Autophagy : Moving benchside promises to patient bedsides

Current Cancer Drug Targets

Volumn 15, Issue 8, 2015, Pages 684-702

  Belaid, Amine ^a,b,c,d   Ndiaye, Papa Diogop ^a,b,c   Filippakis, Harilaos ^d   Roux, Jérémie ^a,b,c   Röttinger, Éric ^a,b   Graba, Yacine ^e   Brest, Patrick ^a,b,c   Hofman, Paul ^a,b,c,f   Mograbi, Baharia ^a,b,c  

^a UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c Equipe Labellisée Ligue Nationale contre le Cancer   (France)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e AIX MARSEILLE UNIVERSITÉ   (France)

^f PASTEUR HOSPITAL   (France)

Author keywords

Antineoplastic agents; Autophagy addiction; Autophagy targeted therapy; BRAF driven cancers; Drug effects; KRAS; Translational medicine; Tumor dormancy; Tumor metabolism; Tumor metastasis; Tumor relapse; Tumor resistance

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO [3', 2':4, 5] FURO [3, 2 D] PYRIMIDINE; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; B RAF KINASE; BECLIN 1; BRCA1 PROTEIN; CETUXIMAB; CURCUMIN; DACTOLISIB; DEXAMETHASONE; ERLOTINIB; EVEROLIMUS; HEAT SHOCK COGNATE PROTEIN 70; IMATINIB; INTERLEUKIN 1ALPHA; LINIFANIB; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; QUERCETIN; RAB7 PROTEIN; RAPAMYCIN; SALINOSPORAMIDE A; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VORINOSTAT; ANTINEOPLASTIC AGENT;

ARTICLE; AUTOPHAGY; CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CHAPERONE-MEDIATED AUTOPHAGY; COMPLEMENTARITY DETERMINING REGION; DNA DAMAGE; DORMANCY; DRUG SENSITIZATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HUMAN; INFLAMMATION; MACROAUTOPHAGY; METASTASIS; MICROAUTOPHAGY; MITOCHONDRIAL RESPIRATION; NEOPLASM; NONHUMAN; OXIDATIVE STRESS; PROTON TRANSPORT; UBIQUITINATION; DRUG DELIVERY SYSTEM; NEOPLASM METASTASIS; NEOPLASMS; PATHOLOGY; POINT OF CARE TESTING; TUMOR RECURRENCE;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS; POINT-OF-CARE TESTING;

EID: 84945970192     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800961508151001102452     Document Type: Article

References (154)

1. Clark, S.L. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J. Biophys. Biochem. Cytol., 1957, 3(3), 349-362.
2. Arias, E.; Cuervo, A.M. Chaperone-mediated autophagy in protein quality control. Curr. Opin. Cell Biol., 2011, 23(2), 184-189.
3. Li, W.W.; Li, J.; Bao, J.K. Microautophagy: lesser-known selfeating. Cell Mol. Life Sci., 2012, 69(7), 1125-1136.
4. Cuervo, A.M.; Knecht, E.; Terlecky, S.R.; Dice, J.F. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am. J. Physiol., 1995, 269(5), 1200-1208.
5. Pfeifer, U. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J. Cell Biol., 1978, 78(1), 152-167.
6. Belaid, A.; Ndiaye, P.D.; Klionsky, D.J.; Hofman, P.; Mograbi, B. Signalphagy Scheduled signal termination by macroautophagy. Autophagy, 2013, 9(10), 1629-1630.
7. Parzych, K. R.; Klionsky, D. J. An Overview of Autophagy: Morphology, Mechanism, and Regulation. Antioxid Redox Signal 2014, 20 (3), 460-473.
8. McEwan, D.G.; Dikic, I. The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol., 2011, 21(4), 195-201.
9. Morselli, E.; Marino, G.; Bennetzen, M.V.; Eisenberg, T.; Megalou, E.; Schroeder, S.; Cabrera, S.; Benit, P.; Rustin, P.; Criollo, A.; Kepp, O.; Galluzzi, L.; Shen, S.; Malik, S.A.; Maiuri, M.C.; Horio, Y.; Lopez-Otin, C.; Andersen, J.S.; Tavernarakis, N.; Madeo, F.; Kroemer, G. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J. Cell Biol., 2011, 192(4), 615-629.
10. Pietrocola, F.; Izzo, V.; Niso-Santano, M.; Vacchelli, E.; Galluzzi, L.; Maiuri, M.C.; Kroemer, G. Regulation of autophagy by stressresponsive transcription factors. Semin. Cancer Biol., 2013, 23(5), 310-322.
11. Choi, A.M.; Ryter, S.W.; Levine, B. Autophagy in human health and disease. N. Engl. J. Med., 2013, 368(19), 1845-1846.
12. Aita, V.M.; Liang, X.H.; Murty, V.; Pincus, D.L.; Yu, W.P.; Cayanis, E.; Kalachikov, S.; Gilliam, T.C.; Levine, B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics, 1999, 59(1), 59-65.
13. Liang, X.H.; Jackson, S.; Seaman, M.; Brown, K.; Kempkes, B.; Hibshoosh, H.; Levine, B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature, 1999, 402(6762), 672-676.
14. Qu, X.; Yu, J.; Bhagat, G.; Furuya, N.; Hibshoosh, H.; Troxel, A.; Rosen, J.; Eskelinen, E.L.; Mizushima, N.; Ohsumi, Y.; Cattoretti, G.; Levine, B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest, 2003, 112(12), 1809-1820.
15. Yue, Z.; Jin, S.; Yang, C.; Levine, A.J.; Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA., 2003, 100(25), 15077-15082.
16. Fimia, G.M.; Stoykova, A.; Romagnoli, A.; Giunta, L.; Di Bartolomeo, S.; Nardacci, R.; Corazzari, M.; Fuoco, C.; Ucar, A.; Schwartz, P.; Gruss, P.; Piacentini, M.; Chowdhury, K.; Cecconi, F. Ambra1 regulates autophagy and development of the nervous system. Nature, 2007, 447(7148), 1121-1125.
17. Cianfanelli, V.; Fuoco, C.; Lorente, M.; Salazar, M.; Quondamatteo, F.; Gherardini, P.F.; De Zio, D.; Nazio, F.; Antonioli, M.; D'Orazio, M.; Skobo, T.; Bordi, M.; Rohde, M.; Dalla Valle, L.; Helmer-Citterich, M.; Gretzmeier, C.; Dengjel, J.; Fimia, G.M.; Piacentini, M.; Di Bartolomeo, S.; Velasco, G.; Cecconi, F. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat. Cell Biol., 2015, 17(1), 20-30.
18. Takahashi, Y.; Coppola, D.; Matsushita, N.; Cualing, H.D.; Sun, M.; Sato, Y.; Liang, C.; Jung, J.U.; Cheng, J.Q.; Mule, J.J.; Pledger, W.J.; Wang, H.G. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9, 1142-1151.
19. Liang, C.; Feng, P.; Ku, B.; Dotan, I.; Canaani, D.; Oh, B.H.; Jung, J.U. Autophagic and tumour suppressor activity of a novel Beclin1- binding protein UVRAG. Nat. Cell Biol., 2006, 8(7), 688-699.
20. Liang, C.; Lee, J.S.; Inn, K.S.; Gack, M.U.; Li, Q.; Roberts, E.A.; Vergne, I.; Deretic, V.; Feng, P.; Akazawa, C.; Jung, J.U. Beclin1- binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol., 2008, 10(7), 776-787.
21. Takamura, A.; Komatsu, M.; Hara, T.; Sakamoto, A.; Kishi, C.; Waguri, S.; Eishi, Y.; Hino, O.; Tanaka, K.; Mizushima, N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev., 2011, 25(8), 795-800.
22. Yang, A.; Rajeshkumar, N.V.; Wang, X.X.; Yabuuchi, S.; Alexander, B.M.; Chu, G.C.; Von Hoff, D.D.; Maitra, A.; Kimmelman, A.C. Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations. Cancer Discov., 2014, 4(8), 905-913.
23. Marino, G.; Salvador-Montoliu, N.; Fueyo, A.; Knecht, E.; Mizushima, N.; Lopez-Otin, C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J. Biol. Chem., 2007, 282, 18573-18583.
24. Belaid, A.; Ndiaye, P.D.; Cerezo, M.; Cailleteau, L.; Brest, P.; Klionsky, D.J.; Carle, G.F.; Hofman, P.; Mograbi, B. Autophagy and SQSTM1 on the RHOA(d) again Emerging roles of autophagy in the degradation of signaling proteins. Autophagy, 2014, 10(2), 201-208.
25. Belaid, A.; Cerezo, M.; Chargui, A.; Corcelle-Termeau, E.; Pedeutour, F.; Giuliano, S.; Ilie, M.; Rubera, I.; Tauc, M.; Barale, S.; Bertolotto, C.; Brest, P.; Vouret-Craviari, V.; Klionsky, D.J.; Carle, G.F.; Hofman, P.; Mograbi, B. Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability. Cancer Res., 2013, 73(14), 4311-4322.
26. Joung, I.; Strominger, J.L.; Shin, J. Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc. Natl. Acad. Sci. USA., 1996, 93(12), 5991-5995.
27. Duran, A.; Linares, J.F.; Galvez, A.S.; Wikenheiser, K.; Flores, J. M.; Diaz-Meco, M.T.; Moscat, J. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell, 2008, 13(4), 343-354.
