Nanoscale Nutrient Delivery Systems for Food Applications: Improving Bioactive Dispersibility, Stability, and Bioavailability

Journal of Food Science

Volumn 80, Issue 7, 2015, Pages N1602-N1611

  Mcclements, David Julian ^a,b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Delivery systems; Nanoparticles; Nutraceuticals; Nutrients; Vitamins

Indexed keywords

DELAYED RELEASE FORMULATION; EXCIPIENT; NANOPARTICLE; VITAMIN;

BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DIETARY SUPPLEMENT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FOOD HANDLING; PHYSICAL CHEMISTRY; PROCEDURES;

BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DIETARY SUPPLEMENTS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FOOD TECHNOLOGY; NANOPARTICLES; PHYSICOCHEMICAL PHENOMENA; VITAMINS;

EID: 84947059626     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12919     Document Type: Article

References (74)

1. Aserin A. 2008. Multiple emulsions: technology and applications. John Wiley and Sons, Hoboken, NJ.
2. Augustin MA, Sanguansri L. 2012. Challenges in developing delivery systems for food additives, nutraceuticals, and dietary supplements. In: Garti N, McClements DJ, editors. Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Cambridge, UK: Woodhead Publishing, p 19-48.
3. Babbar N, Oberoi HS, Sandhu SK. 2015. Therapeutic and nutraceutical potential of bioactive compounds extracted from fruit residues. Crit Rev in Food Sci and Nutr 55(3):319-37.
4. Belitz HD, Grosch W, Schieberle P. 2009. Food chemistry, 4th ed. Berlin, Germany: Springer.
5. Boon CS, McClements DJ, Weiss J, Decker EA. 2010. Factors influencing the chemical stability of carotenoids in foods. Crit Rev Food Sci Nutr 50(6):515-32.
6. Borel T, Sabliov CM. 2014. Nanodelivery of bioactive components for food applications: types of delivery systems, properties, and their effect on adme profiles and toxicity of nanoparticles. Ann Rev Food Sci Technol 5(5):197-213.
7. Bouwmeester H, Dekkers S, Noordam MY, Hagens WI, Bulder AS, deHeer C, ten Voorde SECG, Wijnhoven SWP, Marvin HJP, Sips AJAM. 2009. Review of health safety aspects of nanotechnologies in food production. Regul Toxicol Pharmacol 53(1):52-62.
8. Braithwaite MC, Tyagi C, Tomar LK, Kumar P, Choonara YE, Pillay V. 2014. Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: an overview. J Funct Foods 6:82-99.
9. Chen G, Wang H, Zhang X, Yang ST. 2014. Nutraceuticals and functional foods in the management of hyperlipidemia. Crit Rev Food Sci Nutr 54(9):1180-201.
10. Cho HT, Salvia-Trujillo L, Kim J, Park Y, Xiao H, McClements DJ. 2014. Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and coenzyme Q10. Food Chem 156:117-22.
11. Choi K-O, Ryu J, Kwak H-S, Ko S. 2010a. Spray-dried conjugated linoleic acid encapsulated with maillard reaction products of whey proteins and maltodextrin. Food Sci Biotechnol 19(4):957-65.
12. Choi SJ, Decker EA, Henson L, Popplewell LM, McClements DJ. 2009. Stability of citral in oil-in-water emulsions prepared with medium-chain triacylglycerols and triacetin. J Agric Food Chem 57(23):11349-53.
13. Choi SJ, Decker EA, Henson L, Popplewell LM, McClements DJ. 2010b. Inhibition of citral degradation in model beverage emulsions using micelles and reverse micelles. Food Chem 122(1):111-16.
14. Daftardar S, Kaur G, Addepalli V. 2014. Nutraceutical approaches in the management of cardiovascular dysfunctions associated with diabetes mellitus. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms 9:377-396.
15. Davidov-Pardo G, McClements DJ. 2014. Resveratrol encapsulation: designing delivery systems to overcome solubility, stability, and bioavailability issues. Trends Food Sci Technol 38(2):88-103.
16. Davidov-Pardo G, McClements DJ. 2015. Nutraceutical delivery systems: resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification. Food Chem 167:205-12.
17. Farias GA, Guzman-Martinez L, Delgado C, Maccioni RB. 2014. Nutraceuticals: a novel concept in prevention and treatment of alzheimer's disease and related disorders. J Alzheimers Dis 42(2):357-67.
18. Garcia-Rios A, Delgado-Lista J, Alcala-Diaz JF, Lopez-Miranda J, Perez-Martinez P. 2013. Nutraceuticals and coronary heart disease. Curr Opin Cardiol 28(4):475-82.
19. Garti N, Aserin A. 2012. Micelles and microemulsions as food ingredient and nutraceutical delivery systems. In: Garti N, McClements DJ, editors. Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Cambridge, UK: Woodhead Publishing, p 211-251.
