-
1
-
-
0042023711
-
Alzheimer disease in the US population: prevalence estimates using the 2000 census
-
Hebert L.E., et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 2003, 60:1119-1122.
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1119-1122
-
-
Hebert, L.E.1
-
2
-
-
80054904670
-
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years
-
Braak H., et al. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J. Neuropathol. Exp. Neurol. 2011, 70:960-969.
-
(2011)
J. Neuropathol. Exp. Neurol.
, vol.70
, pp. 960-969
-
-
Braak, H.1
-
3
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
4
-
-
0029013727
-
Staging of Alzheimer's disease-related neurofibrillary changes
-
Braak H., Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging 1995, 16:271-278.
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 271-278
-
-
Braak, H.1
Braak, E.2
-
5
-
-
84860215480
-
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
-
Nelson P.T., et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J. Neuropathol. Exp. Neurol. 2012, 71:362-381.
-
(2012)
J. Neuropathol. Exp. Neurol.
, vol.71
, pp. 362-381
-
-
Nelson, P.T.1
-
6
-
-
0037172826
-
Phases of A beta-deposition in the human brain and its relevance for the development of AD
-
Thal D.R., et al. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58:1791-1800.
-
(2002)
Neurology
, vol.58
, pp. 1791-1800
-
-
Thal, D.R.1
-
7
-
-
84912143249
-
The evolution of preclinical Alzheimer's disease: implications for prevention trials
-
Sperling R., et al. The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron 2014, 84:608-622.
-
(2014)
Neuron
, vol.84
, pp. 608-622
-
-
Sperling, R.1
-
8
-
-
67649104088
-
APOE genotype-specific differences in the innate immune response
-
Vitek M.P., et al. APOE genotype-specific differences in the innate immune response. Neurobiol. Aging 2009, 30:1350-1360.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1350-1360
-
-
Vitek, M.P.1
-
9
-
-
79957894209
-
Apolipoprotein E isoform-dependent microglia migration
-
Cudaback E., et al. Apolipoprotein E isoform-dependent microglia migration. FASEB J. 2011, 25:2082-2091.
-
(2011)
FASEB J.
, vol.25
, pp. 2082-2091
-
-
Cudaback, E.1
-
10
-
-
84911984944
-
APOE genotype-dependent modulation of astrocyte chemokine CCL3 production
-
Cudaback E., et al. APOE genotype-dependent modulation of astrocyte chemokine CCL3 production. Glia 2015, 63:51-65.
-
(2015)
Glia
, vol.63
, pp. 51-65
-
-
Cudaback, E.1
-
11
-
-
33646242262
-
Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK
-
Maezawa I., et al. Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. FASEB J. 2006, 20:797-799.
-
(2006)
FASEB J.
, vol.20
, pp. 797-799
-
-
Maezawa, I.1
-
12
-
-
33749414025
-
Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity
-
Maezawa I., et al. Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity. J. Neuroinflammation 2006, 3:21.
-
(2006)
J. Neuroinflammation
, vol.3
, pp. 21
-
-
Maezawa, I.1
-
13
-
-
84932624921
-
Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia
-
Li X., et al. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB J. 2015, 29:1754-1762.
-
(2015)
FASEB J.
, vol.29
, pp. 1754-1762
-
-
Li, X.1
-
14
-
-
84876786043
-
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease
-
Cruchaga C., et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron 2013, 78:256-268.
-
(2013)
Neuron
, vol.78
, pp. 256-268
-
-
Cruchaga, C.1
-
15
-
-
84872057940
-
TREM2 variants in Alzheimer's disease
-
Guerreiro R., et al. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 2013, 368:117-127.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 117-127
-
-
Guerreiro, R.1
-
16
-
-
84876907931
-
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
-
Zhang B., et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell 2013, 153:707-720.
-
(2013)
Cell
, vol.153
, pp. 707-720
-
-
Zhang, B.1
-
17
-
-
77956238665
-
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
-
Melchior B., et al. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN Neuro 2010, 2:e00037.
-
(2010)
ASN Neuro
, vol.2
, pp. e00037
-
-
Melchior, B.1
-
18
-
-
84924737031
-
+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
-
+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J. Exp. Med. 2015, 212:287-295.
