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Volumn 14, Issue 10, 2015, Pages 681-692

Current status of pluripotent stem cells: Moving the first therapies to the clinic

Author keywords

[No Author keywords available]

Indexed keywords

AGE RELATED MACULAR DEGENERATION; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; AUTOIMMUNE DISEASE; BLACKFAN DIAMOND ANEMIA; CELL CULTURE; CELL DIFFERENTIATION; CLINICAL EFFECTIVENESS; COL7A1 GENE; CYSTIC FIBROSIS; CYTOPLASM; DEGENERATIVE DISEASE; DISEASE MODEL; DOPAMINERGIC NERVE CELL; DRUG DEVELOPMENT; ENDODERM; FANCONI ANEMIA; GENE MUTATION; GOOD MANUFACTURING PRACTICE; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE CELL; HUMAN; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINAL ORGANOID; KERATINOCYTE; LIVER CELL; LUPUS VULGARIS; MACULAR DEGENERATION; MESENCHYMAL STEM CELL; MYOPIA; MYOPIC MACULAR DEGENERATION; NONHUMAN; PANCREAS CELL; PANCREATIC ENDODERM CELL; PARKINSON DISEASE; PATIENT SAFETY; PERIPHERAL VISION; PIGMENT EPITHELIUM; PLURIPOTENT STEM CELL; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGERIA; QUALITY OF LIFE; REGENERATIVE MEDICINE; REVIEW; STARGARDT DISEASE; STEM CELL TRANSPLANTATION; VISUAL ACUITY; WERNER SYNDROME; WET MACULAR DEGENERATION; CLINICAL TRIAL (TOPIC); HEART DISEASES; LUNG DISEASES; NEURODEGENERATIVE DISEASES; TRANSPLANTATION;

EID: 84942985344     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4738     Document Type: Review
Times cited : (220)

References (177)
  • 1
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1
  • 2
    • 0037386324 scopus 로고    scopus 로고
    • Human embryonic stem cells: Research, ethics and policy
    • de Wert, G. & Mummery, C. Human embryonic stem cells: research, ethics and policy. Hum. Reprod. 18, 672-682 (2003).
    • (2003) Hum. Reprod. , vol.18 , pp. 672-682
    • De Wert, G.1    Mummery, C.2
  • 3
    • 84942991366 scopus 로고    scopus 로고
    • NIH Stem Cell Information [online]
    • National Institutes of Health. Federal policy on human embryonic stem cells. NIH Stem Cell Information [online], http://stemcells.nih.gov/policy/pages/2001policy.aspx (2001).
    • (2001) Federal Policy on Human Embryonic Stem Cells
  • 4
    • 84942987603 scopus 로고    scopus 로고
    • (Aug. 9, 2001-Mar. 9, 2009). NIH Stem Cell Information [online]
    • National Institutes of Health. Human embryonic stem cell policy under former President Bush (Aug. 9, 2001-Mar. 9, 2009). NIH Stem Cell Information [online], http://stemcells.nih.gov/staticresources/research/registry/PDFs/FormerRegistry.pdf (2001).
    • (2001) Human Embryonic Stem Cell Policy under Former President Bush
  • 8
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 9
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 10
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 11
  • 12
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren, L. et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1
  • 13
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu, J. et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797-801 (2009).
    • (2009) Science , vol.324 , pp. 797-801
    • Yu, J.1
  • 14
    • 79955634826 scopus 로고    scopus 로고
    • A more efficient method to generate integration-free human iPS cells
    • Okita, K. et al. A more efficient method to generate integration-free human iPS cells. Nat. Methods 8, 409-412 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 409-412
    • Okita, K.1
  • 15
    • 77649275936 scopus 로고    scopus 로고
    • A nonviral minicircle vector for deriving human iPS cells
    • Jia, F. et al. A nonviral minicircle vector for deriving human iPS cells. Nat. Methods 7, 197-199 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 197-199
    • Jia, F.1
  • 16
    • 64749083939 scopus 로고    scopus 로고
    • PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
    • Woltjen, K. et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458, 766-770 (2009).
    • (2009) Nature , vol.458 , pp. 766-770
    • Woltjen, K.1
  • 17
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim, D. et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 4, 472-476 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1
  • 18
    • 70450265981 scopus 로고    scopus 로고
    • Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
    • Fusaki, N., Ban, H., Nishiyama, A., Saeki, K. & Hasegawa, M. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 85, 348-362 (2009).
    • (2009) Proc. Jpn Acad. Ser. B Phys. Biol. Sci. , vol.85 , pp. 348-362
    • Fusaki, N.1    Ban, H.2    Nishiyama, A.3    Saeki, K.4    Hasegawa, M.5
  • 19
    • 70349873363 scopus 로고    scopus 로고
    • Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration
    • Lu, B. et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells 27, 2126-2135 (2009).
    • (2009) Stem Cells , vol.27 , pp. 2126-2135
    • Lu, B.1
  • 20
    • 84893748014 scopus 로고    scopus 로고
    • Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
    • Kamao, H. et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep. 2, 205-218 (2014).
    • (2014) Stem Cell Rep. , vol.2 , pp. 205-218
    • Kamao, H.1
  • 21
    • 84907752479 scopus 로고    scopus 로고
    • Japan stem-cell trial stirs envy: Researchers elsewhere can't wait to test iPS cells in humans
    • Reardon, S. & Cyranoski, D. Japan stem-cell trial stirs envy: researchers elsewhere can't wait to test iPS cells in humans. Nature 513, 278-288 (2014).
    • (2014) Nature , vol.513 , pp. 278-288
    • Reardon, S.1    Cyranoski, D.2
  • 23
    • 84857643783 scopus 로고    scopus 로고
    • Embryonic stem cell trials for macular degeneration: A preliminary report
    • Schwartz, S. D. et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 379, 713-720 (2012).
    • (2012) Lancet , vol.379 , pp. 713-720
    • Schwartz, S.D.1
  • 24
    • 84923014395 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: Follow-up of two open-label Phase 1/2 studies
    • Schwartz, S. D. et al. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label Phase 1/2 studies. Lancet 385, 7-13 (2015).
