The Three Musketeers of Autophagy: Phosphorylation, ubiquitylation and acetylation

Trends in Cell Biology

Volumn 21, Issue 4, 2011, Pages 195-201

  McEwan, David G ^a   Dikic, Ivan ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATG PROTEIN; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE 6; HUNTINGTIN; I KAPPA B KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PARKIN; PROTEIN P62; RAPAMYCIN; SIRTUIN 1; SUMO PROTEIN; TARGET OF RAPAMYCIN KINASE; UBIQUITIN; UNCLASSIFIED DRUG;

ACETYLATION; AMINO TERMINAL SEQUENCE; AUTOPHAGY; CELL ORGANELLE; CELL STRESS; CELL SURVIVAL; CYTOSOL; HUMAN; MAMMAL CELL; MICROTUBULE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; UBIQUITINATION; YEAST;

ACETYLATION; ANIMALS; AUTOPHAGY; HUMANS; PHOSPHORYLATION; UBIQUITINATION;

EID: 79953163464     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2010.12.006     Document Type: Short Survey

References (60)

1. Yang Z., Klionsky D.J. Eaten alive: a history of macroautophagy. Nat. Cell Biol. 2010, 12:814-822.
2. Hayashi-Nishino M., et al. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 2009, 11:1433-1437.
3. Yen W.L., et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J. Cell Biol. 2010, 188:101-114.
4. van der Vaart A., et al. Exit from the golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae. Mol. Biol. Cell 2010, 21:2270-2284.
5. Hailey D.W., et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010, 141:656-667.
6. Komatsu M., et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 2005, 169:425-434.
7. Kuma A., et al. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
8. Qu X., et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 2003, 112:1809-1820.
9. Yue Z., et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:15077-15082.
10. Weidberg H., et al. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 2010, 29:1792-1802.
11. Hara T., et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 2008, 181:497-510.
12. Betin V.M., Lane J.D. Atg4D at the interface between autophagy and apoptosis. Autophagy 2009, 5:1057-1059.
13. Tanida I., et al. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J. Biol. Chem. 2004, 279:36268-36276.
14. Blommaart E.F., et al. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 1995, 270:2320-2326.
15. Brown E.J., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994, 369:756-758.
16. Kunz J., et al. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 1993, 73:585-596.
17. Kamada Y., et al. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 2000, 150:1507-1513.
18. Stephan J.S., et al. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:17049-17054.
19. Wullschleger S., et al. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
20. Jung C.H., et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 2009, 20:1992-2003.
21. Hosokawa N., et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 2009, 20:1981-1991.
22. Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 2010, 22:132-139.
23. Yang Z., Klionsky D.J. Mammalian autophagy: core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 2010, 22:124-131.
24. Wei Y., et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 2008, 30:678-688.
25. Zalckvar E., et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009, 10:285-292.
26. Criollo A., et al. The IKK complex contributes to the induction of autophagy. EMBO J. 2010, 29:619-631.
27. Cherra S.J., 3rd, et al. Regulation of the autophagy protein LC3 by phosphorylation. J. Cell Biol. 2010, 190:533-539.
28. Jiang H., et al. Protein kinase C inhibits autophagy and phosphorylates LC3. Biochem. Biophys. Res. Commun. 2010, 395:471-476.
29. Shvets E., et al. The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J. Cell Sci. 2008, 121:2685-2695.
30. Stehmeier P., Muller S. Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling. Mol. Cell 2009, 33:400-409.
31. Ikeda F., Dikic I. Atypical ubiquitin chains: new molecular signals. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008, 9:536-542.
32. Hanada T., et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 2007, 282:37298-37302.
33. Radoshevich L., et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 2010, 142:590-600.
34. Bjorkoy G., et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
35. Kirkin V., et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 2009, 33:505-516.
36. Pankiv S., et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282:24131-24145.
37. Geisler S., et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 2010, 12:119-131.
38. Kim P.K., et al. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:20567-20574.
39. Thurston T.L., et al. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 2009, 10:1215-1221.
40. Narendra D., et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 2008, 183:795-803.
41. Narendra D.P., et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010, 6:1090-1096.
42. Novak I., et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep. 2010, 11:45-51.
43. Schweers R.L., et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:19500-19505.
44. Ding W.X., et al. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J. Biol. Chem. 2010, 285:27879-27890.
45. Vives-Bauza C., et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:378-383.
46. Michiorri S., et al. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ. 2010, 17:962-974.
47. Kirkin V., et al. A role for ubiquitin in selective autophagy. Mol. Cell 2009, 34:259-269.
48. Hayden M.S., Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132:344-362.
49. Kraft C., et al. Selective autophagy: ubiquitin-mediated recognition and beyond. Nat. Cell Biol. 2010, 12:836-841.
50. Deribe Y.L., et al. Post-translational modifications in signal integration. Nat. Struct. Mol. Biol. 2010, 17:666-672.
51. Iwata A., et al. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 2005, 280:40282-40292.
52. Lee J.Y., et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. 2010, 29:969-980.
53. Lee J.Y., et al. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation and HDAC6-dependent mitophagy. J. Cell Biol. 2010, 189:671-679.
54. Pandey U.B., et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007, 447:859-863.
55. Lee I.H., Finkel T. Regulation of autophagy by the p300 acetyltransferase. J. Biol. Chem. 2009, 284:6322-6328.
56. Jeong H., et al. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 2009, 137:60-72.
57. Geeraert C., et al. Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J. Biol. Chem. 2010, 285:24184-24194.
58. Deribe Y.L., et al. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci. Signal. 2009, 2:ra84.
59. Lee I.H., et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:3374-3379.
60. Choudhary C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.