-
2
-
-
55949104665
-
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
-
McCoy MK, Tansey MG, (2008) TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5: 45.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 45
-
-
McCoy, M.K.1
Tansey, M.G.2
-
3
-
-
79954451355
-
Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family
-
Pfizenmaier K, Szymkowski DE, (2011) Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family. Adv Exp Med Biol 691: 487-491.
-
(2011)
Adv Exp Med Biol
, vol.691
, pp. 487-491
-
-
Pfizenmaier, K.1
Szymkowski, D.E.2
-
4
-
-
73949090103
-
Inflammation in neurodegenerative diseases
-
Amor S, Puentes F, Baker D, van der Valk P, (2010) Inflammation in neurodegenerative diseases. Immunology 129: 154-169.
-
(2010)
Immunology
, vol.129
, pp. 154-169
-
-
Amor, S.1
Puentes, F.2
Baker, D.3
van der Valk, P.4
-
5
-
-
0033546665
-
TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
-
Anonymous, (1999) TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology 53: 457-465.
-
(1999)
Neurology
, vol.53
, pp. 457-465
-
-
Anonymous1
-
6
-
-
77953136143
-
TNF receptor 2 pathway: drug target for autoimmune diseases
-
Faustman D, Davis M, (2010) TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov 9: 482-493.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 482-493
-
-
Faustman, D.1
Davis, M.2
-
7
-
-
3543046113
-
Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
-
Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL, (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-32881.
-
(2004)
J Biol Chem
, vol.279
, pp. 32869-32881
-
-
Marchetti, L.1
Klein, M.2
Schlett, K.3
Pfizenmaier, K.4
Eisel, U.L.5
-
8
-
-
54349120339
-
TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels
-
Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, et al. (2008) TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels. J Neurochem 107: 1158-1167.
-
(2008)
J Neurochem
, vol.107
, pp. 1158-1167
-
-
Dolga, A.M.1
Granic, I.2
Blank, T.3
Knaus, H.G.4
Spiess, J.5
-
9
-
-
0036548875
-
Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2
-
Fontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K, et al. (2002) Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22: RC216.
-
(2002)
J Neurosci
, vol.22
-
-
Fontaine, V.1
Mohand-Said, S.2
Hanoteau, N.3
Fuchs, C.4
Pfizenmaier, K.5
-
10
-
-
0035705454
-
TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination
-
Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, et al. (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4: 1116-1122.
-
(2001)
Nat Neurosci
, vol.4
, pp. 1116-1122
-
-
Arnett, H.A.1
Mason, J.2
Marino, M.3
Suzuki, K.4
Matsushima, G.K.5
-
11
-
-
0031659763
-
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
-
Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, et al. (1998) Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153: 801-813.
-
(1998)
Am J Pathol
, vol.153
, pp. 801-813
-
-
Akassoglou, K.1
Bauer, J.2
Kassiotis, G.3
Pasparakis, M.4
Lassmann, H.5
-
12
-
-
0027382150
-
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors
-
Loetscher H, Stueber D, Banner D, Mackay F, Lesslauer W, (1993) Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. J Biol Chem 268: 26350-26357.
-
(1993)
J Biol Chem
, vol.268
, pp. 26350-26357
-
-
Loetscher, H.1
Stueber, D.2
Banner, D.3
Mackay, F.4
Lesslauer, W.5
-
13
-
-
50849154466
-
Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity
-
Krippner-Heidenreich A, Grunwald I, Zimmermann G, Kuhnle M, Gerspach J, et al. (2008) Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 180: 8176-8183.
-
(2008)
J Immunol
, vol.180
, pp. 8176-8183
-
-
Krippner-Heidenreich, A.1
Grunwald, I.2
Zimmermann, G.3
Kuhnle, M.4
Gerspach, J.5
-
14
-
-
77952290633
-
Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2
-
Boschert V, Krippner-Heidenreich A, Branschadel M, Tepperink J, Aird A, et al. (2010) Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. Cell Signal 22: 1088-1096.
-
(2010)
Cell Signal
, vol.22
, pp. 1088-1096
-
-
Boschert, V.1
Krippner-Heidenreich, A.2
Branschadel, M.3
Tepperink, J.4
Aird, A.5
-
15
-
-
0028866022
-
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
-
Grell M, Douni E, Wajant H, Lohden M, Clauss M, et al. (1995) The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83: 793-802.
-
(1995)
Cell
, vol.83
, pp. 793-802
-
-
Grell, M.1
Douni, E.2
Wajant, H.3
Lohden, M.4
Clauss, M.5
-
16
-
-
77951234694
-
Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)
-
Rauert H, Wicovsky A, Muller N, Siegmund D, Spindler V, et al. (2010) Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2). J Biol Chem 285: 7394-7404.