    • (2015) Lancet , vol.385 , pp. 7-13
    • Schwartz, S.D.1
  • 25
    • 84929295709 scopus 로고    scopus 로고
    • Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: Preliminary results in Asian patients
    • Song, W. K. et al. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients. Stem Cell Rep. 4, 860-872 (2015).
    • (2015) Stem Cell Rep. , vol.4 , pp. 860-872
    • Song, W.K.1
  • 26
    • 84877657445 scopus 로고    scopus 로고
    • Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium
    • Buchholz, D. E. et al. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Translat. Med. 2, 384-393 (2013).
    • (2013) Stem Cells Translat. Med. , vol.2 , pp. 384-393
    • Buchholz, D.E.1
  • 28
    • 33748086466 scopus 로고    scopus 로고
    • Efficient generation of retinal progenitor cells from human embryonic stem cells
    • Lamba, D. A., Karl, M. O., Ware, C. B. & Reh, T. A. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 12769-12774 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12769-12774
    • Lamba, D.A.1    Karl, M.O.2    Ware, C.B.3    Reh, T.A.4
  • 29
    • 23844475078 scopus 로고    scopus 로고
    • + neural retinal precursors from embryonic stem cells
    • + neural retinal precursors from embryonic stem cells. Proc. Natl Acad. Sci. USA 102, 11331-11336 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11331-11336
    • Ikeda, H.1
  • 30
    • 60349118322 scopus 로고    scopus 로고
    • In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors
    • Jagatha, B. et al. In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors. Biochem. Biophys. Res. Commun. 380, 230-235 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 230-235
    • Jagatha, B.1
  • 31
    • 84897488292 scopus 로고    scopus 로고
    • Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells
    • Riazifar, H., Jia, Y., Chen, J., Lynch, G. & Huang, T. Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells. Stem Cells Translat. Med. 3, 424-432 (2014).
    • (2014) Stem Cells Translat. Med. , vol.3 , pp. 424-432
    • Riazifar, H.1    Jia, Y.2    Chen, J.3    Lynch, G.4    Huang, T.5
  • 32
    • 84942364183 scopus 로고    scopus 로고
    • Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells
    • Tanaka, T. et al. Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells. Scientif. Rep. 5, 8344 (2015).
    • (2015) Scientif. Rep. , vol.5 , pp. 8344
    • Tanaka, T.1
  • 33
    • 84916209395 scopus 로고    scopus 로고
    • Duplication of TBK1 stimulates autophagy in iPSC-derived retinal cells from a patient with normal tension glaucoma
    • Tucker, B. A. et al. Duplication of TBK1 stimulates autophagy in iPSC-derived retinal cells from a patient with normal tension glaucoma. J. Stem Cell Res. Ther. 3, 161 (2014).
    • (2014) J. Stem Cell Res. Ther. , vol.3 , pp. 161
    • Tucker, B.A.1
  • 35
    • 84902476568 scopus 로고    scopus 로고
    • The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa
    • Yoshida, T. et al. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol. Brain 7, 45 (2014).
    • (2014) Mol. Brain , vol.7 , pp. 45
    • Yoshida, T.1
  • 36
    • 84874629422 scopus 로고    scopus 로고
    • Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
    • Welsbie, D. S. et al. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc. Natl Acad. Sci. USA 110, 4045-4050 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4045-4050
    • Welsbie, D.S.1
  • 37
    • 84902303813 scopus 로고    scopus 로고
    • Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
    • Zhong, X. et al. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat. Commun. 5, 4047 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 4047
    • Zhong, X.1
  • 38
    • 84905484384 scopus 로고    scopus 로고
    • A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium
    • Ferrer, M. et al. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. Stem Cells Translat. Med. 3, 911-922 (2014).
    • (2014) Stem Cells Translat. Med. , vol.3 , pp. 911-922
    • Ferrer, M.1
  • 39
    • 84940053268 scopus 로고    scopus 로고
    • Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: A translational experience
    • Menasche, P. et al. Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience. Eur. Heart J. 36, 743-750 (2015).
    • (2015) Eur. Heart J. , vol.36 , pp. 743-750
    • Menasche, P.1
  • 40
    • 84938956437 scopus 로고    scopus 로고
    • Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold
    • Bellamy, V. et al. Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold. J. Heart Lung Transplant. 34, 1198-1207 (2015).
    • (2015) J. Heart Lung Transplant. , vol.34 , pp. 1198-1207
    • Bellamy, V.1
  • 41
    • 84902312015 scopus 로고    scopus 로고
    • Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
    • Chong, J. J. et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature 510, 273-277 (2014).
    • (2014) Nature , vol.510 , pp. 273-277
    • Chong, J.J.1
  • 42
    • 84919460805 scopus 로고    scopus 로고
    • Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells
    • Ye, L. et al. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell 15, 750-761 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 750-761
    • Ye, L.1
  • 43
    • 84883791986 scopus 로고    scopus 로고
    • Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
    • Navarrete, E. G. et al. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 128, S3-S13 (2013).
    • (2013) Circulation , vol.128 , pp. S3-S13
    • Navarrete, E.G.1
  • 44
    • 84876526111 scopus 로고    scopus 로고
    • Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    • Liang, P. et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 127, 1677-1691 (2013).
    • (2013) Circulation , vol.127 , pp. 1677-1691
    • Liang, P.1
  • 45
    • 84919764228 scopus 로고    scopus 로고
    • Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
    • Drawnel, F. M. et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 9, 810-821 (2014).
    • (2014) Cell Rep. , vol.9 , pp. 810-821
    • Drawnel, F.M.1
  • 46
    • 84874741888 scopus 로고    scopus 로고
    • Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    • Kim, C. et al. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature 494, 105-110 (2013).
    • (2013) Nature , vol.494 , pp. 105-110
    • Kim, C.1
  • 47
    • 84908377652 scopus 로고    scopus 로고
    • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
    • Ebert, A. D. et al. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci. Transl. Med. 6, 255ra130 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 255ra130
    • Ebert, A.D.1
  • 48
    • 84907587769 scopus 로고    scopus 로고
    • RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model
    • Aggarwal, P. et al. RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model. PloS One 9, e108051 (2014).
