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Volumn 111, Issue 39, 2014, Pages 14147-14152

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Author keywords

ADI PEG20; Arginine auxotrophy; Cancer therapy; Metabolic stress; Prostate cancer

Indexed keywords

ANTINEOPLASTIC AGENT; ARGININE; ARGININOSUCCINATE SYNTHASE; CHROMATIN; DNA; HYDROLASE; MACROGOL DERIVATIVE; PEGARGIMINASE; REACTIVE OXYGEN METABOLITE;

EID: 84907587227     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404171111     Document Type: Article
Times cited : (129)

References (35)
  • 1
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV (2006) Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66(18):8927-8930.
    • (2006) Cancer Res , vol.66 , Issue.18 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 2
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324(5930):1029-1033.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 3
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking the Warburg effect with Myc micromanaging glutamine metabolism
    • Dang CV (2010) Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 70(3):859-862.
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 859-862
    • Dang, C.V.1
  • 4
    • 45549107064 scopus 로고    scopus 로고
    • Arginine deprivation as a targeted therapy for cancer
    • Feun L, et al. (2008) Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des 14(11):1049-1057.
    • (2008) Curr Pharm des , vol.14 , Issue.11 , pp. 1049-1057
    • Feun, L.1
  • 5
    • 84869507054 scopus 로고    scopus 로고
    • Arginine deprivation as a new treatment strategy for head and neck cancer
    • Huang CC, et al. (2012) Arginine deprivation as a new treatment strategy for head and neck cancer. Oral Oncol 48(12):1227-1235.
    • (2012) Oral Oncol , vol.48 , Issue.12 , pp. 1227-1235
    • Huang, C.C.1
  • 6
    • 0032145202 scopus 로고    scopus 로고
    • Use of L-asparaginase in childhood ALL
    • Müller HJ, Boos J (1998) Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol 28(2):97-113.
    • (1998) Crit Rev Oncol Hematol , vol.28 , Issue.2 , pp. 97-113
    • Müller, H.J.1    Boos, J.2
  • 7
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato R, et al. (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476(7360):346-350.
    • (2011) Nature , vol.476 , Issue.7360 , pp. 346-350
    • Possemato, R.1
  • 8
    • 0041976909 scopus 로고    scopus 로고
    • Arginine deprivation, growth inhibition and tumour cell death: 3. Deficient utilisation of citrulline by malignant cells
    • Wheatley DN, Campbell E (2003) Arginine deprivation, growth inhibition and tumour cell death: 3. Deficient utilisation of citrulline by malignant cells. Br J Cancer 89(3): 573-576.
    • (2003) Br J Cancer , vol.89 , Issue.3 , pp. 573-576
    • Wheatley, D.N.1    Campbell, E.2
  • 9
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • Wise DR, Thompson CB (2010) Glutamine addiction: A new therapeutic target in cancer. Trends Biochem Sci 35(8):427-433.
    • (2010) Trends Biochem Sci , vol.35 , Issue.8 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 10
    • 32944469353 scopus 로고    scopus 로고
    • Pegylated arginine deiminase treatment of patients with metastatic melanoma: Results from phase i and II studies
    • Ascierto PA, et al. (2005) Pegylated arginine deiminase treatment of patients with metastatic melanoma: Results from phase I and II studies. J Clin Oncol 23(30): 7660-7668.
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7660-7668
    • Ascierto, P.A.1
  • 11
    • 34248325307 scopus 로고    scopus 로고
    • Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511
    • Wetzler M, et al. (2007) Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511. Blood 109(10):4164-4167.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4164-4167
    • Wetzler, M.1
  • 12
    • 0342748603 scopus 로고    scopus 로고
    • Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis
    • Gong H, Zölzer F, von Recklinghausen G, Havers W, Schweigerer L (2000) Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. Leukemia 14(5):826-829.
    • (2000) Leukemia , vol.14 , Issue.5 , pp. 826-829
    • Gong, H.1    Zölzer, F.2    Von Recklinghausen, G.3    Havers, W.4    Schweigerer, L.5
  • 13
    • 0036792124 scopus 로고    scopus 로고
    • Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo
    • Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA (2002) Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res 62(19):5443-5450.
    • (2002) Cancer Res , vol.62 , Issue.19 , pp. 5443-5450
    • Ensor, C.M.1    Holtsberg, F.W.2    Bomalaski, J.S.3    Clark, M.A.4
  • 14
    • 51949087021 scopus 로고    scopus 로고
    • Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase
    • Bowles TL, et al. (2008) Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. Int J Cancer 123(8):1950-1955.
    • (2008) Int J Cancer , vol.123 , Issue.8 , pp. 1950-1955
    • Bowles, T.L.1
  • 15
    • 77949735952 scopus 로고    scopus 로고
    • Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    • Kobayashi E, et al. (2010) Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol Cancer Ther 9(3):535-544.
    • (2010) Mol Cancer Ther , vol.9 , Issue.3 , pp. 535-544
    • Kobayashi, E.1
  • 16
    • 84862187475 scopus 로고    scopus 로고
    • Deprivation of arginine by recombinant human arginase in prostate cancer cells
    • Hsueh EC, et al. (2012) Deprivation of arginine by recombinant human arginase in prostate cancer cells. J Hematol Oncol 5:17.
