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Volumn 36, Issue 4, 2013, Pages 209-217

Microglia: Actively surveying and shaping neuronal circuit structure and function

Author keywords

Brain immune cells; Glia; Microglia; Psychiatric disease; Synapse; Synaptic plasticity

Indexed keywords

BRAIN FUNCTION; CELL DEATH; CELL EXPANSION; CELL MIGRATION; CELL PROLIFERATION; HOMEOSTASIS; MENTAL DISEASE; MICROGLIA; MOLECULAR INTERACTION; NERVE CELL PLASTICITY; NERVE FUNCTION; NERVE GROWTH; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM PARAMETERS; NEUROLOGIC DISEASE; NEURONAL CIRCUIT STRUCTURE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYNAPSE;

EID: 84875870356     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2012.11.007     Document Type: Review
Times cited : (372)

References (96)
  • 1
    • 79955605102 scopus 로고    scopus 로고
    • Physiology of microglia
    • Kettenmann H., et al. Physiology of microglia. Physiol. Rev. 2011, 91:461-553.
    • (2011) Physiol. Rev. , vol.91 , pp. 461-553
    • Kettenmann, H.1
  • 2
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • Perry V.H., et al. Microglia in neurodegenerative disease. Nat. Rev. Neurol. 2010, 6:193-201.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 193-201
    • Perry, V.H.1
  • 3
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • Prinz M., et al. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 2011, 14:1227-1235.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1227-1235
    • Prinz, M.1
  • 4
    • 0035399993 scopus 로고    scopus 로고
    • Origin of microglia
    • Kaur C., et al. Origin of microglia. Microsc. Res. Tech. 2001, 54:2-9.
    • (2001) Microsc. Res. Tech. , vol.54 , pp. 2-9
    • Kaur, C.1
  • 5
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 6
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson L.J., et al. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990, 39:151-170.
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1
  • 7
    • 0022387412 scopus 로고
    • Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
    • Perry V.H., et al. Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 1985, 15:313-326.
    • (1985) Neuroscience , vol.15 , pp. 313-326
    • Perry, V.H.1
  • 8
    • 78650233802 scopus 로고    scopus 로고
    • Microglia in the CNS: immigrants from another world
    • Prinz M., Mildner A. Microglia in the CNS: immigrants from another world. Glia 2011, 59:177-187.
    • (2011) Glia , vol.59 , pp. 177-187
    • Prinz, M.1    Mildner, A.2
  • 9
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • Beers D.R., et al. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:16021-16026.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 16021-16026
    • Beers, D.R.1
  • 10
    • 0025179936 scopus 로고
    • Microglia and cell death in the developing mouse cerebellum
    • Ashwell K. Microglia and cell death in the developing mouse cerebellum. Brain Res. 1990, 55:219-230.
    • (1990) Brain Res. , vol.55 , pp. 219-230
    • Ashwell, K.1
  • 11
    • 33846571886 scopus 로고    scopus 로고
    • The origin and cell lineage of microglia: new concepts
    • Chan W.Y., et al. The origin and cell lineage of microglia: new concepts. Brain Res. Rev. 2007, 53:344-354.
    • (2007) Brain Res. Rev. , vol.53 , pp. 344-354
    • Chan, W.Y.1
  • 12
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330:841-845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 13
    • 84869156976 scopus 로고    scopus 로고
    • Development and homeostasis of 'resident' myeloid cells: the case of the microglia
    • Gomez Perdiguero E., et al. Development and homeostasis of 'resident' myeloid cells: the case of the microglia. Glia 2013, 61:112-120.
    • (2013) Glia , vol.61 , pp. 112-120
    • Gomez Perdiguero, E.1
  • 14
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz C., et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (New York, N.Y.) 2012, 336:86-90.
    • (2012) Science (New York, N.Y.) , vol.336 , pp. 86-90
    • Schulz, C.1
  • 15
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • Lawson L.J., et al. Turnover of resident microglia in the normal adult mouse brain. Neuroscience 1992, 48:405-415.
    • (1992) Neuroscience , vol.48 , pp. 405-415
    • Lawson, L.J.1
  • 16
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • Alliot F., et al. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res. 1999, 117:145-152.
    • (1999) Brain Res. , vol.117 , pp. 145-152
    • Alliot, F.1
  • 17
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 2007, 10:1538-1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1
  • 18
    • 84865022665 scopus 로고    scopus 로고
    • Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor runx1
    • Zusso M., et al. Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor runx1. J. Neurosci. 2012, 32:11285-11298.
