Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

Science Translational Medicine

Volumn 6, Issue 255, 2014, Pages

  Ebert, Antje D ^a   Kodo, Kazuki ^a   Liang, Ping ^a   Wu, Haodi ^a   Huber, Bruno C ^a   Riegler, Johannes ^a   Churko, Jared ^a   Lee, Jaecheol ^a   De Almeida, Patricia ^a   Lan, Feng ^a   Diecke, Sebastian ^a   Burridge, Paul W ^a   Gold, Joseph D ^a   Mochly Rosen, Daria ^a   Wu, Joseph C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; REACTIVE OXYGEN METABOLITE; 4-HYDROXY-2-NONENAL; ALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN; ENZYME INHIBITOR; STRESS ACTIVATED PROTEIN KINASE;

ADULT; APOPTOSIS; ARTICLE; CARDIOVASCULAR RISK; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENZYME ACTIVITY; GENE MUTATION; GENETIC CODE; GENETIC POLYMORPHISM; GENOTYPE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; HUMAN CELL; MALE; MOLECULAR MECHANICS; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; POINT MUTATION; RISK MANAGEMENT; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE CELL; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; YOUNG ADULT;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ALDEHYDES; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL LINE; ENZYME INHIBITORS; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PHENOTYPE; POLYMORPHISM, GENETIC; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; YOUNG ADULT;

EID: 84908377652     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3009027     Document Type: Article

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