Systematic Review of Efficacy of Nutraceuticals to Alleviate Clinical Signs of Osteoarthritis

Journal of Veterinary Internal Medicine

Volumn 26, Issue 3, 2012, Pages 448-456

  Vandeweerd, J M ^a   Coisnon, C ^a   Clegg, P ^b   Cambier, C ^c   Pierson, A ^c   Hontoir, F ^a   Saegerman, C ^c   Gustin, P ^c   Buczinski, S ^d  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Dietary supplements; EBM; Evidence; Locomotion

Indexed keywords

ANIMAL; ANIMAL DISEASE; CAT; CAT DISEASE; CLINICAL TRIAL (TOPIC); DIET SUPPLEMENTATION; DIET THERAPY; DOG; DOG DISEASE; EVIDENCE BASED MEDICINE; HORSE; HORSE DISEASE; METHODOLOGY; OSTEOARTHRITIS; REVIEW;

ANIMALS; CAT DISEASES; CATS; CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; DOG DISEASES; DOGS; EVIDENCE-BASED MEDICINE; HORSE DISEASES; HORSES; OSTEOARTHRITIS;

CANIS FAMILIARIS; EQUIDAE;

EID: 84860567006     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2012.00901.x     Document Type: Review

References (71)

1. Jeffcott LB, Rossdale PD, Freestone J, et al. An assessment of wastage in Thoroughbred racing from conception to 4 years of age. Equine Vet J 1982;14:185-198.
2. Innes J. Diagnosis and treatment of osteoarthritis in dogs. In Practice 1995;17:102-109.
3. Goodrich LR, Nixon AJ. Medical treatment of osteoarthritis in the horse. A review. Vet J 2006;171:51-69.
4. Gingerich DA, Strobel JD. Use of client-specific outcome measures to assess treatment effects in geriatric, arthritic dogs: Controlled clinical evaluation of a nutraceutical. Vet Ther 2003;4:56-66.
5. Sanderson RO, Beata C, Flipo RM, et al. Systematic review of the management of canine osteoarthritis. Vet Rec 2009;164:418-424.
6. Aragon CL, Hofmeister EH, Budsberg SC. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J Am Vet Med Assoc 2007;230:514-521.
7. Brower V. Nutraceuticals: Poised for a healthy slice of the healthcare market? Nat Biotechnol 1998;16:728-731.
8. Zeisel SH. Regulation of "Nutraceuticals." Science 1999;285:185-186.
9. FDA/CFSAN resources page. Food and Drug Administration Web site. Dietary Supplements. Available at:. Accessed May 2011.
10. Boothe DM. Nutraceuticals in veterinary medicine, Part 1: Definitions and regulations. Compend Contin Educ Pract Vet 1997;19:1248-1255.
11. Directive 2004/28/ec of the european parliament and of the council of 31 March 2004 amending. Directive 2001/82/EC on the Community code relating to veterinary medicinal products. Official Journal of the European Union (30.4.2004).
12. Cockcroft P, Holmes M. Handbook of Evidence-Based Veterinary Medicine. Oxford, UK: Blackwell Publishing; 2003.
13. Vandeweerd JM, Saegerman C. Guide pratique de médecine factuelle. Paris, France: Les Éditions du Point Vétérinaire; 2009.
14. Vandeweerd JM, Kirschvink N, Clegg P, et al. Is evidence-based medicine so evident in veterinary research and practice? History, obstacles and perspectives. Vet J 2012;191(1):28-34.
15. Mair TS, Cohen ND. AEEP and BEVA Member-based observational research studies: A novel approach to epidemiological and evidence-based medicine studies in equine medicine. Equine Vet J 2003;35:339-340.
16. Arlt S, Dicty V, Heuwieser W. Evidence-based medicine in canine reproduction: Quality of current available literature. Reprod Domest Anim 2010;45:1052-1058.
17. Parkin T. Evidence based medicine: An academic's viewpoint - not so different to that of the clinician. J Small Anim Pract 2010;51:509-510.
18. Muir W. Is evidence-based medicine our only choice? Equine Vet J 2003;35:337-338.
19. Murphy SA. Searching for veterinary evidence: Strategies and resources for locating clinical research. Vet Clin North Am Small Anim Pract 2007;37:433-445.
