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Volumn 65, Issue 4, 2013, Pages 928-938

Tumor necrosis factor α Induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

A20 BINDING INHIBITOR OF NUCLEAR FACTOR KAPPA B ACTIVATION 3; ACTIVATING TRANSCRIPTION FACTOR 3; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MESSENGER RNA; RANTES; RNA POLYMERASE II; STROMELYSIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84875721405     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37853     Document Type: Article
Times cited : (124)

References (50)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G,. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-19.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 84872859424 scopus 로고    scopus 로고
    • Mortality in rheumatoid arthritis over the last fifty years: Systematic review and meta-analysis
    • E-pub ahead of print
    • Dadoun S, Zeboulon-Ktorza N, Combescure C, Elhai M, Rozenberg S, Gossec L, et al. Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine 2012. E-pub ahead of print.
    • (2012) Joint Bone Spine
    • Dadoun, S.1    Zeboulon-Ktorza, N.2    Combescure, C.3    Elhai, M.4    Rozenberg, S.5    Gossec, L.6
  • 3
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS,. Evolving concepts of rheumatoid arthritis. Nature 2003; 423: 356-61.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 4
    • 79953162113 scopus 로고    scopus 로고
    • Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
    • Klareskog L, Malmstrom V, Lundberg K, Padyukov L, Alfredsson L,. Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis. Semin Immunol 2011; 23: 92-8.
    • (2011) Semin Immunol , vol.23 , pp. 92-98
    • Klareskog, L.1    Malmstrom, V.2    Lundberg, K.3    Padyukov, L.4    Alfredsson, L.5
  • 5
    • 67650766977 scopus 로고    scopus 로고
    • Translating molecular insights in autoimmunity into effective therapy
    • Feldmann M,. Translating molecular insights in autoimmunity into effective therapy. Annu Rev Immunol 2009; 27: 1-27.
    • (2009) Annu Rev Immunol , vol.27 , pp. 1-27
    • Feldmann, M.1
  • 7
    • 0030970556 scopus 로고    scopus 로고
    • The role of T cells in the immunopathogenesis of rheumatoid arthritis: New perspectives
    • [review]
    • Fox DA,. The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives [review]. Arthritis Rheum 1997; 40: 598-609.
    • (1997) Arthritis Rheum , vol.40 , pp. 598-609
    • Fox, D.A.1
  • 8
    • 78651474359 scopus 로고    scopus 로고
    • Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells
    • Murakami M, Okuyama Y, Ogura H, Asano S, Arima Y, Tsuruoka M, et al. Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J Exp Med 2011; 208: 103-14.
    • (2011) J Exp Med , vol.208 , pp. 103-114
    • Murakami, M.1    Okuyama, Y.2    Ogura, H.3    Asano, S.4    Arima, Y.5    Tsuruoka, M.6
  • 9
    • 0036230130 scopus 로고    scopus 로고
    • How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
    • Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 2002; 3: 360-5.
    • (2002) Nat Immunol , vol.3 , pp. 360-365
    • Matsumoto, I.1    MacCioni, M.2    Lee, D.M.3    Maurice, M.4    Simmons, B.5    Brenner, M.6
  • 10
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • [published erratum appears in Nature 2007;446:102]
    • Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages [published erratum appears in Nature 2007;446:102]. Nature 2006; 443: 998-1002.
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1    Ohtani, M.2    Miwa, K.3    Kizawa, T.4    Kanbara, Y.5    Yoshioka, Y.6
  • 11
    • 78650606709 scopus 로고    scopus 로고
    • Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
    • Kawane K, Tanaka H, Kitahara Y, Shimaoka S, Nagata S,. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A 2010; 107: 19432-7.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19432-19437
    • Kawane, K.1    Tanaka, H.2    Kitahara, Y.3    Shimaoka, S.4    Nagata, S.5
  • 12
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G,. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999; 10: 387-98.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 13
    • 39549089300 scopus 로고    scopus 로고
    • Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    • Armaka M, Apostolaki M, Jacques P, Kontoyiannis DL, Elewaut D, Kollias G,. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 2008; 205: 331-7.