-
(2010)
J Biol Chem
, vol.285
, pp. 7394-7404
-
-
Rauert, H.1
Wicovsky, A.2
Muller, N.3
Siegmund, D.4
Spindler, V.5
-
17
-
-
0037064078
-
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
-
Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, et al. (2002) Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem 277: 38884-38894.
-
(2002)
J Biol Chem
, vol.277
, pp. 38884-38894
-
-
Lotharius, J.1
Barg, S.2
Wiekop, P.3
Lundberg, C.4
Raymon, H.K.5
-
18
-
-
21844442345
-
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
-
Lotharius J, Falsig J, van Beek J, Payne S, Dringen R, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci 25: 6329-6342.
-
(2005)
J Neurosci
, vol.25
, pp. 6329-6342
-
-
Lotharius, J.1
Falsig, J.2
van Beek, J.3
Payne, S.4
Dringen, R.5
-
19
-
-
70350031056
-
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells
-
Schildknecht S, Poltl D, Nagel DM, Matt F, Scholz D, et al. (2009) Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharmacol 241: 23-35.
-
(2009)
Toxicol Appl Pharmacol
, vol.241
, pp. 23-35
-
-
Schildknecht, S.1
Poltl, D.2
Nagel, D.M.3
Matt, F.4
Scholz, D.5
-
20
-
-
81055127451
-
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line
-
Scholz D, Poltl D, Genewsky A, Weng M, Waldmann T, et al. (2011) Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem.
-
(2011)
J Neurochem
-
-
Scholz, D.1
Poltl, D.2
Genewsky, A.3
Weng, M.4
Waldmann, T.5
-
21
-
-
0037113868
-
Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction
-
Krippner-Heidenreich A, Tubing F, Bryde S, Willi S, Zimmermann G, et al. (2002) Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction. J Biol Chem 277: 44155-44163.
-
(2002)
J Biol Chem
, vol.277
, pp. 44155-44163
-
-
Krippner-Heidenreich, A.1
Tubing, F.2
Bryde, S.3
Willi, S.4
Zimmermann, G.5
-
22
-
-
0027315251
-
TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis
-
Grell M, Scheurich P, Meager A, Pfizenmaier K, (1993) TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis. Lymphokine Cytokine Res 12: 143-148.
-
(1993)
Lymphokine Cytokine Res
, vol.12
, pp. 143-148
-
-
Grell, M.1
Scheurich, P.2
Meager, A.3
Pfizenmaier, K.4
-
23
-
-
77957809137
-
Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFkappaB pathway
-
Fischer R, Maier O, Naumer M, Krippner-Heidenreich A, Scheurich P, et al. (2011) Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFkappaB pathway. Cell Signal 23: 161-170.
-
(2011)
Cell Signal
, vol.23
, pp. 161-170
-
-
Fischer, R.1
Maier, O.2
Naumer, M.3
Krippner-Heidenreich, A.4
Scheurich, P.5
-
24
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG, (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14: 381-395.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
25
-
-
0036237137
-
Akt phosphorylation and neuronal survival after traumatic brain injury in mice
-
Noshita N, Lewen A, Sugawara T, Chan PH, (2002) Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol Dis 9: 294-304.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 294-304
-
-
Noshita, N.1
Lewen, A.2
Sugawara, T.3
Chan, P.H.4
-
26
-
-
0035094532
-
Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis
-
Gary DS, Mattson MP, (2001) Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J Neurochem 76: 1485-1496.
-
(2001)
J Neurochem
, vol.76
, pp. 1485-1496
-
-
Gary, D.S.1
Mattson, M.P.2
-
27
-
-
0035048206
-
Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
-
Yano S, Morioka M, Fukunaga K, Kawano T, Hara T, et al. (2001) Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab 21: 351-360.
-
(2001)
J Cereb Blood Flow Metab
, vol.21
, pp. 351-360
-
-
Yano, S.1
Morioka, M.2
Fukunaga, K.3
Kawano, T.4
Hara, T.5
-
28
-
-
0034993599
-
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
-
Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, et al. (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65: 135-172.
-
(2001)
Prog Neurobiol
, vol.65
, pp. 135-172
-
-
Blum, D.1
Torch, S.2
Lambeng, N.3
Nissou, M.4
Benabid, A.L.5
-
29
-
-
0033152828
-
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF
-
Grell M, Zimmermann G, Gottfried E, Chen CM, Grunwald U, et al. (1999) Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J 18: 3034-3043.
-
(1999)
EMBO J
, vol.18
, pp. 3034-3043
-
-
Grell, M.1
Zimmermann, G.2
Gottfried, E.3
Chen, C.M.4
Grunwald, U.5
-
30
-
-
0026335446
-
Soluble and cell surface receptors for tumor necrosis factor
-
Wallach D, Engelmann H, Nophar Y, Aderka D, Kemper O, et al. (1991) Soluble and cell surface receptors for tumor necrosis factor. Agents Actions Suppl 35: 51-57.
