AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Nature Cell Biology

Volumn 17, Issue 1, 2015, Pages 20-30

  Cianfanelli, Valentina ^a,b   Fuoco, Claudia ^c   Lorente, Mar ^d,e   Salazar, Maria ^d,e,l   Quondamatteo, Fabio ^f   Gherardini, Pier Federico ^c,m   De Zio, Daniela ^a   Nazio, Francesca ^b   Antonioli, Manuela ^c,g   D'Orazio, Melania ^c   Skobo, Tatjana ^h   Bordi, Matteo ^b   Rohde, Mikkel ^a   Dalla Valle, Luisa ^h   Helmer Citterich, Manuela ^c   Gretzmeier, Christine ^i,j   Dengjel, Joern ^i,j   Fimia, Gian Maria ^g,k   Piacentini, Mauro ^c,g   Di Bartolomeo, Sabrina ^c   Velasco, Guillermo ^d,e   Cecconi, Francesco ^a,b,c   more..

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b Post Coma Unit and Headache Center   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^f NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^g NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^h UNIVERSITY OF PADOVA   (Italy)

ⁱ UNIVERSITY OF FREIBURG   (Germany)

^j UNIVERSITY OF FREIBURG   (Germany)

^k UNIVERSITY OF SALENTO   (Italy)

^l Centro Nacional de Investigaciones Oncológicas   (Spain)

^m STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN AMBRA1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; AMBRA1 PROTEIN, HUMAN; AMBRA1 PROTEIN, MOUSE; MTOR PROTEIN, HUMAN; MYC PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARCINOGENESIS; CELL DIVISION; CELL PROLIFERATION; DOWNSTREAM PROCESSING; EMBRYO; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL TRANSFORMATION; GENETICS; HAPLOINSUFFICIENCY; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE; ZEBRA FISH;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; CELL DIVISION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENES, TUMOR SUPPRESSOR; HAPLOINSUFFICIENCY; HEK293 CELLS; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES; ZEBRAFISH;

EID: 84926145894     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3072     Document Type: Article

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