    • (2012) J Hematol Oncol , vol.5 , pp. 17
    • Hsueh, E.C.1
  • 17
    • 84856458783 scopus 로고    scopus 로고
    • Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase
    • Kelly MP, et al. (2012) Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase. Br J Cancer 106(2): 324-332.
    • (2012) Br J Cancer , vol.106 , Issue.2 , pp. 324-332
    • Kelly, M.P.1
  • 18
    • 58349098150 scopus 로고    scopus 로고
    • Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
    • Kim RH, et al. (2009) Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res 69(2):700-708.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 700-708
    • Kim, R.H.1
  • 19
    • 66349091716 scopus 로고    scopus 로고
    • ADI, autophagy and apoptosis: Metabolic stress as a therapeutic option for prostate cancer
    • Kim RH, Bold RJ, Kung HJ (2009) ADI, autophagy and apoptosis: Metabolic stress as a therapeutic option for prostate cancer. Autophagy 5(4):567-568.
    • (2009) Autophagy , vol.5 , Issue.4 , pp. 567-568
    • Kim, R.H.1    Bold, R.J.2    Kung, H.J.3
  • 20
    • 84867238654 scopus 로고    scopus 로고
    • Autophagy: Resetting glutamine-dependent metabolism and oxygen consumption
    • Lin TC, et al. (2012) Autophagy: Resetting glutamine-dependent metabolism and oxygen consumption. Autophagy 8(10):1477-1493.
    • (2012) Autophagy , vol.8 , Issue.10 , pp. 1477-1493
    • Lin, T.C.1
  • 21
    • 84872184647 scopus 로고    scopus 로고
    • Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma
    • Syed N, et al. (2013) Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis 4:e458.
    • (2013) Cell Death Dis , vol.4 , pp. e458
    • Syed, N.1
  • 22
    • 18744390391 scopus 로고    scopus 로고
    • Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis
    • Shchepina LA, et al. (2002) Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene 21(53):8149-8157.
    • (2002) Oncogene , vol.21 , Issue.53 , pp. 8149-8157
    • Shchepina, L.A.1
  • 23
    • 33749433230 scopus 로고    scopus 로고
    • Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation
    • Brennan JP, et al. (2006) Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc Res 72(2):313-321.
    • (2006) Cardiovasc Res , vol.72 , Issue.2 , pp. 313-321
    • Brennan, J.P.1
  • 24
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100(25):15077-15082.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.25 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 25
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • Pyo JO, et al. (2005) Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 280(21):20722-20729.
    • (2005) J Biol Chem , vol.280 , Issue.21 , pp. 20722-20729
    • Pyo, J.O.1
  • 26
    • 34248203863 scopus 로고    scopus 로고
    • Structure of Atg5.Atg16, a complex essential for autophagy
    • Matsushita M, et al. (2007) Structure of Atg5.Atg16, a complex essential for autophagy. J Biol Chem 282(9):6763-6772.
    • (2007) J Biol Chem , vol.282 , Issue.9 , pp. 6763-6772
    • Matsushita, M.1
  • 27
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT, Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18(4):571-580.
    • (2011) Cell Death Differ , vol.18 , Issue.4 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 28
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky DJ, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544.
    • (2012) Autophagy , vol.8 , Issue.4 , pp. 445-544
    • Klionsky, D.J.1
  • 29
    • 84904421955 scopus 로고    scopus 로고
    • Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells
    • Qiu F, et al. (2014) Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal 7(319):ra31.
    • (2014) Sci Signal , vol.7 , Issue.319 , pp. ra31
    • Qiu, F.1
  • 30
    • 33846429217 scopus 로고    scopus 로고
    • Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion
    • Cheng PNM, et al. (2007) Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res 67(1):309-317.
    • (2007) Cancer Res , vol.67 , Issue.1 , pp. 309-317
    • Cheng, P.N.M.1
  • 31
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells
    • Shvets E, Fass E, Elazar Z (2008) Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4(5):621-628.
    • (2008) Autophagy , vol.4 , Issue.5 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 32
    • 69449083200 scopus 로고    scopus 로고
    • Autophagic degradation of nuclear components in mammalian cells
    • Park YE, et al. (2009) Autophagic degradation of nuclear components in mammalian cells. Autophagy 5(6):795-804.
    • (2009) Autophagy , vol.5 , Issue.6 , pp. 795-804
    • Park, Y.E.1
  • 33
    • 84855712059 scopus 로고    scopus 로고
    • Autophagic removal of micronuclei
    • Rello-Varona S, et al. (2012) Autophagic removal of micronuclei. Cell Cycle 11(1): 170-176.
    • (2012) Cell Cycle , vol.11 , Issue.1 , pp. 170-176
    • Rello-Varona, S.1
  • 34
    • 84882938509 scopus 로고    scopus 로고
    • Direct uptake and degradation of DNA by lysosomes
    • Fujiwara Y, et al. (2013) Direct uptake and degradation of DNA by lysosomes. Autophagy 9(8):1167-1171.
    • (2013) Autophagy , vol.9 , Issue.8 , pp. 1167-1171
    • Fujiwara, Y.1
  • 35
    • 0038107749 scopus 로고    scopus 로고
    • Microtubule network facilitates targeting of human cytomegalovirus capsid
    • Ogawa-Goto K, et al. (2003) Microtubule network facilitates targeting of human cytomegalovirus capsid. J Virol 77(15):8451-8547.
    • (2003) J Virol , vol.77 , Issue.15 , pp. 8451-8547
    • Ogawa-Goto, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.