-
1
-
-
84906852294
-
Mitochondrial apoptosis is dispensable for NLRP3 infammasome activation but non-apoptotic caspase-8 is required for infammasome priming
-
Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE. 2014. Mitochondrial apoptosis is dispensable for NLRP3 infammasome activation but non-apoptotic caspase-8 is required for infammasome priming. EMBO Reports 15:982-990. doi: 10.15252/embr.201438463.
-
(2014)
EMBO Reports
, vol.15
, pp. 982-990
-
-
Allam, R.1
Lawlor, K.E.2
Yu, E.C.3
Mildenhall, A.L.4
Moujalled, D.M.5
Lewis, R.S.6
Ke, F.7
Mason, K.D.8
White, M.J.9
Stacey, K.J.10
Strasser, A.11
O'reilly, L.A.12
Alexander, W.13
Kile, B.T.14
Vaux, D.L.15
Vince, J.E.16
-
3
-
-
24744459035
-
Cutting edge: Innate immunity conferred by B cells is regulated by caspase-8
-
Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. 2005. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. The Journal of Immunology 175:3469-3473. doi: 10.4049/jimmunol.175.6.3469.
-
(2005)
The Journal of Immunology
, vol.175
, pp. 3469-3473
-
-
Beisner, D.R.1
Ch'en, I.L.2
Kolla, R.V.3
Hoffmann, A.4
Hedrick, S.M.5
-
4
-
-
84901678314
-
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of infammation in SHARPIN-defcient mice
-
Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ. 2014. Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of infammation in SHARPIN-defcient mice. The Journal of Immunology 192:5476-5480. doi: 10.4049/jimmunol.1400499.
-
(2014)
The Journal of Immunology
, vol.192
, pp. 5476-5480
-
-
Berger, S.B.1
Kasparcova, V.2
Hoffman, S.3
Swift, B.4
Dare, L.5
Schaeffer, M.6
Capriotti, C.7
Cook, M.8
Finger, J.9
Hughes-Earle, A.10
Harris, P.A.11
Kaiser, W.J.12
Mocarski, E.S.13
Bertin, J.14
Gough, P.J.15
-
5
-
-
84869429707
-
Immunodefciency, autoinfammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC defciency
-
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika AM, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debré M, Mazzolari E, Vairo D, Agou F, Virgin HW, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet JC, Pascual V, Chaussabel D, Notarangelo LD, Puel A, Israël A, Casanova JL, Picard C. 2012. Immunodefciency, autoinfammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC defciency. Nature Immunology 13:1178-1186. doi: 10.1038/ni.2457.
-
(2012)
Nature Immunology
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
Laplantine, E.2
Prando, C.3
Giliani, S.4
Israelsson, E.5
Xu, Z.6
Abhyankar, A.7
Israel, L.8
Trevejo-Nunez, G.9
Bogunovic, D.10
Cepika, A.M.11
Macduff, D.12
Chrabieh, M.13
Hubeau, M.14
Bajolle, F.15
Debré, M.16
Mazzolari, E.17
Vairo, D.18
Agou, F.19
Virgin, H.W.20
Bossuyt, X.21
Rambaud, C.22
Facchetti, F.23
Bonnet, D.24
Quartier, P.25
Fournet, J.C.26
Pascual, V.27
Chaussabel, D.28
Notarangelo, L.D.29
Puel, A.30
Israël, A.31
Casanova, J.L.32
Picard, C.33
more..
-
6
-
-
80755132824
-
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin infamma-tion
-
Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin infamma-tion. Immunity 35:572-582. doi: 10.1016/j.immuni.2011.08.014.
-
(2011)
Immunity
, vol.35
, pp. 572-582
-
-
Bonnet, M.C.1
Preukschat, D.2
Welz, P.S.3
Van Loo, G.4
Ermolaeva, M.A.5
Bloch, W.6
Haase, I.7
Pasparakis, M.8
-
7
-
-
84875809939
-
Fas/CD95-induced chemokines can serve as “fnd-me” signals for apoptotic cells
-
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ. 2013. Fas/CD95-induced chemokines can serve as “fnd-me” signals for apoptotic cells. Molecular Cell 49:1034-1048. doi: 10.1016/j.molcel.2013.01.025.
