Autophagy and crohn's disease: At the crossroads of infection, inflammation, immunity, and cancer

Current Molecular Medicine

Volumn 10, Issue 5, 2010, Pages 486-502

  Brest, P ^a   Corcelle, E A ^b   Cesaro, A ^a   Chargui, A ^a   Belaid A ^a   Klionsky, D J ^c   Vouret Craviari, V ^a   Hebuterne, X ^a,d   Hofman, P ^a,e   Mograbi, B ^a  

^a INSERM   (France)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c UNIVERSITY OF MICHIGAN   (United States)

^d CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^e PASTEUR HOSPITAL   (France)

Author keywords

Autophagy; Cancer; Crohn's disease; Immunity; Infection; Inflammation

Indexed keywords

AUTOPHAGY RELATED PROTEIN 16 LIKE 1; AZATHIOPRINE; CORTICOSTEROID; EVEROLIMUS; FLUOROURACIL; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; IMMUNITY RELATED GTPASE M; INFLIXIMAB; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 4; MERCAPTOPURINE; METHOTREXATE; PLACEBO; PROTEIN; RAPAMYCIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BACTERIAL INFECTION; CANCER RISK; CELL DEATH; CLINICAL TRIAL; COLITIS; COLORECTAL CANCER; CROHN DISEASE; CYTOLOGY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; ENTERITIS; EUROPE; GENE LOCUS; GENE MUTATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIGH RISK POPULATION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; INCIDENCE; INFECTION; INFLAMMATION; INNATE IMMUNITY; MORBIDITY; MORTALITY; NONHUMAN; NORTH AMERICA; OXIDATIVE STRESS; PATHOGENESIS; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; TREATMENT RESPONSE; ULCERATIVE COLITIS; ANIMAL; COMPLICATION; IMMUNOLOGY; MICROBIOLOGY; NEOPLASM; PATHOLOGY;

ANIMALS; AUTOPHAGY; BACTERIAL INFECTIONS; CROHN DISEASE; HUMANS; IMMUNITY; INFLAMMATION; NEOPLASMS;

BACTERIA (MICROORGANISMS);

EID: 77954754620     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652410791608252     Document Type: Article

References (142)

1. Jess, T., Riis, L., Vind, I., Winther, K.V., Borg, S., Binder, V., Langholz, E., Thomsen, O.O. and Munkholm, P. (2007) Inflamm. Bowel Dis., 13, 481-489.
2. Stone, M., Mayberry, J. and Baker, R. (2003) Eur. J. Gastroenterol. Hepatol., 15, 1275-1280.
3. Bernstein, C.N., Blanchard, J.F., Kliewer, E. and Wajda, A. (2001) Cancer, 91, 854-862.
4. Jess, T., Riis, L., Jespersgaard, C., Hougs, L., Andersen, P.S., Orholm, M.K., Binder, V. and Munkholm, P. (2005) Am. J. Gastroenterol., 100, 2486-2492.
5. Baumgart, D.C. and Sandborn, W.J. (2007) Lancet, 369, 1641-1657.
6. [6] Hugot, J.P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J.P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C.A., Gassull, M., Binder, V., Finkel, Y., Cortot, A., Modigliani, R., Laurent-Puig, P., Gower-Rousseau, C., Macry, J., Colombel, J.F., Sahbatou, M. and Thomas, G. (2001) Nature, 411, 599-603.
7. Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R.H., Achkar, J.P., Brant, S.R., Bayless, T.M., Kirschner, B.S., Hanauer, S.B., Nunez, G. and Cho, J.H. (2001) Nature, 411, 603-606.
8. Hampe, J., Cuthbert, A., Croucher, P.J., Mirza, M.M., Mascheretti, S., Fisher, S.A., Frenzel, H., King, K., Hasselmeyer, A., MacPherson, A.J., Bridger, S., van Deventer, S., Forbes, A., Nikolaus, S., Lennard-Jones, J.E., Foelsch, U.R., Krawczak, M., Lewis, C., Schreiber, S. and Mathew, C.G. (2001) Lancet, 357, 1925-1928.
9. [9] Bonen, D.K., Ogura, Y., Nicolae, D.L., Inohara, N., Saab, L., Tanabe, T., Chen, F.F., Foster, S.J., Duerr, R.H., Brant, S.R., Cho, J.H. and Nunez, G. (2003) Gastroenterology, 124, 140-146.