28. Duran, A.; Amanchy, R.; Linares, J. F.; Joshi, J.; Abu-Baker, S.; Porollo, A.; Hansen, M.; Moscat, J.; Diaz-Meco, M.T. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol. Cell, 2011, 44(1), 134-146.
29. Komatsu, M.; Kurokawa, H.; Waguri, S.; Taguchi, K.; Kobayashi, A.; Ichimura, Y.; Sou, Y.S.; Ueno, I.; Sakamoto, A.; Tong, K.I.; Kim, M.; Nishito, Y.; Iemura, S.; Natsume, T.; Ueno, T.; Kominami, E.; Motohashi, H.; Tanaka, K.; Yamamoto, M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol., 2010, 12(3), 213-223.
30. Qiang, L.; Zhao, B.Z.; Ming, M.; Wang, N.; He, T.C.; Hwang, S.; Thorburn, A.; He, Y. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc. Natl. Acad. Sci. USA., 2014, 111(25), 9241-9246.
31. Ling, J.; Kang, Y.; Zhao, R.; Xia, Q.; Lee, D.F.; Chang, Z.; Li, J.; Peng, B.; Fleming, J.B.; Wang, H.; Liu, J.; Lemischka, I.R.; Hung, M.C.; Chiao, P.J. KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell, 2012, 21(1), 105-120.
32. Moscat, J.; Diaz-Meco, M.T. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell, 2009, 137(6), 1001-1004.
33. Bjorkoy, G.; Lamark, T.; Brech, A.; Outzen, H.; Perander, M.; Overvatn, A.; Stenmark, H.; Johansen, T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol., 2005, 171(4), 603-614.
34. Inami, Y.; Waguri, S.; Sakamoto, A.; Kouno, T.; Nakada, K.; Hino, O.; Watanabe, S.; Ando, J.; Iwadate, M.; Yamamoto, M.; Lee, M. S.; Tanaka, K.; Komatsu, M. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J. Cell Biol., 2011, 193(2), 275-284.
35. Mathew, R.; Karp, C.M.; Beaudoin, B.; Vuong, N.; Chen, G.; Chen, H.Y.; Bray, K.; Reddy, A.; Bhanot, G.; Gelinas, C.; Dipaola, R.S.; Karantza-Wadsworth, V.; White, E. Autophagy suppresses tumorigenesis through elimination of p62. Cell, 2009, 137(6), 1062-1075.
36. Karantza-Wadsworth, V.; Patel, S.; Kravchuk, O.; Chen, G.; Mathew, R.; Jin, S.; White, E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev., 2007, 21(13), 1621-1635.
37. Mathew, R.; Kongara, S.; Beaudoin, B.; Karp, C.M.; Bray, K.; Degenhardt, K.; Chen, G.; Jin, S.; White, E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev., 2007, 21(11), 1367-1381.
38. Robert, T.; Vanoli, F.; Chiolo, I.; Shubassi, G.; Bernstein, K.A.; Rothstein, R.; Botrugno, O.A.; Parazzoli, D.; Oldani, A.; Minucci, S.; Foiani, M. HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature, 2011, 471(7336), 74-79.
39. Katayama, M.; Kawaguchi, T.; Berger, M.S.; Pieper, R.O. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ., 2007, 14(3), 548-558.
40. Dyavaiah, M.; Rooney, J.P.; Chittur, S.V.; Lin, Q.S.; Begley, T.J. Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase 1. Mol. Cancer Res., 2011, 9(4), 462-475.
41. Changou, C.A.; Chen, Y.R.; Xing, L.; Yen, Y.; Chuang, F. Y.; Cheng, R.H.; Bold, R.J.; Ann, D.K.; Kung, H.J. Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy. Proc. Natl. Acad. Sci. USA., 2014, 111(39), 14147-14152.
42. SenGupta, T.; Torgersen, M.L.; Kassahun, H.; Vellai, T.; Simonsen, A.; Nilsen, H. Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. Nat. Commun., 2013, 4, 2674.
43. Guo, H.; Chitiprolu, M.; Gagnon, D.; Meng, L.; Perez-Iratxeta, C.; Lagace, D.; Gibbings, D. Autophagy supports genomic stability by degrading retrotransposon RNA. Nat. Commun., 2014, 5, 5276.
44. Matsui, A.; Kamada, Y.; Matsuura, A. The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation. PLoS Genet., 2013, 9(1), 1003245.
45. Xie, R.; Wang, F.; McKeehan, W.L.; Liu, L.Y. Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis. Cancer Res., 2011, 71(24), 7537-7546.
46. Berry, D.L.; Baehrecke, E.H. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007, 131(6), 1137-1148.
47. Takacs-Vellai, K.; Vellai, T.; Puoti, A.; Passannante, M.; Wicky, C.; Streit, A.; Kovacs, A.L.; Muller, F. Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C-elegans. Curr. Biol., 2005, 15(16), 1513-1517.
48. Liu, Y.; Levine, B. Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ., 2014, 22, 367-376.
49. Byun, J.Y.; Yoon, C.H.; An, S.; Park, I.C.; Kang, C.M.; Kim, M. J.; Lee, S.J. The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis, 2009, 30(11), 1880-1888.
50. Elgendy, M.; Sheridan, C.; Brumatti, G.; Martin, S.J. Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival. Mol. Cell 2011, 42(1), 23-35.
51. Young, A.R.; Narita, M.; Ferreira, M.; Kirschner, K.; Sadaie, M.; Darot, J.F.; Tavare, S.; Arakawa, S.; Shimizu, S.; Watt, F.M. Autophagy mediates the mitotic senescence transition. Genes Dev., 2009, 23(7), 798-803.
52. Wang, Y.H.; Wang, X.D.; Lapi, E.; Sullivan, A.; Jia, W.; He, Y. W.; Ratnayaka, I.; Zhong, S.; Goldin, R.D.; Goemans, C.G.; Tolkovsky, A.M.; Lu, X. Autophagic activity dictates the cellular response to oncogenic RAS. Proc. Natl. Acad. Sci. USA., 2012, 109(33), 13325-13330.
53. Drullion, C.; Tregoat, C.; Lagarde, V.; Tan, S.; Gioia, R.; Priault, M.; Djavaheri-Mergny, M.; Brisson, A.; Auberger, P.; Mahon, F. X.; Pasquet, J.M. Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence. Cell Death Dis. 2012, 3, 373.
54. Biggers, J.W.; Nguyen, T.; Di, X.; Gupton, J.T.; Henderson, S.C.; Emery, S.M.; Alotaibi, M.; White, K.L.; Brown, R.; Almenara, J.; Gewirtz, D.A. Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14. Cancer Chemother. Pharmacol., 2013, 71(2), 441-455.
55. Knizhnik, A.V.; Roos, W.P.; Nikolova, T.; Quiros, S.; Tomaszowski, K.H.; Christmann, M.; Kaina, B. Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage. PLoS One, 2013, 8(1), 55665.
56. Dorr, J.R.; Yu, Y.; Milanovic, M.; Beuster, G.; Zasada, C.; Dabritz, J.H.M.; Lisec, J.; Lenze, D.; Gerhardt, A.; Schleicher, K.; Kratzat, S.; Purfurst, B.; Walenta, S.; Mueller-Klieser, W.; Graler, M.; Hummel, M.; Keller, U.; Buck, A.K.; Dorken, B.; Willmitzer, L.; Reimann, M.; Kempa, S.; Lee, S.; Schmitt, C.A. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature, 2013, 501(7467), 421-425.
57. Goehe, R.W.; Di, X.; Sharma, K.; Bristol, M.L.; Henderson, S.C.; Valerie, K.; Rodier, F.; Davalos, A.R.; Gewirtz, D.A. The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep? J. Pharmacol. Exp. Ther., 2012, 343(3), 763-778.
58. Brest, P.; Corcelle, E.A.; Cesaro, A.; Chargui, A.; Belaid, A.; Klionsky, D.J.; Vouret-Craviari, V.; Hebuterne, X.; Hofman, P.; Mograbi, B. Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr. Mol. Med., 2010, 10(5), 486-502.
59. Degenhardt, K.; Mathew, R.; Beaudoin, B.; Bray, K.; Anderson, D.; Chen, G.; Mukherjee, C.; Shi, Y.; Gelinas, C.; Fan, Y.; Nelson, D.A.; Jin, S.; White, E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell, 2006, 10(1), 51-64.
60. Qu, X.; Zou, Z.; Sun, Q.; Luby-Phelps, K.; Cheng, P.; Hogan, R. N.; Gilpin, C.; Levine, B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell, 2007, 128(5), 931-946.
61. Zhu, X.; Messer, J.S.; Wang, Y.; Lin, F.; Cham, C.M.; Chang, J.; Billiar, T.R.; Lotze, M.T.; Boone, D.L.; Chang, E.B. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J. Clin. Invest, 2015, 125(3), 1098-1110.
62. Saitoh, T.; Fujita, N.; Jang, M.H.; Uematsu, S.; Yang, B.G.; Satoh, T.; Omori, H.; Noda, T.; Yamamoto, N.; Komatsu, M.; Tanaka, K.; Kawai, T.; Tsujimura, T.; Takeuchi, O.; Yoshimori, T.; Akira, S. Loss of the autophagy protein Atg16L1 enhances endotoxininduced IL-1b production. Nature, 2008, 456, 264-268.
