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1
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58149299735
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Analysis of islet inflammation in human type 1 diabetes
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COI: 1:STN:280:DC%2BD1M%2FlslKltw%3D%3D, PID: 19128359
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Willcox A, Richardson SJ, Bone AJ, et al. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol. 2009;155:173–81.
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Clin Exp Immunol
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Willcox, A.1
Richardson, S.J.2
Bone, A.J.3
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2
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84856825977
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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
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COI: 1:CAS:528:DC%2BC38XhtFSqurk%3D, PID: 22213807
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Coppieters KT, Dotta F, Amirian N, et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med. 2012;209:51–60.
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J Exp Med
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Coppieters, K.T.1
Dotta, F.2
Amirian, N.3
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4
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67649364114
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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
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COI: 1:CAS:528:DC%2BD1MXjs1ymt7Y%3D, PID: 19352320
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Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol. 2009;5:219–26.
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Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
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5
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78049320362
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Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study
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COI: 1:CAS:528:DC%2BC3cXhsV2nsb%2FL, PID: 20699420
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Keenan HA, Sun JK, Levine J, et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010;59:2846–53.
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Diabetes
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Keenan, H.A.1
Sun, J.K.2
Levine, J.3
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6
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67349268443
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Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft
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COI: 1:CAS:528:DC%2BD1MXms1yhs7s%3D, PID: 19418039
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Liu EH, Digon III BJ, Hirshberg B, et al. Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia. 2009;52:1369–80.
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Diabetologia
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Liu, E.H.1
Digon, B.J.2
Hirshberg, B.3
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7
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77949267089
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Dimorphic histopathology of long-standing childhood-onset diabetes
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COI: 1:STN:280:DC%2BC3c7nsF2mtg%3D%3D, PID: 20062967
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Gianani R, Campbell-Thompson M, Sarkar SA, et al. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010;53:690–8.
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Diabetologia
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Gianani, R.1
Campbell-Thompson, M.2
Sarkar, S.A.3
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8
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84962097619
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Krogvold L, Skog O, Sundström G, et al.: Function of isolated pancreatic islets from patients at onset of type 1 diabetes; Insulin secretion can be restored after some days in a non-diabetogenic environment in vitro. Results from the DiViD study. Diabetes. 2015. This study shows that restoration of specific function of the isolated islets removed from patients at onset of type 1 diabetes can be obtained after
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Krogvold L, Skog O, Sundström G, et al.: Function of isolated pancreatic islets from patients at onset of type 1 diabetes; Insulin secretion can be restored after some days in a non-diabetogenic environment in vitro. Results from the DiViD study. Diabetes. 2015. This study shows that restoration of specific function of the isolated islets removed from patients at onset of type 1 diabetes can be obtained afterin vitroculture.
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9
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78751662679
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Type 1 diabetes: etiology, immunology, and therapeutic strategies
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PID: 21248163
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van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev. 2011;91:79–118.
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(2011)
Physiol Rev
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van Belle, T.L.1
Coppieters, K.T.2
von Herrath, M.G.3
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10
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84872035827
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β-cell mass and turnover in humans: effects of obesity and aging
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PID: 22875233, This autopsy study of a non-diabetic population suggests that the beta-cell mass may vary a log-fold between individuals
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Saisho Y, Butler AE, Manesso E, et al. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013;36:111–7. This autopsy study of a non-diabetic population suggests that the beta-cell mass may vary a log-fold between individuals.
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(2013)
Diabetes Care
, vol.36
, pp. 111-117
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Saisho, Y.1
Butler, A.E.2
Manesso, E.3
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11
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56749183605
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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
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COI: 1:CAS:528:DC%2BD1cXhsVWhurvK, PID: 18978792
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Cooper JD, Smyth DJ, Smiles AM, et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet. 2008;40:1399–401.
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(2008)
Nat Genet
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Cooper, J.D.1
Smyth, D.J.2
Smiles, A.M.3
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12
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67349199566
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
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COI: 1:CAS:528:DC%2BD1MXls1Cmt7c%3D, PID: 19430480
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Barrett JC, Clayton DG, Concannon P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41:703–7.
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(2009)
Nat Genet
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Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
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13
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80053439315
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A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
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COI: 1:CAS:528:DC%2BC3MXhtlCmtrjM, PID: 21980299
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Bradfield JP, Qu HQ, Wang K, et al. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet. 2011;7, e1002293.
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PLoS Genet
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Bradfield, J.P.1
Qu, H.Q.2
Wang, K.3
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14
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84930408328
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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
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COI: 1:CAS:528:DC%2BC2MXjvFOgurk%3D, PID: 25751624, The ImmunoChip study of type 1 diabetes susceptibility loci confirms results from previous genome-wide association studies and identifies novel loci and risk variants
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Onengut-Gumuscu S, Chen WM, Burren O, et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet. 2015;47:381–6. The ImmunoChip study of type 1 diabetes susceptibility loci confirms results from previous genome-wide association studies and identifies novel loci and risk variants.
