SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

Nature Medicine

Volumn 8, Issue 9, 2002, Pages 943-949

  Takeshita, Sunao ^a   Namba, Noriyuki ^a,b   Zhao, Jenny J ^c   Jiang, Yebin ^c   Genant, Harry K ^c   Silva, Matthew J ^a   Brodt, Michael D ^a   Helgason, Cheryl D ^d   Kalesnikoff, Janet ^d   Rauh, Michael J ^d   Humphries, R Keith ^d   Krystal, Gerald ^d   Teitelbaum, Steven L ^a   Ross, F Patrick ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; INTERLEUKIN 6; MYOINOSITOL 1 PHOSPHATE SYNTHASE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; SRC HOMOLOGY 2 CONTAINING INOSITOL 5 PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERALIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPHOSPHORYLATION; ENZYME DEFECT; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; FRACTURE; HEMATOPOIESIS; HYPERSENSITIVITY; LIFESPAN; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PAGET BONE DISEASE; PRIORITY JOURNAL; PROTEIN RESTRICTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STEM CELL; THICKNESS; TRABECULAR BONE;

ANIMALS; APOPTOSIS; BONE DENSITY; BONE RESORPTION; CARRIER PROTEINS; CELL COUNT; CELLS, CULTURED; INTERLEUKIN-6; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, MUTANT STRAINS; OSTEOCLASTS; OSTEOPOROSIS; PHOSPHORIC MONOESTER HYDROLASES; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B;

ANIMALIA;

EID: 0036732410     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm752     Document Type: Article

References (45)

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