20. Marr CM, Newton JR. Clinical evidence articles in Equine Veterinary Journal: Progress since inception. Equine Vet J 2006;38:110-112.
21. Glasziou P, Irwig L, Bain C, et al. Systematic Reviews in Health Care. Cambridge, UK: Cambridge University Press; 2001.
22. Richardson DW, Loinaz R. An evidence-based approach to selected joint therapies in horses. Vet Clin North Am Equine Pract 2007;23:443-460.
23. Pearson W, Lindinger M. Low quality of evidence for glucosamine-based nutraceutical compounds in equine joint disease: Review of in vivo studies. Equine Vet J 2009;41:706-712.
24. FDA/CFSAN. 2003. Guidance for industry and FDA: Interim evidence-based ranking for scientific data. [Online] Available at:. Consulted 01/10/10.
25. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacother 2010;1:100-107.
26. Jone J, Hunter D. Consensus methods for medical and service research. BMJ 1995;311:376-380.
27. Innes JF, Fuller CJ, Grover ER, et al. Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec 2003;152:457-460.
28. Gupta RC, Canerdy TD, Skaggs P, et al. Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther 2009;32:577-584.
29. Keegan KG, Hughes FE, Lane T, et al. Effects of an oral nutraceutical on clinical aspects of joint disease in blinded, controlled clinical trial: 39 horses. Am Assoc Equine Pract 2007;53:252-255.
30. Kawcak CE, Frisbie DD, McIlwraith CW, et al. Evaluation of avocado and soybean unsaponifiable extracts for treatment of horses with experimentally induced osteoarthritis. Am J Vet Res 2007;68:598-604.
31. Verde CR, Simpson MI, Villarino N, et al. Therapeutical and hematological effects of native and low molecular weight chondroitin sulfate administered orally in horses with experimental osteoarthritis. Available at.
32. Clayton MH, Almeida PE, Prades M, et al. Double-blind study of the effects of an oral supplement intended to support joint health in horses with tarsal degenerative joint disease. Am Assoc Equine Pract Proc 2002;48:314-317.
33. Beynen AC, Legerstee E. Influence of dietary beta-1, 3/1, 6-glucans on clinical signs of canine osteoarthritis in a double-blind, placebo-controlled trial. Am J Anim Vet Sci 2010;5:97-101.
34. Beynen AC, Van Geene HW, Grim HV, et al. Oral administration of gelatin hydrosylate reduces clinical signs of canine osteoarthritis in a double-blind, placebo-controlled trial. Am J Anim Vet Sci 2010;5:102-106.
35. Fritsch D, Allen TA, Dodd CE, et al. Dose-titration effects of fish oil in osteoarthritis dogs. J Vet Intern Med 2010;24:1020-1026.
36. Fritsch DA, Allen TA, Dodd CE, et al. A multicenter study of the effects of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. J Am Vet Med Assoc 2010;236:535-539.
37. Roush JK, Dodd CE, Fritsch DA, et al. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Am Vet Med Assoc 2010;236:59-66.
38. Roush JK, Cross AR, Renberg WC, et al. Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. J Am Vet Med Assoc 2010;236:67-73.
39. Peal A, D'Altillo M, Simms C, et al. Therapeutic efficacy and safety of undenatured type-II collagen (UC-II) alone or in combination with (-)-hydroxycitric acid and chromemate in arthritic dogs. J Vet Pharmacol Ther 2007;30:275-278.
40. McCarthy G, O'Donovan J, Jones B, et al. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J 2007;174:54-61.
41. Pollard B, Guilford WG, Ankenbauer-Perkins KL, et al. Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease. N Z Vet J 2006;54:114-118.
42. Bierer TL, Bui LM. Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). J Nutr 2002;132:1634S-1636S.
43. Bui LM, Bierer TL. Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Vet Ther 2001;4:397-407.