    • (2014) PloS One , vol.9 , pp. e108051
    • Aggarwal, P.1
  • 49
    • 84866946017 scopus 로고    scopus 로고
    • Human pluripotent stem cell-derived cardiomyocytes: Response to TTX and lidocain reveals strong cell to cell variability
    • Sheng, X. et al. Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability. PloS One 7, e45963 (2012).
    • (2012) PloS One , vol.7 , pp. e45963
    • Sheng, X.1
  • 50
    • 84922599592 scopus 로고    scopus 로고
    • Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells
    • Foldes, G. et al. Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells. Stem Cell Rep. 3, 905-914 (2014).
    • (2014) Stem Cell Rep. , vol.3 , pp. 905-914
    • Foldes, G.1
  • 51
    • 79961175124 scopus 로고    scopus 로고
    • Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
    • Kelly, O. G. et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat. Biotech. 29, 750-756 (2011).
    • (2011) Nat. Biotech. , vol.29 , pp. 750-756
    • Kelly, O.G.1
  • 52
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour, K. A. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotech. 24, 1392-1401 (2006).
    • (2006) Nat. Biotech. , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1
  • 53
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon, E. et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotech. 26, 443-452 (2008).
    • (2008) Nat. Biotech. , vol.26 , pp. 443-452
    • Kroon, E.1
  • 54
    • 84862059081 scopus 로고    scopus 로고
    • A scalable system for production of functional pancreatic progenitors from human embryonic stem cells
    • Schulz, T. C. et al. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PloS One 7, e37004 (2012).
    • (2012) PloS One , vol.7 , pp. e37004
    • Schulz, T.C.1
  • 55
    • 84910673362 scopus 로고    scopus 로고
    • Generation of functional human pancreatic β cells in vitro
    • Pagliuca, F. W. et al. Generation of functional human pancreatic β cells in vitro. Cell 159, 428-439 (2014).
    • (2014) Cell , vol.159 , pp. 428-439
    • Pagliuca, F.W.1
  • 56
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence, J. R. et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105-109 (2011).
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1
  • 57
    • 84964313624 scopus 로고    scopus 로고
    • An in vivo model of human small intestine using pluripotent stem cells
    • Watson, C. L. et al. An in vivo model of human small intestine using pluripotent stem cells. Nat. Med. 20, 1310-1314 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1310-1314
    • Watson, C.L.1
  • 58
    • 0020822437 scopus 로고
    • Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes
    • Clayton, D. F. & Darnell, J. E. Jr. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol. Cell. Biol. 3, 1552-1561 (1983).
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 1552-1561
    • Clayton, D.F.1    Darnell, J.E.2
  • 60
    • 34248634898 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional hepatic cells
    • Cai, J. et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 45, 1229-1239 (2007).
    • (2007) Hepatology , vol.45 , pp. 1229-1239
    • Cai, J.1
  • 61
    • 47949092668 scopus 로고    scopus 로고
    • Efficient differentiation of functional hepatocytes from human embryonic stem cells
    • Agarwal, S., Holton, K. L. & Lanza, R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 26, 1117-1127 (2008).
    • (2008) Stem Cells , vol.26 , pp. 1117-1127
    • Agarwal, S.1    Holton, K.L.2    Lanza, R.3
  • 62
    • 60449098836 scopus 로고    scopus 로고
    • Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    • Basma, H. et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 136, 990-999 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 990-999
    • Basma, H.1
  • 63
    • 84856974289 scopus 로고    scopus 로고
    • Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction
    • Takayama, K. et al. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol. Ther. 20, 127-137 (2012).
    • (2012) Mol. Ther. , vol.20 , pp. 127-137
    • Takayama, K.1
  • 64
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 19, 1233-1242 (2009).
    • (2009) Cell Res. , vol.19 , pp. 1233-1242
    • Song, Z.1
  • 65
    • 78651386407 scopus 로고    scopus 로고
    • Robust differentiation of fetal hepatocytes from human embryonic stem cells and iPS
    • (in French)
    • Touboul, T., Vallier, L. & Weber, A. Robust differentiation of fetal hepatocytes from human embryonic stem cells and iPS. Med. Sci. (Paris) 26, 1061-1066 (in French) (2010).
    • (2010) Med. Sci. (Paris) , vol.26 , pp. 1061-1066
    • Touboul, T.1    Vallier, L.2    Weber, A.3
  • 66
    • 84878756211 scopus 로고    scopus 로고
    • Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells
    • Ma, X. et al. Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Translat. Med. 2, 409-419 (2013).
    • (2013) Stem Cells Translat. Med. , vol.2 , pp. 409-419
    • Ma, X.1
  • 67
    • 84899644210 scopus 로고    scopus 로고
    • Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture
    • Gieseck, R. L. 3rd et al. Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PloS One 9, e86372 (2014).
    • (2014) PloS One , vol.9 , pp. e86372
    • Gieseck, R.L.1
  • 68
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484 (2013).
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1
  • 69
    • 84883394324 scopus 로고    scopus 로고
    • Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy
    • Eggenschwiler, R. et al. Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy. Stem Cells Translat. Med. 2, 641-654 (2013).
    • (2013) Stem Cells Translat. Med. , vol.2 , pp. 641-654
    • Eggenschwiler, R.1
  • 70
    • 84942996028 scopus 로고    scopus 로고
    • Abandoning the stem cell clinical trial ship
    • [online]
    • Varughese, A. Abandoning the stem cell clinical trial ship. Biotechniques [online], http://www. biotechniques.com/news/Abandoning-the-Stem-Cell-Clinical-Trial-Ship/biotechniques-324708.html (2011).
    • (2011) Biotechniques
    • Varughese, A.1
  • 72
    • 5444238034 scopus 로고    scopus 로고
    • Stem cell therapy for Parkinson's disease
    • Bjorklund, L. M. Stem cell therapy for Parkinson's disease. Dialogues Clin. Neurosci. 6, 303-311 (2004).
    • (2004) Dialogues Clin. Neurosci. , vol.6 , pp. 303-311
    • Bjorklund, L.M.1
  • 73
    • 0037019332 scopus 로고    scopus 로고
    • Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    • Kim, J. H. et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418, 50-56 (2002).
