Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

Nature

Volumn 518, Issue 7539, 2015, Pages 365-369

  Gjoneska, Elizabeta ^a,b   Pfenning, Andreas R ^b,c   Mathys, Hansruedi ^a   Quon, Gerald ^b,c   Kundaje, Anshul ^b,c,d   Tsai, Li Huei ^a,b   Kellis, Manolis ^b,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; E1A ASSOCIATED P300 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR PU 1; CHROMATIN; ONCOPROTEIN; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

BRAIN; CELL ORGANELLE; CHROMOSOME; DISEASE PREVALENCE; GENE EXPRESSION; GENETIC VARIATION; GENOME; GENOMICS; IMMUNE RESPONSE; NEUROLOGY; NUMERICAL MODEL; PLASTICITY; RODENT; SIGNAL;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DNA BINDING MOTIF; DOWN REGULATION; EMBRYO; ENHANCER REGION; ENVIRONMENTAL FACTOR; EPIGENETICS; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HETEROCHROMATIN; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE GENE; IMMUNITY; IMMUNOGENETICS; IN VITRO STUDY; MOUSE; MOUSE MODEL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE TRAIT LOCUS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STIMULUS RESPONSE; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION SITE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; MEMORY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY;

MUS;

ALZHEIMER DISEASE; ANIMALS; CHROMATIN; CONSERVED SEQUENCE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HIPPOCAMPUS; HUMANS; IMMUNITY; MEMORY; MICE; MODELS, BIOLOGICAL; NEURONAL PLASTICITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84923377359     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14252     Document Type: Article

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