Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration

Stem Cells

Volumn 27, Issue 9, 2009, Pages 2126-2135

  Lu, Bin ^a   Malcuit, Christopher ^b   Wang, Shaomei ^a   Girman, Sergej ^a   Francis, Peter ^a   Lemieux, Linda ^b   Lanza, Robert ^b   Lund, Raymond ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Advanced Cell Technology   (United States)

Author keywords

Clinical trials; Embryonic stem cells; Macular degeneration; Retinal pigment epithelium

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE EXPRESSION; GOOD MANUFACTURING PRACTICE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; RAT; RETINA DEGENERATION; RETINA MACULA DEGENERATION; STARGARDT DISEASE; TERATOMA; TUMOR GROWTH; VISION;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; COMPUTATIONAL BIOLOGY; EMBRYONIC STEM CELLS; GENE EXPRESSION; HUMANS; MACULAR DEGENERATION; MICE; PRINCIPAL COMPONENT ANALYSIS; RATS; RETINA; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION;

ANIMALIA; RATTUS;

EID: 70349873363     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.149     Document Type: Article

References (30)

1. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
2. Gullapalli VK, Khodair M, Wang H, et al. Retinal pigment epithelium and photoreceptor transplantation frontiers. In: Ryan SJ, ed. Retina. 4th ed. Philadelphia: Elsevier Mosby, 2006:2597-2613.
3. Friedman DS, O'Colmain BJ, Munoz B et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004;122:564-572. (Pubitemid 38456293)
4. Bird AC, Bressler NM, Bressler SB et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International Arm Epidemiological Study Group. Surv Ophthalmol 1995;39:367-374.
5. Klein R, Peto T, Bird A et al. The epidemiology of age-related macular degeneration. Am J Ophthalmol 2004;137:486-495.
6. Haddad S, Chen CA, Santangelo SL et al. The genetics of age-related macular degeneration: a review of progress to date. Surv Ophthalmol 2006;51:316-363. (Pubitemid 43970736)
7. Gal A, Li Y, Thompson DA et al. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet 2000;26:270-271. (Pubitemid 30824602)
8. Lund RD, Adamson P, Sauve Y et al. Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proc Natl Acad Sci U S A 2001;98:9942-9947. (Pubitemid 32769408)
9. Lund RD, Wang S, Klimanskaya I et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells 2006;8:189-199. (Pubitemid 44735173)
10. Wang S, Lu B, Lund RD. Morphological changes in the Royal College of Surgeons rat retina during photoreceptor degeneration and after cell-based therapy. J Comp Neurol 2005;491:400-417. (Pubitemid 41376988)
11. Abe T, Tomita H, Kano T et al. Autologous iris pigment epithelial cell transplantation in monkey subretinal region. Curr Eye Res 2000;20:268-275. (Pubitemid 30428156)
12. Coffey PJ, Girman S, Wang SM et al. Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nat Neurosci 2002;5:53-56. (Pubitemid 34038783)
13. Gouras P, Kong J, Tsang SH. Retinal degeneration and RPE transplantation in Rpe65(-/-) mice. Invest Ophthalmol Vis Sci 2002;43:3307-3311.
14. D'Cruz PM, Yasumura D, Weir J et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 2000;9:645-651. (Pubitemid 30154023)
15. Dowling JE, Sidman RL. Inherited retinal dystrophy in the rat. J Cell Biol 1962;14:73-107.
16. Zhang K, Kniazeva M, Han M et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet 2001;27:89-93. (Pubitemid 32044525)
17. Gullapalli VK, Sugino IK, Van Patten Y et al. Impaired RPE survival on aged submacular human Bruch's membrane. Exp Eye Res 2005;80:235-248.
18. Klimanskaya I, Hipp J, Rezai KA et al. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells 2004;6:217-245. (Pubitemid 39391307)
19. Gamm DM, Wang S, Lu B et al. Protection of visual functions by human neural progenitors in a rat model of retinal disease. PLoS ONE 2007;2:e338.
20. Girman SV, Wang S, Lund RD. Time course of deterioration of rod and cone function in RCS rat and the effects of subretinal cell grafting: a light- and dark-adaptation study. Vision Res 2005;45:343-354. (Pubitemid 39647496)
21. Wang S, Lu B, Wood P et al. Grafting of ARPE-19 and Schwann Cells to the Subretinal Space in RCS Rats. Invest Ophthalmol Vis Sci 2005;46:2552-2560. (Pubitemid 43119505)
22. Bäumer N, Marquardt T, Stoykova A et al. Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 2003;130:2903-2915. (Pubitemid 36857239)
23. Villegas-Pérez MP, Lawrence JM, Vidal-Sanz M et al. Ganglion cell loss in RCS rat retina: a result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J Comp Neurol 1998;392:58-77. (Pubitemid 28104022)
24. Wang S, Villegas-Perez MP, Holmes T et al. Evolving neurovascular relationships in the RCS rat with age. Curr Eye Res 2003;27:183-196. (Pubitemid 37159483)
25. Ayyagari R, Zhang K, Hutchinson A et al. Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Ophthalmic Genet 2001;22:233-239. (Pubitemid 34497304)
26. LaVail MM, Unoki K, Yasumura D et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A 1992;89:11249-11253.
27. Lawrence JM, Keegan DJ, Muir EM et al. Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci 2004;45:267-274.
28. Cayouette M, Behn D, Sendtner M et al. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 1998;18:9282-9293. (Pubitemid 28512459)
29. Lawrence JM, Sauve Y, Keegan DJ et al. Schwann cell grafting into the retina of the dystrophic RCS rat limits functional deterioration. Royal College of Surgeons. Invest Ophthalmol Vis Sci 2000;41:518-528.
30. Del Priore LV, Ishida O, Johnson EW et al. Triple immune suppression increases short-term survival of porcine fetal retinal pigment epithelium xenografts. Invest Ophthalmol Vis Sci 2003;44:4044-4053.