Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and ca2+ dysregulation in aged rats

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Sama, Diana M ^a   Abdul, Hafiz Mohmmad ^b   Furman, Jennifer L ^a   Artiushin, Irina A ^b   Szymkowski, David E ^c   Scheff, Stephen W ^b   Norris, Christopher M ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Xencor Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; GLUTAMATE RECEPTOR 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; XENP 1595; XPRO 1595; AMPA RECEPTOR; CALCIUM; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; TUMOR NECROSIS FACTOR ALPHA;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; COGNITIVE DEFECT; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; LONG TERM DEPRESSION; MAZE TEST; MICROGLIA; NERVE CELL PLASTICITY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SYNAPSE; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; CYTOLOGY; DEPRESSION; DISEASE PREDISPOSITION; DRUG ANTAGONISM; DRUG EFFECT; FISCHER 344 RAT; GENE EXPRESSION REGULATION; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; SOLUBILITY;

RATTUS;

AGING; ANIMALS; BEHAVIOR, ANIMAL; CALCIUM; CALCIUM CHANNELS, L-TYPE; DEPRESSIVE DISORDER; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MICROGLIA; PHENOTYPE; RATS; RATS, INBRED F344; RECEPTORS, AMPA; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SOLUBILITY; SYNAPSES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861556594     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038170     Document Type: Article

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