-
2
-
-
34447314728
-
MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
-
Kaina B, Christmann M, Naumann S, Roos WP, (2007) MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst) 6: 1079-1099.
-
(2007)
DNA Repair (Amst)
, vol.6
, pp. 1079-1099
-
-
Kaina, B.1
Christmann, M.2
Naumann, S.3
Roos, W.P.4
-
3
-
-
0027502938
-
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
-
Branch P, Aquilina G, Bignami M, Karran P, (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 362: 652-654.
-
(1993)
Nature
, vol.362
, pp. 652-654
-
-
Branch, P.1
Aquilina, G.2
Bignami, M.3
Karran, P.4
-
4
-
-
4944242445
-
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system
-
Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, et al. (2004) DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Mol Pharmacol 66: 478-491.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 478-491
-
-
Caporali, S.1
Falcinelli, S.2
Starace, G.3
Russo, M.T.4
Bonmassar, E.5
-
5
-
-
74549186666
-
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles
-
Quiros S, Roos WP, Kaina B, (2010) Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles. Cell Cycle 9: 168-178.
-
(2010)
Cell Cycle
, vol.9
, pp. 168-178
-
-
Quiros, S.1
Roos, W.P.2
Kaina, B.3
-
6
-
-
0034667383
-
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
-
Ochs K, Kaina B, (2000) Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res 60: 5815-5824.
-
(2000)
Cancer Res
, vol.60
, pp. 5815-5824
-
-
Ochs, K.1
Kaina, B.2
-
7
-
-
33846252663
-
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
-
Roos WP, Batista LF, Naumann SC, Wick W, Weller M, et al. (2007) Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 26: 186-197.
-
(2007)
Oncogene
, vol.26
, pp. 186-197
-
-
Roos, W.P.1
Batista, L.F.2
Naumann, S.C.3
Wick, W.4
Weller, M.5
-
8
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, et al. (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11: 448-457.
-
(2004)
Cell Death Differ
, vol.11
, pp. 448-457
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
-
9
-
-
79956220703
-
DNA damage and autophagy
-
Rodriguez-Rocha H, Garcia-Garcia A, Panayiotidis MI, Franco R, (2011) DNA damage and autophagy. Mutat Res 711: 158-166.
-
(2011)
Mutat Res
, vol.711
, pp. 158-166
-
-
Rodriguez-Rocha, H.1
Garcia-Garcia, A.2
Panayiotidis, M.I.3
Franco, R.4
-
10
-
-
79956095420
-
Autophagosome formation and molecular mechanism of autophagy
-
Tanida I, (2011) Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal 14: 2201-2214.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 2201-2214
-
-
Tanida, I.1
-
11
-
-
67549142261
-
Life and death partners: apoptosis, autophagy and the cross-talk between them
-
Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A, (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 16: 966-975.
-
(2009)
Cell Death Differ
, vol.16
, pp. 966-975
-
-
Eisenberg-Lerner, A.1
Bialik, S.2
Simon, H.U.3
Kimchi, A.4
-
12
-
-
33845338765
-
Cellular senescence and cancer treatment
-
Schmitt CA, (2007) Cellular senescence and cancer treatment. Biochim Biophys Acta 1775: 5-20.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 5-20
-
-
Schmitt, C.A.1
-
13
-
-
0037428798
-
Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids
-
Gunther W, Pawlak E, Damasceno R, Arnold H, Terzis AJ, (2003) Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids. Br J Cancer 88: 463-469.
-
(2003)
Br J Cancer
, vol.88
, pp. 463-469
-
-
Gunther, W.1
Pawlak, E.2
Damasceno, R.3
Arnold, H.4
Terzis, A.J.5
-
14
-
-
84856233300
-
Balancing repair and tolerance of DNA damage caused by alkylating agents
-
Fu D, Calvo JA, Samson LD, (2012) Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12: 104-120.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 104-120
-
-
Fu, D.1
Calvo, J.A.2
Samson, L.D.3
-
15
-
-
0035231422
-
BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis
-
Kaina B, Ochs K, Grosch S, Fritz G, Lips J, et al. (2001) BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Prog Nucleic Acid Res Mol Biol 68: 41-54.