    • (2012) J. Neurosci. , vol.32 , pp. 11285-11298
    • Zusso, M.1
  • 19
    • 42749094922 scopus 로고    scopus 로고
    • From bone marrow to microglia: barriers and avenues
    • Davoust N., et al. From bone marrow to microglia: barriers and avenues. Trends Immunol. 2008, 29:227-234.
    • (2008) Trends Immunol. , vol.29 , pp. 227-234
    • Davoust, N.1
  • 20
    • 0029076362 scopus 로고
    • Microglia: intrinsic immuneffector cell of the brain
    • Gehrmann J., et al. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Brain Res. Rev. 1995, 20:269-287.
    • (1995) Brain Res. Brain Res. Rev. , vol.20 , pp. 269-287
    • Gehrmann, J.1
  • 21
    • 17844402957 scopus 로고    scopus 로고
    • Microglial cell population dynamics in the injured adult central nervous system
    • Ladeby R., et al. Microglial cell population dynamics in the injured adult central nervous system. Brain Res. Brain Res. Rev. 2005, 48:196-206.
    • (2005) Brain Res. Brain Res. Rev. , vol.48 , pp. 196-206
    • Ladeby, R.1
  • 22
    • 4744355622 scopus 로고    scopus 로고
    • CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion
    • Rappert A., et al. CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J. Neurosci. 2004, 24:8500-8509.
    • (2004) J. Neurosci. , vol.24 , pp. 8500-8509
    • Rappert, A.1
  • 23
    • 16344393716 scopus 로고    scopus 로고
    • Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia
    • Bechmann I., et al. Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J. 2005, 19:647-649.
    • (2005) FASEB J. , vol.19 , pp. 647-649
    • Bechmann, I.1
  • 24
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami B., et al. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 2011, 14:1142-1149.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1142-1149
    • Ajami, B.1
  • 25
    • 0029865887 scopus 로고    scopus 로고
    • Microglioma, a histiocytic neoplasm of the central nervous system
    • Hulette C.M. Microglioma, a histiocytic neoplasm of the central nervous system. Mod. Pathol. 1996, 9:316-319.
    • (1996) Mod. Pathol. , vol.9 , pp. 316-319
    • Hulette, C.M.1
  • 26
    • 0034307632 scopus 로고    scopus 로고
    • Cell death in early neural development: beyond the neurotrophic theory
    • de la Rosa E.J., de Pablo F. Cell death in early neural development: beyond the neurotrophic theory. Trends Neurosci. 2000, 23:454-458.
    • (2000) Trends Neurosci. , vol.23 , pp. 454-458
    • de la Rosa, E.J.1    de Pablo, F.2
  • 27
    • 0344172793 scopus 로고    scopus 로고
    • Naturally occurring cell death and migration of microglial precursors in the quail retina during normal development
    • Marin-Teva J.L., et al. Naturally occurring cell death and migration of microglial precursors in the quail retina during normal development. J. Comp. Neurol. 1999, 412:255-275.
    • (1999) J. Comp. Neurol. , vol.412 , pp. 255-275
    • Marin-Teva, J.L.1
  • 28
    • 0033811463 scopus 로고    scopus 로고
    • Programmed cell death in the developing human telencephalon
    • Rakic S., Zecevic N. Programmed cell death in the developing human telencephalon. Eur. J. Neurosci. 2000, 12:2721-2734.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 2721-2734
    • Rakic, S.1    Zecevic, N.2
  • 29
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis A., et al. Microglial control of neuronal death and synaptic properties. Glia 2007, 55:233-238.
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1
  • 30
    • 84864702760 scopus 로고    scopus 로고
    • Microglia and neuronal cell death
    • Marin-Teva J.L., et al. Microglia and neuronal cell death. Neuron Glia Biol. 2011, 7:25-40.
    • (2011) Neuron Glia Biol. , vol.7 , pp. 25-40
    • Marin-Teva, J.L.1
  • 31
    • 1942447829 scopus 로고    scopus 로고
    • Microglia promote the death of developing Purkinje cells
    • Marin-Teva J.L., et al. Microglia promote the death of developing Purkinje cells. Neuron 2004, 41:535-547.