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(2015)
Nat Genet
, vol.47
, pp. 381-386
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Onengut-Gumuscu, S.1
Chen, W.M.2
Burren, O.3
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15
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84888321284
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Genetics of diabetes--are we missing the genes or the disease?
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COI: 1:CAS:528:DC%2BC3sXnsVyqu7g%3D, PID: 23587769
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Groop L, Pociot F. Genetics of diabetes--are we missing the genes or the disease? Mol Cell Endocrinol. 2014;382:726–39.
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Mol Cell Endocrinol
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Groop, L.1
Pociot, F.2
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16
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77649209124
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The genetic interpretation of area under the ROC curve in genomic profiling
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PID: 20195508
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Wray NR, Yang J, Goddard ME, et al. The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet. 2010;6, e1000864.
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(2010)
PLoS Genet
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Wray, N.R.1
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Goddard, M.E.3
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Prediction and interaction in complex disease genetics: experience in type 1 diabetes
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PID: 19584936
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Clayton DG. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet. 2009;5, e1000540.
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(2009)
PLoS Genet
, vol.5
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Clayton, D.G.1
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18
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84880920122
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Bringing genome-wide association findings into clinical use
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COI: 1:CAS:528:DC%2BC3sXhtVKru7rL, PID: 23835440
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Manolio TA. Bringing genome-wide association findings into clinical use. Nat Rev Genet. 2013;14:549–58.
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Nat Rev Genet
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Manolio, T.A.1
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77954288805
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Genetics of type 1 diabetes: what’s next?
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COI: 1:CAS:528:DC%2BC3cXpsVOmu7g%3D, PID: 20587799
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Pociot F, Akolkar B, Concannon P, et al. Genetics of type 1 diabetes: what’s next? Diabetes. 2010;59:1561–71.
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(2010)
Diabetes
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Pociot, F.1
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20
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84942358150
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Brorsson CA, Onengut S, Chen W-M, et al.: Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes. Diabetes. 2015. The most comprehensive study to demonstrate the genetic association to autoimmunity antibody positivity in type 1 diabetes
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Brorsson CA, Onengut S, Chen W-M, et al.: Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes. Diabetes. 2015. The most comprehensive study to demonstrate the genetic association to autoimmunity antibody positivity in type 1 diabetes.
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21
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84965186550
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Brorsson CA, Pociot F, T1DGC. Shared genetic basis for type 1 diabetes, islet autoantibodies and autoantibodies associated with other immune-mediated diseases in type 1 diabetes families. Diabetes Care. 2015;In Press
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Brorsson CA, Pociot F, T1DGC. Shared genetic basis for type 1 diabetes, islet autoantibodies and autoantibodies associated with other immune-mediated diseases in type 1 diabetes families. Diabetes Care. 2015;In Press.
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22
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84859526125
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Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression
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COI: 1:CAS:528:DC%2BC38XkslCht7c%3D, PID: 22344559, This study provides evidence that many of the genes in the type 1 diabetes susceptibility loci interact in functional networks and that the majority of these genes are expressed in human islets. Furthermore, this study highlights the advantage of integrating several types of data to understand complex diseases including type 1 diabetes
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Bergholdt R, Brorsson C, Palleja A, et al. Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression. Diabetes. 2012;61:954–62. This study provides evidence that many of the genes in the type 1 diabetes susceptibility loci interact in functional networks and that the majority of these genes are expressed in human islets. Furthermore, this study highlights the advantage of integrating several types of data to understand complex diseases including type 1 diabetes.
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(2012)
Diabetes
, vol.61
, pp. 954-962
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Bergholdt, R.1
Brorsson, C.2
Palleja, A.3
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23
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84859254586
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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
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COI: 1:CAS:528:DC%2BC38XktF2htb0%3D, PID: 22412385, This study provides the most comprehensive transcriptome analysis of human islets under control conditions and following exposure to pro-inflammatory cytokines. It demonstrates that many of the candidate genes for type 1 diabetes are expressed in human islets
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Eizirik DL, Sammeth M, Bouckenooghe T, et al. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 2012;8, e1002552. This study provides the most comprehensive transcriptome analysis of human islets under control conditions and following exposure to pro-inflammatory cytokines. It demonstrates that many of the candidate genes for type 1 diabetes are expressed in human islets.
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(2012)
PLoS Genet
, vol.8
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Eizirik, D.L.1
Sammeth, M.2
Bouckenooghe, T.3
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24
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84884590165
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Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes
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COI: 1:CAS:528:DC%2BC3sXhsVOgtrvM, PID: 23925433
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Storling J, Brorsson CA. Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2013;13:633–41.