-
(2015)
J. Exp. Med.
, vol.212
, pp. 287-295
-
-
Jay, T.R.1
-
19
-
-
84925464993
-
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
-
Wang Y., et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell 2015, 160:1061-1071.
-
(2015)
Cell
, vol.160
, pp. 1061-1071
-
-
Wang, Y.1
-
20
-
-
84925535352
-
TREM2 regulates microglial cell activation in response to demyelination in vivo
-
Cantoni C., et al. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathol. 2015, 129:429-447.
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 429-447
-
-
Cantoni, C.1
-
21
-
-
84929012585
-
TREM2 sustains microglial expansion during aging and response to demyelination
-
Poliani P.L., et al. TREM2 sustains microglial expansion during aging and response to demyelination. J. Clin. Invest. 2015, 125:2161-2170.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2161-2170
-
-
Poliani, P.L.1
-
22
-
-
84887853222
-
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage
-
Wunderlich P., et al. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage. J. Biol. Chem. 2013, 288:33027-33036.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 33027-33036
-
-
Wunderlich, P.1
-
23
-
-
34948821265
-
TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
-
Schenk M., et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007, 117:3097-3106.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3097-3106
-
-
Schenk, M.1
-
24
-
-
84893749296
-
TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance
-
Weber B., et al. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS Pathog. 2014, 10:e1003900.
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1003900
-
-
Weber, B.1
-
25
-
-
84923666918
-
A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology
-
Replogle J.M., et al. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann. Neurol. 2015, 77:469-477.
-
(2015)
Ann. Neurol.
, vol.77
, pp. 469-477
-
-
Replogle, J.M.1
-
26
-
-
84894330602
-
CD33 in Alzheimer's disease
-
Jiang T., et al. CD33 in Alzheimer's disease. Mol. Neurobiol. 2014, 49:529-535.
-
(2014)
Mol. Neurobiol.
, vol.49
, pp. 529-535
-
-
Jiang, T.1
-
27
-
-
84891706947
-
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
-
Bradshaw E.M., et al. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat. Neurosci. 2013, 16:848-850.
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 848-850
-
-
Bradshaw, E.M.1
-
28
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A., et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013, 78:631-643.
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
-
29
-
-
84881503738
-
CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing
-
Malik M., et al. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J. Neurosci. 2013, 33:13320-13325.
-
(2013)
J. Neurosci.
, vol.33
, pp. 13320-13325
-
-
Malik, M.1
-
30
-
-
0032479929
-
Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide
-
Bradt B.M., et al. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J. Exp. Med. 1998, 188:431-438.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 431-438
-
-
Bradt, B.M.1
-
31
-
-
33750031006
-
Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes
-
Rogers J., et al. Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes. Neurobiol. Aging 2006, 27:1733-1739.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1733-1739
-
-
Rogers, J.1
-
32
-
-
0035877077
-
Complement activation by neurofibrillary tangles in Alzheimer's disease
-
Shen Y., et al. Complement activation by neurofibrillary tangles in Alzheimer's disease. Neurosci. Lett. 2001, 305:165-168.
-
(2001)
Neurosci. Lett.
, vol.305
, pp. 165-168
-
-
Shen, Y.1
-
33
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert J.C., et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 2009, 41:1094-1099.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
-
34
-
-
79953277743
-
CR1 is associated with amyloid plaque burden and age-related cognitive decline
-
Chibnik L.B., et al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann. Neurol. 2011, 69:560-569.
-
(2011)
Ann. Neurol.
, vol.69
, pp. 560-569
-
-
Chibnik, L.B.1
-
35
-
-
84863393134
-
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
-
Biffi A., et al. Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology 2012, 78:334-341.
-
(2012)
Neurology
, vol.78
, pp. 334-341
-
-
Biffi, A.1
-
36
-
-
84904298593
-
Meta-analysis of the association between CR1 polymorphisms and risk of late-onset Alzheimer's disease
-
Luo J., et al. Meta-analysis of the association between CR1 polymorphisms and risk of late-onset Alzheimer's disease. Neurosci. Lett. 2014, 578:165-170.
-
(2014)
Neurosci. Lett.