    • (2004) Neuron , vol.41 , pp. 535-547
    • Marin-Teva, J.L.1
  • 32
    • 84856770080 scopus 로고    scopus 로고
    • Cerebellum: links between development, developmental disorders and motor learning
    • Manto M.U., Jissendi P. Cerebellum: links between development, developmental disorders and motor learning. Front. Neuroanat. 2012, 6:1.
    • (2012) Front. Neuroanat. , vol.6 , pp. 1
    • Manto, M.U.1    Jissendi, P.2
  • 33
    • 84867409344 scopus 로고    scopus 로고
    • Alteration of brain volume in IL-6 overexpressing mice related to autism
    • Wei H., et al. Alteration of brain volume in IL-6 overexpressing mice related to autism. Int. J. Dev. Neurosci. 2012, 30:554-559.
    • (2012) Int. J. Dev. Neurosci. , vol.30 , pp. 554-559
    • Wei, H.1
  • 35
    • 77957328867 scopus 로고    scopus 로고
    • Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    • Sierra A., et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 2010, 7:483-495.
    • (2010) Cell Stem Cell , vol.7 , pp. 483-495
    • Sierra, A.1
  • 36
    • 49849085127 scopus 로고    scopus 로고
    • Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation
    • Choi S.H., et al. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron 2008, 59:568-580.
    • (2008) Neuron , vol.59 , pp. 568-580
    • Choi, S.H.1
  • 37
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • Parent J.M., et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 1997, 17:3727-3738.
    • (1997) J. Neurosci. , vol.17 , pp. 3727-3738
    • Parent, J.M.1
  • 38
    • 34548040659 scopus 로고    scopus 로고
    • The effect of neurodegenerative diseases on the subventricular zone
    • Curtis M.A., et al. The effect of neurodegenerative diseases on the subventricular zone. Nat. Rev. Neurosci. 2007, 8:712-723.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 712-723
    • Curtis, M.A.1
  • 39
    • 0035836656 scopus 로고    scopus 로고
    • Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
    • Jin K., et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:4710-4715.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 4710-4715
    • Jin, K.1
  • 40
    • 51849123324 scopus 로고    scopus 로고
    • Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease
    • Rodriguez J.J., et al. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS ONE 2008, 3:e2935.
    • (2008) PLoS ONE , vol.3
    • Rodriguez, J.J.1
  • 41
    • 67651100556 scopus 로고    scopus 로고
    • Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model
    • Rodriguez J.J., et al. Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model. Neuroreport 2009, 20:907-912.
    • (2009) Neuroreport , vol.20 , pp. 907-912
    • Rodriguez, J.J.1
  • 42
    • 77954651068 scopus 로고    scopus 로고
    • Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates
    • Taffe M.A., et al. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11104-11109.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11104-11109
    • Taffe, M.A.1
  • 43
    • 79955675449 scopus 로고    scopus 로고
    • Adult neurogenesis and modulation of neural circuit function
    • Inokuchi K. Adult neurogenesis and modulation of neural circuit function. Curr. Opin. Neurobiol. 2011, 21:360-364.
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 360-364
    • Inokuchi, K.1
  • 44
    • 31544460682 scopus 로고    scopus 로고
    • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    • Ziv Y., et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 2006, 9:268-275.
    • (2006) Nat. Neurosci. , vol.9 , pp. 268-275
    • Ziv, Y.1
  • 45
    • 80755168022 scopus 로고    scopus 로고
    • CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
    • Rogers J.T., et al. CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J. Neurosci. 2011, 31:16241-16250.
    • (2011) J. Neurosci. , vol.31 , pp. 16241-16250
    • Rogers, J.T.1
  • 46
    • 84860666072 scopus 로고    scopus 로고
    • Microglia modulate hippocampal neural precursor activity in response to exercise and aging
    • Vukovic J., et al. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J. Neurosci. 2012, 32:6435-6443.
    • (2012) J. Neurosci. , vol.32 , pp. 6435-6443
    • Vukovic, J.1
  • 47
    • 1842455828 scopus 로고    scopus 로고
    • Neural activity and the dynamics of central nervous system development
    • Hua J.Y., Smith S.J. Neural activity and the dynamics of central nervous system development. Nat. Neurosci. 2004, 7:327-332.
    • (2004) Nat. Neurosci. , vol.7 , pp. 327-332
    • Hua, J.Y.1    Smith, S.J.2
  • 48
    • 0033764559 scopus 로고    scopus 로고
    • Synapse elimination and indelible memory
    • Lichtman J.W., Colman H. Synapse elimination and indelible memory. Neuron 2000, 25:269-278.
