메뉴 건너뛰기




Volumn 32, Issue 3, 2008, Pages 412-419

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Author keywords

Alzheimer; Amyloid; Microglia; PET; PIB; PK11195

Indexed keywords

AMYLOID PROTEIN; CARBON 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

EID: 56349144614     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.08.001     Document Type: Article
Times cited : (436)

References (53)
  • 1
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H., et al. Inflammation and Alzheimer's disease. Neurobiol. Aging 21 (2000) 383-421
    • (2000) Neurobiol. Aging , vol.21 , pp. 383-421
    • Akiyama, H.1
  • 2
    • 34247225480 scopus 로고    scopus 로고
    • A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    • Anderson A.N., et al. A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195. Neuroimage 36 (2007) 28-37
    • (2007) Neuroimage , vol.36 , pp. 28-37
    • Anderson, A.N.1
  • 3
    • 33745700402 scopus 로고    scopus 로고
    • Amyloid load and cerebral atrophy in Alzheimer's disease: An (11)C-PIB positron emission tomography study
    • Archer H.A., et al. Amyloid load and cerebral atrophy in Alzheimer's disease: An (11)C-PIB positron emission tomography study. Ann. Neurol. 60 (2006) 145-147
    • (2006) Ann. Neurol. , vol.60 , pp. 145-147
    • Archer, H.A.1
  • 4
    • 0033768486 scopus 로고    scopus 로고
    • The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity
    • Banati R.B., et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123 Pt 11 (2000) 2321-2337
    • (2000) Brain , vol.123 , Issue.PART 11 , pp. 2321-2337
    • Banati, R.B.1
  • 5
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F., et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6 (2000) 916-919
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1
  • 6
    • 0034128874 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptors: a review
    • Beurdeley-Thomas A., et al. The peripheral benzodiazepine receptors: a review. J. Neurooncol. 46 (2000) 45-56
    • (2000) J. Neurooncol. , vol.46 , pp. 45-56
    • Beurdeley-Thomas, A.1
  • 7
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl). 82 (1991) 239-259
    • (1991) Acta Neuropathol. (Berl). , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 8
    • 9844227354 scopus 로고    scopus 로고
    • Performance evaluation of a whole-body PET scanner using the NEMA protocol. National Electrical Manufacturers Association
    • Brix G., et al. Performance evaluation of a whole-body PET scanner using the NEMA protocol. National Electrical Manufacturers Association. J. Nucl. Med. 38 (1997) 1614-1623
    • (1997) J. Nucl. Med. , vol.38 , pp. 1614-1623
    • Brix, G.1
  • 9
    • 0035845283 scopus 로고    scopus 로고
    • In-vivo measurement of activated microglia in dementia
    • Cagnin A., et al. In-vivo measurement of activated microglia in dementia. Lancet. 358 (2001) 461-467
    • (2001) Lancet. , vol.358 , pp. 461-467
    • Cagnin, A.1
  • 10
    • 0034774203 scopus 로고    scopus 로고
    • In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion
    • Cagnin A., et al. In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain 124 (2001) 2014-2027
    • (2001) Brain , vol.124 , pp. 2014-2027
    • Cagnin, A.1
  • 11
    • 0003176673 scopus 로고    scopus 로고
    • Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus
    • DiPatre P.L., and Gelman B.B. Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus. J. Neuropathol. Exp. Neurol. 56 (1997) 143-149
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 143-149
    • DiPatre, P.L.1    Gelman, B.B.2
  • 12
    • 33847062118 scopus 로고    scopus 로고
    • Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study
    • Edison P., et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 68 (2007) 501-508
    • (2007) Neurology , vol.68 , pp. 501-508
    • Edison, P.1
  • 13
    • 0036850023 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and prion disease
    • Eikelenboom P., et al. Neuroinflammation in Alzheimer's disease and prion disease. Glia 40 (2002) 232-239
    • (2002) Glia , vol.40 , pp. 232-239
    • Eikelenboom, P.1
  • 14
    • 33749506795 scopus 로고    scopus 로고
    • Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    • Engler H., et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 129 (2006) 2856-2866
    • (2006) Brain , vol.129 , pp. 2856-2866
    • Engler, H.1
  • 15
    • 33644832047 scopus 로고    scopus 로고
    • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    • Fagan A.M., et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann. Neurol. 59 (2006) 512-519
    • (2006) Ann. Neurol. , vol.59 , pp. 512-519
    • Fagan, A.M.1
  • 16
    • 0026783591 scopus 로고
    • Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
    • Frackowiak J., et al. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol. (Berl). 84 (1992) 225-233
    • (1992) Acta Neuropathol. (Berl). , vol.84 , pp. 225-233
    • Frackowiak, J.1
  • 17
