, L. et al. Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression. J. Autoimmun. 41, 6-16 (2013).
    • (2013) J. Autoimmun , vol.41 , pp. 6-16
    • De La Rica, L.1
  • 37
    • 84863685954 scopus 로고    scopus 로고
    • Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis
    • Ishida, K. et al. Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. J. Periodontol. 83, 917-925 (2012).
    • (2012) J. Periodontol , vol.83 , pp. 917-925
    • Ishida, K.1
  • 38
    • 84873576566 scopus 로고    scopus 로고
    • Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
    • Liu, Y. et al. Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat. Biotechnol. 31, 142-147 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 142-147
    • Liu, Y.1
  • 40
    • 84871778727 scopus 로고    scopus 로고
    • Duality of fibroblast-like synoviocytes in RA: Passive responders and imprinted aggressors
    • Bottini, N. & Firestein, G. S. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat. Rev. Rheumatol. 9, 24-33 (2013).
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 24-33
    • Bottini, N.1    Firestein, G.S.2
  • 41
    • 84877602531 scopus 로고    scopus 로고
    • The ascent of acetylation in the epigenetics of rheumatoid arthritis
    • Grabiec, A. M. & Reedquist, K. A. The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat. Rev. Rheumatol. 9, 311-318 (2013).
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 311-318
    • Grabiec, A.M.1    Reedquist, K.A.2
  • 42
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird, P. W. Principles and challenges of genomewide DNA methylation analysis. Nat. Rev. Genet. 11, 191-203 (2010).
    • (2010) Nat. Rev. Genet , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 43
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343, 1350-1354 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 1350-1354
    • Esteller, M.1
  • 44
    • 0037005988 scopus 로고    scopus 로고
    • Hypermethylation of the DNA repair gene O-6-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    • Esteller, M. et al. Hypermethylation of the DNA repair gene O-6-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J. Natl Cancer Inst. 94, 26-32 (2002).
    • (2002) J. Natl Cancer Inst , vol.94 , pp. 26-32
    • Esteller, M.1
  • 45
    • 78650223983 scopus 로고    scopus 로고
    • Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer
    • Kawakami, K. et al. Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer. Cancer Sci. 102, 166-174 (2011).
    • (2011) Cancer Sci , vol.102 , pp. 166-174
    • Kawakami, K.1
  • 46
    • 1642586763 scopus 로고    scopus 로고
    • Molecular biology of 5,10-methylenetetrahydrofolate reductase
    • Fodinger, M., Horl, W. H. & Sunder-Plassmann, G. Molecular biology of 5,10-methylenetetrahydrofolate reductase. J. Nephrol. 13, 20-33 (2000).
    • (2000) J. Nephrol , vol.13 , pp. 20-33
    • Fodinger, M.1    Horl, W.H.2    Sunder-Plassmann, G.3
  • 47
    • 0029926820 scopus 로고    scopus 로고
    • S-adenosylmethionine and methylation
    • Chiang, P. K. et al. S-adenosylmethionine and methylation. FASEB J. 10, 471-480 (1996).
    • (1996) FASEB J , vol.10 , pp. 471-480
    • Chiang, P.K.1
  • 48
    • 0030205396 scopus 로고    scopus 로고
    • DNA hypomethylation in inflammatory arthritis: Reversal with methotrexate
    • Kim, Y. I., Logan, J. W., Mason, J. B. & Roubenoff, R. DNA hypomethylation in inflammatory arthritis: reversal with methotrexate. J. Lab. Clin. Med. 128, 165-172 (1996).
    • (1996) J. Lab. Clin. Med , vol.128 , pp. 165-172
    • Kim, Y.I.1    Logan, J.W.2    Mason, J.B.3    Roubenoff, R.4
  • 49
    • 84874962763 scopus 로고    scopus 로고
    • + T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease
    • Ellis, J. A. et al. Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease. Clin. Epigenetics 4, 20 (2012).
    • Clin. Epigenetics , vol.4 , Issue.20 , pp. 2012
    • Ellis, J.A.1
  • 50
    • 84883171525 scopus 로고    scopus 로고
    • Epigenetic alteration: New insights moving from tissue to plasma-the example of PCDH10 promoter methylation in colorectal cancer
    • Danese, E. et al. Epigenetic alteration: new insights moving from tissue to plasma-the example of PCDH10 promoter methylation in colorectal cancer. Br. J. Cancer 109, 807-813 (2013).