, vol.578
, pp. 165-170
-
-
Luo, J.1
-
37
-
-
84856228504
-
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
-
Brouwers N., et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol. Psychiatry 2012, 17:223-233.
-
(2012)
Mol. Psychiatry
, vol.17
, pp. 223-233
-
-
Brouwers, N.1
-
38
-
-
80052632430
-
CR1 genotype is associated with entorhinal cortex volume in young healthy adults
-
Bralten J., et al. CR1 genotype is associated with entorhinal cortex volume in young healthy adults. Neurobiol. Aging 2011, 32. 2106 e2107-2111.
-
(2011)
Neurobiol. Aging
, vol.32
, pp. e2107-2111
-
-
Bralten, J.1
-
39
-
-
0034644671
-
Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle
-
Xu Q., et al. Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle. J. Biol. Chem. 2000, 275:31770-31777.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31770-31777
-
-
Xu, Q.1
-
40
-
-
0034663037
-
Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein
-
Cole G.M., Ard M.D. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microsc. Res. Tech. 2000, 50:316-324.
-
(2000)
Microsc. Res. Tech.
, vol.50
, pp. 316-324
-
-
Cole, G.M.1
Ard, M.D.2
-
41
-
-
84893736391
-
Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro
-
Mulder S.D., et al. Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia 2014, 62:493-503.
-
(2014)
Glia
, vol.62
, pp. 493-503
-
-
Mulder, S.D.1
-
42
-
-
0032411158
-
Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease
-
Lidstrom A.M., et al. Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease. Exp. Neurol. 1998, 154:511-521.
-
(1998)
Exp. Neurol.
, vol.154
, pp. 511-521
-
-
Lidstrom, A.M.1
-
43
-
-
79953747266
-
Plasma clusterin and the risk of Alzheimer disease
-
Schrijvers E.M., et al. Plasma clusterin and the risk of Alzheimer disease. JAMA 2011, 305:1322-1326.
-
(2011)
JAMA
, vol.305
, pp. 1322-1326
-
-
Schrijvers, E.M.1
-
44
-
-
0036678856
-
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease
-
DeMattos R.B., et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10843-10848.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 10843-10848
-
-
DeMattos, R.B.1
-
45
-
-
84945478415
-
Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals
-
Published online December 10, 2014
-
Lancaster T.M., et al. Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals. Alzheimers Dement. 2014, Published online December 10, 2014. 10.1016/j.jalz.2014.10.012.
-
(2014)
Alzheimers Dement.
-
-
Lancaster, T.M.1
-
46
-
-
84875711900
-
Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort
-
Elias-Sonnenschein L.S., et al. Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLoS ONE 2013, 8:e59676.
-
(2013)
PLoS ONE
, vol.8
, pp. e59676
-
-
Elias-Sonnenschein, L.S.1
-
47
-
-
84893870491
-
The role of clusterin in amyloid-beta-associated neurodegeneration
-
Desikan R.S., et al. The role of clusterin in amyloid-beta-associated neurodegeneration. JAMA Neurol. 2014, 71:180-187.
-
(2014)
JAMA Neurol.
, vol.71
, pp. 180-187
-
-
Desikan, R.S.1
-
48
-
-
84870584668
-
Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
-
Karch C.M., et al. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS ONE 2012, 7:e50976.
-
(2012)
PLoS ONE
, vol.7
, pp. e50976
-
-
Karch, C.M.1
-
49
-
-
84933496517
-
ABCA7 in Alzheimer's disease
-
Zhao Q.F., et al. ABCA7 in Alzheimer's disease. Mol. Neurobiol. 2015, 51:1008-1016.
-
(2015)
Mol. Neurobiol.
, vol.51
, pp. 1008-1016
-
-
Zhao, Q.F.1
-
50
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth P., et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011, 43:429-435.
-
(2011)
Nat. Genet.
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
-
51
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
Naj A.C., et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat. Genet. 2011, 43:436-441.
-
(2011)
Nat. Genet.
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
-
52
-
-
84883748375
-
Genetic susceptibility for Alzheimer disease neuritic plaque pathology
-
Shulman J.M., et al. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol. 2013, 70:1150-1157.
-
(2013)
JAMA Neurol.
