Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

Nature Neuroscience

Volumn 13, Issue 4, 2010, Pages 411-413

  Fuhrmann, Martin ^a   Bittner, Tobias ^a   Jung, Christian K E ^a   Burgold, Steffen ^a   Page, Richard M ^a   Mitteregger, Gerda ^a   Haass, Christian ^a   Laferla, Frank M ^b   Kretzschmar, Hans ^a   Herms, Jochen ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL COMMUNICATION; CELL DENSITY; CELL LOSS; CELL MIGRATION; IN VIVO STUDY; KNOCKOUT MOUSE; MICROGLIA; MOUSE; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; TRANSGENIC MOUSE; VELOCITY;

ALZHEIMER DISEASE; ANIMALS; CELL COMMUNICATION; CELL COUNT; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NEURONS; RECEPTORS, CHEMOKINE;

EID: 77950188666     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2511     Document Type: Article

References (15)

1. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Science 308, 1314-1318 (2005).
2. Hanisch, U.K. & Kettenmann, H. Nat. Neurosci. 10, 1387-1394 (2007).
3. Grathwohl, S.A. et al. Nat. Neurosci. 12, 1361-1363 (2009
4. Wyss-Coray, T. Nat. Med. 12, 1005-1015 (2006).
5. London, J.A., Biegel, D. & Pachter, J.S. Proc. Natl. Acad. Sci. USA 93, 4147-4152 (1996).
6. Giulian, D. et al. J. Neurosci. 16, 6021-6037 (1996).
7. Oddo, S. et al. Neuron 39, 409-421 (2003).
8. Fuhrmann, M. et al. J. Neurosci. 27, 6224-6233 (2007).
9. Harrison, J.K. et al. Proc. Natl. Acad. Sci. USA 95, 10896-10901 (1998).
10. Chapman, G.A. et al. J. Neurosci. 20, RC87 (2000).
11. Bolmont, T. et al. J. Neurosci. 28, 4283-4292 (2008).
12. Cardona, A.E. et al. Nat. Neurosci. 9, 917-924 (2006).
13. Dénes, A. et al. J. Cereb. Blood Flow Metab. 28, 1707-1721 (2008).
14. Davalos, D. et al. Nat. Neurosci. 8, 752-758 (2005).
15. Jung, S. et al. Mol. Cell. Biol. 20, 4106-4114 (2000).