Modeling human lung development and disease using pluripotent stem cells

Development (Cambridge)

Volumn 142, Issue 1, 2015, Pages 13-16

  Snoeck, Hans Willem ^a  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL TYPE; DISEASE MODEL; DISEASE PREDISPOSITION; HUMAN; LUNG DEVELOPMENT; LUNG DISEASE; NONHUMAN; ORGANOGENESIS; PATHOGENESIS; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; TISSUE REGENERATION; TISSUE REPAIR; EMBRYOLOGY; LUNG; PATHOLOGY;

HUMANS; LUNG; LUNG DISEASES; MODELS, BIOLOGICAL; PLURIPOTENT STEM CELLS;

EID: 84918509558     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.115469     Document Type: Article

References (64)

1. Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A.III, (2007).Telomerasemutations in families with idiopathic pulmonary fibrosis. N. Engl. J. Med. 356, 1317-1326.
2. Ban, N., Matsumura, Y., Sakai, H., Takanezawa, Y., Sasaki, M., Arai, H. and Inagaki, N. (2007). ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J. Biol. Chem. 282, 9628-9634.
3. Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W. and Hogan, B. L. (2013). Type 2 alveolar cells are stem cells in adult lung. J. Clin. Invest. 123, 3025-3036.
4. Bednarczyk, D., Sasiadek, M. M. and Smigiel, R. (2013). Chromosome aberrations and gene mutations in patients with esophageal atresia. J. Pediatr. Gastroenterol. Nutr. 57, 688-693.
5. Blanpain, C. and Fuchs, E. (2009). Epidermal homeostasis: a balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 10, 207-217.
6. Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M. and Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280.
7. Chapman, H. A., Li, X., Alexander, J. P., Brumwell, A., Lorizio, W., Tan, K., Sonnenberg, A., Wei, Y. and Vu, T. H. (2011). Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J. Clin. Invest. 121, 2855-2862.
8. Clark, J. C., Wert, S. E., Bachurski, C. J., Stahlman, M. T., Stripp, B. R., Weaver, T. E. and Whitsett, J. A. (1995). Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc. Natl. Acad. Sci. USA 92, 7794-7798.
9. Clevers, H. (2013). The intestinal crypt, a prototype stem cell compartment. Cell 154, 274-284.
10. Desai, T. J., Brownfield, D. G. and Krasnow, M. A. (2014). Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507, 190-194.
11. Deterding, R. R., Pye, C., Fan, L. L. and Langston, C. (2005). Persistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia. Pediatr. Pulmonol. 40, 157-165.
12. Dishop, M. K. (2011). Paediatric interstitial lung disease: classification and definitions. Paediatr. Respir. Rev. 12, 230-237.
13. D’Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E. and Baetge, E. E. (2005). Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23, 1534-1541.
14. Fitzgerald, M. L., Xavier, R., Haley, K. J., Welti, R., Goss, J. L., Brown, C. E., Zhuang, D. Z., Bell, S. A., Lu, N., McKee, M. et al. (2007). ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J. Lipid Res. 48, 621-632.
15. Fox, I. J., Daley, G. Q., Goldman, S. A., Huard, J., Kamp, T. J. and Trucco, M. (2014). Use of differentiated pluripotent stem cells in replacement therapy for treating disease. Science 345, 1247391.
16. Gillespie, L. M., Fenton, A. C. and Wright, C. (2004). Acinar dysplasia: a rare cause of neonatal respiratory failure. Acta Paediatr. 93, 712-713.
17. Glasser, S.W., Burhans, M. S., Korfhagen, T. R., Na, C.-L., Sly, P. D., Ross, G. F., Ikegami, M. and Whitsett, J. A. (2001). Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc. Natl. Acad. Sci. USA 98, 6366-6371.
18. Gouon-Evans, V, Boussemart, L., Gadue, P., Nierhoff, D., Koehler, C. I., Kubo, A., Shafritz, D. A. and Keller, G. (2006). BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat. Biotechnol. 24, 1402-1411.