63. Bafica, A.; Feng, C.G.; Santiago, H.C.; Aliberti, J.; Cheever, A.; Thomas, K.E.; Taylor, G.A.; Vogel, S.N.; Sher, A. The IFNinducible GTPase LRG47 (Irgm1) negatively regulates TLR4- triggered proinflammatory cytokine production and prevents endotoxemia. J. Immunol., 2007, 179, 5514-5522.
64. Levine, B.; Mizushima, N.; Virgin, H. W. Autophagy in immunity and inflammation. Nature, 2011, 469(7330), 323-335.
65. Nakahira, K.; Haspel, J.A.; Rathinam, V.A.; Lee, S.J.; Dolinay, T.; Lam, H.C.; Englert, J.A.; Rabinovitch, M.; Cernadas, M.; Kim, H. P.; Fitzgerald, K.A.; Ryter, S.W.; Choi, A.M. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol., 2011, 12(3), 222-230.
66. Oka, T.; Hikoso, S.; Yamaguchi, O.; Taneike, M.; Takeda, T.; Tamai, T.; Oyabu, J.; Murakawa, T.; Nakayama, H.; Nishida, K.; Akira, S.; Yamamoto, A.; Komuro, I.; Otsu, K. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature, 2012, 490(7419), 251-255.
67. Harris, J.; Hartman, M.; Roche, C.; Zeng, S.G.; O'Shea, A.; Sharp, F.A.; Lambe, E.M.; Creagh, E.M.; Golenbock, D.T.; Tschopp, J.; Kornfeld, H.; Fitzgerald, K.A.; Lavelle, E.C. Autophagy Controls IL-1 beta Secretion by Targeting Pro-IL-1 beta for Degradation. J. Biol. Chem., 2011, 286(11), 9587-9597.
68. Shi, C.S.; Shenderov, K.; Huang, N.N.; Kabat, J.; Abu-Asab, M.; Fitzgerald, K.A.; Sher, A.; Kehrl, J.H. Activation of autophagy by inflammatory signals limits IL-1 beta production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol., 2012, 13(3), 255-263.
69. Laddha, S.V.; Ganesan, S.; Chan, C.S.; White, E. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers. Mol. Cancer Res., 2014, 12(4), 485-490.
70. Guo, J.Y.; Karsli-Uzunbas, G.; Mathew, R.; Aisner, S.C.; Kamphorst, J.J.; Strohecker, A.M.; Chen, G.; Price, S.; Lu, W.; Teng, X.; Snyder, E.; Santanam, U.; Dipaola, R.S.; Jacks, T.; Rabinowitz, J.D.; White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev., 2013, 27(13), 1447-1461.
71. Rao, S.; Tortola, L.; Perlot, T.; Wirnsberger, G.; Novatchkova, M.; Nitsch, R.; Sykacek, P.; Frank, L.; Schramek, D.; Komnenovic, V.; Sigl, V.; Aumayr, K.; Schmauss, G.; Fellner, N.; Handschuh, S.; Glosmann, M.; Pasierbek, P.; Schlederer, M.; Resch, G. P.; Ma, Y. T.; Yang, H.; Popper, H.; Kenner, L.; Kroemer, G.; Penninger, J. M. A dual role for autophagy in a murine model of lung cancer. Nat. Commun., 2014, 5, 3056.
72. Strohecker, A.M.; Guo, J.Y.; Karsli-Uzunbas, G.; Price, S.M.; Chen, G.J.; Mathew, R.; McMahon, M.; White, E. Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors. Cancer Discov., 2013, 3(11), 1272-1285.
73. Guo, J.Y.; Chen, H.Y.; Mathew, R.; Fan, J.; Strohecker, A.M.; Karsli-Uzunbas, G.; Kamphorst, J.J.; Chen, G.; Lemons, J.M.; Karantza, V.; Coller, H.A.; Dipaola, R.S.; Gelinas, C.; Rabinowitz, J.D.; White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev., 2011, 25(5), 460-470.
74. Karsli-Uzunbas, G.; Guo, J.Y.; Price, S.; Teng, X.; Laddha, S.V.; Khor, S.; Kalaany, N.Y.; Jacks, T.; Chan, C.S.; Rabinowitz, J.D.; White, E. Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov., 2014, 4(8), 914-927.
75. Lock, R.; Roy, S.; Kenific, C.M.; Su, J.S.; Salas, E.; Ronen, S.M.; Debnath, J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell, 2011, 22(2), 165-178.
76. Yang, S.; Wang, X.; Contino, G.; Liesa, M.; Sahin, E.; Ying, H.; Bause, A.; Li, Y.; Stommel, J.M.; Dell'antonio, G.; Mautner, J.; Tonon, G.; Haigis, M.; Shirihai, O.S.; Doglioni, C.; Bardeesy, N.; Kimmelman, A.C. Pancreatic cancers require autophagy for tumor growth. Genes Dev., 2011, 25(7), 717-729.
77. Wei, H.; Wei, S.; Gan, B.; Peng, X.; Zou, W.; Guan, J.L. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev., 2011, 25(14), 1510-1527.
78. Ney, P.A. Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX. Biochim. Biophys. Acta., 2015, 0167-4889.
79. Kim, M.J.; Woo, S.J.; Yoon, C.H.; Lee, J.S.; An, S.; Choi, Y.H.; Hwang, S.G.; Yoon, G.; Lee, S.J. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J. Biol. Chem., 2011, 286(15), 12924-12932.
80. Galluzzi, L.; Kepp, O.; Vander Heiden, M.G.; Kroemer, G. Metabolic targets for cancer therapy. Nat. Rev. Drug Discov., 2013, 12(11), 829-846.
81. Ko, Y.H.; Lin, Z.; Flomenberg, N.; Pestell, R.G.; Howell, A.; Sotgia, F.; Lisanti, M.P.; Martinez-Outschoorn, U.E. Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells Implications for preventing chemotherapy resistance. Cancer Biol. Ther., 2011, 12(12), 1085-1097.
82. Eng, C.H.; Yu, K.; Lucas, J.; White, E.; Abraham, R.T. Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy. Sci. Signal, 2010, 3(119).
83. Fung, C.; Lock, R.; Gao, S.; Salas, E.; Debnath, J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell, 2008, 19(3), 797-806.
84. Peng, Y.F.; Shi, Y.H.; Ding, Z.B.; Ke, A.W.; Gu, C.Y.; Hui, B.; Zhou, J.; Qiu, S.J.; Dai, Z.; Fan, J. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells. Autophagy, 2013, 9(12), 2056-2068.
85. Giatromanolaki, A.N.; Charitoudis, G.S.; Bechrakis, N.E.; Kozobolis, V.P.; Koukourakis, M.I.; Foerster, M.H.; Sivridis, E.L. Autophagy patterns and prognosis in uveal melanomas. Mod. Pathol, 2011, 24(8), 1036-1045.
86. Lazova, R.; Camp, R.L.; Klump, V.; Siddiqui, S.F.; Amaravadi, R.K.; Pawelek, J.M. Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome. Clin. Cancer Res., 2012, 18(2), 370-379.
87. Jo, Y.K.; Kim, S.C.; Park, I.J.; Park, S.J.; Jin, D.H.; Hong, S.W.; Cho, D.H.; Kim, J.C. Increased Expression of ATG10 in Colorectal Cancer Is Associated with Lymphovascular Invasion and Lymph Node Metastasis. PLoS One, 2012, 7(12), 52705.
88. Carew, J.S.; Nawrocki, S.T.; Kahue, C.N.; Zhang, H.; Yang, C.Y.; Chung, L.; Houghton, J.A.; Huang, P.; Giles, F.J.; Cleveland, J.L. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood, 2007, 110(1), 313-322.
89. Shao, Y.F.; Gao, Z.H.; Marks, P.A.; Jiang, X.J. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Natl. Acad. Sci. USA., 2004, 101(52), 18030-18035.
90. Ellis, L.; Bots, M.; Lindemann, R.K.; Bolden, J.E.; Newbold, A.; Cluse, L.A.; Scott, C.L.; Strasser, A.; Atadja, P.; Lowe, S.W.; Johnstone, R.W. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 2009, 114(2), 380-393.
91. Ben Sahra, I.; Laurent, K.; Giuliano, S.; Larbret, F.; Ponzio, G.; Gounon, P.; Le Marchand-Brustel, Y.; Giorgetti-Peraldi, S.; Cormont, M.; Bertolotto, C.; Deckert, M.; Auberger, P.; Tanti, J. F.; Bost, F. Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells. Cancer Res., 2010, 70(6), 2465-2475.
92. Takeuchi, H.; Kondo, Y.; Fujiwara, K.; Kanzawa, T.; Aoki, H.; Mills, G.B.; Kondo, S. Synergistic augmentation of rapamycininduced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res., 2005, 65(8), 3336-3346.
93. Carayol, N.; Vakana, E.; Sassano, A.; Kaur, S.; Goussetis, D.J.; Glaser, H.; Druker, B.J.; Donato, N.J.; Altman, J.K.; Barr, S.; Platanias, L.C. Critical roles for mTORC2-and rapamycininsensitive mTORC1-complexes in growth and survival of BCR ABL-expressing leukemic cells. Proc. Natl. Acad. Sci. USA., 2010, 107(28), 12469-12474.
