Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

FASEB Journal

Volumn 29, Issue 5, 2015, Pages 1754-1762

  Li, Xianwu ^a   Montine, Kathleen S ^a   Keene, C Dirk ^a   Montine, Thomas J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alzheimer disease; Apolipoprotein e genotype; Brain immunity; Neuroinflammation; PGE2

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRIGERRING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; ISOMERASE; ISOPROTEIN; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR; TREM2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOE EPSILON4 GENE; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; IMMUNOSTIMULATION; INFLAMMATION; INHERITANCE; INNATE IMMUNITY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RECEPTOR GENE; TREM2 GENE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MURINAE; MUS;

ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INTRAMOLECULAR OXIDOREDUCTASES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MYELOID CELLS; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTORS;

EID: 84932624921     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-262683     Document Type: Article

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