    • (2002) Nature , vol.418 , pp. 50-56
    • Kim, J.H.1
  • 74
    • 84942996030 scopus 로고    scopus 로고
    • Stem cell crusader offers hope in battle against neurological diseases
    • Research Institute [online]
    • Biomics, M. Stem cell crusader offers hope in battle against neurological diseases. Scripps Research Institute [online], http://www.scripps.edu/loring/-Docs/news-Docs/2014-NEWS-Docs- andPREVIOUS/2014MaverixBiomics-JeanneLoring. pdf (2014).
    • (2014) Scripps
    • Biomics, M.1
  • 75
    • 84863094725 scopus 로고    scopus 로고
    • Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    • Kirkeby, A. et al. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep. 1, 703-714 (2012).
    • (2012) Cell Rep. , vol.1 , pp. 703-714
    • Kirkeby, A.1
  • 76
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    • Kriks, S. et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 480, 547-551 (2011).
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1
  • 77
    • 84922662454 scopus 로고    scopus 로고
    • Human ESC-derived dopamine neurons show similar preclinical efficacy and potenc to fetal neurons when grafted in a rat model of Parkinson's disease
    • Grealish, S. et al. Human ESC-derived dopamine neurons show similar preclinical efficacy and potenc to fetal neurons when grafted in a rat model of Parkinson's disease. Cell Stem Cell 15, 653-665 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 653-665
    • Grealish, S.1
  • 78
    • 84896084435 scopus 로고    scopus 로고
    • Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation
    • Doi, D. et al. Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation. Stem Cell Rep 2, 337-350 (2014).
    • (2014) Stem Cell Rep , vol.2 , pp. 337-350
    • Doi, D.1
  • 79
    • 84884981311 scopus 로고    scopus 로고
    • Neural stem cell-based treatment for neurodegenerative diseases
    • Kim, S. U., Lee, H. J. & Kim, Y. B. Neural stem cell-based treatment for neurodegenerative diseases. Neuropathol. 33, 491-504 (2013).
    • (2013) Neuropathol. , vol.33 , pp. 491-504
    • Kim, S.U.1    Lee, H.J.2    Kim, Y.B.3
  • 80
    • 84908461163 scopus 로고    scopus 로고
    • Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2
    • Takamatsu, K. et al. Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2. Stem Cell Res 13, 442-453 (2014).
    • (2014) Stem Cell Res , vol.13 , pp. 442-453
    • Takamatsu, K.1
  • 81
    • 84895798799 scopus 로고    scopus 로고
    • Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model
    • Nizzardo, M. et al. Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model. Hum. Mol. Genet. 23, 342-354 (2014).
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 342-354
    • Nizzardo, M.1
  • 82
    • 84864628471 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes
    • HD iPSC Consortium. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11, 264-278 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 264-278
    • HD iPSC Consortium.1
  • 83
    • 84861231381 scopus 로고    scopus 로고
    • Modeling Parkinson's disease using induced pluripotent stem cells
    • Byers, B., Lee, H. L. & Reijo Pera, R. Modeling Parkinson's disease using induced pluripotent stem cells. Curr. Neurol. Neurosci. Rep. 12, 237-242 (2012).
    • (2012) Curr. Neurol. Neurosci. Rep. , vol.12 , pp. 237-242
    • Byers, B.1    Lee, H.L.2    Reijo Pera, R.3
  • 84
    • 80052419902 scopus 로고    scopus 로고
    • Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    • Devine, M. J. et al. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat. Commun. 2, 440 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 440
    • Devine, M.J.1
  • 85
    • 79952172335 scopus 로고    scopus 로고
    • LRRK2 mutant iPSC-derived da neurons demonstrate increased susceptibility to oxidative stress
    • Nguyen, H. N. et al. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 267-280 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 267-280
    • Nguyen, H.N.1
  • 86
    • 84860510280 scopus 로고    scopus 로고
    • Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
    • Sanchez-Danes, A. et al. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol. Med. 4, 380-395 (2012).
    • (2012) EMBO Mol. Med. , vol.4 , pp. 380-395
    • Sanchez-Danes, A.1
  • 87
    • 84902201548 scopus 로고    scopus 로고
    • IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis
    • Schondorf, D. C. et al. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nat. Commun. 5, 4028 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 4028
    • Schondorf, D.C.1
  • 88
    • 84856956771 scopus 로고    scopus 로고
    • Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
    • Israel, M. A. et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482, 216-220 (2012).
    • (2012) Nature , vol.482 , pp. 216-220
    • Israel, M.A.1
  • 89
    • 81255169342 scopus 로고    scopus 로고
    • Modeling familial Alzheimer's disease with induced pluripotent stem cells
    • Yagi, T. et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum. Mol. Genet. 20, 4530-4539 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4530-4539
    • Yagi, T.1
  • 90
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos, J. T. et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-1221 (2008).
    • (2008) Science , vol.321 , pp. 1218-1221
    • Dimos, J.T.1
  • 91
    • 84882749423 scopus 로고    scopus 로고
    • A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
    • Burkhardt, M. F. et al. A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol. Cell. Neurosciences 56, 355-364 (2013).
    • (2013) Mol. Cell. Neurosciences , vol.56 , pp. 355-364
    • Burkhardt, M.F.1
  • 92
    • 84902134581 scopus 로고    scopus 로고
    • Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons
    • Chen, H. et al. Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14, 796-809 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 796-809
    • Chen, H.1
  • 93
    • 84886389563 scopus 로고    scopus 로고
    • Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
    • Sareen, D. et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci. Transl. Med. 5, 208ra149 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 208ra149
    • Sareen, D.1
  • 94
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert, A. D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1
  • 95
    • 81855206164 scopus 로고    scopus 로고
    • Brief report: Phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient
    • Chang, T. et al. Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient. Stem Cells 29, 2090-2093 (2011).
    • (2011) Stem Cells , vol.29 , pp. 2090-2093
    • Chang, T.1
  • 96
    • 84871591068 scopus 로고    scopus 로고
    • VPA response in SMA is suppressed by the fatty acid translocase CD36
    • Garbes, L. et al. VPA response in SMA is suppressed by the fatty acid translocase CD36. Hum. Mol. Genet. 22, 398-407 (2013).
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 398-407
    • Garbes, L.1
  • 97
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M. C. et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539 (2010).