-
(2013)
Molecular Cell
, vol.49
, pp. 1034-1048
-
-
Cullen, S.P.1
Henry, C.M.2
Kearney, C.J.3
Logue, S.E.4
Feoktistova, M.5
Tynan, G.A.6
Lavelle, E.C.7
Leverkus, M.8
Martin, S.J.9
-
9
-
-
84907210946
-
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
-
Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. 2014. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513:90-94. doi: 10.1038/nature13608.
-
(2014)
Nature
, vol.513
, pp. 90-94
-
-
Dannappel, M.1
Vlantis, K.2
Kumari, S.3
Polykratis, A.4
Kim, C.5
Wachsmuth, L.6
Eftychi, C.7
Lin, J.8
Corona, T.9
Hermance, N.10
Zelic, M.11
Kirsch, P.12
Basic, M.13
Bleich, A.14
Kelliher, M.15
Pasparakis, M.16
-
10
-
-
0028277665
-
Abnormal development of peripheral lymphoid organs in mice defcient in lymphotoxin
-
De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, Smith SC, Carlson R, Shornick L P, Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD. 1994. Abnormal development of peripheral lymphoid organs in mice defcient in lymphotoxin. Science 264:703-707. doi: 10.1126/science.8171322.
-
(1994)
Science
, vol.264
, pp. 703-707
-
-
De Togni, P.1
Goellner, J.2
Ruddle, N.H.3
Streeter, P.R.4
Fick, A.5
Mariathasan, S.6
Smith, S.C.7
Carlson, R.8
Shornick, L.P.9
Strauss-Schoenberger, J.10
Russell, J.H.11
Karr, R.12
Chaplin, D.D.13
-
11
-
-
84861712290
-
Survival function of the FADD-CASPASE-8-cFLIP(L) complex
-
Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR. 2012. Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Reports 1:401-407. doi: 10.1016/j.celrep.2012.03.010.
-
(2012)
Cell Reports
, vol.1
, pp. 401-407
-
-
Dillon, C.P.1
Oberst, A.2
Weinlich, R.3
Janke, L.J.4
Kang, T.B.5
Ben-Moshe, T.6
Mak, T.W.7
Wallach, D.8
Green, D.R.9
-
12
-
-
84901386193
-
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3
-
Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. 2014. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell 157:1189-1202. doi: 10.1016/j.cell.2014.04.018.
-
(2014)
Cell
, vol.157
, pp. 1189-1202
-
-
Dillon, C.P.1
Weinlich, R.2
Rodriguez, D.A.3
Cripps, J.G.4
Quarato, G.5
Gurung, P.6
Verbist, K.C.7
Brewer, T.L.8
Llambi, F.9
Gong, Y.N.10
Janke, L.J.11
Kelliher, M.A.12
Kanneganti, T.D.13
Green, D.R.14
-
13
-
-
77949534538
-
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
-
Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F. 2010. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLOS ONE 5:e9258. doi: 10.1371/journal.pone.0009258.
-
(2010)
PLOS ONE
, vol.5
-
-
Dumortier, A.1
Durham, A.D.2
Di Piazza, M.3
Vauclair, S.4
Koch, U.5
Ferrand, G.6
Ferrero, I.7
Demehri, S.8
Song, L.L.9
Farr, A.G.10
Leonard, W.J.11
Kopan, R.12
Miele, L.13
Hohl, D.14
Finke, D.15
Radtke, F.16
-
14
-
-
84886095480
-
Lymphotoxin alpha induces apoptosis, necroptosis and infammatory signals with the same potency as tumour necrosis factor
-
Etemadi N, Holien JK, Chau D, Dewson G, Murphy JM, Alexander WS, Parker MW, Silke J, Nachbur U. 2013. Lymphotoxin alpha induces apoptosis, necroptosis and infammatory signals with the same potency as tumour necrosis factor. The FEBS Journal 280:5283-5297. doi: 10.1111/febs.12419.
-
(2013)
The FEBS Journal
, vol.280
, pp. 5283-5297
-
-
Etemadi, N.1
Holien, J.K.2
Chau, D.3
Dewson, G.4
Murphy, J.M.5
Alexander, W.S.6
Parker, M.W.7
Silke, J.8
Nachbur, U.9
-
15
-
-
79953240109
-
Linear ubiquitination prevents infammation and regulates immune signalling
-
Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H. 2011. Linear ubiquitination prevents infammation and regulates immune signalling. Nature 471:591-596. doi: 10.1038/nature09816.
