Genetic variation at CR1 increases risk of cerebral amyloid angiopathy

Neurology

Volumn 78, Issue 5, 2012, Pages 334-341

  Biffi, A ^a,b   Shulman, J M ^b,c   Jagiella, J M ^d   Cortellini, L ^a,b   Ayres, A M ^a   Schwab, K ^a   Brown, D L ^e   Silliman, S L ^f   Selim, M ^g   Worrall, B B ^h   Meschia, J F ⁱ   Slowik, A ^k   De Jager, P L ^b,c   Greenberg, S M ^a   Schneider, J A ^j   Bennett, D A ^j   Rosand, J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^h UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

ⁱ MAYO CLINIC   (United States)

^j RUSH UNIVERSITY MEDICAL CENTER   (United States)

^k NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ARTICLE; AUTOPSY; BRAIN HEMORRHAGE; CONTROLLED STUDY; CR1 GENE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; VASCULAR AMYLOIDOSIS; AGE; ALZHEIMER DISEASE; CONFIDENCE INTERVAL; FOLLOW UP; GENETIC ASSOCIATION; GENETICS; GENOTYPE; KAPLAN MEIER METHOD; LONGITUDINAL STUDY; MIDDLE AGED; RISK; SEX DIFFERENCE; STATISTICAL ANALYSIS;

APOLIPOPROTEIN E; COMPLEMENT COMPONENT C3B RECEPTOR; CR1 PROTEIN, HUMAN;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; AUTOPSY; CEREBRAL AMYLOID ANGIOPATHY; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; FEMALE; FOLLOW-UP STUDIES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, COMPLEMENT 3B; RISK; SEX FACTORS;

EID: 84863393134     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182452b40     Document Type: Article

References (32)

1. Vinters HV, Gilbert JJ. Cerebral amyloid angiopathy: incidence and complications in the aging brain: II: the distribution of amyloid vascular changes. Stroke 1983; 14:924-928. (Pubitemid 14205243)
2. Vinters HV. Cerebral amyloid angiopathy: a critical review. Stroke 1987;18:311-324. (Pubitemid 17059655)
3. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med 2001;344:1450-1460. (Pubitemid 32402103)
4. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689-701.
5. Vinters HV. Cerebral amyloid angiopathy: a microvascular link between parenchymal and vascular dementia? Ann Neurol 2001;49:691-693. (Pubitemid 32530232)
6. Greenberg SM, Gurol ME, Rosand J, Smith EE. Amyloid angiopathy-related vascular cognitive impairment. Stroke 2004;35:2616-2619. (Pubitemid 39458351)
7. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001;56:537-539. (Pubitemid 32172884)
8. Van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol 2010; 9:167-176.
9. O'Donnell HC, Rosand J, Knudsen KA, et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med 2000;342:240-245. (Pubitemid 30058955)
10. Biffi A, Halpin A, Towfighi A, et al. Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology 2010;75:693-698.
11. Vinters HV, Wang ZZ, Secor DL. Brain parenchymal and microvascular amyloid in Alzheimer's disease. Brain Pathol 1996;6:179-195. (Pubitemid 26160505)
12. Bekris LM, Yu CE, Bird TD, et al. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol 2010;23:213-227.
13. Revesz T, Holton JL, Lashley T, et al. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol 2009;118:115-130.
14. Biffi A, Sonni A, Anderson CD, et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010;68:934-943.
15. Harold D, Abraham R, Hollingworth P, et al. Genomewide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009;41:1088-1093.
16. Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009;41:1094-1099.
17. Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832-1840.
18. Chibnik LB, Shulman JM, Leurgans SE, et al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann Neurol 2011;69:560-569.
19. Genes for Cerebral Hemorrhage on Anticoagulation (GOCHA) Collaborative Group. Exploiting common genetic variation to make anticoagulation safer. Stroke 2009;40:S64-S66.
20. Arvanitakis Z, Leurgans SE, Wang Z, et al. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol 2011;69:320-327.
21. Bennett DA, Schneider JA, Buchman AS, et al. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 2005;25:163-175. (Pubitemid 41540657)
22. Bennett DA, Schneider JA, Arvanitakis Z, et al. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 2006;66: 1837-1844. (Pubitemid 44049813)
23. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575. (Pubitemid 47330214)
24. Revesz T, Holton JL, Lashley T, et al. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol 2009;118:115-130.
25. Biffi A, Anderson CD, Desikan RS, et al. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol 2010;67:677-685.
26. Tian C, Gregersen PK, Seldin MF. Accounting for ancestry: population substructure and genome-wide association studies. Hum Mol Genet 2008;17:R143-R150.
27. Hess KR. Graphical methods for assessing violations of the proportional hazards assumption in Cox regression. Stat Med 1995;14:1707-1723.
28. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19:149-150. (Pubitemid 36150192)
29. Xiao R, Boehnke M. Quantifying and correcting for the winner's curse in genetic association studies. Genet Epidemiol 2009;33:453-462.
30. Kraft P. Curses-winner's and otherwise-in genetic epidemiology. Epidemiology 2008;19:649-651.
31. Bennett DA, De Jager PL, Leurgans SE, Schneider JA. Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology 2009; 72:1495-1503.
32. Corneveaux JJ, Myers AJ, Allen AN, et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 2010;19: 3295-3301.