94. Yazbeck, V.Y.; Buglio, D.; Georgakis, G.V.; Li, Y.; Iwado, E.; Romaguera, J.E.; Kondo, S.; Younes, A. Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp. Hematol., 2008, 36(4), 443-450.
95. Crazzolara, R.; Cisterne, A.; Thien, M.; Hewson, J.; Baraz, R.; Bradstock, K.F.; Bendall, L.J. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood, 2009, 113(14), 3297-3306.
96. Fu, L.; Kim, Y.A.; Wang, X.R.; Wu, X.Y.; Yue, P.; Lonial, S.; Khuri, F.R.; Sun, S.Y. Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy. Cancer Res., 2009, 69(23), 8967-8976.
97. Bruning, A.; Rahmeh, M.; Friese, K. Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation. Mol. Oncol., 2013, 7(6), 1012-1018.
98. Zhu, K.; Dunner, K.; McConkey, D.J. Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene, 2010, 29(3), 451-462.
99. Ding, W.X.; Ni, H.M.; Gao, W.T.; Chen, X.Y.; Kang, J.H.; Stolz, D.B.; Liu, J.S.; Yin, X.M. Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol. Cancer Ther., 2009, 8(7), 2036- 2045.
100. Ertmer, A.; Huber, V.; Gilch, S.; Yoshimori, T.; Erfle, V.; Duyster, J.; Elsasser, H.P.; Schatzl, H.M. The anticancer drug imatinib induces cellular autophagy. Leukemia, 2007, 21(5), 936- 942.
101. Wang, K.; Liu, R.; Li, J.; Mao, J.; Lei, Y.; Wu, J.; Zeng, J.; Zhang, T.; Wu, H.; Chen, L.; Huang, C.; Wei, Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of AktmTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy, 2011, 7(9), 966-978.
102. Scarlatti, F.; Maffei, R.; Beau, I.; Codogno, P.; Ghidoni, R. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ., 2008, 15(8), 1318-1329.
103. Zhang, X.; Chen, L.X.; Ouyang, L.; Cheng, Y.; Liu, B. Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif., 2012, 45(5), 466-476.
104. Laane, E.; Tamm, K.P.; Buentke, E.; Ito, K.; Kharaziha, P.; Oscarsson, J.; Corcoran, M.; Bjorklund, A.C.; Hultenby, K.; Lundin, J.; Heyman, M.; Soderhall, S.; Mazur, J.; Porwit, A.; Pandolfi, P.P.; Zhivotovsky, B.; Panaretakis, T.; Grander, D. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ., 2009, 16(7), 1018-1029.
105. Liu, T.J.; Koul, D.; LaFortune, T.; Tiao, N.Y.; Shen, R.J.; Maira, S. M.; Garcia-Echevrria, C.; Yung, W.K.A. NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol. Cancer Ther., 2009, 8(8), 2204-2210.
106. Fan, Q.W.; Weiss, W.A. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. Methods Mol. Biol., 2012, 821, 349-359.
107. Pan, H.M.; Wang, Z.G.; Jiang, L.M.; Sui, X.B.; You, L.K.; Shou, J. W.; Jing, Z.; Xie, J.S.; Ge, W.T.; Cai, X.J.; Huang, W.D.; Han, W. D. Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib. Sci. Rep., 2014, 4, 6683.
108. Milano, V.; Piao, Y.; LaFortune, T.; de Groot, J. Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Mol. Cancer Ther., 2009, 8(2), 394-406.
109. Gorzalczany, Y.; Gilad, Y.; Amihai, D.; Hammel, I.; Sagi- Eisenberg, R.; Merimsky, O. Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer. Cancer Lett., 2011, 310(2), 207-215.
110. Chang, C.Y.; Kuan, Y.H.; Ou, Y.C.; Li, J.R.; Wu, C.C.; Pan, P.H.; Chen, W.Y.; Huang, H.Y.; Chen, C.J. Autophagy contributes to gefitinib-induced glioma cell growth inhibition. Exp. Cell Res., 2014, 327(1), 102-112.
111. D'Amato, V.; Rosa, R.; D'Amato, C.; Formisano, L.; Marciano, R.; Nappi, L.; Raimondo, L.; Di Mauro, C.; Servetto, A.; Fusciello, C.; Veneziani, B. M.; De Placido, S.; Bianco, R. The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFRresistant human head and neck cancer models. Br. J. Cancer, 2014, 110(12), 2887-2895.
112. Vazquez-Martin, A.; Oliveras-Ferraros, C.; Menendez, J.A. Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab. PLoS One, 2009, 4(7), 6251.
113. John, S.; Nayvelt, I.; Hsu, H.C.; Yang, P.A.; Liu, W.S.; Das, G.M.; Thomas, T.; Thomas, T.J. Regulation of estrogenic effects by Beclin 1 in breast cancer cells. Cancer Res., 2008, 68(19), 7855- 7863.
114. Schoenlein, P.V.; Periyasamy-Thandavan, S.; Samaddar, J.S.; Jackson, W.H.; Barrett, J.T. Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance. Autophagy, 2009, 5(3), 400-403.
115. Hoyer-Hansen, M.; Bastholm, L.; Mathiasen, I.S.; Elling, F.; Jaattela, M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ., 2005, 12(10), 1297-1309.
116. Qian, W.; Liu, J.; Jin, J.; Ni, W.; Xu, W. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk. Res., 2007, 31(3), 329- 339.
117. Kanzawa, T.; Kondo, Y.; Ito, H.; Kondo, S.; Germano, I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res., 2003, 63(9), 2103-2108.
118. Martin, A.P.; Park, M.A.; Mitchell, C.; Walker, T.; Rahmani, M.; Thorburn, A.; Haussinger, D.; Reinehr, R.; Grant, S.; Dent, P. BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing. Mol. Pharmacol., 2009, 76(2), 327-341.
119. Wei, Y.; Kadia, T.; Tong, W.G.; Zhang, M.; Jia, Y.; Yang, H.; Hu, Y.M.; Tambaro, F.P.; Viallet, J.; O'Brien, S.; Garcia-Manero, G. The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy. Clin. Cancer Res., 2010, 16(15), 3923-3932.
120. Oltersdorf, T.; Elmore, S.W.; Shoemaker, A.R.; Armstrong, R.C.; Augeri, D.J.; Belli, B.A.; Bruncko, M.; Deckwerth, T.L.; Dinges, J.; Hajduk, P.J.; Joseph, M.K.; Kitada, S.; Korsmeyer, S.J.; Kunzer, A.R.; Letai, A.; Li, C.; Mitten, M.J.; Nettesheim, D.G.; Ng, S.; Nimmer, P.M.; O'Connor, J.M.; Oleksijew, A.; Petros, A.M.; Reed, J.C.; Shen, W.; Tahir, S.K.; Thompson, C.B.; Tomaselli, K.J.; Wang, B.L.; Wendt, M.D.; Zhang, H.C.; Fesik, S.W.; Rosenberg, S.H. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature, 2005, 435(7042), 677-681.
121. Chaachouay, H.; Ohneseit, P.; Toulany, M.; Kehlbach, R.; Multhoff, G.; Rodemann, H. P. Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother. Oncol., 2011, 99(3), 287-292.
122. Zhang, W.; Li, Q.; Song, C.; Lao, L. Knockdown of autophagyrelated protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells. Tumour Biol., 2015, 36(4), 2531-2539.
123. Abedin, M.J.; Wang, D.; McDonnell, M.A.; Lehmann, U.; Kelekar, A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ., 2007, 14(3), 500-510.
124. Li, J.; Hou, N.; Faried, A.; Tsutsumi, S.; Kuwano, H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur. J. Cancer, 2010, 46(10), 1900-1909.
125. Boya, P.; Gonzalez-Polo, R.A.; Casares, N.; Perfettini, J.L.; Dessen, P.; Larochette, N.; Metivier, D.; Meley, D.; Souquere, S.; Yoshimori, T.; Pierron, G.; Codogno, P.; Kroemer, G. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol., 2005, 25(3), 1025-1040.
126. Kanzawa, T.; Germano, I.M.; Komata, T.; Ito, H.; Kondo, Y.; Kondo, S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ., 2004, 11(4), 448-457.
127. Amaravadi, R.K.; Yu, D.N.; Lum, J.J.; Bui, T.; Christophorou, M. A.; Evan, G.I.; Thomas-Tikhonenko, A.; Thompson, C.B. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Cli Invest, 2007, 117(2), 326- 336.
128. Maclean, K.H.; Dorsey, F.C.; Cleveland, J.L.; Kastan, M.B. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. Cli Invest., 2008, 118(1), 79-88.
129. Han, J.; Hou, W.; Goldstein, L.A.; Lu, C.; Stolz, D.B.; Yin, X.M.; Rabinowich, H. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J. Biol. Chem., 2008, 283(28), 19665-19677.
130. Erdelyi, P.; Borsos, E.; Takacs-Vellai, K.; Kovacs, T.; Kovacs, A. L.; Sigmond, T.; Hargitai, B.; Pasztor, L.; SenGupta, T.; Dengg, M.; Pecsi, I.; Toth, J.; Nilsen, H.; Vertessy, B. G.; Vellai, T. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J. Cell Sci., 2011, 124(9), 1510-1518.
