Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism

Science

Volumn 347, Issue 6221, 2015, Pages 555-558

  Li, Fei ^a   Liu, Jian ^a   Zheng, Yi ^a,b   Garavito, R Michael ^a   Ferguson Miller, Shelagh ^a  

^a Michigan State University   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MUTANT PROTEIN; PORPHYRIN; PREGNENOLONE; 4 AMINOBUTYRIC ACID RECEPTOR; BACTERIAL PROTEIN; CHOLESTEROL; ISOQUINOLINE DERIVATIVE; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTOPORPHYRIN; TSPO PROTEIN, HUMAN;

BACTERIUM; CANCER; CRYSTAL STRUCTURE; DISEASE PREVALENCE; LIGAND; MITOCHONDRION; MUTATION; NEUROLOGY; PHYSIOLOGY; POLYMORPHISM; PROTEIN;

ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; CRYSTAL STRUCTURE; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RHODOBACTER SPHAEROIDES; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; X RAY CRYSTALLOGRAPHY;

RHODOBACTER SPHAEROIDES;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; ISOQUINOLINES; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PORPHYRINS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTOPORPHYRINS; RECEPTORS, GABA; RHODOBACTER SPHAEROIDES;

EID: 84921829870     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1260590     Document Type: Article

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