    • (2000) Neuron , vol.25 , pp. 269-278
    • Lichtman, J.W.1    Colman, H.2
  • 49
    • 43949084738 scopus 로고    scopus 로고
    • Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
    • Mei L., Xiong W.C. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat. Rev. Neurosci. 2008, 9:437-452.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 437-452
    • Mei, L.1    Xiong, W.C.2
  • 50
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
    • Palop J.J., Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 2010, 13:812-818.
    • (2010) Nat. Neurosci. , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 51
    • 79951960867 scopus 로고    scopus 로고
    • Dendritic spine pathology in neuropsychiatric disorders
    • Penzes P., et al. Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. 2011, 14:285-293.
    • (2011) Nat. Neurosci. , vol.14 , pp. 285-293
    • Penzes, P.1
  • 54
    • 84864722164 scopus 로고    scopus 로고
    • Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping
    • Jinno S., Yamada J. Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping. Neuron Glia Biol. 2011, 7:55-66.
    • (2011) Neuron Glia Biol. , vol.7 , pp. 55-66
    • Jinno, S.1    Yamada, J.2
  • 55
    • 0035939448 scopus 로고    scopus 로고
    • Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice
    • Kalla R., et al. Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice. J. Comp. Neurol. 2001, 436:182-201.
    • (2001) J. Comp. Neurol. , vol.436 , pp. 182-201
    • Kalla, R.1
  • 56
    • 0014369295 scopus 로고
    • Displacement of synaptic terminals from regenerating motoneurons by microglial cells
    • Blinzinger K., Kreutzberg G. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z. Zellforsch. Mikrosk. Anat. 1968, 85:145-157.
    • (1968) Z. Zellforsch. Mikrosk. Anat. , vol.85 , pp. 145-157
    • Blinzinger, K.1    Kreutzberg, G.2
  • 57
    • 33846953580 scopus 로고    scopus 로고
    • Evidence for synaptic stripping by cortical microglia
    • Trapp B.D., et al. Evidence for synaptic stripping by cortical microglia. Glia 2007, 55:360-368.
    • (2007) Glia , vol.55 , pp. 360-368
    • Trapp, B.D.1
  • 58
    • 79955482517 scopus 로고    scopus 로고
    • Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy
    • Yamada J., et al. Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy. Neuroscience 2011, 182:1-10.
    • (2011) Neuroscience , vol.182 , pp. 1-10
    • Yamada, J.1
  • 59
    • 84856384517 scopus 로고    scopus 로고
    • Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
    • Pascual O., et al. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E197-E205.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109
    • Pascual, O.1
  • 60
    • 84866516735 scopus 로고    scopus 로고
    • MEK is a key regulator of gliogenesis in the developing brain
    • Li X., et al. MEK is a key regulator of gliogenesis in the developing brain. Neuron 2012, 75:1035-1050.
    • (2012) Neuron , vol.75 , pp. 1035-1050
    • Li, X.1
  • 61
    • 84861595502 scopus 로고    scopus 로고
    • Panglial gap junctional communication is essential for maintenance of myelin in the CNS
    • Tress O., et al. Panglial gap junctional communication is essential for maintenance of myelin in the CNS. J. Neurosci. 2012, 32:7499-7518.
    • (2012) J. Neurosci. , vol.32 , pp. 7499-7518
    • Tress, O.1
  • 62
    • 0025342635 scopus 로고
    • Two-photon laser scanning fluorescence microscopy
    • Denk W., et al. Two-photon laser scanning fluorescence microscopy. Science 1990, 248:73-76.
    • (1990) Science , vol.248 , pp. 73-76
    • Denk, W.1
  • 63
    • 0030993430 scopus 로고    scopus 로고
    • Photon upmanship: why multiphoton imaging is more than a gimmick
    • Denk W., Svoboda K. Photon upmanship: why multiphoton imaging is more than a gimmick. Neuron 1997, 18:351-357.
    • (1997) Neuron , vol.18 , pp. 351-357
    • Denk, W.1    Svoboda, K.2
  • 64
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay M.E., et al. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 2010, 8:e1000527.
    • (2010) PLoS Biol. , vol.8
    • Tremblay, M.E.1
  • 65
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H., et al. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 2009, 29:3974-3980.