10. Girardin, S.E., Boneca, I.G., Viala, J., Chamaillard, M., Labigne, A., Thomas, G., Philpott, D.J. and Sansonetti, P.J. (2003) J. Biol. Chem., 278, 8869-8872.
11. Halfvarson, J., Bresso, F., D'Amato, M., Jarnerot, G., Pettersson, S. and Tysk, C. (2005) Dig. Liver Dis., 37, 768-772.
12. Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A., Dassopoulos, T., Bitton, A., Yang, H., Targan, S., Datta, L.W., Kistner, E.O., Schumm, L.P., Lee, A.T., Gregersen, P.K., Barmada, M.M., Rotter, J.I., Nicolae, D.L. and Cho, J.H. (2006) Science, 314, 1461-1463.
13. Kugathasan, S., Baldassano, R., Bradfield, J., Sleiman, P., Imielinski, M., Guthery, S., Cucchiara, S., Kim, C., Frackelton, E., Annaiah, K., Glessner, J., Santa, E., Willson, T., Eckert, A., Bonkowski, E., Shaner, J., Smith, R., Otieno, F., Peterson, N., Abrams, D., Chiavacci, R., Grundmeier, R., Mamula, P., Tomer, G., Piccoli, D., Monos, D., Annese, V., Denson, L., Grant, S. and Hakonarson, H. (2008) Nat. Genet., 40, 1211-1215.
14. Hampe, J., Franke, A., Rosenstiel, P., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., De La Vega, F.M., Briggs, J., Gunther, S., Prescott, N.J., Onnie, C.M., Hasler, R., Sipos, B., Folsch, U.R., Lengauer, T., Platzer, M., Mathew, C.G., Krawczak, M. and Schreiber, S. (2007) Nat. Genet., 39, 207-211.
15. Rioux, J.D., Xavier, R.J., Taylor, K.D., Silverberg, M.S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M.M., Datta, L.W., Shugart, Y.Y., Griffiths, A.M., Targan, S.R., Ippoliti, A.F., Bernard, E.J., Mei, L., Nicolae, D.L., Regueiro, M., Schumm, L.P., Steinhart, A.H., Rotter, J.I., Duerr, R.H., Cho, J.H., Daly, M.J. and Brant, S.R. (2007) Nat. Genet., 39, 596-604.
16. Wellcome Trust Case Control Consortium. (2007) Nature, 447, 661-678.
17. Libioulle, C., Louis, E., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D., Vermeire, S., Dewit, O., de Vos, M., Dixon, A., Demarche, B., Gut, I., Heath, S., Foglio, M., Liang, L., Laukens, D., Mni, M., Zelenika, D., Van Gossum, A., Rutgeerts, P., Belaiche, J., Lathrop, M. and Georges, M. (2007) PLoS. Genet, 3, e58.
18. Parkes, M., Barrett, J.C., Prescott, N.J., Tremelling, M., Anderson, C.A., Fisher, S.A., Roberts, R.G., Nimmo, E.R., Cummings, F.R., Soars, D., Drummond, H., Lees, C.W.,Khawaja, S.A., Bagnall, R., Burke, D.A., Todhunter, C.E., Ahmad, T., Onnie, C.M., McArdle, W., Strachan, D., Bethel, G., Bryan, C., Lewis, C.M., Deloukas, P., Forbes, A., Sanderson, J., Jewell, D.P., Satsangi, J., Mansfield, J.C., Cardon, L. and Mathew, C.G. (2007) Nat. Genet., 39, 830-832.
19. Raelson, J., Little, R., Ruether, A., Fournier, H., Paquin, B., Van Eerdewegh, P., Bradley, W., Croteau, P., Nguyen-Huu, Q., Segal, J., Debrus, S., Allard, R., Rosenstiel, P., Franke, A., Jacobs, G., Nikolaus, S., Vidal, J., Szego, P., Laplante, N., Clark, H., Paulussen, R., Hooper, J., Keith, T., Belouchi, A. and Schreiber, S. (2007) Proc. Natl. Acad. Sci. USA, 104, 14747-14752.
