Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Journal of Immunology

Volumn 182, Issue 11, 2009, Pages 6879-6888

  Timmermans, Frank ^a   Velghe, Imke ^a   Vanwalleghem, Lieve ^b   De Smedt, Magda ^a   Van Coppernolle, Stefanie ^a   Taghon, Tom ^a   Moore, Harry D ^c   Leclercq, Georges ^a   Langerak, Anton W ^d   Kerre, Tessa ^a   Plum, Jean ^a   Vandekerckhove, Bart ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b General Hospital St Jan   (Belgium)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; LEUKOSIALIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LEUKOCYTE ANTIGEN;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL POPULATION; CYTOKINE RELEASE; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; LYMPHOCYTOPOIESIS; MULTIPOTENT STEM CELL; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; COCULTURE; CULTURE TECHNIQUE; CYTOLOGY; HEMATOPOIESIS;

ANTIGENS, CD; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; COCULTURE TECHNIQUES; EMBRYONIC STEM CELLS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; STROMAL CELLS; T-LYMPHOCYTES;

EID: 67449132064     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803670     Document Type: Article

References (30)

1. Thomson, J. A., J. Itskovitz-Eldor, S. S. Shapiro, M. A. Waknitz, J. J. Swiergiel, V. S. Marshall, and J. M. Jones. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
2. Zambidis, E. T., B. Peault, T. S. Park, F. Bunz, and C. I. Civin. 2005. Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood 106: 860-870.
3. + cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood 105: 617-626.
4. Jokubaitis, V. J., L. Sinka, R. Driessen, G. Whitty, D. N. Haylock, I. Bertoncello, I. Smith, B. Peault, M. Tavian, and P. J. Simmons. 2008. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood 111: 4055-4063.
5. Ledran, M. H., A. Krassowska, L. Armstrong, I. Dimmick, J. Renstrom, R. Lang, S. Yung, M. Santibanez-Coref, E. Dzierzak, M. Stojkovic, R. A. Oostendorp, L. Forrester, and M. Lako. 2008. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Stem Cell 3: 85-98.
6. Vodyanik, M. A., J. A. Thomson, and I. I. Slukvin. 2006. Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood 108: 2095-2105.
7. Martin, C. H., P. S. Woll, Z. Ni, J. C. Zuniga-Pflucker, and D. S. Kaufman. 2008. Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells. Blood 112: 2730-2737.
8. Galic, Z., S. G. Kitchen, A. Kacena, A. Subramanian, B. Burke, R. Cortado, and J. A. Zack. 2006. T lineage differentiation from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 103: 11742-11747.
9. Galic Z., S. G. Kitchen, A. Subramanian, G. Bristol, M. D. Marsden, A. Balamurugan, A. Kacena, O. Yang, and J. A. Zack. 2009. Generation of T lineage cells from human embryonic stem cells in a feeder free system. Stem Cells 27: 100-109.
10. Fleming, H. E., and D. T. Scadden. 2006. Embryonic stem cells make human T cells. Proc. Natl. Acad. Sci. USA 103: 12213-12214.
11. Takayama, N., H. Nishikii, J. Usui, H. Tsukui, A. Sawaguchi, T. Hiroyama, K. Eto, and H. Nakauchi. 2008. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood 111: 5298-5306.
12. Takahashi, K., K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
13. Schmitt, T. M., and J. C. Zuniga-Pflucker. 2002. Induction of T cell development from hematopoietic progenitor cells by δ-like-1 in vitro. Immunity 17: 749-756.
14. Dik, W. A., K. Pike-Overzet, F. Weerkamp, D. de Ridder, E. F. de Haas, M. R. Baert, P. van der Spek, E. E. Koster, M. J. Reinders, J. J. van Dongen, A. W. Langerak, and F. J. Staal. 2005. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J. Exp. Med. 201: 1715-1723.
15. Cumano, A., and I. Godin. 2007. Ontogeny of the hematopoietic system. Annu. Rev. Immunol. 25: 745-785.
16. + progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol. Dis. 33: 227-232.
17. La Motte-Mohs, R. N., E. Herer, and J. C. Zuniga-Pflucker. 2005. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 105: 1431-1439.
18. De Smedt, M., T. Taghon, I. Van de Walle, G. De Smet, G. Leclercq, and J. Plum. 2007. Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells. Blood 110: 2696-2703.
19. Spits, H. 2002. Development of αβ T cells in the human thymus. Nat. Rev. Immunol. 2: 760-772.
20. Six, E. M., D. Bonhomme, M. Monteiro, K. Beldjord, M. Jurkowska, C. Cordier-Garcia, A. Garrigue, L. Dal Cortivo, B. Rocha, A. Fischer, M. Cavazzana-Calvo, and I. André-Schmutz. 2007. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J. Exp. Med. 204: 3085-3093.
21. Hao, Q. L., A. A. George, J. Zhu, L. Barsky, E. Zielinska, X. Wang, M. Price, S. Ge, and G. M. Crooks. 2008. Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Blood 111: 1318-1326.
22. + thymocytes and identification of thymic emigrants. J. Immunol. 155: 1862-1872.
23. + cells. J. Immunol. 155: 4711-4718.
24. Kim, I., Ö. H. Yilmaz, and S. J. Morrison. 2005. CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood 106: 903-905.
25. + hematopoietic precursors. Arterioscler. Thromb. Vasc. Biol. 27: 1572-1579.
26. Tian, X., P. S. Woll, J. K. Morris, J. L. Linehan, and D. S. Kaufman. 2006. Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells 24: 1370-1380. (Pubitemid 44464705)
27. Hao, Q. L., J. Zhu, M. A. Price, K. J. Payne, L. W. Barsky, and G. M. Crooks. 2001. Identification of a novel, human multilymphoid progenitor in cord blood. Blood 97: 3683-3690.
28. Davis, R. P., E. S. Ng, M. Costa, A. K. Mossman, K. Sourris, A. G. Elefanty, and E. G. Stanley. 2008. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 111: 1876-1884.
29. van Lent, A. U., M. Nagasawa, M. M. van Loenen, R. Schotte, T. N. Schumacher, M. H. Heemskerk, H. Spits, and N. Legrand. 2007. Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors. J. Immunol. 179: 4959-4968.
30. Offner, F., T. Kerre, M. De Smedt, and J. Plum. 1999. Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy. Br. J. Haematol. 104: 801-808. (Pubitemid 29143501)