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Volumn 17, Issue 9, 2014, Pages 1164-1170

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(21)  Lunnon, Katie a   Smith, Rebecca b   Hannon, Eilis a   De Jager, Philip L c,d,e   Srivastava, Gyan c,e   Volta, Manuela b   Troakes, Claire b   Al Sarraj, Safa b   Burrage, Joe a   Macdonald, Ruby a   Condliffe, Daniel b   Harries, Lorna W a   Katsel, Pavel f   Haroutunian, Vahram f,g   Kaminsky, Zachary h,i   Joachim, Catharine j   Powell, John b   Lovestone, Simon b,k   Bennett, David A l   Schalkwyk, Leonard C b   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ANK1 PROTEIN, HUMAN; TRANSCRIPTOME;

EID: 84906716826     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3782     Document Type: Article
Times cited : (429)

References (45)
  • 2
    • 57349112108 scopus 로고    scopus 로고
    • UK: the Full report. (Alzheimer's Society)
    • Knapp, M. & Prince, M. Dementia UK: the Full report. (Alzheimer's Society, 2007).
    • (2007) Dementia
    • Knapp, M.1    Prince, M.2
  • 3
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy, J.A. & Higgins, G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185 (1992).
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J. & Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • Wenk, G.L. Neuropathologic changes in Alzheimer's disease. J. Clin. Psychiatry 64 (suppl. 9), 7-10 (2003).
    • (2003) J. Clin. Psychiatry , vol.64 , pp. 7-10
    • Wenk, G.L.1
  • 6
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • Lambert, J.C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45, 1452-1458 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1452-1458
    • Lambert, J.C.1
  • 7
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Encode Project Consortium et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
  • 8
    • 84887100129 scopus 로고    scopus 로고
    • Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies
    • Lunnon, K. & Mill, J. Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 162B, 789-799 (2013).
    • (2013) Am. J. Med. Genet. B. Neuropsychiatr. Genet. , vol.162 B , pp. 789-799
    • Lunnon, K.1    Mill, J.2
  • 9
    • 84880924522 scopus 로고    scopus 로고
    • From promises to practical strategies in epigenetic epidemiology
    • Mill, J. & Heijmans, B.T. From promises to practical strategies in epigenetic epidemiology. Nat. Rev. Genet. 14, 585-594 (2013).
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 585-594
    • Mill, J.1    Heijmans, B.T.2
  • 10
    • 84901792809 scopus 로고    scopus 로고
    • Epigenetics in health and disease: Heralding the EWAS era
    • Murphy, T.M. & Mill, J. Epigenetics in health and disease: heralding the EWAS era. Lancet 383, 1952-1954 (2014).
    • (2014) Lancet , vol.383 , pp. 1952-1954
    • Murphy, T.M.1    Mill, J.2
  • 11
    • 84876806540 scopus 로고    scopus 로고
    • A data-driven approach to preprocessing Illumina 450K methylation array data
    • Pidsley, R. et al. A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics 14, 293 (2013).
    • (2013) BMC Genomics , vol.14 , pp. 293
    • Pidsley, R.1
  • 12
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239-259 (1991).
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 13
    • 0026077783 scopus 로고
    • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice
    • Kordeli, E. & Bennett, V. Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. J. Cell Biol. 114, 1243-1259 (1991).
    • (1991) J. Cell Biol. , vol.114 , pp. 1243-1259
    • Kordeli, E.1    Bennett, V.2
  • 14
    • 33846441246 scopus 로고    scopus 로고
    • Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule
    • Boiko, T. et al. Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule. J. Neurosci. 27, 590-603 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 590-603
    • Boiko, T.1
  • 15
    • 19444361832 scopus 로고    scopus 로고
    • Expression of Nkx6 genes in the hindbrain and gut of the developing mouse
    • Nelson, S.B., Janiesch, C. & Sander, M. Expression of Nkx6 genes in the hindbrain and gut of the developing mouse. J. Histochem. Cytochem. 53, 787-790 (2005).
    • (2005) J. Histochem. Cytochem. , vol.53 , pp. 787-790
    • Nelson, S.B.1    Janiesch, C.2    Sander, M.3
  • 16
    • 30444438875 scopus 로고    scopus 로고
    • Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development
    • Alanentalo, T. et al. Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr. Patterns 6, 162-170 (2006).
