Immune and inflammatory responses in TNFα-deficient mice: A critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1397-1411

  Pasparakis, Manolis ^a   Alexopoulou, Lena ^a   Episkopou, Vasso ^b   Kollias, George ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSAMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL MATURATION; CONTACT SENSITIZATION; GENE TARGETING; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPH NODE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CELL COMMUNICATION; DENDRITIC CELLS; DERMATITIS, CONTACT; FEMALE; GERMINAL CENTER; IMMUNE SYSTEM; LIPOPOLYSACCHARIDES; LISTERIA MONOCYTOGENES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029989339     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1397     Document Type: Article

References (55)

1. Vassali, P. 1992. The pathophysiology of tumour necrosis factor. Annu. Rev. Immunol. 10:411-452.
2. Kriegler, M., C. Perez, K. DeFay, I. Albert, and S.D. Lu. 1988. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell. 53:45-53.
3. Paul, N.L., and N.H. Ruddle. 1988. Lymphotoxin. Annu. Rev. Immunol. 6:407-438.
4. Browning, J.L., A. Ngamek, P. Lawton, J. DeMarinis, R. Tizard, E.P. Chow, C. Hession, B. O'Brine-Greco, S.F. Foley, and C.F. Ware. 1993. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 72:847-856.
5. Crowe, P.D., T.L. VanArsdale, B.N. Walter, C.F. Ware, C. Hession, B. Ehrenfels, J.L. Browning, W.S. Din, R.G. Goodwin, and C.A. Smith. 1994. A lymphotoxin-beta-specific receptor. Science (Wash. DC). 264:707-710.
6. Vandenabeele, P. W. Declercq, R. Beyaert, and W. Fiers. 1995. Two tumour necrosis factor receptors: structure and function. Trends Cell Biol. 5:392-399.
7. Erikstein, B.K., E.B. Smeland, H.K. Blomhoff, S. Funderud, K. Prydz, W. Lesslauer, and T. Espevik. 1991. Independent regulation of 55-kDa and 75-kDa tumour necrosis factor receptors during activation of human peripheral blood B lymphocytes. Eur. J. Immunol. 21:1033-1037.
8. Tartaglia, L.A., D.V. Goeddel, C. Reynolds, I.S. Figari, R.F. Weber, B.M. Fendly, and M.A. Palladino. 1993. Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumour necrosis factor receptor. J. Immunol. 151:4637-4641.
9. Tartaglia, L.A., T.M. Ayres, G.H.W. Wong, and D.V. Goeddel. 1993. A novel domain within the 55kd TNF receptor signals cell death. Cell. 74:845-853.
10. Grell, M., E. Douni, H. Wajant, M. Lohden, M. Clauss, B. Maxeiner, S. Georgopoulos, W. Lesslauer, G. Kollias, K. Pfizenmaier, and P. Scheurich. 1995. The transmembrane form of tumour necrosis factor is the prime activating ligand of the 80 kDa tumour necrosis factor receptor. Cell. 83:793-802.
11. Zheng, L., G., Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (Lond.). 377:348-351.
12. Pfeffer, K., T. Matsuyama, T.M. Kunding, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P.S. Ohashi, M. Kronke, and T.W. Mak. 1993. Mice deficient for the 55 kD tumour necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 73: 457-467.
13. Rothe, J., W. Lesslauer, H. Lotscher, Y. Lang, P. Koebel, F. Kontgen, A. Aithage, R. Zinkernagel, M. Steinmetz, and H. Bluethmann. 1993. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature (Lond.). 364:798-802.
14. Kondo, S., B. Wang, H. Fujisawa, G.M. Shivji, B. Echtenacher, T.W. Mak, and D.N. Sauder. 1995. Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression. J. Immunol. 155:3801-3805.
15. De Togni, P., J. Goellner, N.H. Ruddle, P.R. Streeter, A. Fick, S. Mariathasan, S.C. Smith, R. Carlson, L.P. Shornick, J. Strauss-Schoenberger, J.H. Russel, R. Karr, and D. Chaplin. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science (Wash. DC). 264:703-707.
16. Neumann, B., A. Luz, K. Pfeffer, and B. Holzmann. 1996. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184: 259-264.
17. Matsumoto, M., S. Mariathasan, M.H. Nahm, F. Baranyay, J. Peschon, and D. Chaplin. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science (Wash. DC). 271:1289-1291.
18. Probert, L., K. Akassoglou, M. Pasparakis, G. Kontogeorgos, and G. Kollias. 1995. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor. Proc. Natl. Acad. Sci. USA. 92:11294-11298.
19. Mansour, S.L., K.R. Thomas, and M.R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (Lond.). 336:348-352.
20. Robertson, E., A. Bradley, M. Kuehn, and M. Evans. 1986. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature (Lond.). 336: 445-448.
21. Pasparakis, M., and G. Kollias. 1995. Production of cytokine transgenic and knockout mice. In Cytokines: A Practical Approach, Second edition, F.R. Balkwill, editor. IRL Press, Oxford. 297-325.
22. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162:156-159.
23. Bemelmans, M.H.A., D.J. Gouma, and W.A. Buurman. 1993. LPS-induced sTNF-receptor release in vivo in a murine model. J. Immunol. 151:5554-5562.
24. Vicente, M.F., F. Baquero, and J.C. Perez-Diaz. 1985. Cloning and expression of the Listeria monocytogenes haemolysin in E. coli. FEMS Microbiol. Lett. 30:77-79.
25. Cossart, P., M.F. Vicente, J. Mengaud, F. Baquero, J.C. Perez-Diaz, and P. Berche. 1989. Listeriolysm O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation. Infect. Immunol. 57:3629-3636.
