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Volumn 64, Issue 12, 2012, Pages 3856-3866

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN C JUN; RUXOLITINIB; STAT1 PROTEIN; TOFACITINIB; TUMOR NECROSIS FACTOR;

EID: 84870325487     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37691     Document Type: Article
Times cited : (102)

References (49)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G,. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-19.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 0036584028 scopus 로고    scopus 로고
    • Development of anti-TNF therapy for rheumatoid arthritis
    • Feldmann M,. Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2002; 2: 364-71. (Pubitemid 37328759)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.5 , pp. 364-371
    • Feldmann, M.1
  • 3
    • 0034048349 scopus 로고    scopus 로고
    • Anti-cytokine therapy for rheumatoid arthritis
    • DOI 10.1146/annurev.med.51.1.207
    • Maini RN, Taylor PC,. Anti-cytokine therapy for rheumatoid arthritis. Annu Rev Med 2000; 51: 207-29. (Pubitemid 30216034)
    • (2000) Annual Review of Medicine , vol.51 , pp. 207-229
    • Maini, R.N.1    Taylor, P.C.2
  • 6
    • 79551575494 scopus 로고    scopus 로고
    • Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond
    • Quintas-Cardama A, Kantarjian H, Cortes J, Verstovsek S,. Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond. Nat Rev Drug Discov 2011; 10: 127-40.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 127-140
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3    Verstovsek, S.4
  • 7
    • 62849116942 scopus 로고    scopus 로고
    • Integration of cytokine and heterologous receptor signaling pathways
    • Bezbradica JS, Medzhitov R,. Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol 2009; 10: 333-9.
    • (2009) Nat Immunol , vol.10 , pp. 333-339
    • Bezbradica, J.S.1    Medzhitov, R.2
  • 9
    • 0036731485 scopus 로고    scopus 로고
    • STATs: Transcriptional control and biological impact
    • DOI 10.1038/nrm909
    • Levy DE, Darnell JE Jr,. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3: 651-62. (Pubitemid 34987786)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.9 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 10
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377: 65-8.
    • (1995) Nature , vol.377 , pp. 65-68
    • MacChi, P.1    Villa, A.2    Giliani, S.3    Sacco, M.G.4    Frattini, A.5    Porta, F.6
  • 11
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • DOI 10.1146/annurev.immunol.16.1.293
    • Leonard WJ, O'Shea JJ,. Jaks and STATs: biological implications. Annu Rev Immunol 1998; 16: 293-322. (Pubitemid 28183367)
    • (1998) Annual Review of Immunology , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 14
    • 0033711641 scopus 로고    scopus 로고
    • Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function
    • Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, et al. Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. Immunity 2000; 13: 561-71.
    • (2000) Immunity , vol.13 , pp. 561-571
    • Shimoda, K.1    Kato, K.2    Aoki, K.3    Matsuda, T.4    Miyamoto, A.5    Shibamori, M.6
  • 15
    • 79953176994 scopus 로고    scopus 로고
    • Tasocitinib [published erratum appears in Drugs R D 2012;12:41-3]
    • Tasocitinib [published erratum appears in Drugs R D 2012;12:41-3]. Drugs R D 2010; 10: 271-84.
    • (2010) Drugs R D , vol.10 , pp. 271-284
  • 16
    • 77955375143 scopus 로고    scopus 로고
    • Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
    • Meyer DM, Jesson MI, Li X, Elrick MM, Funckes-Shippy CL, Warner JD, et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond) 2010; 7: 41.
    • (2010) J Inflamm (Lond) , vol.7 , pp. 41
    • Meyer, D.M.1    Jesson, M.I.2    Li, X.3    Elrick, M.M.4    Funckes-Shippy, C.L.5    Warner, J.D.6
  • 17
    • 79955027327 scopus 로고    scopus 로고
    • Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
    • Ghoreschi K, Jesson MI, Li X, Lee JL, Ghosh S, Alsup JW, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol 2011; 186: 4234-43.
    • (2011) J Immunol , vol.186 , pp. 4234-4243
    • Ghoreschi, K.1    Jesson, M.I.2    Li, X.3    Lee, J.L.4    Ghosh, S.5    Alsup, J.W.6
  • 18
    • 77953673416 scopus 로고    scopus 로고
    • Jak inhibitor; Possibility and mechanism as a new disease modifying anti-rheumatic drug
    • Yamaoka K, Tanaka Y,. Jak inhibitor; possibility and mechanism as a new disease modifying anti-rheumatic drug. Nihon Rinsho Meneki Gakkai Kaishi 2009; 32: 85-91.