    • (2006) Gene Expr. Patterns , vol.6 , pp. 162-170
    • Alanentalo, T.1
  • 17
    • 84875700729 scopus 로고    scopus 로고
    • A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
    • Guintivano, J., Aryee, M. & Kaminsky, Z. A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression. Epigenetics 8, 290-302 (2013).
    • (2013) Epigenetics , vol.8 , pp. 290-302
    • Guintivano, J.1    Aryee, M.2    Kaminsky, Z.3
  • 18
    • 84869421697 scopus 로고    scopus 로고
    • Comb-p: Software for combining, analyzing, grouping and correcting spatially correlated P-values
    • Pedersen, B.S., Schwartz, D.A., Yang, I.V. & Kechris, K.J. Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values. Bioinformatics 28, 2986-2988 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 2986-2988
    • Pedersen, B.S.1    Schwartz, D.A.2    Yang, I.V.3    Kechris, K.J.4
  • 19
    • 0031781988 scopus 로고    scopus 로고
    • Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    • Haroutunian, V. et al. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch. Neurol. 55, 1185-1191 (1998).
    • (1998) Arch. Neurol. , vol.55 , pp. 1185-1191
    • Haroutunian, V.1
  • 20
    • 0027337409 scopus 로고
    • Brain banks: The Oxford experience
    • Esiri, M.M. Brain banks: the Oxford experience. J. Neural Transm. Suppl. 39, 25-30 (1993).
    • (1993) J. Neural Transm. Suppl. , vol.39 , pp. 25-30
    • Esiri, M.M.1
  • 21
    • 84919784465 scopus 로고    scopus 로고
    • Alzheimer's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1 and other loci
    • 17 August
    • De Jager, P.L. et al. Alzheimer's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1 and other loci. Nat. Neurosci. doi:10.1038/nn.3786 (17 August 2014).
    • (2014) Nat. Neurosci.
    • De Jager, P.L.1
  • 22
    • 78649461131 scopus 로고    scopus 로고
    • Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways
    • Soranzo, N. et al. Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways. Diabetes 59, 3229-3239 (2010).
    • (2010) Diabetes , vol.59 , pp. 3229-3239
    • Soranzo, N.1
  • 23
    • 84863503465 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
    • Imamura, M. et al. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum. Mol. Genet. 21, 3042-3049 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 3042-3049
    • Imamura, M.1
  • 24
    • 84876219189 scopus 로고    scopus 로고
    • Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased beta-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    • Harder, M.N. et al. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased beta-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J. Clin. Endocrinol. Metab. 98, E801-E806 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. E801-E806
    • Harder, M.N.1
  • 25
    • 80051669619 scopus 로고    scopus 로고
    • The projected effect of risk factor reduction on Alzheimer's disease prevalence
    • Barnes, D.E. & Yaffe, K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 10, 819-828 (2011).
    • (2011) Lancet Neurol. , vol.10 , pp. 819-828
    • Barnes, D.E.1    Yaffe, K.2
  • 26
    • 78649982418 scopus 로고    scopus 로고
    • Searching for biomarkers in neurodegeneration
    • Lovestone, S. Searching for biomarkers in neurodegeneration. Nat. Med. 16, 1371-1372 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1371-1372
    • Lovestone, S.1
  • 27
    • 45749109439 scopus 로고    scopus 로고
    • Alzheimer's disease, diagnosis and the need for biomarkers
    • Hooper, C., Lovestone, S. & Sainz-Fuertes, R. Alzheimer's disease, diagnosis and the need for biomarkers. Biomark. Insights 3, 317-323 (2008).
    • (2008) Biomark. Insights , vol.3 , pp. 317-323
    • Hooper, C.1    Lovestone, S.2    Sainz-Fuertes, R.3
  • 28
    • 73249130406 scopus 로고    scopus 로고
    • Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression
    • Fehlbaum-Beurdeley, P. et al. Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression. Alzheimers Dement. 6, 25-38 (2010).
    • (2010) Alzheimers Dement. , vol.6 , pp. 25-38
    • Fehlbaum-Beurdeley, P.1
  • 29
    • 78651371164 scopus 로고    scopus 로고
    • A novel blood test for the early detection of Alzheimer's disease
    • Rye, P.D. et al. A novel blood test for the early detection of Alzheimer's disease. J. Alzheimers Dis. 23, 121-129 (2011).