    • (2008) J Exp Med , vol.205 , pp. 331-337
    • Armaka, M.1    Apostolaki, M.2    Jacques, P.3    Kontoyiannis, D.L.4    Elewaut, D.5    Kollias, G.6
  • 14
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok B, Firestein GS,. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-55.
    • (2010) Immunol Rev , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 15
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996; 149: 1607-15.
    • (1996) Am J Pathol , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1    Kriegsmann, J.2    Franklin, B.N.3    Matsumoto, S.4    Geiler, T.5    Gay, R.E.6
  • 16
    • 47249086030 scopus 로고    scopus 로고
    • The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
    • Noss EH, Brenner MB,. The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev 2008; 223: 252-70.
    • (2008) Immunol Rev , vol.223 , pp. 252-270
    • Noss, E.H.1    Brenner, M.B.2
  • 17
    • 0024592982 scopus 로고
    • Synovium as a source of interleukin 6 in vitro: Contribution to local and systemic manifestations of arthritis
    • Guerne PA, Zuraw BL, Vaughan JH, Carson DA, Lotz M,. Synovium as a source of interleukin 6 in vitro: contribution to local and systemic manifestations of arthritis. J Clin Invest 1989; 83: 585-92.
    • (1989) J Clin Invest , vol.83 , pp. 585-592
    • Guerne, P.A.1    Zuraw, B.L.2    Vaughan, J.H.3    Carson, D.A.4    Lotz, M.5
  • 18
    • 0025348745 scopus 로고
    • How important are T cells in chronic rheumatoid synovitis?
    • [editorial]
    • Firestein GS, Zvaifler NJ,. How important are T cells in chronic rheumatoid synovitis? [editorial]. Arthritis Rheum 1990; 33: 768-73.
    • (1990) Arthritis Rheum , vol.33 , pp. 768-773
    • Firestein, G.S.1    Zvaifler, N.J.2
  • 19
    • 10444242596 scopus 로고    scopus 로고
    • CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients
    • Garcia-Vicuna R, Gomez-Gaviro MV, Dominguez-Luis MJ, Pec MK, Gonzalez-Alvaro I, Alvaro-Gracia JM, et al. CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum 2004; 50: 3866-77.
    • (2004) Arthritis Rheum , vol.50 , pp. 3866-3877
    • Garcia-Vicuna, R.1    Gomez-Gaviro, M.V.2    Dominguez-Luis, M.J.3    Pec, M.K.4    Gonzalez-Alvaro, I.5    Alvaro-Gracia, J.M.6
  • 20
    • 0034657793 scopus 로고    scopus 로고
    • CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor
    • Cho CS, Cho ML, Min SY, Kim WU, Min DJ, Lee SS, et al. CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor. J Immunol 2000; 164: 5055-61.
    • (2000) J Immunol , vol.164 , pp. 5055-5061
    • Cho, C.S.1    Cho, M.L.2    Min, S.Y.3    Kim, W.U.4    Min, D.J.5    Lee, S.S.6
  • 21
    • 79957774659 scopus 로고    scopus 로고
    • Why does chronic inflammation persist: An unexpected role for fibroblasts
    • Buckley CD,. Why does chronic inflammation persist: an unexpected role for fibroblasts. Immunol Lett 2011; 138: 12-4.
    • (2011) Immunol Lett , vol.138 , pp. 12-14
    • Buckley, C.D.1
  • 22
    • 80052159733 scopus 로고    scopus 로고
    • Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states
    • Ivashkiv LB,. Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states. Eur J Immunol 2011; 41: 2477-81.
    • (2011) Eur J Immunol , vol.41 , pp. 2477-2481
    • Ivashkiv, L.B.1
  • 23
    • 79959373435 scopus 로고    scopus 로고
    • Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
    • Park SH, Park-Min KH, Chen J, Hu X, Ivashkiv LB,. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol 2011; 12: 607-15.