    • (2009) J. Neurosci. , vol.29 , pp. 3974-3980
    • Wake, H.1
  • 66
    • 25444469608 scopus 로고    scopus 로고
    • Visualization of microglia in living tissues using Iba1-EGFP transgenic mice
    • Hirasawa T., et al. Visualization of microglia in living tissues using Iba1-EGFP transgenic mice. J. Neurosci. Res. 2005, 81:357-362.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 357-362
    • Hirasawa, T.1
  • 67
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G., et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000, 28:41-51.
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1
  • 68
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli R.C., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333:1456-1458.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 69
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer D.P., et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 2012, 74:691-705.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1
  • 70
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., et al. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1
  • 71
    • 42249105396 scopus 로고    scopus 로고
    • Resting microglial motility is independent of synaptic plasticity in mammalian brain
    • Wu L.J., Zhuo M. Resting microglial motility is independent of synaptic plasticity in mammalian brain. J. Neurophysiol. 2008, 99:2026-2032.
    • (2008) J. Neurophysiol. , vol.99 , pp. 2026-2032
    • Wu, L.J.1    Zhuo, M.2
  • 72
    • 79551570269 scopus 로고    scopus 로고
    • Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission
    • Fontainhas A.M., et al. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission. PLoS ONE 2011, 6:e15973.
    • (2011) PLoS ONE , vol.6
    • Fontainhas, A.M.1
  • 73
    • 0032168898 scopus 로고    scopus 로고
    • Regulation of class I MHC gene expression in the developing and mature CNS by neural activity
    • Corriveau R.A., et al. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 1998, 21:505-520.
    • (1998) Neuron , vol.21 , pp. 505-520
    • Corriveau, R.A.1
  • 74
    • 36849076770 scopus 로고    scopus 로고
    • The classical complement cascade mediates CNS synapse elimination
    • Stevens B., et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007, 131:1164-1178.
    • (2007) Cell , vol.131 , pp. 1164-1178
    • Stevens, B.1
  • 75
    • 0034671891 scopus 로고    scopus 로고
    • Functional requirement for class I MHC in CNS development and plasticity
    • Huh G.S., et al. Functional requirement for class I MHC in CNS development and plasticity. Science 2000, 290:2155-2159.
    • (2000) Science , vol.290 , pp. 2155-2159
    • Huh, G.S.1
  • 76
    • 34548444083 scopus 로고    scopus 로고
    • The microglial networks of the brain and their role in neuronal network plasticity after lesion
    • Cullheim S., Thams S. The microglial networks of the brain and their role in neuronal network plasticity after lesion. Brain Res. Rev. 2007, 55:89-96.
    • (2007) Brain Res. Rev. , vol.55 , pp. 89-96
    • Cullheim, S.1    Thams, S.2
  • 77
    • 0034638245 scopus 로고    scopus 로고
    • Ultrastructural evidence for a preferential elimination of glutamate-immunoreactive synaptic terminals from spinal motoneurons after intramedullary axotomy
    • Linda H., et al. Ultrastructural evidence for a preferential elimination of glutamate-immunoreactive synaptic terminals from spinal motoneurons after intramedullary axotomy. J. Comp. Neurol. 2000, 425:10-23.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 10-23
    • Linda, H.1
  • 78
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 2007, 10:1387-1394.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 79
    • 0034123060 scopus 로고    scopus 로고
    • Methyl-CpG-binding protein 2 mutations in Rett syndrome
    • Van den Veyver I.B., Zoghbi H.Y. Methyl-CpG-binding protein 2 mutations in Rett syndrome. Curr. Opin. Genet. Dev. 2000, 10:275-279.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 275-279
    • Van den Veyver, I.B.1    Zoghbi, H.Y.2
  • 80
    • 60749102039 scopus 로고    scopus 로고
    • Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology
    • Ballas N., et al. Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology. Nat. Neurosci. 2009, 12:311-317.
    • (2009) Nat. Neurosci. , vol.12 , pp. 311-317
    • Ballas, N.1
  • 81
    • 77955717245 scopus 로고    scopus 로고
    • MeCP2 mutant protein is expressed in astrocytes as well as in neurons and localizes in the nucleus
    • Kifayathullah L.A., et al. MeCP2 mutant protein is expressed in astrocytes as well as in neurons and localizes in the nucleus. Cytogenet. Genome Res. 2010, 129:290-297.
    • (2010) Cytogenet. Genome Res. , vol.129 , pp. 290-297
    • Kifayathullah, L.A.1
  • 82
    • 79960907896 scopus 로고    scopus 로고
    • A role for glia in the progression of Rett's syndrome
    • Lioy D.T., et al. A role for glia in the progression of Rett's syndrome. Nature 2011, 475:497-500.