20. Yamazaki, K., McGovern, D., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D., Cardon, L., Takazoe, M., Tanaka, T., Ichimori, T., Saito, S., Sekine, A., Iida, A., Takahashi, A., Tsunoda, T., Lathrop, M. and Nakamura, Y. (2005) Hum. Mol. Genet., 14, 3499-3506.
21. Wang, K., Zhang, H., Kugathasan, S., Annese, V., Bradfield, J., Russell, R., Sleiman, P., Imielinski, M., Glessner, J., Hou, C., Wilson, D., Walters, T., Kim, C., Frackelton, E., Lionetti, P., Barabino, A., Van Limbergen, J., Guthery, S., Denson, L., Piccoli, D., Li, M., Dubinsky, M., Silverberg, M., Griffiths, A., Grant, S., Satsangi, J., Baldassano, R. and Hakonarson, H. (2009) Am. J. Hum. Genet., 84, 399-405.
22. Zhernakova, A., Festen, E., Franke, L., Trynka, G., van Diemen, C., Monsuur, A., Bevova, M., Nijmeijer, R., van 't Slot, R., Heijmans, R., Boezen, H., van Heel, D., van Bodegraven, A., Stokkers, P., Wijmenga, C., Crusius, J. and Weersma, R. (2008) Am. J. Hum. Genet., 82, 1202-1210.
23. Barrett, J.C., Hansoul, S., Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada, MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, RJ; X., NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, E;, L., Consortium;, B.-F.I., Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M and Daly, M. (2008) Nat. Genet., 40, 955-962.
24. Fisher, S.A., Tremelling, M., Anderson, C.A., Gwilliam, R., Bumpstead, S., Prescott, N.J., Nimmo, E.R., Massey, D., Berzuini, C., Johnson, C., Barrett, J.C., Cummings, F.R., Drummond, H. and Lees, C.W. (2008) Nat. Genet., 40, 710-712.
25. Franke, A., Balschun, T., Karlsen, T.H., Hedderich, J., May, S., Lu, T., Schuldt, D., Nikolaus, S., Rosenstiel, P., Krawczak, M. and Schreiber, S. (2008) Nat. Genet., 40, 713-715.
26. Zhi, J., Zhi, F.C., Chen, Z.Y., Yao, G.P., Guan, J., Lin, Y. and Zhang, Y.C. (2008) Nan. Fang. Yi. Ke. Da. Xue. Xue. Bao., 28, 649-651.
27. Zhang, H.F., Qiu, L.X., Chen, Y., Zhu, W.L., Mao, C., Zhu, L.G., Zheng, M.H., Wang, Y., Lei, L. and Shi, J. (2009) Hum. Genet., 125, 627-631.
28. Perricone, C., Borgiani, P., Romano, S., Ciccacci, C., Fusco, G., Novelli, G., Biancone, L., Calabrese, E. and Pallone, F. (2008) Gastroenterology, 134, 368-370.
29. Latiano, A., Palmieri, O., Valvano, M.R., D'Incà, R., Cucchiara, S., Riegler, G., Staiano, A.M., Ardizzone, S., Accomando, S., de Angelis, G.L., Corritore, G., Bossa, F. and Annese, V. (2008) World J. Gastroenterol., 14, 4643-4651.
30. Yamazaki, K., Onouchi, Y., Takazoe, M., Kubo, M., Nakamura, Y. and Hata, A. (2007) J. Hum. Genet., 52, 575-583.
31. Baptista, M.L., Amarante, H., Picheth, G., Sdepanian, V.L., Peterson, N., Babasukumar, U., Lima, H.C. and Kugathasan, S. (2008) Inflamm. Bowel Dis., 14, 674-679. 500 Current Molecular Medicine, 2010, Vol. 10, No. 5
32. McCarroll, S.A., Huett, A., Kuballa, P., Chilewski, S.D., Landry, A., Goyette, P., Zody, M.C., Hall, J.L., Brant, S.R., Cho, J.H., Duerr, R.H., Silverberg, M.S., Taylor, K.D., Rioux, J.D., Altshuler, D., Daly, M.J. and Xavier, R.J. (2008) Nat. Genet., 40, 1107-1112.
33. Roberts, R.L., Hollis-Moffatt, J.E., Gearry, R.B., Kennedy, M.A., Barclay, M.L. and Merriman, T.R. (2008) Genes Immun., 9, 561-565.