, vol.70
, pp. 1150-1157
-
-
Shulman, J.M.1
-
53
-
-
33745054649
-
Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells
-
Kim W.S., et al. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport 2006, 17:891-896.
-
(2006)
Neuroreport
, vol.17
, pp. 891-896
-
-
Kim, W.S.1
-
54
-
-
13544251745
-
Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels
-
Kim W.S., et al. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J. Biol. Chem. 2005, 280:3989-3995.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3989-3995
-
-
Kim, W.S.1
-
55
-
-
33747177861
-
ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
-
Jehle A.W., et al. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J. Cell Biol. 2006, 174:547-556.
-
(2006)
J. Cell Biol.
, vol.174
, pp. 547-556
-
-
Jehle, A.W.1
-
56
-
-
84874612598
-
Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease
-
Kim W.S., et al. Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease. J. Neurosci. 2013, 33:4387-4394.
-
(2013)
J. Neurosci.
, vol.33
, pp. 4387-4394
-
-
Kim, W.S.1
-
57
-
-
84887247060
-
Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood
-
Proitsi P., et al. Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol. Aging 2014, 35:279-290.
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 279-290
-
-
Proitsi, P.1
-
58
-
-
84983160352
-
The MS4A family: counting past 1, 2 and 3
-
Published online April 3, 2015
-
Eon Kuek L., et al. The MS4A family: counting past 1, 2 and 3. Immunol. Cell Biol. 2015, Published online April 3, 2015. 10.1038/icb.2015.48.
-
(2015)
Immunol. Cell Biol.
-
-
Eon Kuek, L.1
-
59
-
-
44849108347
-
MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes
-
Koslowski M., et al. MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes. Cancer Res. 2008, 68:3458-3466.
-
(2008)
Cancer Res.
, vol.68
, pp. 3458-3466
-
-
Koslowski, M.1
-
60
-
-
0023789193
-
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
-
McGeer P.L., et al. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291.
-
(1988)
Neurology
, vol.38
, pp. 1285-1291
-
-
McGeer, P.L.1
-
61
-
-
84921025171
-
Association of brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease
-
Yu L., et al. Association of brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. JAMA Neurol. 2015, 72:15-24.
-
(2015)
JAMA Neurol.
, vol.72
, pp. 15-24
-
-
Yu, L.1
-
62
-
-
84878508881
-
MHCII is required for alpha-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
-
Harms A.S., et al. MHCII is required for alpha-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J. Neurosci. 2013, 33:9592-9600.
-
(2013)
J. Neurosci.
, vol.33
, pp. 9592-9600
-
-
Harms, A.S.1
-
63
-
-
0030894683
-
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
-
Han J., et al. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 1997, 386:296-299.
-
(1997)
Nature
, vol.386
, pp. 296-299
-
-
Han, J.1
-
64
-
-
84896492109
-
A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination
-
Johnson M.E., et al. A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination. Calcif. Tissue Int. 2014, 94:396-402.
-
(2014)
Calcif. Tissue Int.
, vol.94
, pp. 396-402
-
-
Johnson, M.E.1
-
65
-
-
84906901689
-
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
-
Zhang Y., et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 2014, 34:11929-11947.
-
(2014)
J. Neurosci.
, vol.34
, pp. 11929-11947
-
-
Zhang, Y.1
-
66
-
-
0033794917
-
Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling
-
Zhang J., et al. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin. Immunol. 2000, 12:361-378.
-
(2000)
Semin. Immunol.
, vol.12
, pp. 361-378
-
-
Zhang, J.1
-
67
-
-
0036732410
-
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
-
Takeshita S., et al. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat. Med. 2002, 8:943-949.
-
(2002)
Nat. Med.
, vol.8
, pp. 943-949
-
-
Takeshita, S.1
-
68
-
-
84901846034
-
Discovery and development of small molecule SHIP phosphatase modulators
-
Viernes D.R., et al. Discovery and development of small molecule SHIP phosphatase modulators. Med. Res. Rev. 2014, 34:795-824.
-
(2014)
Med. Res. Rev.
, vol.34
, pp. 795-824
-
-
Viernes, D.R.1
-
69
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
Lambert J.C., et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 2013, 45:1452-1458.