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
Cordier, S.M.2
Schmukle, A.C.3
Emmerich, C.H.4
Rieser, E.5
Haas, T.L.6
Webb, A.I.7
Rickard, J.A.8
Erton, H.9
Wong, W.W.10
Nachbur, U.11
Gangoda, L.12
Warnken, U.13
Purcell, A.W.14
Silke, J.15
Walczak, H.16
-
16
-
-
84925364967
-
The ratio of Mcl-1 and Noxa determines ABT737resistance in squamous cell carcinoma of the skin
-
Geserick P, Wang J, Feoktistova M, Leverkus M. 2014. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death & Disease 5:e1412. doi: 10.1038/cddis.2014.379.
-
(2014)
Cell Death & Disease
, vol.5
-
-
Geserick, P.1
Wang, J.2
Feoktistova, M.3
Leverkus, M.4
-
17
-
-
0029590181
-
Maintenance of donor phenotype afterfull-thickness skin transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Kaand nude mice and vice versa
-
Gijbels MJ, HogenEsch H, Bruijnzeel PL, Elliott GR, Zurcher C. 1995. Maintenance of donor phenotype after full-thickness skin transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa. The Journal of Investigative Dermatology 105:769-773. doi: 10.1111/1523-1747.ep12325599.
-
(1995)
The Journal of Investigative Dermatology
, vol.105
, pp. 769-773
-
-
Gijbels, M.J.1
Hogenesch, H.2
Bruijnzeel, P.L.3
Elliott, G.R.4
Zurcher, C.5
-
18
-
-
0030091271
-
Pathogenesisof skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm)
-
Gijbels MJ, Zurcher C, Kraal G, Elliott GR, HogenEsch H, Schijff G, Savelkoul H F, Bruijnzeel PL. 1996. Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). The American Journal of Pathology 148:941-950.
-
(1996)
The American Journal of Pathology
, vol.148
, pp. 941-950
-
-
Gijbels, M.J.1
Zurcher, C.2
Kraal, G.3
Elliott, G.R.4
Hogenesch, H.5
Schijff, G.6
Savelkoul, H.F.7
Bruijnzeel, P.L.8
-
19
-
-
71149105333
-
Recruitment of the linear ubiquitin chain assembly complexstabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
-
Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H. 2009. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Molecular Cell 36:831-844. doi: 10.1016/j.molcel.2009.10.013.
-
(2009)
Molecular Cell
, vol.36
, pp. 831-844
-
-
Haas, T.L.1
Emmerich, C.H.2
Gerlach, B.3
Schmukle, A.C.4
Cordier, S.M.5
Rieser, E.6
Feltham, R.7
Vince, J.8
Warnken, U.9
Wenger, T.10
Koschny, R.11
Komander, D.12
Silke, J.13
Walczak, H.14
-
20
-
-
66749183275
-
Receptor interacting protein kinase-3 determinescellular necrotic response to TNF-alpha
-
He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. 2009. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137:1100-1111. doi: 10.1016/j.cell.2009.05.021.
-
(2009)
Cell
, vol.137
, pp. 1100-1111
-
-
He, S.1
Wang, L.2
Miao, L.3
Wang, T.4
Du, F.5
Zhao, L.6
Wang, X.7
-
21
-
-
0027773019
-
A spontaneousmutation characterized by chronic proliferative dermatitis in C57BL mice
-
HogenEsch H, Gijbels MJ, Offerman E, van Hooft J, van Bekkum DW, Zurcher C. 1993. A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. The American Journal of Pathology 143:972-982.
-
(1993)
The American Journal of Pathology
, vol.143
, pp. 972-982
-
-
Hogenesch, H.1
Gijbels, M.J.2
Offerman, E.3
Van Hooft, J.4
Van Bekkum, D.W.5
Zurcher, C.6
-
22
-
-
0033120961
-
Absence of Peyer's patches and abnormal lymphoidarchitecture in chronic proliferative dermatitis (cpdm/cpdm) mice
-
HogenEsch H, Janke S, Boggess D, Sundberg J P. 1999. Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. The Journal of Immunology 162:3890-3896.