    • (2013) Br. J. Cancer , vol.109 , pp. 807-813
    • Danese, E.1
  • 51
    • 84872252722 scopus 로고    scopus 로고
    • Clinical and prognostic significance of protocadherin-10 (PCDH10) promoter methylation in bladder cancer
    • Lin, Y. L., Li, Z. G., He, Z. K., Guan, T. Y. & Ma, J. G. Clinical and prognostic significance of protocadherin-10 (PCDH10) promoter methylation in bladder cancer. J. Int. Med. Res. 40, 2117-2123 (2012).
    • (2012) J. Int. Med. Res , vol.40 , pp. 2117-2123
    • Lin, Y.L.1    Li, Z.G.2    He, Z.K.3    Guan, T.Y.4    Ma, J.G.5
  • 52
    • 84878413517 scopus 로고    scopus 로고
    • Downregulation of protocadherin-10 expression correlates with malignant behaviour and poor prognosis in human bladder cancer
    • Ma, J. G., He, Z. K., Ma, J. H., Li, W. P. & Sun, G. Downregulation of protocadherin-10 expression correlates with malignant behaviour and poor prognosis in human bladder cancer. J. Int. Med. Res. 41, 38-47 (2013).
    • (2013) J. Int. Med. Res , vol.41 , pp. 38-47
    • Ma, J.G.1    He, Z.K.2    Ma, J.H.3    Li, W.P.4    Sun, G.5
  • 53
    • 84872846920 scopus 로고    scopus 로고
    • Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer
    • Tang, X. et al. Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. Cancer Biomark. 12, 11-19 (2012).
    • (2012) Cancer Biomark , vol.12 , pp. 11-19
    • Tang, X.1
  • 54
    • 80053654718 scopus 로고    scopus 로고
    • Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance
    • Narayan, G. et al. Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance. Genes Chromosomes Cancer 50, 1043-1053 (2011).
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 1043-1053
    • Narayan, G.1
  • 55
    • 44149098042 scopus 로고    scopus 로고
    • Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier
    • Yang, R. et al. Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer 8, 124 (2008).
    • (2008) BMC Cancer , vol.8 , pp. 124
    • Yang, R.1
  • 56
    • 0035955602 scopus 로고    scopus 로고
    • Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells
    • Worm, J., Kirkin, A. F., Dzhandzhugazyan, K. N. & Guldberg, P. Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells. J. Biol. Chem. 276, 39990-40000 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 39990-40000
    • Worm, J.1    Kirkin, A.F.2    Dzhandzhugazyan, K.N.3    Guldberg, P.4
  • 57
    • 55349093579 scopus 로고    scopus 로고
    • Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: A study of polymorphisms affecting methotrexate transport and folate metabolism
    • Bohanec, G. P., Logar, D., Lestan, B. & Dolzan, V. Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism. Eur. J. Clin. Pharmacol. 64, 1057-1068 (2008).
    • (2008) Eur. J. Clin. Pharmacol , vol.64 , pp. 1057-1068
    • Bohanec, G.P.1    Logar, D.2    Lestan, B.3    Dolzan, V.4
  • 58
    • 34547843568 scopus 로고    scopus 로고
    • Transcription regulatory polymorphism-43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy
    • Chatzikyriakidou, A. et al. Transcription regulatory polymorphism- 43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy. Rheumatol. Int. 27, 1057-1061 (2007).
    • (2007) Rheumatol. Int , vol.27 , pp. 1057-1061
    • Chatzikyriakidou, A.1
  • 59
    • 83655201266 scopus 로고    scopus 로고
    • Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
    • Dervieux, T. et al. Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis. Pharmacogenet. Genomics 22, 1-9 (2012).
    • (2012) Pharmacogenet. Genomics , vol.22 , pp. 1-9
    • Dervieux, T.1
  • 60
    • 36649028325 scopus 로고    scopus 로고
    • Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis
    • Drozdzik, M. et al. Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis. Pharmacogenomics J. 7, 404-407 (2007).