-
(2013)
Nat. Genet.
, vol.45
, pp. 1452-1458
-
-
Lambert, J.C.1
-
70
-
-
77953819536
-
TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
-
Peng Q., et al. TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci. Signal. 2010, 3:ra38.
-
(2010)
Sci. Signal.
, vol.3
, pp. ra38
-
-
Peng, Q.1
-
71
-
-
84863616381
-
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
-
Bao M., et al. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J. Immunol. 2012, 189:786-792.
-
(2012)
J. Immunol.
, vol.189
, pp. 786-792
-
-
Bao, M.1
-
72
-
-
84920476702
-
Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
-
Carrasquillo M.M., et al. Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease. Neurobiol. Aging 2015, 36:60-67.
-
(2015)
Neurobiol. Aging
, vol.36
, pp. 60-67
-
-
Carrasquillo, M.M.1
-
73
-
-
84920845318
-
Effect of EPHA1 genetic variation on cerebrospinal fluid and neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts
-
Wang H.F., et al. Effect of EPHA1 genetic variation on cerebrospinal fluid and neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts. J. Alzheimers Dis. 2015, 44:115-123.
-
(2015)
J. Alzheimers Dis.
, vol.44
, pp. 115-123
-
-
Wang, H.F.1
-
74
-
-
79955669799
-
Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells
-
Sakamoto A., et al. Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells. J. Int. Med. Res. 2011, 39:522-527.
-
(2011)
J. Int. Med. Res.
, vol.39
, pp. 522-527
-
-
Sakamoto, A.1
-
75
-
-
84955342527
-
Inflammaging decreases adaptive and innate immune responses in mice and humans
-
Published online April 29, 2015
-
Frasca D., Blomberg B.B. Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology 2015, Published online April 29, 2015. 10.1007/s10522-015-9578-8.
-
(2015)
Biogerontology
-
-
Frasca, D.1
Blomberg, B.B.2
-
76
-
-
84861427387
-
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
-
Schafer D.P., et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 2012, 74:691-705.
-
(2012)
Neuron
, vol.74
, pp. 691-705
-
-
Schafer, D.P.1
-
77
-
-
84875870356
-
Microglia: actively surveying and shaping neuronal circuit structure and function
-
Wake H., et al. Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci. 2013, 36:209-217.
-
(2013)
Trends Neurosci.
, vol.36
, pp. 209-217
-
-
Wake, H.1
-
78
-
-
84894574217
-
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
-
Parkhurst C.N., et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 2013, 155:1596-1609.
-
(2013)
Cell
, vol.155
, pp. 1596-1609
-
-
Parkhurst, C.N.1
-
79
-
-
34848843543
-
Neurotransmitter receptors on microglia
-
Pocock J.M., Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci. 2007, 30:527-535.
-
(2007)
Trends Neurosci.
, vol.30
, pp. 527-535
-
-
Pocock, J.M.1
Kettenmann, H.2
-
80
-
-
84920724792
-
Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
-
Gosselin D., et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 2014, 159:1327-1340.
-
(2014)
Cell
, vol.159
, pp. 1327-1340
-
-
Gosselin, D.1
-
81
-
-
84920724791
-
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
-
Lavin Y., et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014, 159:1312-1326.
-
(2014)
Cell
, vol.159
, pp. 1312-1326
-
-
Lavin, Y.1
-
82
-
-
84934756346
-
Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease
-
Wes P.D., et al. Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease. PLoS ONE 2014, 9:e106050.
-
(2014)
PLoS ONE
, vol.9
, pp. e106050
-
-
Wes, P.D.1
-
83
-
-
64549107543
-
Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy
-
Zilka N., et al. Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. J. Neuroimmunol. 2009, 209:16-25.
-
(2009)
J. Neuroimmunol.
, vol.209
, pp. 16-25
-
-
Zilka, N.1
-
84
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama Y., et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007, 53:337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
-
85
-
-
69949118284
-
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
-
Streit W.J., et al. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol. 2009, 118:475-485.
-
(2009)
Acta Neuropathol.