-
(1991)
Agents Actions Suppl
, vol.35
, pp. 51-57
-
-
Wallach, D.1
Engelmann, H.2
Nophar, Y.3
Aderka, D.4
Kemper, O.5
-
31
-
-
0037315457
-
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex
-
Holler N, Tardivel A, Kovacsovics-Bankowski M, Hertig S, Gaide O, et al. (2003) Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol 23: 1428-1440.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1428-1440
-
-
Holler, N.1
Tardivel, A.2
Kovacsovics-Bankowski, M.3
Hertig, S.4
Gaide, O.5
-
32
-
-
0036929017
-
Pathophysiology of Parkinson's disease: from clinical neurology to basic neuroscience and back
-
Bergman H, Deuschl G, (2002) Pathophysiology of Parkinson's disease: from clinical neurology to basic neuroscience and back. Mov Disord 17 (Suppl 3): S28-40.
-
(2002)
Mov Disord
, vol.17
, Issue.SUPPL. 3
, pp. 28-40
-
-
Bergman, H.1
Deuschl, G.2
-
33
-
-
0027496238
-
A radical hypothesis for neurodegeneration
-
Olanow CW, (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16: 439-444.
-
(1993)
Trends Neurosci
, vol.16
, pp. 439-444
-
-
Olanow, C.W.1
-
34
-
-
0027500793
-
Free radicals in the genesis of Alzheimer's disease
-
Richardson JS, (1993) Free radicals in the genesis of Alzheimer's disease. Ann N Y Acad Sci 695: 73-76.
-
(1993)
Ann N Y Acad Sci
, vol.695
, pp. 73-76
-
-
Richardson, J.S.1
-
35
-
-
0025790342
-
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
-
Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, et al. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A 88: 10540-10543.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 10540-10543
-
-
Smith, C.D.1
Carney, J.M.2
Starke-Reed, P.E.3
Oliver, C.N.4
Stadtman, E.R.5
-
36
-
-
0025960006
-
Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation
-
Richter C, Kass GE, (1991) Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation. Chem Biol Interact 77: 1-23.
-
(1991)
Chem Biol Interact
, vol.77
, pp. 1-23
-
-
Richter, C.1
Kass, G.E.2
-
37
-
-
0027931558
-
Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons
-
Whittemore ER, Loo DT, Cotman CW, (1994) Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. Neuroreport 5: 1485-1488.
-
(1994)
Neuroreport
, vol.5
, pp. 1485-1488
-
-
Whittemore, E.R.1
Loo, D.T.2
Cotman, C.W.3
-
38
-
-
0029067149
-
A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture
-
Whittemore ER, Loo DT, Watt JA, Cotman CW, (1995) A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience 67: 921-932.
-
(1995)
Neuroscience
, vol.67
, pp. 921-932
-
-
Whittemore, E.R.1
Loo, D.T.2
Watt, J.A.3
Cotman, C.W.4
-
39
-
-
0033557640
-
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
-
Lotharius J, Dugan LL, O'Malley KL, (1999) Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 19: 1284-1293.
-
(1999)
J Neurosci
, vol.19
, pp. 1284-1293
-
-
Lotharius, J.1
Dugan, L.L.2
O'Malley, K.L.3
-
40
-
-
77957235446
-
Modeling neuroinflammatory pathogenesis of Parkinson's disease
-
Barnum CJ, Tansey MG, (2010) Modeling neuroinflammatory pathogenesis of Parkinson's disease. Prog Brain Res 184: 113-132.
-
(2010)
Prog Brain Res
, vol.184
, pp. 113-132
-
-
Barnum, C.J.1
Tansey, M.G.2
-
41
-
-
0035900717
-
NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons
-
Yabe T, Wilson D, Schwartz JP, (2001) NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons. J Biol Chem 276: 43313-43319.
-
(2001)
J Biol Chem
, vol.276
, pp. 43313-43319
-
-
Yabe, T.1
Wilson, D.2
Schwartz, J.P.3
-
42
-
-
0032752063
-
Cellular survival: a play in three Akts
-
Datta SR, Brunet A, Greenberg ME, (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
43
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, et al. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
-
44
-
-
1842614395
-
Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells
-
Jordan J, Galindo MF, Tornero D, Gonzalez-Garcia C, Cena V, (2004) Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells. J Neurochem 89: 124-133.
-
(2004)
J Neurochem
, vol.89
, pp. 124-133
-
-
Jordan, J.1
Galindo, M.F.2
Tornero, D.3
Gonzalez-Garcia, C.4
Cena, V.5
|