131. Hou, W.; Han, J.; Lu, C.S.; Goldstein, L.A.; Rabinowich, H. Autophagic degradation of active caspase-8 A crosstalk mechanism between autophagy and apoptosis. Autophagy, 2010, 6(7), 891-900.
132. Cojoc, M.; Mabert, K.; Muders, M.H.; Dubrovska, A. A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms. Semin. Cancer Biol., 2015, 31, 16-27.
133. Wirawan, E.; Vande Walle, L.; Kersse, K.; Cornelis, S.; Claerhout, S.; Vanoverberghe, I.; Roelandt, R.; De Rycke, R.; Verspurten, J.; Declercq, W.; Agostinis, P.; Vanden Berghe, T.; Lippens, S.; Vandenabeele, P. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis., 2010, 1, 18.
134. Li, H.; Wang, P.; Sun, Q.H.; Ding, W.X.; Yin, X.M.; Sobol, R.W.; Stolz, D.B.; Yu, J.; Zhang, L. Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1. Cancer Res., 2011, 71(10), 3625-3634.
135. O'Donovan, T.R.; O'Sullivan, G.C.; McKenna, S.L. Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy, 2011, 7(5), 509-524.
136. Gong, C.; Bauvy, C.; Tonelli, G.; Yue, W.; Delomenie, C.; Nicolas, V.; Zhu, Y.; Domergue, V.; Marin-Esteban, V.; Tharinger, H.; Delbos, L.; Gary-Gouy, H.; Morel, A.P.; Ghavami, S.; Song, E.; Codogno, P.; Mehrpour, M. Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene, 2013, 32(18), 2261-2272.
137. Viale, A.; Pettazzoni, P.; Lyssiotis, C. A.; Ying, H. Q.; Sanchez, N.; Marchesini, M.; Carugo, A.; Green, T.; Seth, S.; Giuliani, V.; Kost-Alimova, M.; Muller, F.; Colla, S.; Nezi, L.; Genovese, G.; Deem, A.K.; Kapoor, A.; Yao, W.T.; Brunetto, E.; Kang, Y.; Yuan, M.; Asara, J.M.; Wang, Y.A.; Heffernan, T.P.; Kimmelman, A.C.; Wang, H.M.; Fleming, J.B.; Cantley, L.C.; DePinho, R.A.; Draetta, G.F. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature, 2014, 514(7524), 628-632.
138. Lu, Z.; Luo, R.Z.; Lu, Y.L.; Zhang, X.H.; Yu, Q.H.; Khare, S.; Kondo, S.; Kondo, Y.; Yu, Y.H.; Mills, G.B.; Liao, W.S.L.; Bast, R.C. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest, 2008, 118(12), 3917-3929.
139. Lu, Z.; Baquero, M.T.; Yang, H.L.; Yang, M.J.; Reger, A.S.; Kim, C.; Levine, D.A.; Clarke, C.H.; Liao, W.S.L.; Bast, R.C. DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy, 2014, 10(6), 1071-1092.
140. Gupta, A.; Roy, S.; Lazar, A.J.F.; Wang, W.L.; McAuliffe, J.C.; Reynoso, D.; McMahon, J.; Taguchi, T.; Floris, G.; Debiec- Rychter, M.; Schoffski, P.; Trent, J.A.; Debnath, J.; Rubin, B.P. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc. Natl. Acad. Sci. USA., 2010, 107(32), 14333-14338.
141. Shimizu, T.; Sugihara, E.; Yamaguchi-Iwai, S.; Tamaki, S.; Koyama, Y.; Kamel, W.; Ueki, A.; Ishikawa, T.; Chiyoda, T.; Osuka, S.; Onishi, N.; Ikeda, H.; Kamei, J.; Matsuo, K.; Fukuchi, Y.; Nagai, T.; Toguchida, J.; Toyama, Y.; Muto, A.; Saya, H. IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress. Cancer Res., 2014, 74(22), 6531-6541.
142. Shen, S.; Kepp, O.; Michaud, M.; Martins, I.; Minoux, H.; Metivier, D.; Maiuri, M.C.; Kroemer, R.T.; Kroemer, G. Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study. Oncogene, 2011, 30(45), 4544-4556.
143. Kroemer, G.; Levine, B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol., 2008, 9(12), 1004-1010.
144. Wei, Y.J.; Zou, Z.J.; Becker, N.; Anderson, M.; Sumpter, R.; Xiao, G.H.; Kinch, L.; Koduru, P.; Christudass, C.S.; Veltri, R.W.; Grishin, N.V.; Peyton, M.; Minna, J.; Bhagat, G.; Levine, B. EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance. Cell, 2013, 154(6), 1269-1284.
145. Kanematsu, S.; Uehara, N.; Miki, H.; Yoshizawa, K.; Kawanaka, A.; Yuri, T.; Tsubura, A. Autophagy Inhibition Enhances Sulforaphane-induced Apoptosis in Human Breast Cancer Cells. Anticancer Res., 2010, 30(9), 3381-3390.
146. Hsu, K.F.; Wu, C.L.; Huang, S.C.; Wu, C.M.; Hsiao, J.R.; Yo, Y. T.; Chen, Y.H.; Shiau, A.L.; Chou, C.Y. Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy, 2009, 5(4), 451-460.
147. Rosenfeldt, M.T.; O'Prey, J.; Morton, J P.; Nixon, C.; MacKay, G.; Mrowinska, A.; Au, A.; Rai, T.S.; Zheng, L.; Ridgway, R.; Adams, P.D.; Anderson, K.I.; Gottlieb, E.; Sansom, O.J.; Ryan, K.M. p53 status determines the role of autophagy in pancreatic tumour development. Nature, 2013, 504(7479), 296-300.
148. Bristol, M.L.; Emery, S.M.; Maycotte, P.; Thorburn, A.; Chakradeo, S.; Gewirtz, D.A. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J. Pharmacol. Exp. Ther., 2013, 344(3), 544-552.
149. Morgan, M.J.; Gamez, G.; Menke, C.; Hernandez, A.; Thorburn, J.; Gidan, F.; Staskiewicz, L.; Morgan, S.; Cummings, C.; Maycotte, P.; Thorburn, A. Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy, 2014, 10(10), 1814-1826.
150. Chi, C.W.; Zhu, H.H.; Han, M.; Zhuang, Y.A.; Wu, X.H.; Xu, T.A. Disruption of Lysosome Function Promotes Tumor Growth and Metastasis in Drosophila. J. Biol. Chem., 2010, 285(28), 21817- 21823.
151. Tu, C.; Ortega-Cava, C.F.; Chen, G.S.; Fernandes, N.D.; Cavallo- Medved, D.; Sloane, B.F.; Band, V.; Band, H. Lysosomal Cathepsin B Participates in the Podosome-Mediated Extracellular Matrix Degradation and Invasion via Secreted Lysosomes in v-Src Fibroblasts. Cancer Res., 2008, 68(22), 9147-9156.
152. Maes, H.; Kuchnio, A.; Peric, A.; Moens, S.; Nys, K.; De Bock, K.; Quaegebeur, A.; Schoors, S.; Georgiadou, M.; Wouters, J.; Vinckier, S.; Vankelecom, H.; Garmyn, M.; Vion, A. C.; Radtke, F.; Boulanger, C.; Gerhardt, H.; Dejana, E.; Dewerchin, M.; Ghesquiere, B.; Annaert, W.; Agostinis, P.; Carmeliet, P. Tumor Vessel Normalization by Chloroquine Independent of Autophagy. Cancer Cell, 2014, 26(2), 190-206.
153. Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; Agnello, M.; Agostinis, P.; Aguirre-Ghiso, J.A.; Ahn, H.J.; Ait-Mohamed, O.; Ait-Si-Ali, S.; Akematsu, T.; Akira, S.; Al-Younes, H.M.; Al-Zeer, M.A.; Albert, M.L.; Albin, R.L.; Alegre-Abarrategui, J.; Aleo, M. F.; Alirezaei, M.; Almasan, A.; Almonte-Becerril, M.; Amano, A.; Amaravadi, R.; Amarnath, S.; Amer, A.O.; Andrieu-Abadie, N.; Anantharam, V.; Ann, D.K.; Anoopkumar-Dukie, S.; Aoki, H.; Apostolova, N.; Arancia, G.; Aris, J.P.; Asanuma, K.; Asare, N.Y. O.; Ashida, H.; Askanas, V.; Askew, D.S.; Auberger, P.; Baba, M.; Backues, S.K.; Baehrecke, E.H.; Bahr, B.A.; Bai, X.Y.; Bailly, Y.; Baiocchi, R.; Baldini, G.; Balduini, W.; Ballabio, A.; Bamber, B. A.; Bampton, E.T.W.; Banhegyi, G.; Bartholomew, C.R.; Bassham, D.C.; Bast, R.C.; Batoko, H.; Bay, B.H.; Beau, I.; Bechet, D.M.; Begley, T.J.; Behl, C.; Behrends, C.; Bekri, S.; Bellaire, B.; Bendall, L.J.; Benetti, L.; Berliocchi, L.; Bernardi, H.; Bernassola, F.; Besteiro, S.; Bhatia-Kissova, I.; Bi, X.N.; Biard-Piechaczyk, M.; Blum, J.S.; Boise, L.H.; Bonaldo, P.; Boone, D.L.; Bornhauser, B.C.; Bortoluci, K.R.; Bossis, I.; Bost, F.; Bourquin, J.P.; Boya, P.; Boyer-Guittaut, M.; Bozhkov, P.V.; Brady, N.R.; Brancolini, C.; Brech, A.; Brenman, J.E.; Brennand, A.; Bresnick, E.H.; Brest, P.; Bridges, D.; Bristol, M.L.; Brookes, P.S.; Brown, E.J.; Brumell, J. H.; Brunetti-Pierri, N.; Brunk, U.T.; Bulman, D.E.; Bultman, S.J.; Bultynck, G.; Burbulla, L.F.; Bursch, W.; Butchar, J.P.; Buzgariu, W.; Bydlowski, S.P.; Cadwell, K.; Cahova, M.; Cai, D.S.; Cai, J. Y.; Cai, Q.; Calabretta, B.; Calvo-Garrido, J.; Camougrand, N.; Campanella, M.; Campos-Salinas, J.; Candi, E.; Cao, L.Z.; Caplan, A.B.; Carding, S.R.; Cardoso, S.M.; Carew, J.S.; Carlin, C.R.; Carmignac, V.; Carneiro, L.A.M.; Carra, S.; Caruso, R.A.; Casari, G.; Casas, C.; Castino, R.; Cebollero, E.; Cecconi, F.; Celli, J.; Chaachouay, H.; Chae, H.J.; Chai, C.Y.; Chan, D.C.; Chan, E.Y.; Chang, R.C.C.; Che, C.M.; Chen, C.C.; Chen, G.C.; Chen, G.Q.; Chen, M.; Chen, Q.; Chen, S.S.L.; Chen, W.L.; Chen, X.; Chen, X. M.; Chen, X.Q.; Chen, Y.G.; Chen, Y.Y.; Chen, Y.Q.; Chen, Y.J.; Chen, Z.X.; Cheng, A.; Cheng, C.H.K.; Cheng, Y.; Cheong, H.; Cheong, J.H.; Cherry, S.; Chess-Williams, R.; Cheung, Z.H.; Chevet, E.; Chiang, H.L.; Chiarelli, R.; Chiba, T.; Chin, L.S.; Chiou, S.H.; Chisari, F.V.; Cho, C.H.; Cho, D.H.; Choi, A.M.K.; Choi, D.; Choi, K.S.; Choi, M.E.; Chouaib, S.; Choubey, D.; Choubey, V.; Chu, C.T.; Chuang, T.H.; Chueh, S.H.; Chun, T.; Chwae, Y.J.; Chye, M.L.; Ciarcia, R.; Ciriolo, M.R.; Clague, M.J.; Clark, R.S.B.; Clarke, P.G.H.; Clarke, R.; Codogno, P.; Coller, H. A.; Colombo, M.I.; Comincini, S.; Condello, M.; Condorelli, F.; Cookson, M.R.; Coppens, G.; Corbalan, R.; Cossart, P.; Costelli, P.; Costes, S.; Coto-Montes, A.; Couve, E.; Coxon, F.P.; Cregg, J. M.; Crespo, J.L.; Cronje, M.J.; Cuervo, A.M.; Cullen, J.J.; Czaja, M.J.; D'Amelio, M.; Darfeuille-Michaud, A.; Davids, L.M.; Davies, F.E.; De Felici, M.; de Groot, J.F.; de Haan, C.A.M.; De Martino, L.; De Milito, A.; De Tata, V.; Debnath, J.; Degterev, A.; Dehay, B.; Delbridge, L.M.D.; Demarchi, F.; Deng, Y.Z.; Dengjel, J.; Dent, P.; Denton, D.; Deretic, V.; Desai, S.D.; Devenish, R.J.; Di Gioacchino, M.; Di Paolo, G.; Di Pietro, C.; Diaz-Araya, G.; Diaz-Laviada, I.; Diaz-Meco, M.T.; Diaz-Nido, J.; Dikic, I.; Dinesh-Kumar, S.P.; Ding, W.X.; Distelhorst, C.W.; Diwan, A.; Djavaheri-Mergny, M.; Dokudovskaya, S.; Dong, Z.; Dorsey, F. C.; Dosenko, V.; Dowling, J.J.; Doxsey, S.; Dreux, M.; Drew, M. E.; Duan, Q.H.; Duchosal, M.A.; Duff, K.; Dugail, I.; Durbeej, M.; Duszenko, M.; Edelstein, C.L.; Edinger, A.L.; Egea, G.; Eichinger, L.; Eissa, N.T.; Ekmekcioglu, S.; El-Deiry, W.S.; Elazar, Z.; Elgendy, M.; Ellerby, L.M.; Eng, K.E.; Engelbrecht, A.M.; Engelender, S.; Erenpreisa, J.; Escalante, R.; Esclatine, A.; Eskelinen, E.L.; Espert, L.; Espina, V.; Fan, H.Z.; Fan, J.; Fan, Q. W.; Fan, Z.; Fang, S.Y.; Fang, Y.Q.; Fanto, M.; Fanzani, A.; Farkas, T.; Farre, J.C.; Faure, M.; Fechheimer, M.; Feng, C.G.; Feng, J.; Feng, Q.L.; Feng, Y.J.; Fesus, L.; Feuer, R.; Figueiredo- Pereira, M.E.; Fimia, G.M.; Fingar, D.C.; Finkbeiner, S.; Finkel, T.; Finley, K.D.; Fiorito, F.; Fisher, E.A.; Fisher, P.B.; Flajolet, M.; Florez-McClure, M.L.; Florio, S.; Fon, E.A.; Fornai, F.; Fortunato, F.; Fotedar, R.; Fowler, D.H.; Fox, H.S.; Franco, R.; Frankel, L.B.; Fransen, M.; Fuentes, J.M.; Fueyo, J.; Fujii, J.; Fujisaki, K.; Fujita, E.; Fukuda, M.; Furukawa, R.H.; Gaestel, M.; Gailly, P.; Gajewska, M.; Galliot, B.; Galy, V.; Ganesh, S.; Ganetzky, B.; Ganley, I.G.; Gao, F.B.; Gao, G.F.; Gao, J.M.; Garcia, L.; Garcia-Manero, G.; Garcia-Marcos, M.; Garmyn, M.; Gartel, A.L.; Gatti, E.; Gautel, M.; Gawriluk, T.R.; Gegg, M.E.; Geng, J.F.; Germain, M.; Gestwicki, J.E.; Gewirtz, D.A.; Ghavami, S.; Ghosh, P.; Giammarioli, A.M.; Giatromanolaki, A.N.; Gibson, S.B.; Gilkerson, R.W.; Ginger, M.L.; Ginsberg, H.N.; Golab, J.; Goligorsky, M.S.; Golstein, P.; Gomez-Manzano, C.; Goncu, E.; Gongora, C.; Gonzalez, C.D.; Gonzalez, R.; Gonzalez-Estevez, C.; Gonzalez-Polo, R.A.; Gonzalez-Rey, E.; Gorbunov, N.V.; Gorski, S.; Goruppi, S.; Gottlieb, R.A.; Gozuacik, D.; Granato, G.E.; Grant, G.D.; Green, K.N.; Gregorc, A.; Gros, F.; Grose, C.; Grunt, T.W.; Gual, P.; Guan, J.L.; Guan, K.L.; Guichard, S.M.; Gukovskaya, A. S.; Gukovsky, I.; Gunst, J.; Gustafsson, A.B.; Halayko, A.J.; Hale, A.N.; Halonen, S.K.; Hamasaki, M.; Han, F.; Han, T.; Hancock, M. K.; Hansen, M.; Harada, H.; Harada, M.; Hardt, S.E.; Harper, J. W.; Harris, A.L.; Harris, J.; Harris, S.D.; Hashimoto, M.; Haspel, J. A.; Hayashi, S.; Hazelhurst, L.A.; He, C.C.; He, Y.W.; Hebert, M. J.; Heidenreich, K.A.; Helfrich, M.H.; Helgason, G.V.; Henske, E. P.; Herman, B.; Herman