    • (2007) Pharmacogenomics J , vol.7 , pp. 404-407
    • Drozdzik, M.1
  • 61
    • 77952425589 scopus 로고    scopus 로고
    • Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate
    • Stamp, L. K. et al. Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenet. Genomics 20, 367-376 (2010).
    • (2010) Pharmacogenet. Genomics , vol.20 , pp. 367-376
    • Stamp, L.K.1
  • 62
    • 33646354882 scopus 로고    scopus 로고
    • Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes
    • Wessels, J. A. et al. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum. 54, 1087-1095 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 1087-1095
    • Wessels, J.A.1
  • 63
    • 54949146894 scopus 로고    scopus 로고
    • Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis
    • Maxwell, J. R. et al. Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Hum. Mol. Genet. 17, 3532-3538 (2008).
    • (2008) Hum. Mol. Genet , vol.17 , pp. 3532-3538
    • Maxwell, J.R.1
  • 64
    • 67349101771 scopus 로고    scopus 로고
    • TNF-α-308 G/A polymorphism and responsiveness to TNF-α blockade therapy in moderate to severe rheumatoid arthritis: A systematic review and meta-analysis
    • O'Rielly, D. D., Roslin, N. M., Beyene, J., Pope, A. & Rahman, P. TNF-α-308 G/A polymorphism and responsiveness to TNF-α blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. Pharmacogenomics J. 9, 161-167 (2009).
    • (2009) Pharmacogenomics J , vol.9 , pp. 161-167
    • O'Rielly, D.D.1    Roslin, N.M.2    Beyene, J.3    Pope, A.4    Rahman, P.5
  • 65
    • 0036712454 scopus 로고    scopus 로고
    • Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes
    • Saccani, S. & Natoli, G. Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev. 16, 2219-2224 (2002).
    • (2002) Genes Dev , vol.16 , pp. 2219-2224
    • Saccani, S.1    Natoli, G.2
  • 66
    • 33749051214 scopus 로고    scopus 로고
    • Keeping up NF-κB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics
    • Vanden, B. W. et al. Keeping up NF-κB appearances: epigenetic control of immunity or inflammation-triggered epigenetics. Biochem. Pharmacol. 72, 1114-1131 (2006).
    • (2006) Biochem. Pharmacol , vol.72 , pp. 1114-1131
    • Vanden, B.W.1
  • 67
    • 34447513163 scopus 로고    scopus 로고
    • Epigenetic regulation of tumor necrosis factor α
    • Sullivan, K. E. et al. Epigenetic regulation of tumor necrosis factor α. Mol. Cell Biol. 27, 5147-5160 (2007).
    • (2007) Mol. Cell Biol , vol.27 , pp. 5147-5160
    • Sullivan, K.E.1
  • 68
    • 19944430797 scopus 로고    scopus 로고
    • Genomic maps and comparative analysis of histone modifications in human and mouse
    • Bernstein, B. E. et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120, 169-181 (2005).
    • (2005) Cell , vol.120 , pp. 169-181
    • Bernstein, B.E.1
  • 69
    • 81455131478 scopus 로고    scopus 로고
    • Age-related loss of CpG methylation in the tumour necrosis factor promoter
    • Gowers, I. R. et al. Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine 56, 792-797 (2011).
    • (2011) Cytokine , vol.56 , pp. 792-797
    • Gowers, I.R.1
  • 70
    • 0030810790 scopus 로고    scopus 로고
    • Tumour necrosis factor α gene polymorphisms in rheumatoid arthritis: Association with susceptibility to, or severity of, disease?
    • Brinkman, B. M. et al. Tumour necrosis factor α gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br. J. Rheumatol. 36, 516-521 (1997).
    • (1997) Br. J. Rheumatol , vol.36 , pp. 516-521
    • Brinkman, B.M.1
  • 71
    • 0036138727 scopus 로고    scopus 로고
    • Tumor necrosis factor-α gene polymorphism in severe and mild-moderate rheumatoid arthritis
    • Fabris, M. et al. Tumor necrosis factor-α gene polymorphism in severe and mild-moderate rheumatoid arthritis. J. Rheumatol. 29, 29-33 (2002).
    • (2002) J. Rheumatol , vol.29 , pp. 29-33
    • Fabris, M.1
  • 72
    • 84860637797 scopus 로고    scopus 로고
    • DNA methylation arrays as surrogate measures of cell mixture distribution
    • Houseman, E. A. et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 13, 86 (2012).