    • 0031974406 scopus 로고    scopus 로고
    • Microglial response to amyloid plaques in APPsw transgenic mice
    • Frautschy S.A., et al. Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pathol. 152 (1998) 307-317
    • (1998) Am. J. Pathol. , vol.152 , pp. 307-317
    • Frautschy, S.A.1
  • 18
    • 0029811105 scopus 로고    scopus 로고
    • Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
    • Giulian D., et al. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci. 16 (1996) 6021-6037
    • (1996) J. Neurosci. , vol.16 , pp. 6021-6037
    • Giulian, D.1
  • 19
    • 0027236235 scopus 로고
    • Synaptic stripping in the human facial nucleus
    • Graeber M.B., et al. Synaptic stripping in the human facial nucleus. Acta Neuropathol. 86 (1993) 179-181
    • (1993) Acta Neuropathol. , vol.86 , pp. 179-181
    • Graeber, M.B.1
  • 20
    • 0041569918 scopus 로고    scopus 로고
    • Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe
    • Hammers A., et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum. Brain Mapp. 19 (2003) 224-247
    • (2003) Hum. Brain Mapp. , vol.19 , pp. 224-247
    • Hammers, A.1
  • 21
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., and Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12 (1991) 383-388
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 22
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk W.E., et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55 (2004) 306-319
    • (2004) Ann. Neurol. , vol.55 , pp. 306-319
    • Klunk, W.E.1
  • 23
    • 33750593789 scopus 로고    scopus 로고
    • Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    • Klunk W.E., et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 129 (2006) 2805-2807
    • (2006) Brain , vol.129 , pp. 2805-2807
    • Klunk, W.E.1
  • 24
    • 0037444535 scopus 로고    scopus 로고
    • The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    • Klunk W.E., et al. The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J. Neurosci. 23 (2003) 2086-2092
    • (2003) J. Neurosci. , vol.23 , pp. 2086-2092
    • Klunk, W.E.1
  • 25
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19 (1996) 312-318
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 26
    • 0030907583 scopus 로고    scopus 로고
    • The cerebellum in Alzheimer's disease
    • Larner A.J. The cerebellum in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 8 (1997) 203-209
    • (1997) Dement. Geriatr. Cogn. Disord. , vol.8 , pp. 203-209
    • Larner, A.J.1
  • 27
    • 33644876596 scopus 로고    scopus 로고
    • Simplified quantification of Pittsburgh compound B Amyloid imaging PET studies: a comparative analysis
    • Lopresti B.J., et al. Simplified quantification of Pittsburgh compound B Amyloid imaging PET studies: a comparative analysis. J. Nucl. Med. 46 (2005) 1959-1972
    • (2005) J. Nucl. Med. , vol.46 , pp. 1959-1972
    • Lopresti, B.J.1
  • 28
    • 0034948192 scopus 로고    scopus 로고
    • Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
    • Lue L.F., et al. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35 (2001) 72-79
    • (2001) Glia , vol.35 , pp. 72-79
    • Lue, L.F.1
  • 29
    • 0024343222 scopus 로고
    • Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome
    • discussion 412-4
    • Mann D.M. Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome. Neurobiol. Aging 10 (1989) 397-399 discussion 412-4
    • (1989) Neurobiol. Aging , vol.10 , pp. 397-399
    • Mann, D.M.1
  • 30
    • 0024992306 scopus 로고
    • Microglia in cerebellar plaques in Alzheimer's disease
    • Mattiace L.A., et al. Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol. (Berl). 80 (1990) 493-498
    • (1990) Acta Neuropathol. (Berl). , vol.80 , pp. 493-498
    • Mattiace, L.A.1
  • 31
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald D.R., et al. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J. Neurosci. 17 (1997) 2284-2294
    • (1997) J. Neurosci. , vol.17 , pp. 2284-2294
    • McDonald, D.R.1
  • 32
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • McGeer P.L., and McGeer E.G. Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging 22 (2001) 799-809
    • (2001) Neurobiol. Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 33
    • 0036949091 scopus 로고    scopus 로고
    • Local neuroinflammation and the progression of Alzheimer's disease
    • McGeer P.L., and McGeer E.G. Local neuroinflammation and the progression of Alzheimer's disease. J. Neurovirol. 8 (2002) 529-538
    • (2002) J. Neurovirol. , vol.8 , pp. 529-538
    • McGeer, P.L.1    McGeer, E.G.2
  • 34
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G., et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 35
    • 0028953529 scopus 로고
    • Activation of microglial cells by beta-amyloid protein and interferon-gamma
    • Meda L., et al. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374 (1995) 647-650
    • (1995) Nature , vol.374 , pp. 647-650
    • Meda, L.1
  • 36