20. Guzey D, McClements DJ. 2006. Formation, stability, and properties of multilayer emulsions for application in the food industry. Adv Colloid Interface Sci 128:227-48.
21. Heger M, van Golen RF, Broekgaarden M, Michel MC. 2014. The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancers. Pharmaco Rev 66(1):222-307.
22. Hu B, Huang Q-r. 2013. Biopolymer based nano-delivery systems for enhancing bioavailability of nutraceuticals. Chin J Polym Sci 31(9):1190-203.
23. Jafari SM, Assadpoor E, He Y, Bhandari B. 2008a. Encapsulation efficiency of food flavours and oils during spray drying. Drying Technol 26(7):816-35.
24. Jafari SM, Assaidpoor E, Bhandari B, He Y. 2008b. Nanoparticle encapsulation of fish oil by spray drying. Food Res Intl 41(2):172-83.
25. Jones OG, McClements DJ. 2010. Functional biopolymer particles: design, fabrication, and applications. Comprehens Rev Food Sci Food Safety 9(4):374-97.
26. Jones OG, McClements DJ. 2011. Recent progress in biopolymer nanoparticle and microparticle formation by heat-treating electrostatic protein-polysaccharide complexes. Adv Colloid Interface Sci 167(1-2):49-62.
27. Joye IJ, McClements DJ. 2013. Production of nanoparticles by antisolvent precipitation for use in food systems. Trends Food Sci Technol 34(2):109-23.
28. Joye IJ, McClements DJ. 2014. Biopolymer-based nanoparticles and microparticles: fabrication, characterization, and application. Curr Opin Colloid, Interface Sci 19(5):417-27.
29. Klinkesorn U, Sophanodora P, Chinachoti P, McClements DJ, Decker EA. 2005. Stability of spray-dried tuna oil emulsions encapsulated with two-layered interfacial membranes. J Agric Food Chem 53(21):8365-71.
30. Li Y, Hu M, Du Y, Xiao H, McClements DJ. 2011. Control of lipase digestibility of emulsified lipids by encapsulation within calcium alginate beads. Food Hydrocolloids 25(1):122-30.
31. Magrone T, de Heredia FP, Jirillo E, Morabito G, Marcos A, Serafini M. 2013. Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases. Can J Physiol Pharmacol 91(6):387-96.
32. Manosso LM, Moretti M, Rodrigues ALS. 2013. Nutritional strategies for dealing with depression. Food Funct 4(12):1776-93.
33. Mao Y, McClements DJ. 2013. Modulation of food texture using controlled heteroaggregation of lipid droplets: principles and applications. J Appl Polym Sci 130(6):3833-41.
34. Matalanis A, Decker EA, McClements DJ. 2012. Inhibition of lipid oxidation by encapsulation of emulsion droplets within hydrogel microspheres. Food Chem 132(2):766-72.
35. Matalanis A, Jones OG, McClements DJ. 2011. Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds. Food Hydrocolloids 25(8):1865-80.
36. Matalanis A, McClements DJ. 2012. Impact of encapsulation within hydrogel microspheres on lipid digestion: an in vitro study. Food Biophys 7(2):145-54.
37. McClements DJ. 2002. Theoretical prediction of emulsion color. Adv Colloid Interface Sci 97(1-3):63-89.
38. McClements DJ. 2010. Design of nanolaminated coatings to control bioavailability of lipophilic food components. J Food Sci 75(1):R30-R42.
39. McClements DJ. 2011. Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter 7(6):2297-316.
40. McClements DJ. 2012a. Advances in fabrication of emulsions with enhanced functionality using structural design principles. Curr Opin Colloid Interface Sci 17(5):235-45.
41. McClements DJ. 2012b. Crystals and crystallization in oil-in-water emulsions: implications for emulsion-based delivery systems. Adv Colloid Interface Sci 174:1-30.
42. McClements DJ. 2012c. Requirements for food ingredient and nutraceutical delivery systems. In: Garti N, McClements DJ, editors. Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Cambridge, UK: Woodhead Publishing, p 3-18.
43. McClements DJ. 2013. Edible lipid nanoparticles: digestion, absorption, and potential toxicity. Progress Lipid Res 52(4):409-23.
44. McClements DJ. 2014. Nanoparticle- and microparticle-based delivery systems. Boca Raton, Fla.: CRC Press.
45. McClements DJ, Decker EA. 2000. Lipid oxidation in oil-in-water emulsions: impact of molecular environment on chemical reactions in heterogeneous food systems. J Food Sci 65(8):1270-82.
46. McClements DJ, Decker EA, Weiss J. 2007. Emulsion-based delivery systems for lipophilic bioactive components. J Food Sci 72(8):R109-24.
47. McClements DJ, Li F, Xiao H. 2015. The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability. Ann Rev Food Sci Technol 6:299-327.
48. McClements DJ, Rao J. 2011. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr 51(4):285-330.
49. McClements DJ, Xiao H. 2014. Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals. Food Funct 5(7):1320-33.