-
(1999)
The Journal of Immunology
, vol.162
, pp. 3890-3896
-
-
Hogenesch, H.1
Janke, S.2
Boggess, D.3
Sundberg, J.P.4
-
23
-
-
79953239980
-
SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis
-
Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg J P, Schaefer L, Rittinger K, Macek B, Dikic I. 2011. SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 471:637-641. doi: 10.1038/nature09814.
-
(2011)
Nature
, vol.471
, pp. 637-641
-
-
Ikeda, F.1
Deribe, Y.L.2
Skanland, S.S.3
Stieglitz, B.4
Grabbe, C.5
Franz-Wachtel, M.6
Van Wijk, S.J.7
Goswami, P.8
Nagy, V.9
Terzic, J.10
Tokunaga, F.11
Roulidaki, A.12
Nakagawa, T.13
Pasparakis, M.14
Iwai, K.15
Sundberg, J.P.16
Schaefer, L.17
Rittinger, K.18
Macek, B.19
Dikic, I.20
more..
-
24
-
-
84874263775
-
Necroptosis: The release of damage-associated molecularpatterns and its physiological relevance
-
Kaczmarek A, Vandenabeele P, Krysko DV. 2013. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 38:209-223. doi: 10.1016/j.immuni.2013.02.003.
-
(2013)
Immunity
, vol.38
, pp. 209-223
-
-
Kaczmarek, A.1
Vandenabeele, P.2
Krysko, D.V.3
-
25
-
-
79952811804
-
RIP3mediates the embryonic lethality of caspase-8-defcient mice
-
Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer L P, Hakem R, Caspary T, Mocarski ES. 2011. RIP3 mediates the embryonic lethality of caspase-8-defcient mice. Nature 471:368-372. doi: 10.1038/nature09857.
-
(2011)
Nature
, vol.471
, pp. 368-372
-
-
Kaiser, W.J.1
Upton, J.W.2
Long, A.B.3
Livingston-Rosanoff, D.4
Daley-Bauer, L.P.5
Hakem, R.6
Caspary, T.7
Mocarski, E.S.8
-
26
-
-
84872764927
-
Caspase-8 blocks kinase RIPK3-mediated activation ofthe NLRP3 infammasome
-
Kang TB, Yang SH, Toth B, Kovalenko A, Wallach D. 2013. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 infammasome. Immunity 38:27-40. doi: 10.1016/j.immuni.2012.09.015.
-
(2013)
Immunity
, vol.38
, pp. 27-40
-
-
Kang, T.B.1
Yang, S.H.2
Toth, B.3
Kovalenko, A.4
Wallach, D.5
-
27
-
-
0030917003
-
Distinct roles in lymphoid organo-genesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-defcient mice
-
Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. 1997. Distinct roles in lymphoid organo-genesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-defcient mice. Immunity 6:491-500. doi: 10.1016/S1074-7613(00)80292-7.
-
(1997)
Immunity
, vol.6
, pp. 491-500
-
-
Koni, P.A.1
Sacca, R.2
Lawton, P.3
Browning, J.L.4
Ruddle, N.H.5
Flavell, R.A.6
-
28
-
-
70350484946
-
Caspase-8 defciency in epidermal keratinocytes triggers an infammatory skin disease
-
Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D. 2009. Caspase-8 defciency in epidermal keratinocytes triggers an infammatory skin disease. The Journal of Experimental Medicine 206:2161-2177. doi: 10.1084/jem.20090616.
-
(2009)
The Journal Ofexperimental Medicine
, vol.206
, pp. 2161-2177
-
-
Kovalenko, A.1
Kim, J.C.2
Kang, T.B.3
Rajput, A.4
Bogdanov, K.5
Dittrich-Breiholz, O.6
Kracht, M.7
Brenner, O.8
Wallach, D.9
-
29
-
-
63649143438
-
Dynamic expression of epidermal caspase 8 simulatesa wound healing response
-
Lee P, Lee DJ, Chan C, Chen SW, Ch'en I, Jamora C. 2009. Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature 458:519-523. doi: 10.1038/nature07687.