34. Cummings, J.R., Cooney, R., Pathan, S., Anderson, C.A., Barrett, J.C., Beckly, J., Geremia, A., Hancock, L., Guo, C., Ahmad, T., Cardon, L. and Jewell, D.P. (2007) Inflamm. Bowel Dis., 13, 941-946.
35. Levine, B. and Kroemer, G. (2008) Cell, 132, 27-42.
36. Hait, W.N., Jin, S. and Yang, J.M. (2006) Clin. Cancer Res., 12, 1961-1965.
37. Klionsky, D.J. and Emr, S.D. (2000) Science, 290, 1717-1721.
38. Kirkegaard, K., Taylor, M.P. and Jackson, W.T. (2004) Nat. Rev. Microbiol., 2, 301-314.
39. Levine, B. (2005) Cell, 120, 159-162.
40. Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T. and Akira, S. (2008) Nature, 456, 264-268.
41. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T. and Mizushima, N. (2004) Nature, 432, 1032-1036.
42. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K. and Chiba, T. (2005) J. Cell Biol., 169, 425-434.
43. Kuballa, P., Huett, A., Rioux, J.D., Daly, M.J. and Xavier, R.J. (2008) PLoS ONE, 3, e3391.
44. Singh, S.B., Davis, A.S., Taylor, G.A. and Deretic, V. (2006) Science, 313, 1438-1441.
45. Feng, C.G., Collazo-Custodio, C.M., Eckhaus, M., Hieny, S., Belkaid, Y., Elkins, K., Jankovic, D., Taylor, G.A. and Sher, A. (2004) J. Immunol., 172, 1163-1168.
46. Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S. and Yoshimori, T. (2004) Science, 306, 1037-1040.
47. Rich, K.A., Burkett, C. and Webster, P. (2003) Cell Microbiol., 5, 455-468.
48. [48] Cossart, P. and Sansonetti, P.J. (2004) Science, 304, 242-248.
49. Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I. and Deretic, V. (2004) Cell, 119, 753-766.
50. Alonso, S., Pethe, K., Russell, D.G. and Purdy, G.E. (2007) Proc. Natl. Acad. Sci. USA, 104, 6031-6036.
51. Gutierrez, M.G., Saka, H.A., Chinen, I., Zoppino, F.C., Yoshimori, T., Bocco, J.L. and Colombo, M.I. (2007) Proc. Natl. Acad. Sci. USA, 104, 1829-1834.
52. Taylor, G.A., Feng, C.G. and Sher, A. (2004) Nat. Rev. Immunol., 4, 100-109.
53. Boehm, U., Guethlein, L., Klamp, T., Ozbek, K., Schaub, A., Fütterer, A., Pfeffer, K. and Howard, J.C. (1998) J. Immunol., 161, 6715-6723.
54. Taylor, G.A., Jeffers, M., Largaespada, D.A., Jenkins, N.A., Copeland, N.G. and Woude, G.F. (1996) J. Biol. Chem., 271, 20399-20405.
55. Uthaiah, R., Praefcke, G.J.M., Howard, J.C. and Herrmann, C. (2003) J. Biol. Chem., 278, 29336-29343.
56. Hunn, J.P., Koenen-Waisman, S., Papic, N., Schroeder, N., Pawlowski, N., Lange, R., Kaiser, F., Zerrahn, J., Martens, S. and Howard, J.C. (2008) EMBO J., 27, 2495-2509.
57. Martens, S., Parvanova, I., Zerrahn, J., Griffiths, G., Schell, G., Reichmann, G. and Howard, J.C. (2005) PLoS. Pathog., 1, e24.
58. Taylor, G.A., Stauber, R., Rulong, S., Hudson, E., Pei, V., Pavlakis, G.N., Resau, J.H. and Vande Woude, G.F. (1997) J. Biol. Chem., 272, 10639-10645.
59. [59] Martens, S., Sabel, K., Lange, R., Uthaiah, R., Wolf, E. and Howard, J.C. (2004) J. Immunol., 173, 2594-2606.
60. MacMicking, J., Taylor, G.A. and McKinney, J. (2003) Science, 302 654-659.
61. Ling, Y.M., Shaw, M.H., Ayala, C., Coppens, I., Taylor, G.A., Ferguson, D.J. and Yap, G.S. (2006) J. Exp. Med., 203, 2063-2071.