    • (2009) Nihon Rinsho Meneki Gakkai Kaishi , vol.32 , pp. 85-91
    • Yamaoka, K.1    Tanaka, Y.2
  • 20
    • 10044296324 scopus 로고    scopus 로고
    • The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing
    • DOI 10.1189/jlb.0504282
    • Conklyn M, Andresen C, Changelian P, Kudlacz E,. The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing. J Leukoc Biol 2004; 76: 1248-55. (Pubitemid 39602962)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.6 , pp. 1248-1255
    • Conklyn, M.1    Andresen, C.2    Changelian, P.3    Kudlacz, E.4
  • 22
    • 66049110306 scopus 로고    scopus 로고
    • The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases
    • [review].
    • Hamilton JA, Tak PP,. The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases [review]. Arthritis Rheum 2009; 60: 1210-21.
    • (2009) Arthritis Rheum , vol.60 , pp. 1210-1221
    • Hamilton, J.A.1    Tak, P.P.2
  • 23
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • DOI 10.1189/jlb.0603252
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA,. Interferon-γ: an overview of signals, mechanisms and functions. J Leukoc Biol 2004; 75: 163-89. (Pubitemid 38174573)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 24
    • 33749345768 scopus 로고    scopus 로고
    • Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages
    • DOI 10.1002/art.22055
    • Antoniv TT, Ivashkiv LB,. Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages. Arthritis Rheum 2006; 54: 2711-21. (Pubitemid 44497750)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.9 , pp. 2711-2721
    • Antoniv, T.T.1    Ivashkiv, L.B.2
  • 25
    • 40949123747 scopus 로고    scopus 로고
    • TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes
    • DOI 10.1038/ni1576, PII NI1576
    • Yarilina A, Park-Min KH, Antoniv T, Hu X, Ivashkiv LB,. TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon- response genes. Nat Immunol 2008; 9: 378-87. (Pubitemid 351405107)
    • (2008) Nature Immunology , vol.9 , Issue.4 , pp. 378-387
    • Yarilina, A.1    Park-Min, K.-H.2    Antoniv, T.3    Hu, X.4    Ivashkiv, L.B.5
  • 26
    • 23044494509 scopus 로고    scopus 로고
    • The role of Toll-like receptor signalling in the pathogenesis of arthritis
    • DOI 10.1016/j.cellimm.2005.04.018, PII S0008874905000559, Molecular and Cellular Interactions in Chronic Inflamatory Autoimmune Diseases
    • Brentano F, Kyburz D, Schorr O, Gay R, Gay S,. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 2005; 233: 90-6. (Pubitemid 41074060)
    • (2005) Cellular Immunology , vol.233 , Issue.2 , pp. 90-96
    • Brentano, F.1    Kyburz, D.2    Schorr, O.3    Gay, R.4    Gay, S.5
  • 27
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-γ: Implications for immune responses and autoimmune diseases
    • Hu X, Ivashkiv LB,. Cross-regulation of signaling pathways by interferon-γ: implications for immune responses and autoimmune diseases. Immunity 2009; 31: 539-50.
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 28
    • 84857239335 scopus 로고    scopus 로고
    • The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type i interferon
    • Rosengren S, Corr M, Firestein GS, Boyle DL,. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis 2012; 71: 440-7.
    • (2012) Ann Rheum Dis , vol.71 , pp. 440-447
    • Rosengren, S.1    Corr, M.2    Firestein, G.S.3    Boyle, D.L.4
  • 32
    • 33748450379 scopus 로고    scopus 로고
    • Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons
    • DOI 10.1016/j.immuni.2006.08.014, PII S1074761306003992
    • Van Boxel-Dezaire AH, Rani MR, Stark GR,. Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 2006; 25: 361-72. (Pubitemid 44354225)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 361-372
    • Van Boxel-Dezaire, A.H.H.1    Rani, M.R.S.2    Stark, G.R.3
  • 34
    • 58149092616 scopus 로고    scopus 로고
    • Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
    • Jiang JK, Ghoreschi K, Deflorian F, Chen Z, Perreira M, Pesu M, et al. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J Med Chem 2008; 51: 8012-8.