-
(2009)
Nature
, vol.458
, pp. 519-523
-
-
Lee, P.1
Lee, D.J.2
Chan, C.3
Chen, S.W.4
Ch'en, I.5
Jamora, C.6
-
30
-
-
78650289998
-
Inhibition of NF-kappaB signaling Retards Eosinophilic dermatitis inSHARPIN-defcient mice
-
Liang Y, Seymour RE, Sundberg J P. 2010. Inhibition of NF-kappaB signaling Retards Eosinophilic dermatitis in SHARPIN-defcient mice. The Journal of Investigative Dermatology 131:141-149. doi: 10.1038/jid.2010.259.
-
(2010)
The Journal of Investigative Dermatology
, vol.131
, pp. 141-149
-
-
Liang, Y.1
Seymour, R.E.2
Sundberg, J.P.3
-
31
-
-
79960905833
-
SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes
-
Liang Y, Sundberg J P. 2011. SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes. Journal of Dermatological Science 63:148-153. doi: 10.1016/j.jdermsci.2011.04.012.
-
(2011)
Journal Ofdermatological Science
, vol.63
, pp. 148-153
-
-
Liang, Y.1
Sundberg, J.P.2
-
32
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signalingcomplexes
-
Micheau O, Tschopp J. 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190. doi: 10.1016/S0092-8674(03)00521-X.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
33
-
-
84884308522
-
The Pseudokinase MLKL mediates necroptosisvia a molecular switch mechanism
-
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. 2013. The Pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 39:443-453. doi: 10.1016/j.immuni.2013.06.018.
-
(2013)
Immunity
, vol.39
, pp. 443-453
-
-
Murphy, J.M.1
Czabotar, P.E.2
Hildebrand, J.M.3
Lucet, I.S.4
Zhang, J.G.5
Alvarez-Diaz, S.6
Lewis, R.7
Lalaoui, N.8
Metcalf, D.9
Webb, A.I.10
Young, S.N.11
Varghese, L.N.12
Tannahill, G.M.13
Hatchell, E.C.14
Majewski, I.J.15
Okamoto, T.16
Dobson, R.C.17
Hilton, D.J.18
Babon, J.J.19
Nicola, N.A.20
Strasser, A.21
Silke, J.22
Alexander, W.S.23
more..
-
34
-
-
79952810024
-
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
-
Oberst A, Dillon C P, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. 2011. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471:363-367. doi: 10.1038/nature09852.
-
(2011)
Nature
, vol.471
, pp. 363-367
-
-
Oberst, A.1
Dillon, C.P.2
Weinlich, R.3
McCormick, L.L.4
Fitzgerald, P.5
Pop, C.6
Hakem, R.7
Salvesen, G.S.8
Green, D.R.9
-
35
-
-
84887023764
-
Cflip regulates skinhomeostasis and protects against TNF-induced keratinocyte apoptosis
-
Panayotova-Dimitrova D, Feoktistova M, Ploesser M, Kellert B, Hupe M, Horn S, Makarov R, Jensen F, Porubsky S, Schmieder A, Zenclussen AC, Marx A, Kerstan A, Geserick P, He YW, Leverkus M. 2013. cflip regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. Cell Reports 5:397-408. doi: 10.1016/j.celrep.2013.09.035.
-
(2013)
Cell Reports
, vol.5
, pp. 397-408
-
-
Panayotova-Dimitrova, D.1
Feoktistova, M.2
Ploesser, M.3
Kellert, B.4
Hupe, M.5
Horn, S.6
Makarov, R.7
Jensen, F.8
Porubsky, S.9
Schmieder, A.10
Zenclussen, A.C.11
Marx, A.12
Kerstan, A.13
Geserick, P.14
He, Y.W.15
Leverkus, M.16
-
36
-
-
84907995994
-
HOIP defciency causes embryonic lethality byAberrant TNFR1-mediated Endothelial cell death
-
Peltzer N, Rieser E, Taraborrelli L, Draber P, Darding M, Pernaute B, Shimizu Y, Sarr A, Draberova H, Montinaro A, Martinez-Barbera J P, Silke J, Rodriguez TA, Walczak H. 2014. HOIP defciency causes embryonic lethality by Aberrant TNFR1-mediated Endothelial cell death. Cell Reports 9:153-165. doi: 10.1016/j.celrep.2014.08.066.