62. Kuma, A., Mizushima, N., Ishihara, N. and Ohsumi, Y. (2002) J. Biol. Chem., 277, 18619-18625.
63. Mizushima, N., Noda T and Ohsumi, Y. (1999) EMBO J., 18, 3888-3896.
64. Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y. and Yoshimori, T. (2003) J. Cell Sci., 116, 1679-1688.
65. Fujita, N., Itoh, T., Fukuda, M., Noda, T. and Yoshimori, T. (2008) Mol. Biol. Cell, 19, 2092-2100.
66. Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Loh, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., Stone, C.D., Brunt, E.M., Xavier, R.J., Sleckman, B.P., Li, E., Mizushima, N., Stappenbeck, T.S. and Virgin 4th, H.W. (2008) Nature, 456, 259-263.
67. Fujita, N., Saitoh, T., Kageyama, S., Akira, S., Noda, T. and Yoshimori, T. (2009) J. Biol. Chem [Epub ahead of print]
68. Okazaki, T., Wang, M.H., Rawsthorne, P., Sargent, M., Datta, L.W., Shugart, Y.Y., Bernstein, C.N. and Brant, S.R. (2008) Inflamm. Bowel Dis., 14, 1528-1541.
69. Crotzer, V.L. and Blum, J.S. (2005) Proc. Natl. Acad. Sci. USA, 102, 7779-7780.
70. Dengjel, J., Schoor, O., Fischer, R., Reich, M., Kraus, M., Muller, M., Kreymborg, K., Altenberend, F., Brandenburg, J., Kalbacher, H., Brock, R., Driessen, C., Rammensee, H.G. and Stevanovic, S. (2005) Proc. Natl. Acad. Sci. USA, 102, 7922-7927.
71. [71] Dorfel, D., Appel, S., Grunebach, F., Weck, M.M., Muller, M.R., Heine, A. and Brossart, P. (2005) Blood, 105, 3199-3205.
72. [72] Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T. and Münz, C. (2005) Science, 307, 593-596.
73. Schmid, D., Pypaert, M. and Münz, C. (2007) Immunity, 26, 79-92.
74. Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S.C., Jin, S. and Lu, B. (2006) J. Immunol., 177, 5163-5168.
75. Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N. and He, Y.W. (2007) J. Exp. Med., 204, 25-31.
76. Feng, C.G., Zheng, L., Jankovic, D., Báfica, A., Cannons, J.L., Watford, W.T., Chaussabel, D., Hieny, S., Caspar, P., Schwartzberg, P.L., Lenardo, M.J. and Sher, A. (2008) Nat. Immunol., 9, 1279-1287.
77. Feng, C.G., Weksberg, D.C., Taylor, G.A., Sher, A. and Goodell, M.A. (2008) Cell Stem Cell, 2, 83-89.
78. Santiago, H.C., Feng, C.G., Bafica, A., Roffe, E., Arantes, R.M., Cheever, A., Taylor, G., Vierira, L.Q., Aliberti, J., Gazzinelli, R.T. and Sher, A. (2005) J. Immunol., 175, 8165-8172.
79. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. and Ohsumi, Y. (2004) Mol. Biol. Cell, 15, 1101-1111.
80. Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N. and Klein, L. (2008) Nature, 455, 396-400.
81. [81] Xu, Y., Jagannath, C., Liu, X.D., Sharafkhaneh, A., Kolodziejska, K.E. and Eissa, N.T. (2007) Immunity, 27, 135-144.
82. Andrade, R.M., Wessendarp, M., Gubbels, M.J., Striepen, B. and Subauste, C.S. (2006) J. Clin. Invest., 116, 2366-2377.
83. Djavaheri-Mergny, M., Amelotti, M., Mathieu, J., Besancon, F., Bauvy, C., Souquere, S., Pierron, G. and Codogno, P. (2006) J. Biol. Chem., 281, 30373-30382.
84. Jia, G., Cheng, G., Gangahar, D.M. and Agrawal, D.K. (2006) Immunol. Cell Biol., 84, 448-454.
85. Mills, K.R., Reginato, M., Debnath, J., Queenan, B. and Brugge, J.S. (2004) Proc. Natl. Acad. Sci. USA, 101, 3438-3443.
86. Subauste, C.S., Andrade, R.M. and Wessendarp, M. (2007) Autophagy, 3, 245-248
87. Thorburn, J., Moore, F., Rao, A., Barclay, W.W., Thomas, L.R., Grant, K.W., Cramer, S.D. and Thorburn, A. (2005) Mol. Biol. Cell., 16, 1189-1199.
88. Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P.F., Meijer, A.J., Codogno, P. and Ogier-Denis, E. (2001) J. Biol. Chem., 276, 35243-35246.
89. Petiot, A., Ogier-Denis, E., Blommaart, E.F., Meijer, A.J. and Codogno, P. (2000) J. Biol. Chem., 275, 992-998.
90. Wright, K., Ward, S.G., Kolios, G. and Westwick, J. (1997) J. Biol. Chem., 272, 12626-12633.
91. [91] Harris, J., De Haro, S.A., Master, S.S., Keane, J., Roberts, E.A., Delgado, M. and Deretic, V. (2007) Immunity, 27, 505-517.
92. Maderna, P. and Godson, C. (2003) Biochim. Biophys. Acta, 1639, 141-151.
93. Qu, X., Zou, Z., Sun, Q., Luby-Phelps, K., Cheng, P., Hogan, R.N., Gilpin, C. and Levine, B. (2007) Cell, 128, 931-946.
94. Huang, J., Canadien, V., Lam, G.Y., Steinberg, B.E., Dinauer, M.C., Magalhaes, M.A., Glogauer, M., Grinstein, S. and Brumell, J.H. (2009) Proc. Natl. Acad. Sci. USA, 106, 6226-6231.
95. Scherz-Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L. and Elazar, Z. (2007) EMBO J., 26, 1749-1760.
96. Bafica, A., Feng, C.G., Santiago, H.C., Aliberti, J., Cheever, A., Thomas, K.E., Taylor, G.A., Vogel, S.N. and Sher, A. (2007) J. Immunol., 179, 5514-5522.
97. Miyairi, I., Tatireddigari, V.R., Mahdi, O.S., Rose, L.A., Belland, R.J., Lu, L., Williams, R.W. and Byrne, G.I. (2007) J. Immunol., 179, 1814-1824.
98. Henry, S.C., Daniell, X., Indaram, M., Whitesides, J.F., Sempowski, G.D., Howell, D., Oliver, T. and Taylor, G.A. (2007) J. Immunol., 179, 6963-6972.
99. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J. and Thun, M.J. (2007) CA Cancer J. Clin., 57, 43-66.
100. Boyle, P. and Ferlay, J. (2005) Nat. Clin. Pract. Oncol., 2, 424-425.
101. Hippert, M.M., O'toole, P.S. and Thorburn, A. (2006) Cancer Res., 66, 9349-9351.
102. Lee, J.W., Jeong, E.G., Lee, S.H., Yoo, N.J. and Lee, S.H. (2007) APMIS., 115, 750-756.
103. Kang, M.R., Kim, M.S., Oh, J.E., Kim, Y.R., Song, S.Y., Kim, S.S., Ahn, C.H., Yoo, N.J. and Lee, S.H. (2009) J. Pathol., 217, 702-706.
104. Liang, C., Feng, P., Ku, B., Dotan, I., Canaani, D., Oh, B.H. and Jung, J.U. (2006) Nat. Cell Biol., 8, 688-699.
105. Kim, M.S., Jeong, E.G., Ahn, C.H., Kim, S.S., Lee, S.H. and Yoo, N.J. (2008) Hum. Pathol., 39 1059-1063.
106. Yoshioka, A., Miyata, H., Doki, Y., Yamasaki, M., Sohma, I., Gotoh, K., Takiguchi, S., Fujiwara, Y., Uchiyama, Y. and Monden, M. (2008) Int. J. Oncol., 33, 461-468.
107. Ahn, C.H., Jeong, E.G., Lee, J.W., Kim, M.S., Kim, S.H., Kim, S.S., Yoo, N.J. and Lee, S.H. (2007) APMIS., 115 1344-1349.
108. Li, B.X., Li, C.Y., Peng, R.Q., Wu, X.J., Wang, H.Y., Wan, D.S., Zhu, X.F. and Zhang, X.S. (2009) Autophagy, 5, 303-306.
109. Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gelinas, C., Fan, Y., Nelson, D.A., Jin, S. and White, E. (2006) Cancer Cell, 10, 51-64.
110. Sato, K., Tsuchihara, K., Fujii, S., Sugiyama, M., Goya, T., Atomi, Y., Ueno, T., Ochiai, A. and Esumi, H. (2007) Cancer Res., 67, 9677-9684.