, P.K.; Hetz, C.; Hilfiker, S.; Hill, J.A.; Hocking, L.J.; Hofman, P.; Hofmann, T.G.; Hohfeld, J.; Holyoake, T.L.; Hong, M.H.; Hood, D.A.; Hotamisligil, G.S.; Houwerzijl, E. J.; Hoyer-Hansen, M.; Hu, B.R.; Hu, C.A.A.; Hu, H.M.; Hua, Y.; Huang, C.H.; Huang, J.; Huang, S.B.; Huang, W.P.; Huber, T.B.; Huh, W.K.; Hung, T.H.; Hupp, T.R.; Hur, G.M.; Hurley, J.B.; Hussain, S.N.A.; Hussey, P.J.; Hwang, J.J.; Hwang, S.M.; Ichihara, A.; Ilkhanizadeh, S.; Inoki, K.; Into, T.; Iovane, V.; Iovanna, J.L.; Ip, N.Y.; Isaka, Y.; Ishida, H.; Isidoro, C.; Isobe, K.; Iwasaki, A.; Izquierdo, M.; Izumi, Y.; Jaakkola, P.M.; Jaattela, M.; Jackson, G. R.; Jackson, W.T.; Janji, B.; Jendrach, M.; Jeon, J.H.; Jeung, E.B.; Jiang, H.; Jiang, H.C.; Jiang, J.X.; Jiang, M.; Jiang, Q.; Jiang, X.J.; Jimenez, A.; Jin, M.Y.; Jin, S.K.; Joe, C.O.; Johansen, T.; Johnson, D.E.; Johnson, G.V.W.; Jones, N.L.; Joseph, B.; Joseph, S.K.; Joubert, A.M.; Juhasz, G.; Juillerat-Jeanneret, L.; Jung, C.H.; Jung, Y.K.; Kaarniranta, K.; Kaasik, A.; Kabuta, T.; Kadowaki, M.; Kagedal, K.; Kamada, Y.; Kaminskyy, V.O.; Kampinga, H.H.; Kanamori, H.; Kang, C.; Kang, K.B.; Kang, K.I.; Kang, R.; Kang, Y.A.; Kanki, T.; Kanneganti, T.D.; Kanno, H.; Kanthasamy, A.G.; Kanthasamy, A.; Karantza, V.; Kaushal, G.P.; Kaushik, S.; Kawazoe, Y.; Ke, P.Y.; Kehrl, J.H.; Kelekar, A.; Kerkhoff, C.; Kessel, D.H.; Khalil, H.; Kiel, J.; Kiger, A.A.; Kihara, A.; Kim, D. R.; Kim, D.H.; Kim, E.K.; Kim, H.R.; Kim, J.S.; Kim, J.H.; Kim, J. C.; Kim, J.K.; Kim, P.K.; Kim, S.W.; Kim, Y.S.; Kim, Y.; Kimchi, A.; Kimmelman, A.C.; King, J.S.; Kinsella, T.J.; Kirkin, V.; Kirshenbaum, L.A.; Kitamoto, K.; Kitazato, K.; Klein, L.; Klimecki, W.T.; Klucken, J.; Knecht, E.; Ko, B.C. B.; Koch, J.C.; Koga, H.; Koh, J.Y.; Koh, Y.H.; Koike, M.; Komatsu, M.; Kominami, E.; Kong, H.J.; Kong, W.J.; Korolchuk, V.I.; Kotake, Y.; Koukourakis, M.I.; Flores, J.B.K.; Kovacs, A.L.; Kraft, C.; Krainc, D.; Kraemer, H.; Kretz-Remy, C.; Krichevsky, A.M.; Kroemer, G.; Krueger, R.; Krut, O.; Ktistakis, N.T.; Kuan, C.Y.; Kucharczyk, R.; Kumar, A.; Kumar, R.; Kumar, S.; Kundu, M.; Kung, H.J.; Kurz, T.; Kwon, H.J.; La Spada, A.R.; Lafont, F.; Lamark, T.; Landry, J.; Lane, J.D.; Lapaquette, P.; Laporte, J.F.; Laszlo, L.; Lavandero, S.; Lavoie, J.N.; Layfield, R.; Lazo, P.A.; Le, W.D.; Le Cam, L.; Ledbetter, D.J.; Lee, A.J. X.; Lee, B.W.; Lee, G.M.; Lee, J.; Lee, J.H.; Lee, M.; Lee, M.S.; Lee, H.; Leeuwenburgh, C.; Legembre, P.; Legouis, R.; Lehmann, M.; Lei, H.Y.; Lei, Q.Y.; Leib, D.A.; Leiro, J.; Lemasters, J.J.; Lemoine, A.; Lesniak, M.S.; Lev, D.; Levenson, V.V.; Levine, B.; Levy, E.; Li, F.Q.; Li, J.L.; Li, L.; Li, S.; Li, W.J.; Li, X.J.; Li, Y.B.; Li, Y.P.; Liang, C.Y.; Liang, Q.R.; Liao, Y.F.; Liberski, P.P.; Lieberman, A.; Lim, H.J.; Lim, K.L.; Lim, K.; Lin, C.F.; Lin, F.C.; Lin, J.; Lin, J.D.D.; Lin, K.; Lin, W.W.; Lin, W.C.; Lin, Y.L.; Linden, R.; Lingor, P.; Lippincott-Schwartz, J.; Lisanti, M.P.; Liton, P.B.; Liu, B.; Liu, C.F.; Liu, K.Y.; Liu, L.Y.; Liu, Q.A.; Liu, W.; Liu, Y.C.; Liu, Y.L.; Lockshin, R.A.; Lok, C.N.; Lonial, S.; Loos, B.; Lopez- Berestein, G.; Lopez-Otin, C.; Lossi, L.; Lotze, M.T.; Low, P.; Lu, B.F.; Lu, B.W.; Lu, B.; Lu, Z.; Luciano, F.; Lukacs, N.W.; Lund, A.H.; Lynch-Day, M.A.; Ma, Y.; Macian, F.; MacKeigan, J.P.; Macleod, K.F.; Madeo, F.; Maiuri, L.; Maiuri, M.C.; Malagoli, D.; Malicdan, M.C.V.; Malorni, W.; Man, N.; Mandelkow, E.M.; Manon, S.; Manov, I.; Mao, K.; Mao, X.; Mao, Z. X.; Marambaud, P.; Marazziti, D.; Marcel, Y.L.; Marchbank, K.; Marchetti, P.; Marciniak, S.J.; Marcondes, M.; Mardi, M.; Marfe, G.; Marino, G.; Markaki, M.; Marten, M.R.; Martin, S.J.; Martinand-Mari, C.; Martinet, W.; Martinez-Vicente, M.; Masini, M.; Matarrese, P.; Matsuo, S.; Matteoni, R.; Mayer, A.; Mazure, N. M.; McConkey, D.J.; McConnell, M.J.; McDermott, C.; McDonald, C.; McInerney, G.M.; McKenna, S.L.; McLaughlin, B.; McLean, P.J.; McMaster, C.R.; McQuibban, G.A.; Meijer, A.J.; Meisler, M.H.; Melendez, A.; Melia, T.J.; Melino, G.; Mena, M.A.; Menendez, J.A.; Menna- Barreto, R.F.S.; Menon, M.B.; Menzies, F.M.; Mercer, C.A.; Merighi, A.; Merry, D.E.; Meschini, S.; Meyer, C.G.; Meyer, T.F.; Miao, C.Y.; Miao, J.Y.; Michels, P.A.M.; Michiels, C.; Mijaljica, D.; Milojkovic, A.; Minucci, S.; Miracco, C.; Miranti, C.K.; Mitroulis, I.; Miyazawa, K.; Mizushima, N.; Mograbi, B.; Mohseni, S.; Molero, X.; Mollereau, B.; Mollinedo, F.; Momoi, T.; Monastyrska, I.; Monick, M.M.; Monteiro, M.J.; Moore, M.N.; Mora, R.; Moreau, K.; Moreira, P.I.; Moriyasu, Y.; Moscat, J.; Mostowy, S.; Mottram, J.C.; Motyl, T.; Moussa, C.E.H.; Muller, S.; Munger, K.; Munz, C.; Murphy, L.O.; Murphy, M.E.; Musaro, A.; Mysorekar, I.; Nagata, E.; Nagata, K.; Nahimana, A.; Nair, U.; Nakagawa, T.; Nakahira, K.; Nakano, H.; Nakataogawa, H.; Nanjundan, M.; Naqvi, N.I.; Narendra, D.P.; Narita, M.; Navarro, M.; Nawrocki, S.T.; Nazarko, T.Y.; Nemchenko, A.; Netea, M.G.; Neufeld, T.P.; Ney, P.A.; Nezis, I.P.; Nguyen, H.P.; Nie, D.T.; Nishino, I.; Nislow, C.; Nixon, R.A.; Noda, T.; Noegel, A.A.; Nogalska, A.; Noguchi, S.; Notterpek, L.; Novak, I.; Nozaki, T.; Nukina, N.; Nuurnberger, T.; Nyfeler, B.; Obara, K.; Oberley, T. D.; Oddo, S.; Ogawa, M.; Ohashi, T.; Okamoto, K.; Oleinick, N. L.; Oliver, F.J.; Olsen, L.J.; Olsson, S.; Opota, O.; Osborne, T.F.; Ostrander, G.K.; Otsu, K.; Ou, J.H.J.; Ouimet, M.; Overholtzer, M.; Ozpolat, B.; Paganetti, P.; Pagnini, U.; Pallet, N.; Palmer, G.E.; Palumbo, C.; Pan, T.H.; Panaretakis, T.; Pandey, U.B.; Papackova, Z.; Papassideri, I.; Paris, I.; Park, J.; Park, O.K.; Parys, J.B.; Parzych, K.R.; Patschan, S.; Patterson, C.; Pattingre, S.; Pawelek, J. M.; Peng, J.X.; Perlmutter, D.H.; Perrotta, I.; Perry, G.; Pervaiz, S.; Peter, M.; Peters, G.J.; Petersen, M.; Petrovski, G.; Phang, J.M.; Piacentini, M.; Pierre, P.; Pierrefite-Carle, V.; Pierron, G.; Pinkas- Kramarski, R.; Piras, A.; Piri, N.; Platanias, L.C.; Poggeler, S.; Poirot, M.; Poletti, A.; Pous, C.; Pozuelo-Rubio, M.; Praetorius- Ibba, M.; Prasad, A.; Prescott, M.; Priault, M.; Produit- Zengaffinen, N.; Progulske-Fox, A.; Proikas-Cezanne, T.; Przedborski, S.; Przyklenk, K.; Puertollano, R.; Puyal, J.; Qian, S. B.; Qin, L.; Qin, Z.H.; Quaggin, S.E.; Raben, N.; Rabinowich, H.; Rabkin, S.W.; Rahman, I.; Rami, A.; Ramm, G.; Randall, G.; Randow, F.; Rao, V.A.; Rathmell, J.C.; Ravikumar, B.; Ray, S.K.; Reed, B.H.; Reed, J.C.; Reggiori, F.; Regnier-Vigouroux, A.; Reichert, A.S.; Reiners, J.J.; Reiter, R.J.; Ren, J.; Revuelta, J.L.; Rhodes, C.J.; Ritis, K.; Rizzo, E.; Robbins, J.; Roberge, M.; Roca, H.; Roccheri, M.C.; Rocchi, S.; Rodemann, H.P.; de