    • 28944450413 scopus 로고    scopus 로고
    • Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's disease
    • Mintun M.A. Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's disease. CNS Spectr. 10 (2005) 13-16
    • (2005) CNS Spectr. , vol.10 , pp. 13-16
    • Mintun, M.A.1
  • 37
    • 0027526364 scopus 로고
    • Peripheral-type benzodiazepine receptors
    • Parola A.L., et al. Peripheral-type benzodiazepine receptors. Life Sci. 52 (1993) 1329-1342
    • (1993) Life Sci. , vol.52 , pp. 1329-1342
    • Parola, A.L.1
  • 38
    • 27544513056 scopus 로고    scopus 로고
    • Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    • Price J.C., et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J. Cereb. Blood Flow Metab. 25 (2005) 1528-1547
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1528-1547
    • Price, J.C.1
  • 39
    • 0036362656 scopus 로고    scopus 로고
    • Elucidating molecular mechanisms of Alzheimer's disease in microglial cultures
    • Rogers J., et al. Elucidating molecular mechanisms of Alzheimer's disease in microglial cultures. Ernst Schering Res. Found. Workshop (2002) 25-44
    • (2002) Ernst Schering Res. Found. Workshop , pp. 25-44
    • Rogers, J.1
  • 40
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D., et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400 (1999) 173-177
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 41
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron 6 (1991) 487-498
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 42
    • 0028358646 scopus 로고
    • Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats
    • Shah F., et al. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl. Med. Biol. 21 (1994) 573-581
    • (1994) Nucl. Med. Biol. , vol.21 , pp. 573-581
    • Shah, F.1
  • 43
    • 0033800364 scopus 로고    scopus 로고
    • Physical characteristics of the ECAT EXACT3D positron tomograph
    • Spinks T.J., et al. Physical characteristics of the ECAT EXACT3D positron tomograph. Phys. Med. Biol. 45 (2000) 2601-2618
    • (2000) Phys. Med. Biol. , vol.45 , pp. 2601-2618
    • Spinks, T.J.1
  • 44
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40 (2002) 133-139
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 45
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit W.J. Microglia and Alzheimer's disease pathogenesis. J. Neurosci. Res. 77 (2004) 1-8
    • (2004) J. Neurosci. Res. , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 46
    • 13344293701 scopus 로고    scopus 로고
    • Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome
    • Teller J.K., et al. Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome. Nat. Med. 2 (1996) 93-95
    • (1996) Nat. Med. , vol.2 , pp. 93-95
    • Teller, J.K.1
  • 47
    • 33847333156 scopus 로고    scopus 로고
    • Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    • Turkheimer F.E., et al. Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J. Nucl. Med. 48 (2007) 158-167
    • (2007) J. Nucl. Med. , vol.48 , pp. 158-167
    • Turkheimer, F.E.1
  • 48
    • 0037333633 scopus 로고    scopus 로고
    • Immune reactive cells in senile plaques and cognitive decline in AD
    • Vehmas A.K., Stewart W.F., and Troncoso J.C. Immune reactive cells in senile plaques and cognitive decline in AD. Neurobiol. Aging 24 (2003) 321-331
    • (2003) Neurobiol. Aging , vol.24 , pp. 321-331
    • Vehmas, A.K.1    Stewart, W.F.2    Troncoso, J.C.3
  • 49
    • 15944366880 scopus 로고    scopus 로고
    • In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
    • Verhoeff N.P., et al. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am. J. Geriatr. Psychiatry 12 (2004) 584-595
    • (2004) Am. J. Geriatr. Psychiatry , vol.12 , pp. 584-595
    • Verhoeff, N.P.1
  • 50
    • 0024434236 scopus 로고
    • Ultrastructural studies of the cells forming amyloid fibers in classical plaques
    • Wisniewski H.M., et al. Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can. J. Neurol. Sci. 16 (1989) 535-542
    • (1989) Can. J. Neurol. Sci. , vol.16 , pp. 535-542
    • Wisniewski, H.M.1
  • 51
    • 0026685656 scopus 로고
    • Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease
    • Wisniewski H.M., et al. Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol. (Berl). 84 (1992) 117-127
    • (1992) Acta Neuropathol. (Berl). , vol.84 , pp. 117-127
    • Wisniewski, H.M.1
  • 52
    • 0025762631 scopus 로고
    • Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type
    • Wisniewski T., et al. Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type. Am. J. Pathol. 138 (1991) 1077-1083
    • (1991) Am. J. Pathol. , vol.138 , pp. 1077-1083
    • Wisniewski, T.1
  • 53
    • 33846538660 scopus 로고    scopus 로고
    • Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    • Yoshiyama Y., et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53 (2007) 337-351
    • (2007) Neuron , vol.53 , pp. 337-351
    • Yoshiyama, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.