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1
  • 98
    • 56549115885 scopus 로고    scopus 로고
    • Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells
    • Marchetto, M. C. et al. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-657 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 649-657
    • Marchetto, M.C.1
  • 99
    • 84864542080 scopus 로고    scopus 로고
    • Drug screening for ALS using patient-specific induced pluripotent stem cells
    • Egawa, N. et al. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci. Transl. Med. 5, 145ra104 (2012).
    • (2012) Sci. Transl. Med. , vol.5 , pp. 145ra104
    • Egawa, N.1
  • 100
    • 84878883307 scopus 로고    scopus 로고
    • A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS
    • Yang, Y. M. et al. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell 12, 713-726 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 713-726
    • Yang, Y.M.1
  • 101
    • 80053604531 scopus 로고    scopus 로고
    • Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease
    • Yahata, N. et al. Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PloS One 6, e25788 (2011).
    • (2011) PloS One , vol.6 , pp. e25788
    • Yahata, N.1
  • 102
    • 84918522964 scopus 로고    scopus 로고
    • Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers
    • Liu, Q. et al. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 71, 1481-1489 (2014).
    • (2014) JAMA Neurol. , vol.71 , pp. 1481-1489
    • Liu, Q.1
  • 103
    • 84861589603 scopus 로고    scopus 로고
    • Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation
    • Koch, P. et al. Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation. Am. J. Pathol. 180, 2404-2416 (2012).
    • (2012) Am. J. Pathol. , vol.180 , pp. 2404-2416
    • Koch, P.1
  • 104
    • 84870895081 scopus 로고    scopus 로고
    • Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
    • Lee, G. et al. Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. Nat. Biotech. 30, 1244-1248 (2012).
    • (2012) Nat. Biotech. , vol.30 , pp. 1244-1248
    • Lee, G.1
  • 105
    • 84919458472 scopus 로고    scopus 로고
    • Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
    • Funato, K., Major, T., Lewis, P. W., Allis, C. D. & Tabar, V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science 346, 1529-1533 (2014).
    • (2014) Science , vol.346 , pp. 1529-1533
    • Funato, K.1    Major, T.2    Lewis, P.W.3    Allis, C.D.4    Tabar, V.5
  • 106
    • 33751544398 scopus 로고    scopus 로고
    • Large-scale production of embryonic red blood cells from human embryonic stem cells
    • Olivier, E. N., Qiu, C., Velho, M., Hirsch, R. E. & Bouhassira, E. E. Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp. Hematol. 34, 1635-1642 (2006).
    • (2006) Exp. Hematol. , vol.34 , pp. 1635-1642
    • Olivier, E.N.1    Qiu, C.2    Velho, M.3    Hirsch, R.E.4    Bouhassira, E.E.5
  • 107
    • 58149386519 scopus 로고    scopus 로고
    • Biologic properties and enucleation of red blood cells from human embryonic stem cells
    • Lu, S. J. et al. Biologic properties and enucleation of red blood cells from human embryonic stem cells. Blood 112, 4475-4484 (2008).
    • (2008) Blood , vol.112 , pp. 4475-4484
    • Lu, S.J.1
  • 108
    • 77957773731 scopus 로고    scopus 로고
    • Red blood cell generation from human induced pluripotent stem cells: Perspectives for transfusion medicine
    • Lapillonne, H. et al. Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine. Haematologica 95, 1651-1659 (2010).
    • (2010) Haematologica , vol.95 , pp. 1651-1659
    • Lapillonne, H.1
  • 109
    • 80052331758 scopus 로고    scopus 로고
    • Generation of red blood cells from human induced pluripotent stem cells
    • Dias, J. et al. Generation of red blood cells from human induced pluripotent stem cells. Stem Cells Dev. 20, 1639-1637 (2011).
    • (2011) Stem Cells Dev. , vol.20 , pp. 1639-1637
    • Dias, J.1
  • 110
    • 45949091014 scopus 로고    scopus 로고
    • Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
    • Takayama, N. et al. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood 111, 5298-5306 (2008).
    • (2008) Blood , vol.111 , pp. 5298-5306
    • Takayama, N.1
  • 111
    • 79952534150 scopus 로고    scopus 로고
    • Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
    • Lu, S. J. et al. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 21, 530-545 (2011).
    • (2011) Cell Res. , vol.21 , pp. 530-545
    • Lu, S.J.1
  • 112
    • 78650352754 scopus 로고    scopus 로고
    • Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
    • Takayama, N. et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J. Exp. Med. 207, 2817-2830 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2817-2830
    • Takayama, N.1
  • 113
    • 84922534997 scopus 로고    scopus 로고
    • Scalable generation of universal platelets from human induced pluripotent stem cells
    • Feng, Q. et al. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Rep. 3, 817-831 (2014).
    • (2014) Stem Cell Rep. , vol.3 , pp. 817-831
    • Feng, Q.1
  • 114
    • 0013826490 scopus 로고
    • Circulating megakaryocytes and platelet release in the lung
    • Kaufman, R. M., Airo, R., Pollack, S. & Crosby, W. H. Circulating megakaryocytes and platelet release in the lung. Blood 26, 720-731 (1965).
    • (1965) Blood , vol.26 , pp. 720-731
    • Kaufman, R.M.1    Airo, R.2    Pollack, S.3    Crosby, W.H.4
  • 115
    • 0031868521 scopus 로고    scopus 로고
    • Megakaryocyte differentiation events
    • Long, M. W. Megakaryocyte differentiation events. Semin. Hematol. 35, 192-199 (1998).
    • (1998) Semin. Hematol. , vol.35 , pp. 192-199
    • Long, M.W.1
  • 116
    • 84907222943 scopus 로고    scopus 로고
    • Platelet bioreactor-on-a-chip
    • Thon, J. N. et al. Platelet bioreactor-on-a-chip. Blood 124, 1857-1867 (2014).
    • (2014) Blood , vol.124 , pp. 1857-1867
    • Thon, J.N.1
  • 117
    • 58149157948 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions
    • Su, Z., Frye, C., Bae, K. M., Kelley, V. & Vieweg, J. Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions. Clin. Cancer Res. 14, 6207-6217 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6207-6217
    • Su, Z.1    Frye, C.2    Bae, K.M.3    Kelley, V.4    Vieweg, J.5
  • 118
    • 43749110294 scopus 로고    scopus 로고
    • Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection
    • Bandi, S. & Akkina, R. Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection. AIDS Res. Ther. 5, 1 (2008).