    • (2011) Nature , vol.475 , pp. 497-500
    • Lioy, D.T.1
  • 83
    • 77951020598 scopus 로고    scopus 로고
    • Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    • Maezawa I., Jin L.W. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J. Neurosci. 2010, 30:5346-5356.
    • (2010) J. Neurosci. , vol.30 , pp. 5346-5356
    • Maezawa, I.1    Jin, L.W.2
  • 84
    • 84859454582 scopus 로고    scopus 로고
    • Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    • Derecki N.C., et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 2012, 484:105-109.
    • (2012) Nature , vol.484 , pp. 105-109
    • Derecki, N.C.1
  • 85
    • 77953282828 scopus 로고    scopus 로고
    • Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
    • Chen S.K., et al. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 2010, 141:775-785.
    • (2010) Cell , vol.141 , pp. 775-785
    • Chen, S.K.1
  • 86
    • 84856273853 scopus 로고    scopus 로고
    • Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids
    • Rademakers R., et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat. Genet. 2012, 44:200-205.
    • (2012) Nat. Genet. , vol.44 , pp. 200-205
    • Rademakers, R.1
  • 87
    • 84869172769 scopus 로고    scopus 로고
    • Microglia as modulators of cognition and neuropsychiatric disorders
    • Blank T., Prinz M. Microglia as modulators of cognition and neuropsychiatric disorders. Glia 2013, 61:62-70.
    • (2013) Glia , vol.61 , pp. 62-70
    • Blank, T.1    Prinz, M.2
  • 88
    • 84868331824 scopus 로고    scopus 로고
    • The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes
    • Beumer W., et al. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J. Leukoc. Biol. 2012, 92:959-975.
    • (2012) J. Leukoc. Biol. , vol.92 , pp. 959-975
    • Beumer, W.1
  • 89
    • 0033103989 scopus 로고    scopus 로고
    • Activation of Heschl's gyrus during auditory hallucinations
    • Dierks T., et al. Activation of Heschl's gyrus during auditory hallucinations. Neuron 1999, 22:615-621.
    • (1999) Neuron , vol.22 , pp. 615-621
    • Dierks, T.1
  • 90
    • 0028847356 scopus 로고
    • A functional neuroanatomy of hallucinations in schizophrenia
    • Silbersweig D.A., et al. A functional neuroanatomy of hallucinations in schizophrenia. Nature 1995, 378:176-179.
    • (1995) Nature , vol.378 , pp. 176-179
    • Silbersweig, D.A.1
  • 91
    • 0347722470 scopus 로고    scopus 로고
    • Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons
    • Lewis D.A., et al. Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons. Ann. N. Y. Acad. Sci. 2003, 1003:102-112.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1003 , pp. 102-112
    • Lewis, D.A.1
  • 92
    • 0031758376 scopus 로고    scopus 로고
    • Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
    • Garey L.J., et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J. Neurol. Neurosurg. Psychiatry 1998, 65:446-453.
    • (1998) J. Neurol. Neurosurg. Psychiatry , vol.65 , pp. 446-453
    • Garey, L.J.1
  • 93
    • 84884288041 scopus 로고    scopus 로고
    • Dendritic spine pathology in schizophrenia
    • Glausier J.R., Lewis D.A. Dendritic spine pathology in schizophrenia. Neuroscience 2012, 10.1016/j.neuroscience.2012.04.044.
    • (2012) Neuroscience
    • Glausier, J.R.1    Lewis, D.A.2
  • 94
    • 80052563683 scopus 로고    scopus 로고
    • Vulnerability to depression: from brain neuroplasticity to identification of biomarkers
    • Blugeot A., et al. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. J. Neurosci. 2011, 31:12889-12899.
    • (2011) J. Neurosci. , vol.31 , pp. 12889-12899
    • Blugeot, A.1
  • 95
    • 84867198044 scopus 로고    scopus 로고
    • Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
    • Kang H.J., et al. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat. Med. 2012, 18:1413-1417.
    • (2012) Nat. Med. , vol.18 , pp. 1413-1417
    • Kang, H.J.1
  • 96
    • 84870832562 scopus 로고    scopus 로고
    • Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo
    • Li Y., et al. Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev. Cell 2012, 23:1189-1202.
    • (2012) Dev. Cell , vol.23 , pp. 1189-1202
    • Li, Y.1


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