    • (2008) J Med Chem , vol.51 , pp. 8012-8018
    • Jiang, J.K.1    Ghoreschi, K.2    Deflorian, F.3    Chen, Z.4    Perreira, M.5    Pesu, M.6
  • 35
    • 79952159585 scopus 로고    scopus 로고
    • TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages
    • Yarilina A, Xu K, Chen J, Ivashkiv LB,. TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proc Natl Acad Sci U S A 2011; 108: 1573-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1573-1578
    • Yarilina, A.1    Xu, K.2    Chen, J.3    Ivashkiv, L.B.4
  • 36
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • DOI 10.1101/gad.1102703
    • Hogan PG, Chen L, Nardone J, Rao A,. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003; 17: 2205-32. (Pubitemid 37128637)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 38
    • 28544442029 scopus 로고    scopus 로고
    • Interplay between interferon and other cytokine systems in bone metabolism
    • Takayanagi H, Sato K, Takaoka A, Taniguchi T,. Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 2005; 208: 181-93. (Pubitemid 41746393)
    • (2005) Immunological Reviews , vol.208 , pp. 181-193
    • Takayanagi, H.1    Sato, K.2    Takaoka, A.3    Taniguchi, T.4
  • 39
    • 79953268311 scopus 로고    scopus 로고
    • Type i IFN and TNFα cross-regulation in immune-mediated inflammatory disease: Basic concepts and clinical relevance
    • Cantaert T, Baeten D, Tak PP, van Baarsen LG,. Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance. Arthritis Res Ther 2010; 12: 219.
    • (2010) Arthritis Res Ther , vol.12 , pp. 219
    • Cantaert, T.1    Baeten, D.2    Tak, P.P.3    Van Baarsen, L.G.4
  • 43
    • 84869017379 scopus 로고    scopus 로고
    • The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment
    • Gordon RA, Grigoriev G, Lee A, Kalliolias GD, Ivashkiv LB,. The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment. Arthritis Rheum 2012; 64: 3119-28.
    • (2012) Arthritis Rheum , vol.64 , pp. 3119-3128
    • Gordon, R.A.1    Grigoriev, G.2    Lee, A.3    Kalliolias, G.D.4    Ivashkiv, L.B.5
  • 44
    • 55149093640 scopus 로고    scopus 로고
    • Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
    • Hu X, Chakravarty SD, Ivashkiv LB,. Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol Rev 2008; 226: 41-56.
    • (2008) Immunol Rev , vol.226 , pp. 41-56
    • Hu, X.1    Chakravarty, S.D.2    Ivashkiv, L.B.3
  • 45
    • 33846922783 scopus 로고    scopus 로고
    • Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs
    • Yarilina A, DiCarlo E, Ivashkiv LB,. Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs. J Immunol 2007; 178: 2204-11. (Pubitemid 46233418)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2204-2211
    • Yarilina, A.1    DiCarlo, E.2    Ivashkiv, L.B.3
  • 46
    • 17644372231 scopus 로고    scopus 로고
    • Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis
    • Van Holten J, Reedquist K, Sattonet-Roche P, Smeets TJ, Plater-Zyberk C, Vervoordeldonk MJ, et al. Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther 2004; 6: R239-49.
    • (2004) Arthritis Res Ther , vol.6
    • Van Holten, J.1    Reedquist, K.2    Sattonet-Roche, P.3    Smeets, T.J.4    Plater-Zyberk, C.5    Vervoordeldonk, M.J.6
  • 47
    • 58849149469 scopus 로고    scopus 로고
    • Synergistic benefit in inflammatory arthritis by targeting IκB kinase η and interferon β
    • Corr M, Boyle DL, Ronacher L, Flores N, Firestein GS,. Synergistic benefit in inflammatory arthritis by targeting IκB kinase η and interferon β. Ann Rheum Dis 2009; 68: 257-63.
    • (2009) Ann Rheum Dis , vol.68 , pp. 257-263
    • Corr, M.1    Boyle, D.L.2    Ronacher, L.3    Flores, N.4    Firestein, G.S.5
  • 48
    • 0035186665 scopus 로고    scopus 로고
    • CXCR3 and CCR5 ligands in rheumatoid arthritis synovium
    • Patel DD, Zachariah JP, Whichard LP,. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol 2001; 98: 39-45.
    • (2001) Clin Immunol , vol.98 , pp. 39-45
    • Patel, D.D.1    Zachariah, J.P.2    Whichard, L.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.