    • (2008) AIDS Res. Ther. , vol.5 , pp. 1
    • Bandi, S.1    Akkina, R.2
  • 119
    • 70349757819 scopus 로고    scopus 로고
    • Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells
    • Tseng, S. Y. et al. Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regenerative Med. 4, 513-526 (2009).
    • (2009) Regenerative Med. , vol.4 , pp. 513-526
    • Tseng, S.Y.1
  • 120
    • 33644505805 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway
    • Slukvin, I. I., Vodyanik, M. A., Thomson, J. A., Gumenyuk, M. E. & Choi, K. D. Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway. J. Immunol. 176, 2924-2932 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 2924-2932
    • Slukvin, I.I.1    Vodyanik, M.A.2    Thomson, J.A.3    Gumenyuk, M.E.4    Choi, K.D.5
  • 121
    • 67449132064 scopus 로고    scopus 로고
    • Generation of T cells from human embryonic stem cell-derived hematopoietic zones
    • Timmermans, F. et al. Generation of T cells from human embryonic stem cell-derived hematopoietic zones. J. Immunol. 182, 6879-6888 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 6879-6888
    • Timmermans, F.1
  • 122
    • 33746846198 scopus 로고    scopus 로고
    • T lineage differentiation from human embryonic stem cells
    • Galic, Z. et al. T lineage differentiation from human embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 11742-11747 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 11742-11747
    • Galic, Z.1
  • 123
    • 25844444505 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity
    • Woll, P. S., Martin, C. H., Miller, J. S. & Kaufman, D. S. Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. J. Immunol. 175, 5095-5103 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 5095-5103
    • Woll, P.S.1    Martin, C.H.2    Miller, J.S.3    Kaufman, D.S.4
  • 124
    • 67650355470 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
    • Woll, P. S. et al. Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity. Blood 113, 6094-6101 (2009).
    • (2009) Blood , vol.113 , pp. 6094-6101
    • Woll, P.S.1
  • 125
    • 78650044727 scopus 로고    scopus 로고
    • Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms
    • Ni, Z. et al. Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms. J. Virol. 85, 43-50 (2011).
    • (2011) J. Virol. , vol.85 , pp. 43-50
    • Ni, Z.1
  • 126
    • 11244285402 scopus 로고    scopus 로고
    • + cells: Efficient production in the coculture with OP9 stromal cells and analysis of lymphohemato poietic potential
    • + cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohemato poietic potential. Blood 1 0 5, 617-626 (2005).
    • (2005) Blood , vol.105 , pp. 617-626
    • Vodyanik, M.A.1    Bork, J.A.2    Thomson, J.A.3    Slukvin, I.I.4
  • 129
    • 33947096532 scopus 로고    scopus 로고
    • Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo
    • Wang, Z. Z. et al. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat. Biotech. 25, 317-318 (2007).
    • (2007) Nat. Biotech. , vol.25 , pp. 317-318
    • Wang, Z.Z.1
  • 130
    • 77953963342 scopus 로고    scopus 로고
    • Derivation of endothelial cells from human embryonic stem cells by directed differentiation: Analysis of microRNA and angiogenesis in vitro and in vivo
    • Kane, N. M. et al. Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 30, 1389-1397 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1389-1397
    • Kane, N.M.1
  • 131
    • 73849105655 scopus 로고    scopus 로고
    • VEGF induces differentiation of functional endothelium from human embryonic stem cells: Implications for tissue engineering
    • Nourse, M. B. et al. VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering. Arterioscler. Thromb. Vasc. Biol. 30, 80-89 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 80-89
    • Nourse, M.B.1
  • 132
    • 34548335261 scopus 로고    scopus 로고
    • Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo
    • Ferreira, L. S. et al. Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circul. Res. 101, 286-294 (2007).
    • (2007) Circul. Res. , vol.101 , pp. 286-294
    • Ferreira, L.S.1
  • 133
    • 76749091589 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function
    • Hill, K. L. et al. Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function. Exp. Hematol. 38, 246-257 (2010).
    • (2010) Exp. Hematol. , vol.38 , pp. 246-257
    • Hill, K.L.1
  • 134
    • 0036714991 scopus 로고    scopus 로고
    • Blood-forming potential of vascular endothelium in the human embryo
    • Oberlin, E., Tavian, M., Blazsek, I. & Peault, B. Blood-forming potential of vascular endothelium in the human embryo. Development 129, 4147-4157 (2002).
    • (2002) Development , vol.129 , pp. 4147-4157
    • Oberlin, E.1    Tavian, M.2    Blazsek, I.3    Peault, B.4
  • 135
    • 84923823755 scopus 로고    scopus 로고
    • Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditions
    • Uenishi, G. et al. Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditions. Stem Cell Rep. 3, 1073-1084 (2014).
    • (2014) Stem Cell Rep. , vol.3 , pp. 1073-1084
    • Uenishi, G.1
  • 136
    • 84934276553 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived B lymphocytes can express sIgM and can be generated via a hemogenic endothelium intermediate
    • French, A., Yang, C. T., Taylor, S., Watt, S. M. & Carpenter, L. Human induced pluripotent stem cell-derived B lymphocytes can express sIgM and can be generated via a hemogenic endothelium intermediate. Stem Cells Dev., http://dx.doi. org/10.1089/scd.2014.0318 (2014).
    • (2014) Stem Cells Dev
    • French, A.1    Yang, C.T.2    Taylor, S.3    Watt, S.M.4    Carpenter, L.5
  • 137
    • 84907219050 scopus 로고    scopus 로고
    • Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
    • Xie, F. et al. Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res. 24, 1526-1533 (2014).
    • (2014) Genome Res. , vol.24 , pp. 1526-1533
    • Xie, F.1
  • 138
    • 84886746010 scopus 로고    scopus 로고
    • Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients
    • Garcon, L. et al. Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients. Blood 122, 912-921 (2013).
    • (2013) Blood , vol.122 , pp. 912-921
    • Garcon, L.1
  • 139
    • 84901791385 scopus 로고    scopus 로고
    • Targeted gene therapy and cell reprogramming in Fanconi anemia
    • Rio, P. et al. Targeted gene therapy and cell reprogramming in Fanconi anemia. EMBO Mol. Med. 6, 835-848 (2014).