44. Dobenecker B, Beetz Y, Kienzle E. A placebo-controlled double-blind study on the effect of nutraceuticals (chondroitin sulfate and mussel extract) in dogs with joint diseases as perceived by their owners. J Nutr 2002;132:1690S-1691S.
45. Moreau M, Dupuis J, Bonneau NH, et al. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Vet Rec 2003;152:323-329.
46. Deparle LA, Gupta RC, Canerdy TD, et al. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J Vet Pharmacol Ther 2005;28:385-390.
47. Lascelles BDX, DePuy V, Hansen B, et al. Evaluation of a therapeutic diet for feline degenerative joint disease. J Vet Intern Med 2010;24:487-495.
48. Calder PC, Zurier RB. Polyunsaturated fatty acids and rheumatoid arthritis. Curr Opin Clin Nutr Metab Care 2001;4:115-121.
49. Curtis CL, Hughes CE, Flannery CR, et al. n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J Biol Chem 2000;275:721-724.
50. Treschow AP, Hodges LD, Wright PF, et al. Novel anti-inflammatory omega-3 PUFAs from New-Zealand green-lipped mussels, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol 2007;147:645-656.
51. Miquel J, Bernd A, Sempere J, et al. The curcuma antioxidants: Pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002;34:37-46.
52. Boumediene K, Felisaz N, Bogdanowicz P, et al. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum 1999;42:148-156.
53. Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-1834.
54. Canapp SO, Mclaughlin R, Hoskinson JJ, et al. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate. Am J Vet Res 1999;60:1552-1557.
55. Lippiello L, Woodward J, Karpman R, et al. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res 2000;381:229-240.
56. Johnson KA, Hulse DA, Hart RC, et al. Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitopes in a canine cruciate ligament transaction model of osteoarthritis. Osteoarthritis Cartilage 2001;9:14-21.
57. Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-536.
58. Lippiello L, Hall D, Mankit J. Collagen synthesis in normal osteoarthritic human cartilage. J Clin Invest 1977;59:593-600.
59. Li J, Li DF, Xing JJ, Cheng ZB, et al. Effects of β-glucan extracted from Saccharomyces cerevisiae on growth performance and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide. J Anim Sci 2006;84:2374-2381.
60. Diehl HW, May EL. Cetyl myristoleate isolated from Swiss albino mice: An apparent protective agent against adjuvant arthritis in rats. J Pharm Sci 1994;83:296-299.
61. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-294.
62. Stelwagen K, Ormrod DJ. An anti-inflammatory component derived from milk of hyperimmunized cows reduces tight junction permeability in vitro. Inflamm Res 1998;47:384-388.
63. Keene BW. Towards evidence-based veterinary medicine. J Vet Intern Med 2000;14:118-119.
64. Sargeant JM, O'Connor AM, Gardner IA, et al. The REFLECT statement: Reporting guidelines for randomized controlled trials in livestock and food safety: Explanation and elaboration. Food Prot 2010;73:579-603.
65. Brown DC. Outcomes based medicine in veterinary surgery: Getting hard measures of subjective outcomes. Vet Surg 2007;36:289-292.
66. Schulz KS. The Outcomes Measures Program: What's in it for you? Vet Surg 2007;36:715-716.
67. Innes JF. Outcomes-based medicine in veterinary surgery: Levels of evidence. Vet Surg 2007;36:610-612.
68. Hardin LE, Robertson S. Learning evidence-based veterinary medicine through development of a critically appraised topic. J Vet Med Educ 2006;33:474-478.
69. Fletcher RH, Fletcher SW. Clinical Epidemiology: The Essentials, 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2005.
70. McAlindon TE, LaValley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis. J Am Med Assoc 2000;283:1469-1475.
71. Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 2007;129:210-223.