Regulation of DNA methylation in rheumatoid arthritis synoviocytes

Journal of Immunology

Volumn 190, Issue 3, 2013, Pages 1297-1303

  Nakano, Kazuhisa ^a,b   Boyle, David L ^a   Firestein, Gary S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; DNA METHYLTRANSFERASE INHIBITOR; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR;

ARTHROPLASTY; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; DEMETHYLATION; DNA METHYLATION; ENZYME ACTIVITY; FIBROBLAST LIKE SYNOVIOCYTE; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; IMMUNOASSAY; LONG INTERSPERSED REPEAT; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; WESTERN BLOTTING;

ADIPOKINES; ARTHRITIS, RHEUMATOID; AZACITIDINE; COLLAGEN TYPE I; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; LECTINS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; OSTEOARTHRITIS; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 84872713887     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202572     Document Type: Article

References (44)

1. Silman, A. J., A. J. MacGregor, W. Thomson, S. Holligan, D. Carthy, A. Farhan, and W. E. Ollier. 1993. Twin concordance rates for rheumatoid arthritis: Results from a nationwide study. Br. J. Rheumatol. 32: 903-907. (Pubitemid 23301303)
2. Jarvinen, P., and K. Aho. 1994. Twin studies in rheumatic diseases. Semin. Arthritis Rheum. 24: 19-28.
3. Robertson, K. D. 2005. DNA methylation and human disease. Nat. Rev. Genet. 6: 597-610. (Pubitemid 41044297)
4. Trenkmann, M., M. Brock, C. Ospelt, and S. Gay. 2010. Epigenetics in rheumatoid arthritis. Clin. Rev. Allergy Immunol. 39: 10-19.
5. Nakano, K., J. W. Whitaker, D. L. Boyle, W. Wang, and G. S. Firestein. 2012. DNA methylome signature in rheumatoid arthritis. Ann. Rheum. Dis. In press.
6. Ballestar, E. 2011. Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol 7: 263-271.
7. Goll, M. G., and T. H. Bestor. 2005. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74: 481-514. (Pubitemid 40995515)
8. Bird, A. 2002. DNA methylation patterns and epigenetic memory. Genes Dev. 16: 6-21. (Pubitemid 34049633)
9. Bartok, B., and G. S. Firestein. 2010. Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunol. Rev. 233: 233-255.
10. Firestein, G. S. 1996. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 39: 1781-1790. (Pubitemid 26378569)
11. Lefevre, S., A. Knedla, C. Tennie, A. Kampmann, C. Wunrau, R. Dinser, A. Korb, E.-M. Schnaker, I. H. Tarner, P. D. Robbins, et al. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat. Med. 15: 1414-1420.
12. Tak, P. P., N. J. Zvaifler, D. R. Green, and G. S. Firestein. 2000. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases. Immunol. Today 21: 78-82. (Pubitemid 30069620)
13. Franz, J. K., T. Pap, K. M. Hummel, M. Nawrath, W. K. Aicher, Y. Shigeyama, U. Muller-Ladner, R. E. Gay, and S. Gay. 2000. Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum. 43: 599-607. (Pubitemid 30394952)
14. Pap, T., J. K. Franz, K. M. Hummel, E. Jeisy, R. Gay, and S. Gay. 2000. Activation of synovial fibroblasts in rheumatoid arthritis: Lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Res. 2: 59-64. (Pubitemid 32223701)
15. Karouzakis, E., R. E. Gay, B. A. Michel, S. Gay, and M. Neidhart. 2009. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 60: 3613-3622.
16. Karouzakis, E., Y. Rengel, A. Jungel, C. Kolling, R. E. Gay, B. A. Michel, P. P. Tak, S. Gay, M. Neidhart, and C. Ospelt. 2011. DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun. 12: 643-652.
17. Takami, N., K. Osawa, Y. Miura, K. Komai, M. Taniguchi, M. Shiraishi, K. Sato, T. Iguchi, K. Shiozawa, A. Hashiramoto, and S. Shiozawa. 2006. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells. Arthritis Rheum. 54: 779-787.
18. Arnett, F. C., S. M. Edworthy, D. A. Bloch, D. J. McShane, J. F. Fries, N. S. Cooper, L. A. Healey, S. R. Kaplan, M. H. Liang, H. S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31: 315-324. (Pubitemid 18091653)
19. Boyle, D. L., S. Rosengren, W. Bugbee, A. Kavanaugh, and G. S. Firestein. 2003. Quantitative biomarker analysis of synovial gene expression by real-time PCR. Arthritis Res. Ther. 5: R352-R360.
