CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32713-32722

  Cho, Seo Hyun ^a,b   Sun, Binggui ^a,b,e   Zhou, Yungui ^a   Kauppinen, Tiina M ^b   Halabisky, Brian ^a,b   Wes, Paul ^c   Ransohoff, Richard M ^d   Gan, Li ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CALBINDIN; COGNITIVE DECLINE; COGNITIVE DEFICITS; CYTOKINE PRODUCTION; DENTATE GYRUS; INFLAMMATORY CYTOKINES; INTERLEUKIN-6; MEMORY LOSS; MEMORY RETENTION; MICROGLIA; MOLECULAR MECHANISM; MOUSE MODELS; NEUROTOXIC EFFECTS; OBJECT RECOGNITION TESTS; PROTEIN SIGNALING; TAU PATHOLOGY; TUMOR NECROSIS FACTORS;

GLYCOPROTEINS; MAMMALS; NEURODEGENERATIVE DISEASES; OBJECT RECOGNITION; SIGNALING;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALBINDIN; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; INTERLEUKIN 6; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CYTOKINE PRODUCTION; DENTATE GYRUS; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MEMORY CONSOLIDATION; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECOGNITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; COGNITION DISORDERS; CYTOKINES; DENTATE GYRUS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; MICROGLIA; NERVE TISSUE PROTEINS; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

MUS;

EID: 80052714655     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.254268     Document Type: Article

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