, vol.118
, pp. 475-485
-
-
Streit, W.J.1
-
86
-
-
77956592281
-
LPS-induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
-
Lee D.C., et al. LPS-induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J. Neuroinflammation 2010, 7:56.
-
(2010)
J. Neuroinflammation
, vol.7
, pp. 56
-
-
Lee, D.C.1
-
87
-
-
25644456097
-
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
-
Kitazawa M., et al. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 2005, 25:8843-8853.
-
(2005)
J. Neurosci.
, vol.25
, pp. 8843-8853
-
-
Kitazawa, M.1
-
88
-
-
77957321869
-
Regulation of tau pathology by the microglial fractalkine receptor
-
Bhaskar K., et al. Regulation of tau pathology by the microglial fractalkine receptor. Neuron 2010, 68:19-31.
-
(2010)
Neuron
, vol.68
, pp. 19-31
-
-
Bhaskar, K.1
-
89
-
-
68849123079
-
Accumulation of tau induced in neurites by microglial proinflammatory mediators
-
Gorlovoy P., et al. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB J. 2009, 23:2502-2513.
-
(2009)
FASEB J.
, vol.23
, pp. 2502-2513
-
-
Gorlovoy, P.1
-
90
-
-
0037336701
-
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
-
Li Y., et al. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J. Neurosci. 2003, 23:1605-1611.
-
(2003)
J. Neurosci.
, vol.23
, pp. 1605-1611
-
-
Li, Y.1
-
91
-
-
84903269246
-
Innate immune activation in neurodegenerative disease
-
Heneka M.T., et al. Innate immune activation in neurodegenerative disease. Nat. Rev. Immunol. 2014, 14:463-477.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 463-477
-
-
Heneka, M.T.1
-
92
-
-
51149120624
-
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
-
Hickman S.E., et al. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 2008, 28:8354-8360.
-
(2008)
J. Neurosci.
, vol.28
, pp. 8354-8360
-
-
Hickman, S.E.1
-
93
-
-
84876006819
-
Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe G., et al. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS ONE 2013, 8:e60921.
-
(2013)
PLoS ONE
, vol.8
, pp. e60921
-
-
Krabbe, G.1
-
94
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
in t' Veld B.A., et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N. Engl. J. Med. 2001, 345:1515-1521.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1515-1521
-
-
in t' Veld, B.A.1
-
95
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use
-
Stewart W.F., et al. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997, 48:626-632.
-
(1997)
Neurology
, vol.48
, pp. 626-632
-
-
Stewart, W.F.1
-
96
-
-
43149102747
-
Protective effects of NSAIDs on the development of Alzheimer disease
-
Vlad S.C., et al. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 2008, 70:1672-1677.
-
(2008)
Neurology
, vol.70
, pp. 1672-1677
-
-
Vlad, S.C.1
-
98
-
-
80555136833
-
Neuronal and vascular protection by the prostaglandin E2 EP4 receptor in a mouse model of cerebral ischemia
-
Liang X., et al. Neuronal and vascular protection by the prostaglandin E2 EP4 receptor in a mouse model of cerebral ischemia. J. Clin. Invest. 2011, 121:4362-4371.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4362-4371
-
-
Liang, X.1
-
99
-
-
84884929175
-
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia
-
Johansson J.U., et al. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. J. Neurosci. 2013, 33:16012-16032.
-
(2013)
J. Neurosci.
, vol.33
, pp. 16012-16032
-
-
Johansson, J.U.1
-
100
-
-
84920405563
-
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
-
Johansson J.U., et al. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J. Clin. Invest. 2015, 125:350-364.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 350-364
-
-
Johansson, J.U.1
-
101
-
-
77953638394
-
The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity
-
Shi J., et al. The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J. Immunol. 2010, 184:7207-7218.
-
(2010)
J. Immunol.
, vol.184
, pp. 7207-7218
-
-
Shi, J.1
-
102
-
-
84899490472
-
Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling
-
Woodling N.S., et al. Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling. J. Neurosci. 2014, 34:5882-5894.
-
(2014)
J. Neurosci.
, vol.34
, pp. 5882-5894
-
-
Woodling, N.S.1
-
103
-
-
80052714655
-
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
-
Cho S.H., et al. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J. Biol. Chem. 2011, 286:32713-32722.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 32713-32722
-
-
Cho, S.H.1
-
104
-
-
77957316313
-
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models
-
Lee S., et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am. J. Pathol. 2010, 177:2549-2562.