-
(2014)
Cell Reports
, vol.9
, pp. 153-165
-
-
Peltzer, N.1
Rieser, E.2
Taraborrelli, L.3
Draber, P.4
Darding, M.5
Pernaute, B.6
Shimizu, Y.7
Sarr, A.8
Draberova, H.9
Montinaro, A.10
Martinez-Barbera, J.P.11
Silke, J.12
Rodriguez, T.A.13
Walczak, H.14
-
37
-
-
84906739952
-
Chronic proliferative dermatitis in Sharpin null mice: Development of an autoinfammatory disease in the absenceof B and T lymphocytes and IL4/IL13 signaling
-
Potter CS, Wang Z, Silva KA, Kennedy VE, Stearns TM, Burzenski L, Shultz LD, Hogenesch H, Sundberg J P. 2014. Chronic proliferative dermatitis in Sharpin null mice: development of an autoinfammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling. PLOS ONE 9:e85666. doi: 10.1371/journal.pone.0085666.
-
(2014)
PLOS ONE
, vol.9
-
-
Potter, C.S.1
Wang, Z.2
Silva, K.A.3
Kennedy, V.E.4
Stearns, T.M.5
Burzenski, L.6
Shultz, L.D.7
Hogenesch, H.8
Sundberg, J.P.9
-
38
-
-
51549095216
-
A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneousapoptosis
-
Pradhan S, Kim HK, Thrash CJ, Cox MA, Mantena SK, Wu JH, Athar M, Katiyar SK, Elmets CA, Timares L. 2008. A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis. The Journal of Immunology 181:3077-3088. doi: 10.4049/jimmunol.181.5.3077.
-
(2008)
The Journal of Immunology
, vol.181
, pp. 3077-3088
-
-
Pradhan, S.1
Kim, H.K.2
Thrash, C.J.3
Cox, M.A.4
Mantena, S.K.5
Wu, J.H.6
Athar, M.7
Katiyar, S.K.8
Elmets, C.A.9
Timares, L.10
-
39
-
-
77149121750
-
Anti-IL5 decreases the number ofeosinophils but not the severity of dermatitis in Sharpin-defcient mice
-
Renninger ML, Seymour RE, Whiteley LO, Sundberg J P, Hogenesch H. 2010. Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-defcient mice. Experimental Dermatology 19:252-258. doi: 10.1111/j.1600-0625.2009.00944.x.
-
(2010)
Experimental Dermatology
, vol.19
, pp. 252-258
-
-
Renninger, M.L.1
Seymour, R.E.2
Whiteley, L.O.3
Sundberg, J.P.4
Hogenesch, H.5
-
40
-
-
84901422731
-
RIPK1 regulates RIPK3-MLKL-driven systemic infammation and emergency hematopoiesis
-
Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J. 2014. RIPK1 regulates RIPK3-MLKL-driven systemic infammation and emergency hematopoiesis. Cell 157:1175-1188. doi: 10.1016/j.cell.2014.04.019.
-
(2014)
Cell
, vol.157
, pp. 1175-1188
-
-
Rickard, J.A.1
O'donnell, J.A.2
Evans, J.M.3
Lalaoui, N.4
Poh, A.R.5
Rogers, T.6
Vince, J.E.7
Lawlor, K.E.8
Ninnis, R.L.9
Erton, H.10
Hall, C.11
Spall, S.K.12
Phesse, T.J.13
Abud, H.E.14
Cengia, L.H.15
Corbin, J.16
Mifsud, S.17
di Rago, L.18
Metcalf, D.19
Ernst, M.20
Dewson, G.21
Roberts, A.W.22
Alexander, W.S.23
Murphy, J.M.24
Ekert, P.G.25
Masters, S.L.26
Vaux, D.L.27
Croker, B.A.28
Gerlic, M.29
Silke, J.30
more..
-
41
-
-
0037380628
-
Essential role for caspase 8 inT-cell homeostasis and T-cell-mediated immunity
-
Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, Hakem R. 2003. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes & Development 17:883-895. doi: 10.1101/gad.1063703.