    • (2011) Nat Immunol , vol.12 , pp. 607-615
    • Park, S.H.1    Park-Min, K.H.2    Chen, J.3    Hu, X.4    Ivashkiv, L.B.5
  • 24
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 25
    • 0022465236 scopus 로고
    • Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
    • Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 1039-49.
    • (1986) Arthritis Rheum , vol.29 , pp. 1039-1049
    • Altman, R.1    Asch, E.2    Bloch, D.3    Bole, G.4    Borenstein, D.5    Brandt, K.6
  • 26
    • 0142029009 scopus 로고    scopus 로고
    • Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns
    • Parsonage G, Falciani F, Burman A, Filer A, Ross E, Bofill M, et al. Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thromb Haemost 2003; 90: 688-97.
    • (2003) Thromb Haemost , vol.90 , pp. 688-697
    • Parsonage, G.1    Falciani, F.2    Burman, A.3    Filer, A.4    Ross, E.5    Bofill, M.6
  • 27
    • 84869017379 scopus 로고    scopus 로고
    • The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment
    • Gordon RA, Grigoriev G, Lee A, Kalliolias GD, Ivashkiv LB,. The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment. Arthritis Rheum 2012; 64: 3119-28.
    • (2012) Arthritis Rheum , vol.64 , pp. 3119-3128
    • Gordon, R.A.1    Grigoriev, G.2    Lee, A.3    Kalliolias, G.D.4    Ivashkiv, L.B.5
  • 28
    • 0036618421 scopus 로고    scopus 로고
    • Role of nuclear factor κb in synovial inflammation
    • Muller-Ladner U, Gay RE, Gay S,. Role of nuclear factor κB in synovial inflammation. Curr Rheumatol Rep 2002; 4: 201-7.
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 201-207
    • Muller-Ladner, U.1    Gay, R.E.2    Gay, S.3
  • 29
  • 30
    • 78650614116 scopus 로고    scopus 로고
    • IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling
    • Chen J, Ivashkiv LB,. IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling. Proc Natl Acad Sci U S A 2010; 107: 19438-43.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19438-19443
    • Chen, J.1    Ivashkiv, L.B.2
  • 31
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications [published erratum appears in Nature 2008;451:102]
    • Foster SL, Hargreaves DC, Medzhitov R,. Gene-specific control of inflammation by TLR-induced chromatin modifications [published erratum appears in Nature 2008;451:102]. Nature 2007; 447: 972-8.
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 32
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP,. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-69.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 33
    • 22644446255 scopus 로고    scopus 로고
    • Tuning of macrophage responses by Stat3-inducing cytokines: Molecular mechanisms and consequences in infection
    • Lang R,. Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection. Immunobiology 2005; 210: 63-76.
    • (2005) Immunobiology , vol.210 , pp. 63-76
    • Lang, R.1
  • 34
    • 34147095832 scopus 로고    scopus 로고
    • Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages
    • Williams LM, Sarma U, Willets K, Smallie T, Brennan F, Foxwell BM,. Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages. J Biol Chem 2007; 282: 6965-75.
    • (2007) J Biol Chem , vol.282 , pp. 6965-6975
    • Williams, L.M.1    Sarma, U.2    Willets, K.3    Smallie, T.4    Brennan, F.5    Foxwell, B.M.6
  • 35
    • 84857239335 scopus 로고    scopus 로고
    • The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type i interferon
    • Rosengren S, Corr M, Firestein GS, Boyle DL,. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis 2012; 71: 440-7.
    • (2012) Ann Rheum Dis , vol.71 , pp. 440-447
    • Rosengren, S.1    Corr, M.2    Firestein, G.S.3    Boyle, D.L.4
  • 36
    • 0034931503 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001; 108: 73-81.
    • (2001) J Clin Invest , vol.108 , pp. 73-81
    • Han, Z.1    Boyle, D.L.2    Chang, L.3    Bennett, B.4    Karin, M.5    Yang, L.6
  • 37
    • 84860114297 scopus 로고    scopus 로고
    • PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis
    • Bartok B, Boyle DL, Liu Y, Ren P, Ball ST, Bugbee WD, et al. PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis. Am J Pathol 2012; 180: 1906-16.