111. Fung, C., Lock, R., Gao, S., Salas, E. and Debnath, J. (2008) Mol. Biol. Cell., 19, 797-806.
112. Li, J., Hou, N., Faried, A., Tsutsumi, S., Takeuchi, T. and Kuwano, H. (2009) Ann. Surg. Oncol., 16, 761-771.
113. Trincheri, N.F., Follo, C., Nicotra, G., Peracchio, C., Castino, R. and Isidoro, C. (2008) Carcinogenesis, 29, 381-389.
114. Comes, F., Matrone, A., Lastella, P., Nico, B., Susca, F.C., Bagnulo, R., Ingravallo, G., Modica, S., Lo Sasso, G., Moschetta, A., Guanti, G. and Simone, C. (2007) Cell Death Differ., 14, 693-702.
115. Ellington, A.A., Berhow, M.A. and Singletary, K.W. (2006) Carcinogenesis, 27, 298-306.
116. Nomura, H., Uzawa, K., Yamano, Y., Fushimi, K., Ishigami, T., Kouzu, Y., Koike, H., Siiba, M., Bukawa, H., Yokoe, H., Kubosawa, H. and Tanzawa, H. (2009) Hum. Pathol., 40, 83-91.
117. Darfeuille-Michaud, A. (2002) Int. J. Med. Microbiol., 292, 185-193.
118. Bekpen, C., Hunn, J.P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, M., Glowalla, E., Leptin, M. and Howard, J.C. (2005) Genome Biol., 6, R92.
119. Zheng, H., Ji, C., Li, J., Jiang, H., Ren, M., Lu, Q., Gu, S., Mao, Y. and Xie, Y. (2004) DNA Seq., 15, 303-305.
120. Chen, Z.H., Kim, H.P., Sciurba, F.C., Lee, S.J., Feghali-Bostwick, C., Stolz, D.B., Dhir, R., Landreneau, R.J.,Schuchert, M.J., Yousem, S.A., Nakahira, K., Pilewski, J.M.,Lee, J.S., Zhang, Y., Ryter, S.W. and Choi, A.M.(2008) PLoS One, 3, e3316.
121. Fowler, E.V., Doecke, J., Simms, L.A., Zhao, Z.Z., Webb, P.M., Hayward, N.K., Whiteman, D.C., Florin, T.H., Montgomery, G.W., Cavanaugh, J.A. and Radford-Smith, G.L. (2008) Am. J. Gastroenterol., 103, 2519-2526.
122. Gutierrez, M.G., Vazquez, C.L., Munafo, D.B., Zoppino, F.C., Beron, W., Rabinovitch, M. and Colombo, M.I. (2005) Cell Microbiol., 7, 981-993.
123. Weersma, R.K., Stokkers, P.C., van Bodegraven, A.A., van Hogezand, R.A., Verspaget, H.W., de Jong, D.J., van der Woude, C.J., Oldenburg, B., Linskens, R.K., Festen, E., van der Steege, G., Hommes, D.W., Crusius, J.B., Wijmenga, C., Nolte, I.M., Dijkstra, G. and Dutch Initiative on Crohn and Colitis, I.C.C. (2009) Gut, 58, 388-395.
124. Baert, F., Noman, M., Vermeire, S., Van Assche, G., D'Haens, G., Carbonez, A. and Rutgeerts, P. (2003) N. Engl. J. Med., 348, 601-608.
125. Cosnes, J., Nion-Larmurier, I., Beaugerie, L., Afchain, P., Tiret, E. and Gendre, J.P. (2005) Gut, 54, 237-241.
126. Webster, A.C., Lee, V.W., Chapman, J.R. and Craig, J.C. (2006) Transplantation, 81, 1234-1248.
127. Matsuda, C., Ito, T., Song, J., Mizushima, T., Tamagawa, H., Kai, Y., Hamanaka, Y., Inoue, M., Nishida, T., Matsuda, H. and Sawa, Y. (2007) Clin. Exp. Immunol., 148, 348-359.
128. Dumortier, J., Lapalus, M., Guillaud, O., Poncet, G., Gagnieu, M., Partensky, C. and Scoazec, J. (2008) Inflamm. Bowel Dis., 14, 874-877.