-
(2001)
Prog Nucleic Acid Res Mol Biol
, vol.68
, pp. 41-54
-
-
Kaina, B.1
Ochs, K.2
Grosch, S.3
Fritz, G.4
Lips, J.5
-
16
-
-
80355123699
-
Rad51 and BRCA2-New molecular targets for sensitizing glioma cells to alkylating anticancer drugs
-
Quiros S, Roos WP, Kaina B, (2011) Rad51 and BRCA2-New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. PLoS One 6: e27183.
-
(2011)
PLoS One
, vol.6
-
-
Quiros, S.1
Roos, W.P.2
Kaina, B.3
-
17
-
-
77953523665
-
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome
-
Sage JM, Gildemeister OS, Knight KL, (2010) Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem 285: 18984-18990.
-
(2010)
J Biol Chem
, vol.285
, pp. 18984-18990
-
-
Sage, J.M.1
Gildemeister, O.S.2
Knight, K.L.3
-
18
-
-
0005677775
-
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
-
Seglen PO, Gordon PB, (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79: 1889-1892.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gordon, P.B.2
-
19
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92: 9363-9367.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
-
20
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23: 798-803.
-
(2009)
Genes Dev
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
Kirschner, K.4
Sadaie, M.5
-
21
-
-
0033016056
-
Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer
-
Baker SD, Wirth M, Statkevich P, Reidenberg P, Alton K, et al. (1999) Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer. Clin Cancer Res 5: 309-317.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 309-317
-
-
Baker, S.D.1
Wirth, M.2
Statkevich, P.3
Reidenberg, P.4
Alton, K.5
-
22
-
-
0032812622
-
Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies
-
Hammond LA, Eckardt JR, Baker SD, Eckhardt SG, Dugan M, et al. (1999) Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies. J Clin Oncol 17: 2604-2613.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2604-2613
-
-
Hammond, L.A.1
Eckardt, J.R.2
Baker, S.D.3
Eckhardt, S.G.4
Dugan, M.5
-
23
-
-
0031589755
-
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models
-
Kaina B, Ziouta A, Ochs K, Coquerelle T, (1997) Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. Mutat Res 381: 227-241.
-
(1997)
Mutat Res
, vol.381
, pp. 227-241
-
-
Kaina, B.1
Ziouta, A.2
Ochs, K.3
Coquerelle, T.4
-
24
-
-
0032851842
-
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
-
Hickman MJ, Samson LD, (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc Natl Acad Sci U S A 96: 10764-10769.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10764-10769
-
-
Hickman, M.J.1
Samson, L.D.2
-
25
-
-
56549122306
-
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
-
Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, et al. (2009) Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst) 8: 72-86.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 72-86
-
-
Roos, W.P.1
Nikolova, T.2
Quiros, S.3
Naumann, S.C.4
Kiedron, O.5
-
26
-
-
37249019677
-
Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA
-
Mojas N, Lopes M, Jiricny J, (2007) Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev 21: 3342-3355.
-
(2007)
Genes Dev
, vol.21
, pp. 3342-3355
-
-
Mojas, N.1
Lopes, M.2
Jiricny, J.3
-
27
-
-
84862997245
-
DNA damage-induced apoptosis: From specific DNA lesions to the DNA damage response and apoptosis
-
Roos WP, Kaina B, (2012) DNA damage-induced apoptosis: From specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett.
-
(2012)
Cancer Lett
-
-
Roos, W.P.1
Kaina, B.2
-
28
-
-
77749233738
-
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
-
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, et al. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107: 4153-4158.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4153-4158
-
-
Alexander, A.1
Cai, S.L.2
Kim, J.3
Nanez, A.4
Sahin, M.5
-
29
-
-
84855450663
-
Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy
-
Lin CJ, Lee CC, Shih YL, Lin TY, Wang SH, et al. (2012) Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. Free Radic Biol Med 52: 377-391.
