메뉴 건너뛰기




Volumn 118, Issue 1, 2008, Pages 79-88

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis (Journal of Clinical Investigation (2008) 118, (79-88) DOI: 10.1172/JCI33700);Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; ATM PROTEIN; CASPASE; CHLOROQUINE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

EID: 38149141767     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI33700C1     Document Type: Erratum
Times cited : (265)

References (59)
  • 1
    • 0037309326 scopus 로고    scopus 로고
    • Tumor suppression by Ink4a-Arf: Progress and puzzles
    • Lowe, S.W., and Sherr, C.J. 2003. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13:77-83.
    • (2003) Curr. Opin. Genet. Dev , vol.13 , pp. 77-83
    • Lowe, S.W.1    Sherr, C.J.2
  • 2
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen, C.M., Weber, J.D., Roussel, M.F., Sherr, C.J., and Cleveland, J.L. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13:2658-2669.
    • (1999) Genes Dev , vol.13 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 3
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt, C.A., McCurrach, M.E., de Stanchina, E., Wallace-Brodeur, R.R., and Lowe, S.W. 1999. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev. 13:2670-2677.
    • (1999) Genes Dev , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    de Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 4
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A.J., and Kastan, M.B. 1998. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12:2973-2983.
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 5
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M.B., and Bartek, J. 2004. Cell-cycle checkpoints and cancer. Nature. 432:316-323.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 6
    • 0031435944 scopus 로고    scopus 로고
    • DNA damage induces phosphorylation of the amino terminus of p53
    • Siliciano, J.D., et al. 1997. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11:3471-3481.
    • (1997) Genes Dev , vol.11 , pp. 3471-3481
    • Siliciano, J.D.1
  • 7
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman, C.E., et al. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1677-1679.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1
  • 8
    • 0033555260 scopus 로고    scopus 로고
    • A role for ATR in the DNA damage-induced phosphorylation of p53
    • Tibbetts, R.S., et al. 1999. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:152-157.
    • (1999) Genes Dev , vol.13 , pp. 152-157
    • Tibbetts, R.S.1
  • 9
    • 31944451363 scopus 로고    scopus 로고
    • ATM promotes apoptosis and suppresses tumorigenesis in response to Myc
    • Pusapati, R.V., et al. 2006. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc. Natl. Acad. Sci. U. S. A. 103:1446-1451.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 1446-1451
    • Pusapati, R.V.1
  • 10
    • 33845893896 scopus 로고    scopus 로고
    • Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
    • Shreeram, S., et al. 2006. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J. Exp. Med. 203:2793-2799.
    • (2006) J. Exp. Med , vol.203 , pp. 2793-2799
    • Shreeram, S.1
  • 11
    • 34547129356 scopus 로고    scopus 로고
    • Atm deficiency affects both apoptosis and proliferation to augment myc-induced lymphomagenesis
    • Maclean, K.H., Kastan, M.B., and Cleveland, J.L. 2007. Atm deficiency affects both apoptosis and proliferation to augment myc-induced lymphomagenesis. Mol. Cancer Res. 5:705-711.
    • (2007) Mol. Cancer Res , vol.5 , pp. 705-711
    • Maclean, K.H.1    Kastan, M.B.2    Cleveland, J.L.3
  • 12
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C.J., and Kastan, M.B. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 13
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa, R., Bakkenist, C.J., McKinnon, P.J., and Kastan, M.B. 2004. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18:1423-1438.
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 14
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
    • Langdon, W.Y., Harris, A.W., Cory, S., and Adams, J.M. 1986. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell. 47:11-18.
    • (1986) Cell , vol.47 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 15
    • 21144448938 scopus 로고    scopus 로고
    • Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    • Nilsson, J.A., et al. 2005. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell. 7:433-444.
    • (2005) Cancer Cell , vol.7 , pp. 433-444
    • Nilsson, J.A.1
  • 16
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T.D., Hancock, D.C., Danielian, P.S., Parker, M.G., and Evan, G.I. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 17
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy, F., et al. 1998. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12:2424-2433.