    • (2014) EMBO Mol. Med. , vol.6 , pp. 835-848
    • Rio, P.1
  • 140
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
    • Tebas, P. et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. New Engl. J. Med. 370, 901-910 (2014).
    • (2014) New Engl. J. Med. , vol.370 , pp. 901-910
    • Tebas, P.1
  • 141
    • 84918509558 scopus 로고    scopus 로고
    • Modeling human lung development and disease using pluripotent stem cells
    • Snoeck, H. W. Modeling human lung development and disease using pluripotent stem cells. Development 142, 13-16 (2015).
    • (2015) Development , vol.142 , pp. 13-16
    • Snoeck, H.W.1
  • 142
    • 34248363665 scopus 로고    scopus 로고
    • A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells
    • Wang, D., Haviland, D. L., Burns, A. R., Zsigmond, E. & Wetsel, R. A. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc. Natl Acad. Sci. USA 104, 4449-4454 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 4449-4454
    • Wang, D.1    Haviland, D.L.2    Burns, A.R.3    Zsigmond, E.4    Wetsel, R.A.5
  • 143
    • 84886750797 scopus 로고    scopus 로고
    • Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix
    • Ghaedi, M. et al. Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. J. Clin. Invest. 123, 4950-4962 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 4950-4962
    • Ghaedi, M.1
  • 144
    • 84866067664 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
    • Wong, A. P. et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat. Biotech. 30, 876-882 (2012).
    • (2012) Nat. Biotech. , vol.30 , pp. 876-882
    • Wong, A.P.1
  • 145
    • 84870585138 scopus 로고    scopus 로고
    • CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury
    • Soh, B. S. et al. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol. Ther. 20, 2335-2346 (2012).
    • (2012) Mol. Ther. , vol.20 , pp. 2335-2346
    • Soh, B.S.1
  • 146
    • 84892149549 scopus 로고    scopus 로고
    • Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
    • Huang, S. X. et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotech. 32, 84-91 (2014).
    • (2014) Nat. Biotech. , vol.32 , pp. 84-91
    • Huang, S.X.1
  • 147
    • 84927755768 scopus 로고    scopus 로고
    • The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor
    • Gazdhar, A. et al. The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor. Stem Cell Res. Ther. 5, 123 (2014).
    • (2014) Stem Cell Res. Ther. , vol.5 , pp. 123
    • Gazdhar, A.1
  • 148
    • 84859098977 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model
    • Banerjee, E. R. et al. Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model. PloS One 7, e33165 (2012).
    • (2012) PloS One , vol.7 , pp. e33165
    • Banerjee, E.R.1
  • 149
    • 77958082207 scopus 로고    scopus 로고
    • Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette
    • Somers, A. et al. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28, 1728-1740 (2010).
    • (2010) Stem Cells , vol.28 , pp. 1728-1740
    • Somers, A.1
  • 150
    • 0347994904 scopus 로고    scopus 로고
    • Marker succession during the development of keratinocytes from cultured human embryonic stem cells
    • Green, H., Easley, K. & Iuchi, S. Marker succession during the development of keratinocytes from cultured human embryonic stem cells. Proc. Natl Acad. Sci. USA 100, 15625-15630 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15625-15630
    • Green, H.1    Easley, K.2    Iuchi, S.3
  • 151
    • 84873706791 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment
    • Kidwai, F. K. et al. Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment. J. Investigative Dermatol. 133, 618-628 (2013).
    • (2013) J. Investigative Dermatol. , vol.133 , pp. 618-628
    • Kidwai, F.K.1
  • 152
    • 84900321798 scopus 로고    scopus 로고
    • 3D in vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells
    • Petrova, A. et al. 3D in vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells. Stem Cell Rep. 2, 675-689 (2014).
    • (2014) Stem Cell Rep. , vol.2 , pp. 675-689
    • Petrova, A.1
  • 153
    • 84914166169 scopus 로고    scopus 로고
    • Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa
    • Sebastiano, V. et al. Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Sci. Transl. Med. 6, 264ra163 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 264ra163
    • Sebastiano, V.1
  • 154
    • 84914132793 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa
    • Umegaki-Arao, N. et al. Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa. Sci. Transl. Med. 6, 264ra164 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 264ra164
    • Umegaki-Arao, N.1
  • 155
    • 84921823490 scopus 로고    scopus 로고
    • Derivation of hair-inducing cell from human pluripotent stem cells
    • Gnedeva, K. et al. Derivation of hair-inducing cell from human pluripotent stem cells. PloS One 10, e0116892 (2015).
    • (2015) PloS One , vol.10 , pp. e0116892
    • Gnedeva, K.1
  • 156
    • 54949154104 scopus 로고    scopus 로고
    • Model of human aging: Recent findings on Werner's and Hutchinson-Gilford progeria syndromes
    • Ding, S. L. & Shen, C. Y. Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. Clin. Intervent. Aging 3, 431-444 (2008).
    • (2008) Clin. Intervent. Aging , vol.3 , pp. 431-444
    • Ding, S.L.1    Shen, C.Y.2
  • 157
    • 81855198150 scopus 로고    scopus 로고
    • In vitro pathological modelling using patient-specific induced pluripotent stem cells: The case of progeria
    • Nissan, X., Blondel, S. & Peschanski, M. In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria. Biochem. Soc. Trans. 39, 1775-1779 (2011).
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 1775-1779
    • Nissan, X.1    Blondel, S.2    Peschanski, M.3
  • 158
    • 79954626173 scopus 로고    scopus 로고
    • Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    • Liu, G. H. et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 472, 221-225 (2011).
    • (2011) Nature , vol.472 , pp. 221-225
    • Liu, G.H.1
  • 159
    • 78650995671 scopus 로고    scopus 로고
    • A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects
    • Zhang, J. et al. A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 8, 31-45 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 31-45
    • Zhang, J.1
  • 160
    • 84898428343 scopus 로고    scopus 로고
    • Telomerase protects werner syndrome lineage-specific stem cells from premature aging
    • Cheung, H. H. et al. Telomerase protects werner syndrome lineage-specific stem cells from premature aging. Stem Cell Rep. 2, 534-546 (2014).