20. Muller-Ladner, U., J. Kriegsmann, B. N. Franklin, S. Matsumoto, T. Geiler, R. E. Gay, and S. Gay. 1996. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am. J. Pathol. 149: 1607-1615. (Pubitemid 26363967)
21. Lafyatis, R., E. F. Remmers, A. B. Roberts, D. E. Yocum, M. B. Sporn, and R. L. Wilder. 1989. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83: 1267-1276. (Pubitemid 19113041)
22. Baier, A., I. Meineckel, S. Gay, and T. Pap. 2003. Apoptosis in rheumatoid arthritis. Curr. Opin. Rheumatol. 15: 274-279. (Pubitemid 36532607)
23. Meinecke, I., G. Pap, H. Mendoza, S. Drange, S. Ender, S. Strietholt, R. E. Gay, C. Seyfert, B. Ink, S. Gay, et al. 2009. Small ubiquitin-like modifier 1 [corrected] mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against Fas-induced apoptosis. Arthritis Rheum. 60: 2065-2070.
24. You, X., D. L. Boyle, D. Hammaker, and G. S. Firestein. 2006. PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53. Arthritis Res. Ther. 8: R157.
25. Firestein, G. S., F. Echeverri, M. Yeo, N. J. Zvaifler, and D. R. Green. 1997. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc. Natl. Acad. Sci. USA 94: 10895-10900. (Pubitemid 27430832)
26. Igarashi, H., J. Hashimoto, T. Tomita, H. Yoshikawa, and K. Ishihara. 2010. TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis. Clin. Exp. Immunol. 161: 71-80.
27. Inazuka, M., T. Tahira, T. Horiuchi, S. Harashima, T. Sawabe, M. Kondo, H. Miyahara, and K. Hayashi. 2000. Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology (Oxford) 39: 262-266. (Pubitemid 30204209)
28. Reme, T., A. Travaglio, E. Gueydon, L. Adla, C. Jorgensen, and J. Sany. 1998. Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue. Clin. Exp. Immunol. 111: 353-358. (Pubitemid 28088317)
29. Bang, H., K. Egerer, A. Gauliard, K. Luthke, P. E. Rudolph, G. Fredenhagen, W. Berg, E. Feist, and G.-R. Burmester. 2007. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56: 2503-2511. (Pubitemid 47237269)
30. Da Sylva, T. R., A. Connor, Y. Mburu, E. Keystone, and G. E. Wu. 2005. Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Arthritis Res. Ther. 7: R844-R851.
31. Portela, A., and M. Esteller. 2010. Epigenetic modifications and human disease. Nat. Biotechnol. 28: 1057-1068.
32. Christophersen, N. S. y., and K. Helin. 2010. Epigenetic control of embryonic stem cell fate. J. Exp. Med. 207: 2287-2295.
33. Liu, C. C., T. J. Fang, T. T. Ou, C. C. Wu, R. N. Li, Y. C. Lin, C. H. Lin, W. C. Tsai, H. W. Liu, and J. H. Yen. 2011. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Immunol. Lett. 135: 96-99.
34. Turek-Plewa, J., and P. P. Jagodzinski. 2005. The role of mammalian DNA methyltransferases in the regulation of gene expression. Cell. Mol. Biol. Lett. 10: 631-647. (Pubitemid 43161688)
35. Detich, N., and M Szyf. 2005. Regulation of DNA methyltransferases in cancer. In DNA Methylation and Cancer Therapy. Springer, New York, 125-141.
36. Bigey, P., S. Ramchandani, J. Theberge, F. D. Araujo, and M. Szyf. 2000. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene 242: 407-418. (Pubitemid 30064527)
37. Jinawath, A., S. Miyake, Y. Yanagisawa, Y. Akiyama, and Y. Yuasa. 2005. Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem. J. 385: 557-564. (Pubitemid 40165090)
38. Denis, H., M. N. Ndlovu, and F. Fuks. 2011. Regulation of mammalian DNA methyltransferases: A route to new mechanisms. EMBO Rep. 12: 647-656.
39. Liu, Y., M. W. Mayo, A. S. Nagji, P. W. Smith, C. S. Ramsey, D. Li, and D. R. Jones. 2012. Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. Oncogene 31: 1143-1154.
40. Rodríguez-Paredes, M., and M. Esteller. 2011. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17: 330-339.
41. Gao, Q., E. J. Steine, M. I. Barrasa, D. Hockemeyer, M. Pawlak, D. Fu, S. Reddy, G. W. Bell, and R. Jaenisch. 2011. Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proc. Natl. Acad. Sci. USA 108: 18061-18066.
42. Chik, F., and M. Szyf. 2011. Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis 32: 224-232.
43. Hervouet, E., F. M. Vallette, and P. F. Cartron. 2009. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4: 487-499.
44. Hervouet, E., L. Lalier, E. Debien, M. Cheray, A. Geairon, H. Rogniaux, D. Loussouarn, S. A. Martin, F. M. Vallette, and P. F. Cartron. 2010. Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS ONE 5: E11333.