    • (1998) Genes Dev , vol.12 , pp. 2424-2433
    • Zindy, F.1
  • 18
    • 0141864362 scopus 로고    scopus 로고
    • c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-X(L)
    • Maclean, K.H., et al. 2003. c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-X(L). Mol. Cell. Biol. 23:7256-7270.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7256-7270
    • Maclean, K.H.1
  • 19
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow, C., et al. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 86:159-171.
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1
  • 20
    • 0027226306 scopus 로고
    • Genetic background alters the spectrum of tumors that develop in p53-deficient mice
    • Harvey, M., McArthur, M.J., Montgomery, C.A., Jr., Bradley, A., and Donehower, L.A. 1993. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J. 7:938-943.
    • (1993) FASEB J , vol.7 , pp. 938-943
    • Harvey, M.1    McArthur, M.J.2    Montgomery Jr., C.A.3    Bradley, A.4    Donehower, L.A.5
  • 21
    • 19944434059 scopus 로고    scopus 로고
    • Inhibition of macroautophagy triggers apoptosis
    • Boya, P., et al. 2005. Inhibition of macroautophagy triggers apoptosis. Mol. Cell. Biol. 25:1025-1040.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 1025-1040
    • Boya, P.1
  • 22
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi, R.K., et al. 2007. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 117:326-336.
    • (2007) J. Clin. Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1
  • 23
    • 0033152390 scopus 로고    scopus 로고
    • c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
    • Juin, P., Hueber, A.O., Littlewood, T., and Evan, G. 1999. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev. 13:1367-1381.
    • (1999) Genes Dev , vol.13 , pp. 1367-1381
    • Juin, P.1    Hueber, A.O.2    Littlewood, T.3    Evan, G.4
  • 24
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew, D.S., Ashmun, R.A., Simmons, B.C., and Cleveland, J.L. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene. 6:1915-1922.
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 25
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • Evan, G.I., et al. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 69:119-128.
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.I.1
  • 26
  • 27
    • 0026688162 scopus 로고
    • Apoptotic cell death induced by c-myc is inhibited by bcl-2
    • Bissonnette, R.P., Echeverri, F., Mahboubi, A., and Green, D.R. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature. 359:552-554.
    • (1992) Nature , vol.359 , pp. 552-554
    • Bissonnette, R.P.1    Echeverri, F.2    Mahboubi, A.3    Green, D.R.4
  • 28
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten, T., et al. 2000. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell. 6:1389-1399.
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1
  • 29
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine, B., and Klionsky, D.J. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell. 6:463-477.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 30
    • 34249798692 scopus 로고    scopus 로고
    • Autophagic and apoptotic response to stress signals in mammalian cells
    • Ferraro, E., and Cecconi, F. 2007. Autophagic and apoptotic response to stress signals in mammalian cells. Arch. Biochem. Biophys. 462:210-219.
    • (2007) Arch. Biochem. Biophys , vol.462 , pp. 210-219
    • Ferraro, E.1    Cecconi, F.2
  • 31
    • 0034815663 scopus 로고    scopus 로고
    • Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent
    • Zaidi, A.U., et al. 2001. Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent. J. Neuropathol. Exp. Neurol. 60:937-945.
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 937-945
    • Zaidi, A.U.1
  • 32
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew, J.S., et al. 2007. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood. 110:313-322.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1
  • 33
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • Paludan, C., et al. 2005. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science. 307:593-596.
    • (2005) Science , vol.307 , pp. 593-596
    • Paludan, C.1
  • 34
    • 33645100369 scopus 로고    scopus 로고
    • Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons
    • Shacka, J.J., et al. 2006. Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol. Pharmacol. 69:1125-1136.
    • (2006) Mol. Pharmacol , vol.69 , pp. 1125-1136
    • Shacka, J.J.1
  • 35
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu, M., et al. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169:425-434.
    • (2005) J. Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1
  • 36
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y., et al. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720-5728.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 37
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima, N., et al. 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152:657-668.
    • (2001) J. Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1
  • 38
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S., et al. 2007. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131-24145.
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1
  • 39
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy, G., et al. 2005. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171:603-614.
    • (2005) J. Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1
  • 40
    • 34250020188 scopus 로고    scopus 로고
    • Lysosomal cysteine cathepsins: Signaling pathways in apoptosis
    • Stoka, V., Turk, V., and Turk, B. 2007. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol. Chem. 388:555-560.