    • (2014) Stem Cell Rep. , vol.2 , pp. 534-546
    • Cheung, H.H.1
  • 161
    • 84864317150 scopus 로고    scopus 로고
    • Unique preservation of neural cells in Hutchinson-Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA
    • Nissan, X. et al. Unique preservation of neural cells in Hutchinson-Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA. Cell Rep. 2, 1-9 (2012).
    • (2012) Cell Rep. , vol.2 , pp. 1-9
    • Nissan, X.1
  • 162
    • 84897510867 scopus 로고    scopus 로고
    • Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome
    • Blondel, S. et al. Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome. Stem Cells Translat. Med. 3, 510-519 (2014).
    • (2014) Stem Cells Translat. Med. , vol.3 , pp. 510-519
    • Blondel, S.1
  • 164
    • 84893725179 scopus 로고    scopus 로고
    • MSC-based product characterization for clinical trials: An FDA perspective
    • Mendicino, M., Bailey, A. M., Wonnacott, K., Puri, R. K. & Bauer, S. R. MSC-based product characterization for clinical trials: an FDA perspective. Cell Stem Cell 14, 141-145 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 141-145
    • Mendicino, M.1    Bailey, A.M.2    Wonnacott, K.3    Puri, R.K.4    Bauer, S.R.5
  • 165
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma-does a negative Phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau, J. The mesenchymal stromal cells dilemma-does a negative Phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 15, 2-8 (2013).
    • (2013) Cytotherapy , vol.15 , pp. 2-8
    • Galipeau, J.1
  • 166
    • 47249166372 scopus 로고    scopus 로고
    • Replicative senescence of mesenchymal stem cells: A continuous and organized process
    • Wagner, W. et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PloS One 3, e2213 (2008).
    • (2008) PloS One , vol.3 , pp. e2213
    • Wagner, W.1
  • 167
    • 84855457616 scopus 로고    scopus 로고
    • Mesenchymal stromal cell migration: Possibilities to improve cellular therapy
    • Maijenburg, M. W., van der Schoot, C. E. & Voermans, C. Mesenchymal stromal cell migration: possibilities to improve cellular therapy. Stem Cells Dev. 21, 19-29 (2012).
    • (2012) Stem Cells Dev. , vol.21 , pp. 19-29
    • Maijenburg, M.W.1    Van Der Schoot, C.E.2    Voermans, C.3
  • 168
    • 79952133599 scopus 로고    scopus 로고
    • Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease
    • Sanchez, L. et al. Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease. Stem Cells 29, 251-262 (2011).
    • (2011) Stem Cells , vol.29 , pp. 251-262
    • Sanchez, L.1
  • 169
    • 84901413698 scopus 로고    scopus 로고
    • Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties
    • Kimbrel, E. A. et al. Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties. Stem Cells Dev. 23, 1611-1624 (2014).
    • (2014) Stem Cells Dev. , vol.23 , pp. 1611-1624
    • Kimbrel, E.A.1
  • 170
    • 84904152341 scopus 로고    scopus 로고
    • Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis
    • Wang, X. et al. Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis. Stem Cell Rep. 3, 115-130 (2014).
    • (2014) Stem Cell Rep. , vol.3 , pp. 115-130
    • Wang, X.1
  • 171
    • 84925338126 scopus 로고    scopus 로고
    • Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
    • Zhang, J. et al. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J. Translat. Med. 13, 49 (2015).
    • (2015) J. Translat. Med. , vol.13 , pp. 49
    • Zhang, J.1
  • 172
    • 84855407207 scopus 로고    scopus 로고
    • Concise review: Induced pluripotent stem cell-derived mesenchymal stem cells: Progress toward safe clinical products
    • Jung, Y., Bauer, G. & Nolta, J. A. Concise review: Induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products. Stem Cells 30, 42-47 (2012).
    • (2012) Stem Cells , vol.30 , pp. 42-47
    • Jung, Y.1    Bauer, G.2    Nolta, J.A.3
  • 173
    • 84865133433 scopus 로고    scopus 로고
    • Balancing tissue and tumor formation in regenerative medicine
    • Bailey, A. M. Balancing tissue and tumor formation in regenerative medicine. Sci. Transl. Med. 6, 147fs128 (2012).
    • (2012) Sci. Transl. Med. , vol.6 , pp. 147fs128
    • Bailey, A.M.1
  • 174
    • 84872113904 scopus 로고    scopus 로고
    • Translation of stem cell research: Points to consider in designing preclinical animal studies
    • Frey-Vasconcells, J., Whittlesey, K. J., Baum, E. & Feigal, E. G. Translation of stem cell research: points to consider in designing preclinical animal studies. Stem Cells Translat. Med. 1, 353-358 (2012).
    • (2012) Stem Cells Translat. Med. , vol.1 , pp. 353-358
    • Frey-Vasconcells, J.1    Whittlesey, K.J.2    Baum, E.3    Feigal, E.G.4
  • 175
    • 67650506083 scopus 로고    scopus 로고
    • Developing safe therapies from human pluripotent stem cells
    • Carpenter, M. K., Frey-Vasconcells, J. & Rao, M. S. Developing safe therapies from human pluripotent stem cells. Nat. Biotech. 27, 606-613 (2009).
    • (2009) Nat. Biotech. , vol.27 , pp. 606-613
    • Carpenter, M.K.1    Frey-Vasconcells, J.2    Rao, M.S.3
  • 176
    • 84865031796 scopus 로고    scopus 로고
    • Assessing iPSC reprogramming methods for their suitability in translational medicine
    • Rao, M. S. & Malik, N. Assessing iPSC reprogramming methods for their suitability in translational medicine. J. Cell. Biochem. 113, 3061-3068 (2012).
    • (2012) J. Cell. Biochem. , vol.113 , pp. 3061-3068
    • Rao, M.S.1    Malik, N.2
  • 177
    • 77149138343 scopus 로고    scopus 로고
    • Roadblocks en route to the clinical application of induced pluripotent stem cells
    • Lowry, W. E. & Quan, W. L. Roadblocks en route to the clinical application of induced pluripotent stem cells. J. Cell Sci. 123, 643-651 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 643-651
    • Lowry, W.E.1    Quan, W.L.2


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