-
(2003)
Genes & Development
, vol.17
, pp. 883-895
-
-
Salmena, L.1
Lemmers, B.2
Hakem, A.3
Matysiak-Zablocki, E.4
Murakami, K.5
Au, P.Y.6
Berry, D.M.7
Tamblyn, L.8
Shehabeldin, A.9
Migon, E.10
Wakeham, A.11
Bouchard, D.12
Yeh, W.C.13
McGlade, J.C.14
Ohashi, P.S.15
Hakem, R.16
-
42
-
-
84858113865
-
No one can whistle a symphony alone - how different ubiquitin linkagescooperate to orchestrate NF-kappaB activity
-
Schmukle AC, Walczak H. 2012. No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF-kappaB activity. Journal of Cell Science 125:549-559. doi: 10.1242/jcs.091793.
-
(2012)
Journal of Cell Science
, vol.125
, pp. 549-559
-
-
Schmukle, A.C.1
Walczak, H.2
-
43
-
-
84873719943
-
Loss of function of the mouse Sharpin generesults in Peyer's patch regression
-
Seymour R, Shirley BJ, Hogenesch H, Shultz LD, Sundberg J P. 2013. Loss of function of the mouse Sharpin gene results in Peyer's patch regression. PLOS ONE 8:e55224. doi: 10.1371/journal.pone.0055224.
-
(2013)
PLOS ONE
, vol.8
-
-
Seymour, R.1
Shirley, B.J.2
Hogenesch, H.3
Shultz, L.D.4
Sundberg, J.P.5
-
44
-
-
34547422758
-
Spontaneousmutations in the mouse Sharpin gene result in multiorgan infammation, immune system dysregulation anddermatitis
-
Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg J P. 2007. Spontaneous mutations in the mouse Sharpin gene result in multiorgan infammation, immune system dysregulation and dermatitis. Genes and Immunity 8:416-421. doi: 10.1038/sj.gene.6364403.
-
(2007)
Genes and Immunity
, vol.8
, pp. 416-421
-
-
Seymour, R.E.1
Hasham, M.G.2
Cox, G.A.3
Shultz, L.D.4
Hogenesch, H.5
Roopenian, D.C.6
Sundberg, J.P.7
-
45
-
-
80053602333
-
The regulation of TNF signalling: What a tangled web we weave
-
Silke J. 2011. The regulation of TNF signalling: what a tangled web we weave. Current Opinion in Immunology 23:620-626. doi: 10.1016/j.coi.2011.08.002.
-
(2011)
Current Opinion in Immunology
, vol.23
, pp. 620-626
-
-
Silke, J.1
-
46
-
-
84925364966
-
IAPs and Necroptotic Cell Death
-
Shen HM, Vandenabeele P, editors, New York: Springer
-
Silke J, Vaux D. 2014. IAPs and Necroptotic Cell Death. In: Shen HM, Vandenabeele P, editors. Necrotic Cell Death. New York: Springer.p. 57-77.
-
(2014)
Necrotic Cell
, pp. 57-77
-
-
Silke, J.1
Vaux, D.2
-
47
-
-
84862907788
-
Mixed lineage kinasedomain-like protein mediates necrosis signaling downstream of RIP3 kinase
-
Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. 2012. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148:213-227. doi: 10.1016/j.cell.2011.11.031.
-
(2012)
Cell
, vol.148
, pp. 213-227
-
-
Sun, L.1
Wang, H.2
Wang, Z.3
He, S.4
Chen, S.5
Liao, D.6
Wang, L.7
Yan, J.8
Liu, W.9
Lei, X.10
Wang, X.11
-
48
-
-
84885339072
-
Linear ubiquitination-mediated NF-kappaB regulation and its related disorders
-
Tokunaga F. 2013. Linear ubiquitination-mediated NF-kappaB regulation and its related disorders. Journal of Biochemistry 154:313-323. doi: 10.1093/jb/mvt079.
-
(2013)
Journal Ofbiochemistry
, vol.154
, pp. 313-323
-
-
Tokunaga, F.1
-
49
-
-
79953237668
-
SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex
-
Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K. 2011. SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature 471:633-636. doi: 10.1038/nature09815.
-
(2011)
Nature
, vol.471
, pp. 633-636
-
-
Tokunaga, F.1
Nakagawa, T.2
Nakahara, M.3
Saeki, Y.4
Taniguchi, M.5
Sakata, S.6
Tanaka, K.7
Nakano, H.8
Iwai, K.9
-
50
-
-
59649103156
-
Involvement of linear polyubiquitylation of NEMO inNF-kappaB activation
-
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K. 2009. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nature Cell Biology 11:123-132. doi: 10.1038/ncb1821.