19. Green, M. D., Chen, A., Nostro, M.-C., d’Souza, S. L., Schaniel, C., Lemischka, I. R., Gouon-Evans, V., Keller, G. and Snoeck, H.-W. (2011). Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat. Biotechnol. 29, 267-272.
20. Green, M. D., Huang, S. X. and Snoeck, H.W. (2013). Stem cells of the respiratory system: from identification to differentiation into functional epithelium. Bioessays. 35, 261-270.
21. Guseh, J. S., Bores, S. A., Stanger, B. Z., Zhou, Q., Anderson, W. J., Melton, D. A. and Rajagopal, J. (2009). Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136, 1751-1759.
22. Hammel, M., Michel, G., Hoefer, C., Klaften, M., Müller-Höcker, J., de Angelis, M. H. and Holzinger, A. (2007). Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies. Biochem. Biophys. Res. Commun. 359, 947-951.
23. Herriges, M. and Morrisey, E. E. (2014). Lung development: orchestrating the generation and regeneration of a complex organ. Development 141, 502-513.
24. Herring, M. J., Putney, L. F., Wyatt, G., Finkbeiner, W. E. and Hyde, D. M. (2014). Growth of alveoli during postnatal development in humans based on stereological estimation. Am. J. Physiol. Lung Cell. Mol. Physiol. 307, L338-L344.
25. Holtzman, M. J., Byers, D. E., Alexander-Brett, J. and Wang, X. (2014). The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat. Rev. Immunol. 14, 686-698.
26. Huang, S. X. L., Islam, M. N., O’Neill, J., Hu, Z., Yang, Y.-G., Chen, Y.-W., Mumau, M., Green, M. D., Vunjak-Novakovic, G., Bhattacharya, J. et al. (2014). Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 32, 84-91.
27. Joseph, N. M. and Morrison, S. J. (2005). Toward an understanding of the physiological function of Mammalian stem cells. Dev. Cell 9, 173-183.
28. Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S., Fehling, H. J. and Keller, G. (2004). Development of definitive endoderm from embryonic stem cells in culture. Development 131, 1651-1662.
29. Kumar, P. A., Hu, Y., Yamamoto, Y., Hoe, N. B., Wei, T. S., Mu, D., Sun, Y., Joo, L. S., Dagher, R., Zielonka, E. M. et al. (2011). Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 147, 525-538.
30. Lancaster, M. A. and Knoblich, J. A. (2014). Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125
31. Lancaster, M.A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., and Knoblich, J. A. (2013).Cerebral organoidsmodel human brain development and microcephaly. Nature 501, 373-379.
32. Lewis, D. R., Clegg, L. X. and Johnson, N. J. (2009). Lung disease mortality in the United States: the National Longitudinal Mortality Study. Int. J. Tuberc. Lung Dis. 13, 1008-1014.
33. Mac, M. H. (1948). Congenital alveolar dysplasia; a developmental anomaly involving pulmonary alveoli. Pediatrics 2, 43-57.
34. McCurry, K. R., Shearon, T. H., Edwards, L. B., Chan, K. M., Sweet, S. C., Valapour, M., Yusen, R. and Murray, S. (2009). Lung transplantation in the United States, 1998-2007. Am. J. Transplant. 9, 942-958.
35. Morrisey, E. E. and Hogan, B. L. M. (2010). Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev. Cell 18, 8-23.
36. Murry, C. E. and Keller, G. (2008). Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661-680.
37. Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M. and Sasai, Y. (2012). Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10, 771-785.
38. Noble, P.W., Barkauskas, C. E. and Jiang, D. (2012). Pulmonary fibrosis: patterns and perpetrators. J. Clin. Invest. 122, 2756-2762.
39. Nostro, M. C. and Keller, G. (2012). Generation of beta cells from human pluripotent stemcells: potential for regenerative medicine. Semin. Cell Dev. Biol. 23, 701--710.
40. Orkin, S. H. and Zon, L. I. (2008). Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132, 631-644.
41. Pagliuca, F.W., Millman, J. R., Gurtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D. and Melton, D. A. (2014). Generation of functional human pancreatic beta cells in vitro. Cell 159, 428-439.
