Quantification of [18 F]DPA-714 binding in the human brain: Initial studies in healthy controls and Alzheimer's disease patients

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 5, 2015, Pages 766-772

  Golla, Sandeep S V ^a   Boellaard, Ronald ^a   Oikonen, Vesa ^b   Hoffmann, Anja ^c   Van Berckel, Bart N M ^a   Windhorst, Albert D ^a   Virta, Jere ^b   Haaparanta Solin, Merja ^b   Luoto, Pauliina ^b   Savisto, Nina ^b   Solin, Olof ^b   Valencia, Ray ^c   Thiele, Andrea ^c   Eriksson, Jonas ^a   Schuit, Robert C ^a   Lammertsma, Adriaan A ^a   Rinne, Juha O ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c BAYER PHARMA AG   (Germany)

Author keywords

Alzheimer's disease; neuroinflammation; PET quantification; TSPO; 18F DPA 714

Indexed keywords

FLUORINE 18 N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 YL]ACETAMIDE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; FLUORINE; N,N-DIETHYL-2-(2-(4-(2-FLUOROETHOXY)PHENYL)-5,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-3-YL)ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD VOLUME; CAUDATE NUCLEUS; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GRAY MATTER; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; INSULA; MALE; MIDDLE AGED; OCCIPITAL CORTEX; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; TEMPORAL CORTEX; THALAMUS; VERY ELDERLY; VOLUME OF DISTRIBUTION; WHITE MATTER; BIOLOGICAL MODEL; CLINICAL TRIAL; KINETICS; METABOLISM; MULTICENTER STUDY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; KINETICS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RECEPTORS, GABA; TIME FACTORS;

EID: 84928826319     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.261     Document Type: Article

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