50. Mei L, Choi SJ, Alamed J, Henson L, Popplewell M, McClements DJ, Decker EA. 2010. Citral stability in oil-in-water emulsions with solid or liquid octadecane. J Agric Food Chem 58(1):533-36.
51. Norton IT, Frith WJ. 2001. Microstructure design in mixed biopolymer composites. Food Hydrocolloids 15(4-6):543-53.
52. Patel AR, Velikov KP. 2011. Colloidal delivery systems in foods: a general comparison with oral drug delivery. LWT-Food Sci Technol 44(9):1958-64.
53. Qian C, Decker EA, Xiao H, McClements DJ. 2012a. Inhibition of beta-carotene degradation in oil-in-water nanoemulsions: influence of oil-soluble and water-soluble antioxidants. Food Chem 135(3):1036-43.
54. Qian C, Decker EA, Xiao H, McClements DJ. 2012b. Nanoemulsion delivery systems: influence of carrier oil on beta-carotene bioaccessibility. Food Chem 135(3):1440-47.
55. Rao JJ, Decker EA, Xiao H, McClements DJ. 2013. Nutraceutical nanoemulsions: influence of carrier oil composition (digestible versus indigestible oil) on -carotene bioavailability. J Sci Food Agric 93(13):3175-83.
56. Romano M, Vitaglione P, Sellitto S, D'Argenio G. 2012. Nutraceuticals for protection and healing of gastrointestinal mucosa. Curr Med Chem 19(1):109-17.
57. Saglam D, Venema P, van der Linden E, deVries R. 2014. Design, properties, and applications of protein micro- and nanoparticles. Curr Opin Colloid Interface Sci 19(5):428-37.
58. Salvia-Trujillo L, Qian C, Martin-Belloso O, McClements DJ. 2013. Influence of particle size on lipid digestion and beta-carotene bioaccessibility in emulsions and nanoemulsions. Food Chem 141(2):1472-80.
59. Shewan HM, Stokes JR. 2013. Review of techniques to manufacture micro-hydrogel particles for the food industry and their applications. J Food Engr 119(4):781-92.
60. Spyropoulos F, Frith WJ, Norton IT, Wolf B, Pacek AW. 2008. Sheared aqueous two-phase biopolymer-surfactant mixtures. Food Hydrocolloids 22(1):121-29.
61. Thompkinson DK, Bhavana V, Kanika P. 2014. Dietary approaches for management of cardio-vascular health- a review. J Food Sci Technol-Mysore 51(10):2318-30.
62. Tiede K, Boxall ABA, Tear SP, Lewis J, David H, Hassellov M. 2008. Detection and characterization of engineered nanoparticles in food and the environment. Food Addit Contam Part A-Chem Anal Control Exposure Risk Assessment 25(7):795-821.
63. Ting YW, Jiang Y, Ho CT, Huang QR. 2014. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods 7:112-28.
64. Vandeweerd JM, Coisnon C, Clegg P, Cambier C, Pierson A, Hontoir F, Saegerman C, Gustin P, Buczinski S. 2012. Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis. J Veterinary Internal Med 26(3):448-56.
65. Visioli F. 2011. Nutritional support in the pharmacological treatment of metabolic syndrome. Eur J Pharmacol 668:S43-49.
66. Wang S, Su R, Nie SF, Sun M, Zhang J, Wu DY, Moustaid-Moussa N. 2014. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem 25(4):363-76.
67. Wang ZJ, Fan J, Liu M, Yeung S, Chang A, Chow MSS, Pon D, Huang Y. 2013. Nutraceuticals for prostate cancer chemoprevention: from molecular mechanisms to clinical application. Expert Opin Invest Drugs 22(12):1613-26.
68. Waraho T, McClements DJ, Decker EA. 2011. Mechanisms of lipid oxidation in food dispersions. Trends Food Sci Technol 22(1):3-13.
69. Weiss J, Decker EA, McClements DJ, Kristbergsson K, Helgason T, Awad T. 2008. Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophys 3(2):146-54.
70. Yada RY, Buck N, Canady R, DeMerlis C, Duncan T, Janer G, Juneja L, Lin MS, McClements J, Noonan G, Oxley J, Sabliov C, Tsytsikova L, Vazquez-Campos S, Yourick J, Zhong QX, Thurmond S. 2014. Engineered nanoscale food ingredients: evaluation of current knowledge on material characteristics relevant to uptake from the gastrointestinal tract. Comprehens Rev Food Sci Food Safety 13(4):730-44.
71. Yi J, Li Y, Zhong F, Yokoyama W. 2014. The physicochemical stability and in vitro bioaccessibility of beta-carotene in oil-in-water sodium caseinate emulsions. Food Hydrocolloids 35:19-27.
72. Zhang Z, Decker EA, McClements DJ. 2014. Encapsulation, protection, and release of polyunsaturated lipids using biopolymer-based hydrogel particles. Food Res Intl 64:520-26.
73. Zhong Q, Jin M. 2009a. Nanoscalar structures of spray-dried zein microcapsules and in vitro release kinetics of the encapsulated lysozyme as affected by formulations. J Agric Food Chem 57(9):3886-94.
74. Zhong Q, Jin M. 2009b. Zein nanoparticles produced by liquid-liquid dispersion. Food Hydrocolloids 23(8):2380-87.