    • BMC Bioinformatics , vol.13 , Issue.86 , pp. 2012
    • Houseman, E.A.1
  • 73
    • 70349312354 scopus 로고    scopus 로고
    • ChIP-seq: Advantages and challenges of a maturing technology
    • Park, P. J. ChIP-seq: advantages and challenges of a maturing technology. Nat. Rev. Genet. 10, 669-680 (2009).
    • (2009) Nat. Rev. Genet , vol.10 , pp. 669-680
    • Park, P.J.1
  • 74
    • 84901934871 scopus 로고    scopus 로고
    • Estimating heritability of response to treatment with anti-TNF biologic agents using linear mixed models [abstract O46]
    • Plant, D. et al. Estimating heritability of response to treatment with anti-TNF biologic agents using linear mixed models [abstract O46]. Rheumatology (Oxford) 52 (Suppl. 1), i48 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , Issue.SUPPL. 1
    • Plant, D.1
  • 75
    • 79953329156 scopus 로고    scopus 로고
    • Should imaging be a component of rheumatoid arthritis remission criteria? A comparison between traditional and modified composite remission scores and imaging assessments
    • Saleem, B. et al. Should imaging be a component of rheumatoid arthritis remission criteria? A comparison between traditional and modified composite remission scores and imaging assessments. Ann. Rheum. Dis. 70, 792-798 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 792-798
    • Saleem, B.1
  • 76
    • 84879835300 scopus 로고    scopus 로고
    • A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study
    • Hirata, S. et al. A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology (Oxford) 52, 1202-1207 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 1202-1207
    • Hirata, S.1
  • 77
    • 84875924025 scopus 로고    scopus 로고
    • An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression
    • van der Helm-van Mil, A. H., Knevel, R., Cavet, G., Huizinga, T. W. & Haney, D. J. An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression. Rheumatology (Oxford) 52, 839-846 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 839-846
    • Van Der Helm-Van Mil, A.H.1    Knevel, R.2    Cavet, G.3    Huizinga, T.W.4    Haney, D.J.5
  • 78
    • 84876036371 scopus 로고    scopus 로고
    • Development of a multi-biomarker disease activity test for rheumatoid arthritis
    • Centola, M. et al. Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS ONE 8, e60635 (2013).
    • (2013) PLoS ONE , vol.8
    • Centola, M.1
  • 79
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen, R. et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148, 1293-1307 (2012).
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1
  • 80
    • 41849093365 scopus 로고    scopus 로고
    • Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis
    • James, H. M. et al. Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis. J. Rheumatol. 35, 562-571 (2008).
    • (2008) J. Rheumatol , vol.35 , pp. 562-571
    • James, H.M.1
  • 81
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • Dervieux, T. et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 50, 2766-2774 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 2766-2774
    • Dervieux, T.1
  • 82
    • 33749370785 scopus 로고    scopus 로고
    • Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis
    • Wessels, J. A. et al. Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 54, 2830-2839 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 2830-2839
    • Wessels, J.A.1
  • 83
    • 67651225612 scopus 로고    scopus 로고
    • Optimalization of the clinical pharmacogenetic model to predict methotrexate treatment response: The influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond
    • Kooloos, W. M. et al. Optimalization of the clinical pharmacogenetic model to predict methotrexate treatment response: the influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond. Ann. Rheum. Dis. 68, 1371 (2009).
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 1371
    • Kooloos, W.M.1
  • 84
    • 32444436350 scopus 로고    scopus 로고
    • Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis
    • Weisman, M. H. et al. Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum. 54, 607-612 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 607-612
    • Weisman, M.H.1
  • 85
    • 23444443994 scopus 로고    scopus 로고
    • Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: Results of a multicentred cross sectional observational study
    • Dervieux, T. et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann. Rheum. Dis. 64, 1180-1185 (2005).
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 1180-1185
    • Dervieux, T.1
  • 86
    • 65849298666 scopus 로고    scopus 로고
    • Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate
    • Lee, Y. C. et al. Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford) 48, 613-617 (2009).
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 613-617
    • Lee, Y.C.1


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