Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation

Molecular Oncology

Volumn 7, Issue 6, 2013, Pages 1012-1018

  Brüning, Ansgar ^a   Rahmeh, Martina ^a   Friese, Klaus ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Autophagy; Bortezomib; Endoplasmic reticulum stress; mTOR; Nelfinavir; SESN2

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; BORTEZOMIB; CARBOPLATIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MAMMALIAN TARGET OF RAPAMYCIN; NELFINAVIR; PACLITAXEL; PROTEIN; SESTRIN 2; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CANCER CELL; CELL CYCLE REGULATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

AUTOPHAGY; BORTEZOMIB; ENDOPLASMIC RETICULUM STRESS; MTOR; NELFINAVIR; SESN2;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BORONIC ACIDS; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HIV PROTEASE INHIBITORS; HUMANS; NELFINAVIR; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; PYRAZINES; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84887999522     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2013.07.010     Document Type: Article

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