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 2549-2562
-
-
Lee, S.1
-
105
-
-
77950188666
-
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
-
Fuhrmann M., et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat. Neurosci. 2010, 13:411-413.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 411-413
-
-
Fuhrmann, M.1
-
106
-
-
84894102230
-
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
-
Xue J., et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014, 40:274-288.
-
(2014)
Immunity
, vol.40
, pp. 274-288
-
-
Xue, J.1
-
107
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
108
-
-
0035845283
-
In vivo measurement of activated microglia in dementia
-
Cagnin A., et al. In vivo measurement of activated microglia in dementia. Lancet 2001, 358:461-467.
-
(2001)
Lancet
, vol.358
, pp. 461-467
-
-
Cagnin, A.1
-
109
-
-
56349144614
-
11C]PIB-PET study
-
11C]PIB-PET study. Neurobiol. Dis. 2008, 32:412-419.
-
(2008)
Neurobiol. Dis.
, vol.32
, pp. 412-419
-
-
Edison, P.1
-
110
-
-
84879901761
-
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
-
Kreisl W.C., et al. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain 2013, 136:2228-2238.
-
(2013)
Brain
, vol.136
, pp. 2228-2238
-
-
Kreisl, W.C.1
-
111
-
-
84947615776
-
18F]-FEPPA
-
Published online February 24, 2015
-
18F]-FEPPA. Mol. Psychiatry 2015, Published online February 24, 2015. 10.1038/mp.2015.1.
-
(2015)
Mol. Psychiatry
-
-
Suridjan, I.1
-
114
-
-
84908511615
-
Analytical tools and current challenges in the modern era of neuroepigenomics
-
Maze I., et al. Analytical tools and current challenges in the modern era of neuroepigenomics. Nat. Neurosci. 2014, 17:1476-1490.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 1476-1490
-
-
Maze, I.1
-
115
-
-
38949175007
-
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
-
Miller J.A., et al. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J. Neurosci. 2008, 28:1410-1420.
-
(2008)
J. Neurosci.
, vol.28
, pp. 1410-1420
-
-
Miller, J.A.1
-
116
-
-
84878007793
-
Genes and pathways underlying regional and cell type changes in Alzheimer's disease
-
Miller J.A., et al. Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome Med. 2013, 5:48.
-
(2013)
Genome Med.
, vol.5
, pp. 48
-
-
Miller, J.A.1
-
117
-
-
84924975742
-
Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression
-
Aubry S., et al. Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. PLoS ONE 2015, 10:e0120352.
-
(2015)
PLoS ONE
, vol.10
, pp. e0120352
-
-
Aubry, S.1
-
118
-
-
84891892050
-
Reverse engineering and identification in systems biology: strategies, perspectives and challenges
-
Villaverde A.F., Banga J.R. Reverse engineering and identification in systems biology: strategies, perspectives and challenges. J. R. Soc. Interface 2014, 11:20130505.
-
(2014)
J. R. Soc. Interface
, vol.11
, pp. 20130505
-
-
Villaverde, A.F.1
Banga, J.R.2
-
119
-
-
79959265543
-
Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays
-
Augustin R., et al. Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays. Int. J. Alzheimers Dis. 2011, 2011:154325.
-
(2011)
Int. J. Alzheimers Dis.
, vol.2011
, pp. 154325
-
-
Augustin, R.1
-
120
-
-
84915815121
-
Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks
-
Chen J.C., et al. Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks. Cell 2014, 159:402-414.
-
(2014)
Cell
, vol.159
, pp. 402-414
-
-
Chen, J.C.1
-
121
-
-
84923377359
-
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
-
Gjoneska E., et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 2015, 518:365-369.
-
(2015)
Nature
, vol.518
, pp. 365-369
-
-
Gjoneska, E.1
-
122
-
-
84943295250
-
Alzheimer's loci: epigenetic associations and interaction with genetic factors
-
Chibnik L.B., et al. Alzheimer's loci: epigenetic associations and interaction with genetic factors. Ann. Clin. Transl. Neurol. 2015, 2:636-647.