26. Kelly, B.S., J.G. Levy, and L. Sikora. 1979. The use of the enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of specific antibody from cell cultures. Immunology. 37:45-52.
27. Tomonari, K. 1988. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics. 28:455-458.
28. Kosco, M.H., E. Pflugfelder, and D. Gray. 1992. Follicular dendritic cell-dependent adhesion and proliferation of B-cells in vitro. J. Immunol. 148:2331-2339.
29. Freudenberg, M.A., and C. Galanos. 1991. Tumour necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice. Infect. Immunol. 59:2110-2115.
30. Lesslauer, W., H. Tabuchi, R. Gentz, M. Brockhaus, E.J. Schlaeger, G. Grau, P.F. Piguet, P. Pointaire, P. Vassali, and H. Loetscher. 1991. Recombinant soluble tumour necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur. J. Immun. 21:2883-2886.
31. Ashkenazi, A., S.A. Marsters, D.J. Capon, S.M. Chamow, I.S. Figari, D. Pennica, D.V. Goeddel, M.A. Palladino, and D.H. Smith. 1991. Protection against endotoxic shock by tumour necrosis factor receptor immunoadhesin. Proc. Natl. Acad. Sci. USA. 88:10535-10539.
32. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld et al. 1995. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1b and resistant to endotoxic shock. Cell. 80:401-411.
33. Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and G. Kollias. 1991. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO (Eur. Mol. Biol. Organ.) J. 10:4025-4031.
34. Decoster, E., B. Vanhaesebroeck, P. Vandenabeele, J. Grooten, and W. Fiers. 1995. Generation and biological characterisation of membrane-bound, uncleavable murine tumour necrosis factor. J. Biol. Chem. 270:18473-18478.
35. Lewis, M., L.A. Tartaglia, A. Lee, G.L. Bennett, G.C. Rice, G.H.W. Wong, E.Y. Chen, and D.V. Goeddel. 1991. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA 88:2830-2834.
36. Piguet, P.F., G.E. Grau, C. Hauser, and P. Vassalli. 1991. Tumour necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions. J. Exp. Med. 173:673-679.
37. Bromberg, J.S., K.D. Chavin, and S.L. Kunkel. 1992. Antitumour necrosis factor antibodies suppress cell-mediated immunity in vivo. J. Immunol. 148:3412-3417.
38. Cumberbatch, M., and I. Kimber. 1995. Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitisation. Immunology. 84:31-35.
39. Cumberbatch, M., and I. Kimber. 1992. Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration. Immunology. 75:257-263.
40. Le Hir, M., H. Bluethmann, M.H. Kosco-Vilbois, M. Muller, F. di Padova, M. Moore, B. Ryffel, and H.P. Eugster. 1996. Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling. J. Exp. Med. 183:2367-2372.
41. Rose, M.L., M.S.C. Birbeck, V.J. Wallis, J.A. Forrester, and A.J.S. Davies. 1980. Peanut lectin binding properties of germinal centres of mouse lymphoid tissue. Nature (Lond.). 284: 364-366.
42. Neumann B., T. Machleidt, A. Lifka, K. Pfeffer, D. Vestweber, T.W. Mak, B. Holtzmann, and M. Kronke. 1996. Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. J. Immunol. 156:1587-1593.
43. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal centre formation. Immunity. 1:167-178.
44. Xu, J., T.M. Foy, J.D. Laman, E.A. Elliot, J.J. Dunn, T.J. Waldschmidt, J. Elsemore, R.J. Noelle, and R.A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity. 1:423-431.
45. Macchia, D., F. Almerigogna, P. Parronchi, A. Ravina, E. Maggi, and S. Romagnani. 1993. Membrane tumour necrosis factor-α is involved in the polyclonal B-cell activation induced by HIV-infected human T cells. Nature (Lond.). 363: 464-466.
46. + T cell clones provides a costimulatory signal for human B cell activation. J. Exp. Med. 177:1575-1585.
47. + T cell clones. Role for membrane TNF-α/TNF-a receptors and CD3/CD58 interactions. J. Immunol. 153:4872-4879.
48. Lens S.M.A., K. Tesselaar, B.F.A. den Drijver, M.H.J. van Oers, and R.A.V. van Lier. 1996. A dual role for both CD40-ligand and TNF-α in controlling human B cell death. J. Immunol. 156:507-514.
49. Drapier, J.C., J. Wietzerbin, and J.B. Hibbs. 1988. Interteron-gamma and tumour necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1587-1592.
50. Ding, A.H., C.F. Nathan, and D.J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
51. Koch, F., C. Heufler, E. Kampgen, D. Schneeweiss, G. Bock, and G. Schuller. 1990. Tumour necrosis factor α maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte macrophage colony-stimulating factor, without inducing their functional maturation. J Exp. Med. 171:159-171.
52. Clark, E.A., K.H. Grabstein, and G.L. Shu. 1992. Cultured human follicular dendritic cells. Growth characteristics and interactions with B lymphocytes. J. Immunol. 148:3327-3335.
53. Mond, J.J., Q. Vos, A. Lees, and C.M. Snapper. 1995. T cell independent antigens. Curr. Opin. Immunol. 7:349-354.
54. Lane, P.J.L., D. Gray, S. Oldfield, and I.C.M. MacLennan. 1986. Differences in the recruitment of virgin B cells into antibody responses to thymus-dependent and thymus-independent type-2 antigens. Eur. J. Immunol. 16:1569-1575.
55. Timens, W., A. Boes, T. Rozeboom-Uiterwijk, and S. Poppema. 1989. Immaturity of the human splenic marginal zone in infancy: possible contribution to the deficient infant immune response. J. Immunol. 143:3200-3206.