Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks

Cell

Volumn 159, Issue 2, 2014, Pages 402-414

  Chen, James C ^a   Alvarez, Mariano J ^a   Talos, Flaminia ^a   Dhruv, Harshil ^b   Rieckhof, Gabrielle E ^a   Iyer, Archana ^a   Diefes, Kristin L ^c   Aldape, Kenneth ^d   Berens, Michael ^b   Shen, Michael M ^a   Califano, Andrea ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; KLHL9 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN MDM2; PROTEIN MDMX; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; CEBPD PROTEIN, HUMAN; KLHL9 PROTEIN, HUMAN; PROTEASOME; PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CELL CYCLE S PHASE; FUNCTIONAL DISEASE; GENE DELETION; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLIOMA; HUMAN; MESENCHYME CELL; MOUSE; MULTIPLE CANCER; NONHUMAN; PHENOTYPE; POINT MUTATION; PROTEIN DEGRADATION; QUANTITATIVE TRAIT LOCUS; UBIQUITINATION; ALGORITHM; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; COPY NUMBER VARIATION; GENE REGULATORY NETWORK; GENETICS; GLIOBLASTOMA; METABOLISM; MUTATION; PATHOLOGY; XENOGRAFT;

ALGORITHMS; ALZHEIMER DISEASE; ANIMALS; BREAST NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; DNA COPY NUMBER VARIATIONS; GENE REGULATORY NETWORKS; GLIOBLASTOMA; HETEROGRAFTS; HUMANS; MICE; MUTATION; NEOPLASM TRANSPLANTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; QUANTITATIVE TRAIT LOCI; UBIQUITINATION;

EID: 84915815121     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.09.021     Document Type: Article

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