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 121-129
    • Rye, P.D.1
  • 30
    • 78651375099 scopus 로고    scopus 로고
    • A gene expression pattern in blood for the early detection of Alzheimer's disease
    • Booij, B.B. et al. A gene expression pattern in blood for the early detection of Alzheimer's disease. J. Alzheimers Dis. 23, 109-119 (2011).
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 109-119
    • Booij, B.B.1
  • 31
    • 84872437471 scopus 로고    scopus 로고
    • A blood gene expression marker of early Alzheimer's disease
    • Lunnon, K. et al. A blood gene expression marker of early Alzheimer's disease. J. Alzheimers Dis. 33, 737-753 (2013).
    • (2013) J. Alzheimers Dis. , vol.33 , pp. 737-753
    • Lunnon, K.1
  • 32
    • 84867511423 scopus 로고    scopus 로고
    • Validation of AclarusDx, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease
    • Fehlbaum-Beurdeley, P. et al. Validation of AclarusDx, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease. J. Alzheimers Dis. 32, 169-181 (2012).
    • (2012) J. Alzheimers Dis. , vol.32 , pp. 169-181
    • Fehlbaum-Beurdeley, P.1
  • 33
    • 79251640948 scopus 로고    scopus 로고
    • Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese
    • Wu, Z.C. et al. Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese. Brain Res. 1374, 129-133 (2011).
    • (2011) Brain Res. , vol.1374 , pp. 129-133
    • Wu, Z.C.1
  • 34
    • 77954546617 scopus 로고    scopus 로고
    • Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study
    • Laumet, G. et al. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. J. Alzheimers Dis. 20, 1181-1188 (2010).
    • (2010) J. Alzheimers Dis. , vol.20 , pp. 1181-1188
    • Laumet, G.1
  • 35
    • 79955391954 scopus 로고    scopus 로고
    • Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein
    • Chapuis, J., Vingtdeux, V., Campagne, F., Davies, P. & Marambaud, P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum. Mol. Genet. 20, 2026-2036 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2026-2036
    • Chapuis, J.1    Vingtdeux, V.2    Campagne, F.3    Davies, P.4    Marambaud, P.5
  • 36
    • 84862861561 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood
    • Lunnon, K. et al. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J. Alzheimers Dis. 30, 685-710 (2012).
    • (2012) J. Alzheimers Dis. , vol.30 , pp. 685-710
    • Lunnon, K.1
  • 37
    • 77957911410 scopus 로고    scopus 로고
    • Allele-specific methylation in the human genome: Implications for genetic studies of complex disease
    • Meaburn, E.L., Schalkwyk, L.C. & Mill, J. Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics 5, 578-582 (2010).
    • (2010) Epigenetics , vol.5 , pp. 578-582
    • Meaburn, E.L.1    Schalkwyk, L.C.2    Mill, J.3
  • 38
    • 77954238686 scopus 로고    scopus 로고
    • Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome
    • Shoemaker, R., Deng, J., Wang, W. & Zhang, K. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 20, 883-889 (2010).
    • (2010) Genome Res. , vol.20 , pp. 883-889
    • Shoemaker, R.1    Deng, J.2    Wang, W.3    Zhang, K.4
  • 39
    • 84862210732 scopus 로고    scopus 로고
    • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    • Davies, M.N. et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 13, R43 (2012).
    • (2012) Genome Biol. , vol.13 , pp. R43
    • Davies, M.N.1
  • 40
    • 81855183787 scopus 로고    scopus 로고
    • Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    • Dempster, E.L. et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum. Mol. Genet. 20, 4786-4796 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4786-4796
    • Dempster, E.L.1
  • 41
    • 84897111264 scopus 로고    scopus 로고
    • Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    • Wong, C.C. et al. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol. Psychiatry 19, 495-503 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 495-503
    • Wong, C.C.1
  • 42
    • 84863304598 scopus 로고    scopus 로고
    • R Foundation for Statistical Computing, Vienna, Austria
    • R Development Core Team. R: a language and environment for statistical computing. (R Foundation for Statistical Computing, Vienna, Austria, 2012).
    • (2012) R: A Language and Environment for Statistical Computing
  • 43
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman, R.C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
    • (2004) Genome Biol. , vol.5 , pp. R80
    • Gentleman, R.C.1
  • 45
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    • Chen, Y.A. et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 8, 203-209 (2013).
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.A.1


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