    • (2007) Biol. Chem , vol.388 , pp. 555-560
    • Stoka, V.1    Turk, V.2    Turk, B.3
  • 41
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen, P.O., and Gordon, P.B. 1982. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 79:1889-1892.
    • (1982) Proc. Natl. Acad. Sci. U. S. A , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 42
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot, A., Ogier-Denis, E., Blommaart, E.F., Meijer, A.J., and Codogno, P. 2000. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275:992-998.
    • (2000) J. Biol. Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 43
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: From initiation to recovery or adaptation
    • Bartek, J., and Lukas, J. 2007. DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opin. Cell Biol. 19:238-245.
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 44
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams, J.M., et al. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533-538.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1
  • 45
    • 0024602207 scopus 로고
    • Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma
    • Geser, A., Brubaker, G., and Draper, C.C. 1989. Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma. Am. J. Epidemiol. 129:740-752.
    • (1989) Am. J. Epidemiol , vol.129 , pp. 740-752
    • Geser, A.1    Brubaker, G.2    Draper, C.C.3
  • 46
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-like systems
    • Ohsumi, Y. 2001. Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell Biol. 2:211-216.
    • (2001) Nat. Rev. Mol. Cell Biol , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 47
    • 0019866088 scopus 로고
    • Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages
    • Poole, B., and Ohkuma, S. 1981. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J. Cell Biol. 90:665-669.
    • (1981) J. Cell Biol , vol.90 , pp. 665-669
    • Poole, B.1    Ohkuma, S.2
  • 48
    • 0023584505 scopus 로고
    • Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity - formation of crinosomes
    • Glaumann, H., and Ahlberg, J. 1987. Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity - formation of crinosomes. Exp. Mol. Pathol. 47:346-362.
    • (1987) Exp. Mol. Pathol , vol.47 , pp. 346-362
    • Glaumann, H.1    Ahlberg, J.2
  • 49
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei, M.C., et al. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 292:727-730.
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1
  • 50
    • 0038677510 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
    • Boya, P., et al. 2003. Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene. 22:3927-3936.
    • (2003) Oncogene , vol.22 , pp. 3927-3936
    • Boya, P.1
  • 51
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D.L., Cory, S., and Adams, J.M. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 335:440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 52
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng, Z., Zhang, H., Levine, A.J., and Jin, S. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. U. S. A. 102:8204-8209.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 53
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton, D., et al. 2006. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 126:121-134.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1
  • 54
    • 34249279169 scopus 로고    scopus 로고
    • GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    • Colell, A., et al. 2007. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 129:983-997.
    • (2007) Cell , vol.129 , pp. 983-997
    • Colell, A.1
  • 55
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • Shiloh, Y., and Kastan, M.B. 2001. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83:209-254.
    • (2001) Adv. Cancer Res , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 56
    • 27644575235 scopus 로고    scopus 로고
    • Macroautophagy versus mitochondrial autophagy: A question of fate?
    • Kundu, M., and Thompson, C.B. 2005. Macroautophagy versus mitochondrial autophagy: a question of fate? Cell Death Differ. 12(Suppl. 2):1484-1489.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1484-1489
    • Kundu, M.1    Thompson, C.B.2
  • 57
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo, Y., Kanzawa, T., Sawaya, R., and Kondo, S. 2005. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer. 5:726-734.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 58
    • 0033169867 scopus 로고    scopus 로고
    • EIIaCre - utility of a general deleter strain
    • Williams-Simons, L., and Westphal, H. 1999. EIIaCre - utility of a general deleter strain. Transgenic Res. 8:53-54.
    • (1999) Transgenic Res , vol.8 , pp. 53-54
    • Williams-Simons, L.1    Westphal, H.2
  • 59
    • 0034953712 scopus 로고    scopus 로고
    • Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis
    • Eischen, C.M., Woo, D., Roussel, M.F., and Cleveland, J.L. 2001. Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol. Cell. Biol. 21:5063-5070.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5063-5070
    • Eischen, C.M.1    Woo, D.2    Roussel, M.F.3    Cleveland, J.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.