42. Plopper, C. G. and Hyde, D. M. (2008). The non-human primate as a model for studying COPD and asthma. Pulm. Pharmacol. Ther. 21, 755-766.
43. Rando, T. A. (2006). Stem cells, ageing and the quest for immortality. Nature 441, 1080-1086.
44. Ratjen, F. and Döring, G. (2003). Cystic fibrosis. Lancet 361, 681-689.
45. Robinton, D. A. and Daley, G. Q. (2012). The promise of induced pluripotent stem cells in research and therapy. Nature 481, 295-305.
46. Rock, J.R. and Hogan, B. L. M. (2011).Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu. Rev. Cell Dev. Biol. 27, 493-512.
47. Rock, J. R., Gao, X., Xue, Y., Randell, S. H., Kong, Y.-Y. and Hogan, B. L. M. (2011). Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell 8, 639-648.
48. Rutledge, J. C. and Jensen, P. (1986). Acinar dysplasia: a new form of pulmonary maldevelopment. Hum. Pathol. 17, 1290-1293.
49. Ryu, J. H., Moua, T., Daniels, C. E., Hartman, T. E., Yi, E. S., Utz, J. P. and Limper, A. H. (2014). Idiopathic pulmonary fibrosis: evolving concepts. Mayo Clin. Proc. 89, 1130-1142.
50. Seibold, M. A., Wise, A. L., Speer, M. C., Steele, M. P., Brown, K. K., Loyd, J. E., Fingerlin, T. E., Zhang, W., Gudmundsson, G., Groshong, S. D. et al. (2011). A common MUC5B promoter polymorphism and pulmonary fibrosis. N. Engl. J. Med. 364, 1503-1512.
51. Shadrach, J. L. and Wagers, A. J. (2011). Stem cells for skeletal muscle repair. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 2297-2306.
52. Sharma, S., Chhabra, D., Kho, A. T., Hayden, L. P., Tantisira, K. G. and Weiss, S. T. (2014). The genomic origins of asthma. Thorax 69, 481-487.
53. Smith, L. J., McKay, K. O., van Asperen, P. P., Selvadurai, H. and Fitzgerald, D. A. (2010). Normal development of the lung and premature birth. Paediatr. Respir. Rev. 11, 135-142.
54. Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M. et al. (2011). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105-109.
55. Taguchi, A., Kaku, Y., Ohmori, T., Sharmin, S., Ogawa, M., Sasaki, H. and Nishinakamura, R. (2014). Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53-67.
56. Takasato, M., Er, P. X., Becroft, M., Vanslambrouck, J. M., Stanley, E. G., Elefanty, A. G. and Little, M. H. (2014). Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat. Cell Biol. 16, 118-126.
57. Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N. et al. (2013). Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484.
58. Treutlein, B., Brownfield, D. G., Wu, A. R., Neff, N. F., Mantalas, G. L., Espinoza, F. H., Desai, T. J., Krasnow, M. A. and Quake, S.R. (2014).Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509, 371-375.
59. Tsao, P.-N., Vasconcelos, M., Izvolsky, K. I., Qian, J., Lu, J. and Cardoso, W. V. (2009). Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 136, 2297-2307.
60. Warburton, D., El-Hashash, A., Carraro, G., Tiozzo, C., Sala, F., Rogers, O., De Langhe, S., Kemp, P. J., Riccardi, D., Torday, J. et al. (2010). Lung organogenesis. Curr. Top. Dev. Biol. 90, 73-158.
61. Weibel, E. R. and Gomez, D. M. (1962). Architecture of the human lung: use of quantitative methods establishes fundamental relations between size and number of lung structures. Science 137, 577-585.
62. Whitsett, J. A., Wert, S. E. and Weaver, T. E. (2010). Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Annu. Rev. Med. 61, 105-119.
63. Xia, Y., Nivet, E., Sancho-Martinez, I., Gallegos, T., Suzuki, K., Okamura, D., Wu, M.-Z., Dubova, I., Esteban, C. R., Montserrat, N. et al. (2013). Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat. Cell Biol. 15, 1507-1515.
64. Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M. et al. (2008). Human cardiovascular progenitor cells develop from a KDR+ embryonic-stemcell-derived population. Nature 453, 524-528.