-
(2009)
Nature Cell Biology
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
Sakata, S.2
Saeki, Y.3
Satomi, Y.4
Kirisako, T.5
Kamei, K.6
Nakagawa, T.7
Kato, M.8
Murata, S.9
Yamaoka, S.10
Yamamoto, M.11
Akira, S.12
Takao, T.13
Tanaka, K.14
Iwai, K.15
-
52
-
-
0032143986
-
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors,Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D. 1998. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9:267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luria, V.3
Chiannilkulchai, N.4
Beckmann, J.S.5
Mett, I.L.6
Rebrikov, D.7
Brodianski, V.M.8
Kemper, O.C.9
Kollet, O.10
Lapidot, T.11
Soffer, D.12
Sobe, T.13
Avraham, K.B.14
Goncharov, T.15
Holtmann, H.16
Lonai, P.17
Wallach, D.18
-
53
-
-
84857404572
-
Inhibitor of apoptosis proteins limit RIP3 kinase-dependentinterleukin-1 activation
-
Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L, Mason K, Gross O, Ma S, Guarda G, Anderton H, Castillo R, Häcker G, Silke J, Tschopp J. 2012. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 36:215-227. doi: 10.1016/j.immuni.2012.01.012.
-
(2012)
Immunity
, vol.36
, pp. 215-227
-
-
Vince, J.E.1
Wong, W.W.2
Gentle, I.3
Lawlor, K.E.4
Allam, R.5
O'reilly, L.6
Mason, K.7
Gross, O.8
Ma, S.9
Guarda, G.10
Erton, H.11
Castillo, R.12
Häcker, G.13
Silke, J.14
Tschopp, J.15
-
54
-
-
84899112438
-
Ciaps and XIAP regulate myelopoiesis throughcytokine production in a RIPK1 and RIPK3 dependent manner
-
Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J. 2014. ciaps and XIAP regulate myelopoiesis through cytokine production in a RIPK1 and RIPK3 dependent manner. Blood 123:2562-2572. doi: 10.1182/blood-2013-06-510743.
-
(2014)
Blood
, vol.123
, pp. 2562-2572
-
-
Wong, W.W.1
Vince, J.E.2
Lalaoui, N.3
Lawlor, K.E.4
Chau, D.5
Bankovacki, A.6
Erton, H.7
Metcalf, D.8
O'reilly, L.9
Jost, P.J.10
Murphy, J.M.11
Alexander, W.S.12
Strasser, A.13
Vaux, D.L.14
Silke, J.15
-
55
-
-
79960993122
-
Systems analysisidentifes an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophageToll-like receptor 2 (TLR2) responses
-
Zak DE, Schmitz F, Gold ES, Diercks AH, Peschon JJ, Valvo JS, Niemisto A, Podolsky I, Fallen SG, Suen R, Stolyar T, Johnson CD, Kennedy KA, Hamilton MK, Siggs OM, Beutler B, Aderem A. 2011. Systems analysis identifes an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proceedings of the National Academy of Sciences of USA 108: 11536-11541. doi: 10.1073/pnas.1107577108.
-
(2011)
Proceedings of the National Academy of Sciences of USA
, vol.108
, pp. 1
-
-
Zak, D.E.1
Schmitz, F.2
Gold, E.S.3
Diercks, A.H.4
Peschon, J.J.5
Valvo, J.S.6
Niemisto, A.7
Podolsky, I.8
Fallen, S.G.9
Suen, R.10
Stolyar, T.11
Johnson, C.D.12
Kennedy, K.A.13
Hamilton, M.K.14
Siggs, O.M.15
Beutler, B.16
Aderem, A.17
-
56
-
-
84859467770
-
Mixed lineage kinase domain-like is a key receptorinteracting protein 3 downstream component of TNF-induced necrosis
-
Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG. 2012. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proceedings of the National Academy of Sciences of USA 109:5322-5327. doi: 10.1073/pnas.1200012109.
-
(2012)
Proceedings of the National Academyof Sciences of USA
, vol.109
, pp. 5322-5327
-
-
Zhao, J.1
Jitkaew, S.2
Cai, Z.3
Choksi, S.4
Li, Q.5
Luo, J.6
Liu, Z.G.7
|