    • (2012) Am J Pathol , vol.180 , pp. 1906-1916
    • Bartok, B.1    Boyle, D.L.2    Liu, Y.3    Ren, P.4    Ball, S.T.5    Bugbee, W.D.6
  • 38
    • 33750347516 scopus 로고    scopus 로고
    • Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis
    • Devauchelle V, Essabbani A, De Pinieux G, Germain S, Tourneur L, Mistou S, et al. Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis. J Immunol 2006; 177: 6471-9.
    • (2006) J Immunol , vol.177 , pp. 6471-6479
    • Devauchelle, V.1    Essabbani, A.2    De Pinieux, G.3    Germain, S.4    Tourneur, L.5    Mistou, S.6
  • 39
    • 83955161650 scopus 로고    scopus 로고
    • Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes
    • Yamana J, Morand EF, Manabu T, Sunahori K, Takasugi K, Makino H, et al. Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes. Cell Immunol 2012; 272: 293-8.
    • (2012) Cell Immunol , vol.272 , pp. 293-298
    • Yamana, J.1    Morand, E.F.2    Manabu, T.3    Sunahori, K.4    Takasugi, K.5    Makino, H.6
  • 41
    • 84864425616 scopus 로고    scopus 로고
    • Lysophosphatidic acid receptor 1 suppression sensitizes rheumatoid fibroblast-like synoviocytes to tumor necrosis factor-induced apoptosis
    • Orosa B, Gonzalez A, Mera A, Gomez-Reino JJ, Conde C,. Lysophosphatidic acid receptor 1 suppression sensitizes rheumatoid fibroblast-like synoviocytes to tumor necrosis factor-induced apoptosis. Arthritis Rheum 2012; 64: 2460-70.
    • (2012) Arthritis Rheum , vol.64 , pp. 2460-2470
    • Orosa, B.1    Gonzalez, A.2    Mera, A.3    Gomez-Reino, J.J.4    Conde, C.5
  • 42
    • 84863828199 scopus 로고    scopus 로고
    • Role of p21-activated kinase 1 in regulating the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
    • Fu D, Yang Y, Xiao Y, Lin H, Ye Y, Zhan Z, et al. Role of p21-activated kinase 1 in regulating the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients. Rheumatology (Oxford) 2012; 51: 1170-80.
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 1170-1180
    • Fu, D.1    Yang, Y.2    Xiao, Y.3    Lin, H.4    Ye, Y.5    Zhan, Z.6
  • 44
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 2008; 371: 987-97.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6
  • 45
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones SA, Scheller J, Rose-John S,. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011; 121: 3375-83.
    • (2011) J Clin Invest , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 47
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • for the ORAL Solo Investigators
    • Fleischmann R, Kremer J, Cush J, Schulze-Koops H, Connell CA, Bradley JD, et al, for the ORAL Solo Investigators. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012; 367: 495-507.
    • (2012) N Engl J Med , vol.367 , pp. 495-507
    • Fleischmann, R.1    Kremer, J.2    Cush, J.3    Schulze-Koops, H.4    Connell, C.A.5    Bradley, J.D.6
  • 48
    • 33845608765 scopus 로고    scopus 로고
    • Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug- induced clinical remission: Evidence from an imaging study may explain structural progression
    • Brown AK, Quinn MA, Karim Z, Conaghan PG, Peterfy CG, Hensor E, et al. Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug- induced clinical remission: evidence from an imaging study may explain structural progression. Arthritis Rheum 2006; 54: 3761-73.
    • (2006) Arthritis Rheum , vol.54 , pp. 3761-3773
    • Brown, A.K.1    Quinn, M.A.2    Karim, Z.3    Conaghan, P.G.4    Peterfy, C.G.5    Hensor, E.6
  • 49
    • 73249137735 scopus 로고    scopus 로고
    • Bone remodeling in rheumatic disease: A question of balance
    • Walsh NC, Gravallese EM,. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev 2010; 233: 301-12.
    • (2010) Immunol Rev , vol.233 , pp. 301-312
    • Walsh, N.C.1    Gravallese, E.M.2


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