Cordoba, S. R.; Rohrer, B.; Roninson, I.B.; Rosen, K.; Rost-Roszkowska, M. M.; Rouis, M.; Rouschop, K.M.A.; Rovetta, F.; Rubin, B.P.; Rubinsztein, D. C.; Ruckdeschel, K.; Rucker, E. B.; Rudich, A.; Rudolf, E.; Ruiz-Opazo, N.; Russo, R.; Rusten, T.E.; Ryan, K.M.; Ryter, S.W.; Sabatini, D.M.; Sadoshima, J.; Saha, T.; Saitoh, T.; Sakagami, H.; Sakai, Y.; Salekdeh, G.H.; Salomoni, P.; Salvaterra, P.M.; Salvesen, G.; Salvioli, R.; Sanchez, A.M.J.; Sanchez- Alcazar, J.A.; Sanchez-Prieto, R.; Sandri, M.; Sankar, U.; Sansanwal, P.; Santambrogio, L.; Saran, S.; Sarkar, S.; Sarwal, M.; Sasakawa, C.; Sasnauskiene, A.; Sass, M.; Sato, K.; Sato, M.; Schapira, A.H.V.; Scharl, M.; Schatzl, H.M.; Scheper, W.; Schiaffino, S.; Schneider, C.; Schneider, M.E.; Schneider-Stock, R.; Schoenlein, P.V.; Schorderet, D.F.; Schuller, C.; Schwartz, G. K.; Scorrano, L.; Sealy, L.; Seglen, P.O.; Segura-Aguilar, J.; Seiliez, I.; Seleverstov, O.; Sell, C.; Seo, J.B.; Separovic, D.; Setaluri, V.; Setoguchi, T.; Settembre, C.; Shacka, J.J.; Shanmugam, M.; Shapiro, I.M.; Shaulian, E.; Shaw, R.J.; Shelhamer, J.H.; Shen, H.M.; Shen, W.C.; Sheng, Z.H.; Shi, Y.; Shibuya, K.; Shidoji, Y.; Shieh, J.J.; Shih, C.M.; Shimada, Y.; Shimizu, S.; Shintani, T.; Shirihai, O.S.; Shore, G.C.; Sibirny, A. A.; Sidhu, S.B.; Sikorska, B.; Silva-Zacarin, E.C.M.; Simmons, A.; Simon, A.K.; Simon, H.U.; Simone, C.; Simonsen, A.; Sinclair, D. A.; Singh, R.; Sinha, D.; Sinicrope, F.A.; Sirko, A.; Siu, P.M.; Sivridis, E.; Skop, V.; Skulachev, V.P.; Slack, R.S.; Smaili, S.S.; Smith, D.R.; Soengas, M.S.; Soldati, T.; Song, X.Q.; Sood, A.K.; Soong, T.W.; Sotgia, F.; Spector, S.A.; Spies, C.D.; Springer, W.; Srinivasula, S.M.; Stefanis, L.; Steffan, J.S.; Stendel, R.; Stenmark, H.; Stephanou, A.; Stern, S.T.; Sternberg, C.; Stork, B.; Stralfors, P.; Subauste, C.S.; Sui, X.B.; Sulzer, D.; Sun, J.R.; Sun, S.Y.; Sun, Z.J.; Sung, J.J.Y.; Suzuki, K.; Suzuki, T.; Swanson, M.S.; Swanton, C.; Sweeney, S.T.; Sy, L.K.; Szabadkai, G.; Tabas, I.; Taegtmeyer, H.; Tafani, M.; Takacs-Vellai, K.; Takano, Y.; Takegawa, K.; Takemura, G.; Takeshita, F.; Talbot, N.J.; Tan, K.S.W.; Tanaka, K.; Tang, D.L.; Tang, D.Z.; Tanida, I.; Tannous, B.A.; Tavernarakis, N.; Taylor, G.S.; Taylor, G.A.; Taylor, J.P.; Terada, L.S.; Terman, A.; Tettamanti, G.; Thevissen, K.; Thompson, C.B.; Thorburn, A.; Thumm, M.; Tian, F.F.; Tian, Y.; Tocchini- Valentini, G.; Tolkovsky, A.M.; Tomino, Y.; Toenges, L.; Tooze, S.A.; Tournier, C.; Tower, J.; Towns, R.; Trajkovic, V.; Travassos, L.H.; Tsai, T.F.; Tschan, M.P.; Tsubata, T.; Tsung, A.; Turk, B.; Turner, L.S.; Tyagi, S.C.; Uchiyama, Y.; Ueno, T.; Umekawa, M.; Umemiya-Shirafuji, R.; Unni, V.K.; Vaccaro, M.I.; Valente, E.M.; Van den Berghe, G.; van der Klei, I.J.; van Doorn, W.G.; van Dyk, L.F.; van Egmond, M.; van Grunsven, L.A.; Vandenabeele, P.; Vandenberghe, W.P.; Vanhorebeek, I.; Vaquero, E.C.; Velasco, G.; Vellai, T.; Vicencio, J.M.; Vierstra, R.D.; Vila, M.; Vindis, C.; Viola, G.; Viscomi, M.T.; Voitsekhovskaja, O.V.; von Haefen, C.; Votruba, M.; Wada, K.; Wade-Martins, R.; Walker, C.L.; Walsh, C.M.; Walter, J.; Wan, X.B.; Wang, A.M.; Wang, C.G.; Wang, D. W.; Wang, F.; Wang, G. H.; Wang, H.C.; Wang, H.G.; Wang, H. D.; Wang, J.; Wang, K.; Wang, M.; Wang, R.C.; Wang, X.L.; Wang, X.J.; Wang, Y.J.; Wang, Y.P.; Wang, Z.; Wang, Z.C.; Wang, Z.N.; Wansink, D.G.; Ward, D.M.; Watada, H.; Waters, S. L.; Webster, P.; Wei, L.X.; Weihl, C.C.; Weiss, W.A.; Welford, S. M.; Wen, L.P.; Whitehouse, C.A.; Whitton, J.L.; Whitworth, A.J.; Wileman, T.; Wiley, J.W.; Wilkinson, S.; Willbold, D.; Williams, R. L.; Williamson, P. R.; Wouters, B.G.; Wu, C.H.; Wu, D.C.; Wu, W.K.K.; Wyttenbach, A.; Xavier, R.J.; Xi, Z.J.; Xia, P.; Xiao, G. F.; Xie, Z.P.; Xie, Z.L.; Xu, D.Z.; Xu, J.Z.; Xu, L.; Xu, X.L.; Yamamoto, A.; Yamashina, S.; Yamashita, M.; Yan, X.H.; Yanagida, M.; Yang, D.S.; Yang, E.; Yang, J.M.; Yang, S.Y.; Yang, W.N.; Yang, W.Y.; Yang, Z.F.; Yao, M.C.; Yao, T.P.; Yeganeh, B.; Yen, W.L.; Yin, J.J.; Yin, X.M.; Yoo, O.J.; Yoon, G.; Yoon, S.Y.; Yorimitsu, T.; Yoshikawa, Y.; Yoshimori, T.; Yoshimoto, K.; You, H.J.; Youle, R.J.; Younes, A.; Yu, L.; Yu, S. W.; Yu, W.H.; Yuan, Z.M.; Yue, Z.Y.; Yun, C.H.; Yuzaki, M.; Zabirnyk, O.; Silva-Zacarin, E.; Zacks, D.; Zacksenhaus, E.; Zaffaroni, N.; Zakeri, Z.; Zeh, H.J.; Zeitlin, S.O.; Zhang, H.; Zhang, H.L.; Zhang, J.H.; Zhang, J.P.; Zhang, L.; Zhang, M.Y.; Zhang, X.D.; Zhao, M.T.; Zhao, Y.F.; Zhao, Y.; Zhao, Z.Z.J.; Zheng, X.X.; Zhivotovsky, B.; Zhong, Q.; Zhou, C.Z.; Zhu, C.L.; Zhu, W.G.; Zhu, X.F.; Zhu, X.W.; Zhu, Y.G.; Zoladek, T.; Zong, W.X.; Zorzano, A.; Zschocke, J.; Zuckerbraun, B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012, 8(4), 445-544.
154. Chargui, A.; Zekri, S.; Jacquillet, G.; Rubera, I.; Ilie, M.; Belaid, A.; Duranton, C.; Tauc, M.; Hofman, P.; Poujeol, P.; El May, M.V.; Mograbi, B. Cadmium-Induced Autophagy in Rat Kidney: An Early Biomarker of Subtoxic Exposure. Toxicol. Sci., 2011, 121(1), 31-42.