Autophagic activity dictates the cellular response to oncogenic RAS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 33, 2012, Pages 13325-13330

  Wang, Yihua ^a   Wang, Xiao Dan ^a,e   Lapi, Eleonora ^a,f   Sullivan, Alexandra ^a,g   Jia, Wei ^b   He, You Wen ^b   Ratnayaka, Indrika ^a   Zhong, Shan ^a   Goldin, Robert D ^c   Goemans, Christoph G ^d   Tolkovsky, Aviva M ^d   Lu, Xin ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CHINESE PLA GENERAL HOSPITAL   (China)

^f IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 16; AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 5; BETA GALACTOSIDASE; CELL PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CARCINOGENICITY; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; SENESCENCE;

ANIMALS; AUTOPHAGY; CELL AGING; EMBRYO, NONMAMMALIAN; FIBROBLASTS; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MULTIPROTEIN COMPLEXES; ONCOGENES; PROTEIN BINDING; PROTEIN STABILITY; PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); TUMOR SUPPRESSOR PROTEINS;

EID: 84865191462     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120193109     Document Type: Article

References (31)

1. Downward J (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3(1):11-22.
2. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602. (Pubitemid 27152402)
3. Wilkinson S, Ryan KM (2010) Autophagy: An adaptable modifier of tumourigenesis. Curr Opin Genet Dev 20(1):57-64.
4. Young AR, et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23:798-803.
5. Lock R, et al. (2011) Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell 22(2):165-178.
6. Kim MJ, et al. (2011) Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem 286:12924-12932.
7. Guo JY, et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 25:460-470.
8. Yang S, et al. (2011) Pancreatic cancers require autophagy for tumor growth. Genes Dev 25:717-729.
9. Furuta S, Hidaka E, Ogata A, Yokota S, Kamata T (2004) Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23:3898-3904. (Pubitemid 38747918)
10. Yoo BH, et al. (2010) Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. J Biol Chem 285:5438-5449.
11. Byun JY, et al. (2009) The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis 30: 1880-1888.
12. Elgendy M, Sheridan C, Brumatti G, Martin SJ (2011) Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell 42:23-35.
13. Scherz-Shouval R, et al. (2010) p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci USA 107: 18511-18516.
14. Tidow H, Andreeva A, Rutherford TJ, Fersht AR (2007) Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. J Mol Biol 371:948-958. (Pubitemid 47101808)
15. Wang XD, et al. (2011) SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence. Cell Death Differ 18:304-314.
16. Samuels-Lev Y, et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8:781-794. (Pubitemid 33030212)
17. Vives V, et al. (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20:1262-1267. (Pubitemid 43727587)
18. Sottocornola R, et al. (2010) ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell 19:126-137.
19. Langton PF, Colombani J, Aerne BL, Tapon N (2007) Drosophila ASPP regulates Cterminal Src kinase activity. Dev Cell 13:773-782. (Pubitemid 350163042)
20. Cong W, et al. (2010) ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol 20:1408-1414.
21. Naumovski L, Cleary ML (1996) The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. Mol Cell Biol 16:3884-3892. (Pubitemid 26199908)
22. Jia W, He Y-W (2011) Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol 186:5313-5322.
23. Shirasawa S, Furuse M, Yokoyama N, Sasazuki T (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260(5104):85-88. (Pubitemid 23122749)
24. Dajee M, Tarutani M, Deng H, Cai T, Khavari PA (2002) Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 21:1527-1538. (Pubitemid 34226140)
25. Wang Y, et al. (2010) Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene 29:4658-4670.
26. Kundu M, Thompson CB (2008) Autophagy: Basic principles and relevance to disease. Annu Rev Pathol 3:427-455. (Pubitemid 351488288)
27. Psahoulia FH, et al. (2007) Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28:1021-1031. (Pubitemid 47072186)
28. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075. (Pubitemid 351317450)
29. Kondo Y, Kondo S (2006) Autophagy and cancer therapy. Autophagy 2(2):85-90.
30. Amaravadi RK, et al. (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326-336. (Pubitemid 46203961)
31. Lossos IS, Natkunam Y, Levy R, Lopez CD (2002) Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: Correlation with clinical outcome. Leuk Lymphoma 43:2309-2317. (Pubitemid 35386153)