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 377-391
-
-
Lin, C.J.1
Lee, C.C.2
Shih, Y.L.3
Lin, T.Y.4
Wang, S.H.5
-
30
-
-
84861062884
-
Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and Temozolomide combined treatments
-
Palumbo S, Pirtoli L, Tini P, Cevenini G, Calderaro F, et al. (2012) Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and Temozolomide combined treatments. J Cell Biochem.
-
(2012)
J Cell Biochem
-
-
Palumbo, S.1
Pirtoli, L.2
Tini, P.3
Cevenini, G.4
Calderaro, F.5
-
31
-
-
79551473364
-
Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway
-
Chen LH, Loong CC, Su TL, Lee YJ, Chu PM, et al. (2011) Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway. Biochem Pharmacol 81: 594-605.
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 594-605
-
-
Chen, L.H.1
Loong, C.C.2
Su, T.L.3
Lee, Y.J.4
Chu, P.M.5
-
32
-
-
0035422203
-
Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells
-
Hirose Y, Berger MS, Pieper RO, (2001) Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res 61: 5843-5849.
-
(2001)
Cancer Res
, vol.61
, pp. 5843-5849
-
-
Hirose, Y.1
Berger, M.S.2
Pieper, R.O.3
-
33
-
-
41549086994
-
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
-
Patschan S, Chen J, Polotskaia A, Mendelev N, Cheng J, et al. (2008) Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. Am J Physiol Heart Circ Physiol 294: H1119-1129.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Patschan, S.1
Chen, J.2
Polotskaia, A.3
Mendelev, N.4
Cheng, J.5
-
34
-
-
84857289515
-
Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
-
Singh K, Matsuyama S, Drazba JA, Almasan A, (2012) Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress. Autophagy 8: 236-251.
-
(2012)
Autophagy
, vol.8
, pp. 236-251
-
-
Singh, K.1
Matsuyama, S.2
Drazba, J.A.3
Almasan, A.4
-
35
-
-
64349105425
-
Eating to exit: autophagy-enabled senescence revealed
-
White E, Lowe SW, (2009) Eating to exit: autophagy-enabled senescence revealed. Genes Dev 23: 784-787.
-
(2009)
Genes Dev
, vol.23
, pp. 784-787
-
-
White, E.1
Lowe, S.W.2
-
36
-
-
33645105856
-
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells
-
Hermisson M, Klumpp A, Wick W, Wischhusen J, Nagel G, et al. (2006) O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem 96: 766-776.
-
(2006)
J Neurochem
, vol.96
, pp. 766-776
-
-
Hermisson, M.1
Klumpp, A.2
Wick, W.3
Wischhusen, J.4
Nagel, G.5
-
37
-
-
1642576969
-
Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines
-
Vasilevskaya IA, Rakitina TV, O'Dwyer PJ, (2004) Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. Mol Pharmacol 65: 235-243.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 235-243
-
-
Vasilevskaya, I.A.1
Rakitina, T.V.2
O'Dwyer, P.J.3
-
38
-
-
58749097764
-
Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53
-
Naumann SC, Roos WP, Jost E, Belohlavek C, Lennerz V, et al. (2009) Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53. Br J Cancer 100: 322-333.
-
(2009)
Br J Cancer
, vol.100
, pp. 322-333
-
-
Naumann, S.C.1
Roos, W.P.2
Jost, E.3
Belohlavek, C.4
Lennerz, V.5
-
39
-
-
74949127989
-
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
-
Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O, (2009) Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 4: 1798-1806.
-
(2009)
Nat Protoc
, vol.4
, pp. 1798-1806
-
-
Debacq-Chainiaux, F.1
Erusalimsky, J.D.2
Campisi, J.3
Toussaint, O.4
-
40
-
-
0009482260
-
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
-
Towbin H, Staehelin T, Gordon J, (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76: 4350-4354.
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, pp. 4350-4354
-
-
Towbin, H.1
Staehelin, T.2
Gordon, J.3
|