129. Massey, D.C., Bredin, F. and Parkes, M. (2008) Gut, 57, 1294-1296.
130. Zhu, J., Wu, J., Frizell, E., Liu, S.L., Bashey, R., Rubin, R., Norton, P. and Zern, M.A. (1999) Gastroenterology, 117, 1198-1204.
131. Reinisch, W., Panés, J., Lémann, M., Schreiber, S., Feagan, B., Schmidt, S., Sturniolo, G., Mikhailova, T., Alexeeva, O., Sanna, L., Haas, T., Korom, S. and Mayer, H. (2008) Am. J. Gastroenterol., 103, 2284-2292.
132. Kahan, B.D., Yakupoglu, Y.K., Schoenberg, L., Knight, R.J., Katz, S.M., Lai, D. and Van Buren, C.T. (2005) Transplantation, 80, 749-758.
133. Peterson, N., Guthery, S., Denson, L., Lee, J., Saeed, S., Prahalad, S., Biank, V., Ehlert, R., Tomer, G., Grand, R., Rudolph, C. and Kugathasan, S. (2008) Gut, 57, 1336-1337.
134. Baldassano, R.N., Bradfield, J.P., Monos, D.S., Kim, C.E., Glessner, J.T., Casalunovo, T., Frackelton, E.C., Otieno, F.G., Kanterakis, S., Shaner, J.L., Smith, R.M., Eckert, A.W., Robinson, L.J., Onyiah, C.C., Abrams, D.J., Chiavacci, R.M., Skraban, R., Devoto, M., Grant, S.F. and Hakonarson, H. (2007) Gut, 56, 1171-1173.
135. Prescott, N.J., Fisher, S.A., Franke, A., Hampe, J., Onnie, C.M., Soars, D., Bagnall, R., Mirza, M.M., Sanderson, J., Forbes, A., Mansfield, J.C., Lewis, C.M., Schreiber, S. and Mathew, C.G. (2007) Gastroenterology, 132, 1665-1671.
136. Hancock, L., Beckly, J., Geremia, A., Cooney, R., Cummings, F.R., Pathan, S., Guo, C., Warren, B.F., Mortensen, N., Ahmad T and Jewell, D. (2008) Inflamm. Bowel Dis., 14, 1667-1677
137. Van Limbergen, J., Russell, R.K., Nimmo, E.R., Drummond, H.E., Smith, L., Anderson, N.H., Davies, G., Gillett, P.M., McGrogan, P., Weaver, L.T., Bisset, W.M., Mahdi, G., Arnott, I.D., Wilson, D.C. and Satsangi, J. (2008) Inflamm. Bowel Dis., 14, 338-346.
138. Glas, J., Konrad, A., Schmechel, S., Dambacher, J., Seiderer, J., Schroff, F., Wetzke, M., Roeske, D., Török, H.P., Tonenchi, L., Pfennig, S., Haller, D., Griga, T., Klein, W., Epplen, J.T., Folwaczny, C., Lohse, P., Göke, B., Ochsenkühn, T., Mussack, T., Folwaczny, M., Müller- Myhsok, B. and Brand, S. (2008) Am. J. Gastroenterol., 103, 682-691.
139. [139] Weersma, R.K., Zhernakova, A., Nolte, I.M., Lefebvre, C., Rioux, J.D., Mulder, F., van Dullemen, H.M., Kleibeuker J.H., Wijmenga, C. and Dijkstra, G. (2008) Am. J. Gastroenterol., 103, 621-627.
140. Gaj, P., Habior, A., Mikula, M. and Ostrowski, J. (2008) BMC Med.Genet., 9, 81.
141. Lakatos, P.L., Szamosi, T., Szilvasi, A., Molnar, E., Lakatos, L., Kovacs, A., Molnar, T., Altorjay, I., Papp, M., Tulassay, Z, Miheller, P., Papp, J., The Hungarian IBD Study Group, Tordai, A. and Andrikovics, H. (2008) Dig. Liver Dis., 40, 867-873.
142. Roberts, R.L., Gearry, R.B., Hollis-Moffatt, J.E., Miller, A.L., Reid, J., Abkevich, V., Timms, K.M., Gutin, A., Lanchbury, J.S., Merriman, T.R., Barclay, M.L. and Kennedy, M.A. (2007) Am. J. Gastroenterol., 102, 2754-2761.