-
(2015)
Ann. Clin. Transl. Neurol.
, vol.2
, pp. 636-647
-
-
Chibnik, L.B.1
-
123
-
-
84919784465
-
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
-
De Jager P.L., et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat. Neurosci. 2014, 17:1156-1163.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 1156-1163
-
-
De Jager, P.L.1
-
124
-
-
84906716826
-
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
-
Lunnon K., et al. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat. Neurosci. 2014, 17:1164-1170.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 1164-1170
-
-
Lunnon, K.1
-
125
-
-
84874238775
-
Impact of molecular imaging on the diagnostic process in a memory clinic
-
Ossenkoppele R., et al. Impact of molecular imaging on the diagnostic process in a memory clinic. Alzheimers Dement. 2013, 9:414-421.
-
(2013)
Alzheimers Dement.
, vol.9
, pp. 414-421
-
-
Ossenkoppele, R.1
-
126
-
-
79959801778
-
PET/CT in diagnosis of dementia
-
Berti V., et al. PET/CT in diagnosis of dementia. Ann. N. Y. Acad. Sci. 2011, 1228:81-92.
-
(2011)
Ann. N. Y. Acad. Sci.
, vol.1228
, pp. 81-92
-
-
Berti, V.1
-
127
-
-
84863446652
-
Noninvasive molecular imaging of neuroinflammation
-
Jacobs A.H., Tavitian B. Noninvasive molecular imaging of neuroinflammation. J. Cereb. Blood Flow Metab. 2012, 32:1393-1415.
-
(2012)
J. Cereb. Blood Flow Metab.
, vol.32
, pp. 1393-1415
-
-
Jacobs, A.H.1
Tavitian, B.2
-
128
-
-
77955415606
-
Regulation of translocator protein 18kDa (TSPO) expression in health and disease states
-
Batarseh A., Papadopoulos V. Regulation of translocator protein 18kDa (TSPO) expression in health and disease states. Mol. Cell. Endocrinol. 2010, 327:1-12.
-
(2010)
Mol. Cell. Endocrinol.
, vol.327
, pp. 1-12
-
-
Batarseh, A.1
Papadopoulos, V.2
-
129
-
-
42649115741
-
Translocator protein 18kDa (TSPO): molecular sensor of brain injury and repair
-
Chen M.K., Guilarte T.R. Translocator protein 18kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol. Ther. 2008, 118:1-17.
-
(2008)
Pharmacol. Ther.
, vol.118
, pp. 1-17
-
-
Chen, M.K.1
Guilarte, T.R.2
-
130
-
-
84865624449
-
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
-
Ching A.S., et al. Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases. Insights Imaging 2012, 3:111-119.
-
(2012)
Insights Imaging
, vol.3
, pp. 111-119
-
-
Ching, A.S.1
-
131
-
-
84868107574
-
11C]PK11195 positron emission tomography study
-
11C]PK11195 positron emission tomography study. Neurobiol. Aging 2013, 34:128-136.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 128-136
-
-
Schuitemaker, A.1
-
132
-
-
58449115240
-
Carbon 11-labeled Pittsburgh compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
-
Wiley C.A., et al. Carbon 11-labeled Pittsburgh compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch. Neurol. 2009, 66:60-67.
-
(2009)
Arch. Neurol.
, vol.66
, pp. 60-67
-
-
Wiley, C.A.1
-
134
-
-
84928826319
-
18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients
-
18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients. J. Cereb. Blood Flow Metab. 2015, 35:766-772.
-
(2015)
J. Cereb. Blood Flow Metab.
, vol.35
, pp. 766-772
-
-
Golla, S.S.1
-
135
-
-
84921931701
-
Structure and activity of tryptophan-rich TSPO proteins
-
Guo Y., et al. Structure and activity of tryptophan-rich TSPO proteins. Science 2015, 347:551-555.
-
(2015)
Science
, vol.347
, pp. 551-555
-
-
Guo, Y.1
-
136
-
-
84921829870
-
Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
-
Li F., et al. Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science 2015, 347:555-558.
-
(2015)
Science
, vol.347
, pp. 555-558
-
-
Li, F.1
|