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Curr Diab Rep
, vol.13
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Storling, J.1
Brorsson, C.A.2
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25
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77649326700
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MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA
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COI: 1:CAS:528:DC%2BD1MXhsFGhu7vM, PID: 19825843
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Colli ML, Moore F, Gurzov EN, et al. MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet. 2010;19:135–46.
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(2010)
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, vol.19
, pp. 135-146
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Colli, M.L.1
Moore, F.2
Gurzov, E.N.3
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26
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84981534746
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Reduced expression of the MDA5 gene IFIH1 prevents autoimmune diabetes
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COI: 1:CAS:528:DC%2BC2MXhtVSrurzM, PID: 25591872, This work identifies MDA5 as an important target for preventative and therapeutic strategies to halt T1D. By reducing MDA5 gene expression in NOD mice a unique IFN-I signature that led to expansion of regulatory T cells at the site of autoimmunity and protection from T1D was identified
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Lincez PJ, Shanina I, Horwitz MS. Reduced expression of the MDA5 gene IFIH1 prevents autoimmune diabetes. Diabetes. 2015;64:2184–93. This work identifies MDA5 as an important target for preventative and therapeutic strategies to halt T1D. By reducing MDA5 gene expression in NOD mice a unique IFN-I signature that led to expansion of regulatory T cells at the site of autoimmunity and protection from T1D was identified.
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(2015)
Diabetes
, vol.64
, pp. 2184-2193
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Lincez, P.J.1
Shanina, I.2
Horwitz, M.S.3
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27
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66649132790
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PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
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COI: 1:CAS:528:DC%2BD1MXntFantbc%3D, PID: 19336676
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Moore F, Colli ML, Cnop M, et al. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes. 2009;58:1283–91.
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Moore, F.1
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28
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84878507398
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Nogueira TC, Paula FM, Villate O, et al. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet. 2013;9, e1003532. This study demonstrates that the type 1 and type 2 diabetes candidate gene GLIS3 has important functions in beta cells and besides its role in insulin transcription also regulates beta cell apoptosis by modulating alternative splicing of the pro-apoptotic protein Bim
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Nogueira TC, Paula FM, Villate O, et al. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet. 2013;9, e1003532. This study demonstrates that the type 1 and type 2 diabetes candidate geneGLIS3has important functions in beta cells and besides its role in insulin transcription also regulates beta cell apoptosis by modulating alternative splicing of the pro-apoptotic protein Bim.
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29
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82255185820
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PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic beta-cell apoptosis via regulation of the BH3-only protein Bim
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COI: 1:CAS:528:DC%2BC38XpvFOgsA%3D%3D, PID: 21984578
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Santin I, Moore F, Colli ML, et al. PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic beta-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes. 2011;60:3279–88.
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84904353328
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Floyel T, Brorsson C, Nielsen LB, et al. CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014;111:10305–10. This study demonstrates that the type 1 diabetes candidate gene CTSH has important functions in beta cells, and that type 1 diabetes risk SNPs affect CTSH expression and beta cell function in type 1 diabetes patients
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Floyel T, Brorsson C, Nielsen LB, et al. CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci U S A. 2014;111:10305–10. This study demonstrates that the type 1 diabetes candidate geneCTSHhas important functions in beta cells, and that type 1 diabetes risk SNPs affectCTSHexpression and beta cell function in type 1 diabetes patients.
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31
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84903136445
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BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2
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PID: 24608439
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Marroqui L, Santin I, Dos Santos RS, et al. BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes. 2014;63:2516–27.
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Diabetes
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Marroqui, L.1
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Soleimanpour SA, Gupta A, Bakay M, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014;157:1577–90. The study describes an important role of the type 1 diabetes candidate gene CLEC16A in beta cell function and indicates that dysregulated autophagy/mitophagy could be implicated in beta cell dysfunction and development of type 1 diabetes
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Soleimanpour SA, Gupta A, Bakay M, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014;157:1577–90. The study describes an important role of the type 1 diabetes candidate geneCLEC16Ain beta cell function and indicates that dysregulated autophagy/mitophagy could be implicated in beta cell dysfunction and development of type 1 diabetes.
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33
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84926683121
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Reduced Tyk2 gene expression in beta-cells due to natural mutation determines susceptibility to virus-induced diabetes
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Izumi K, Mine K, Inoue Y, et al.: Reduced Tyk2 gene expression in beta-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun. 2015;6
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On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth
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Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
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Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
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INS-gene mutations: from genetics and beta cell biology to clinical disease
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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
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Downes K, Pekalski M, Angus KL, et al. Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One. 2010;5, e12646.
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Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and beta-cell apoptosis
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COI: 1:CAS:528:DC%2BC3sXhsVSiurjI, PID: 24003923
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Santin I, Eizirik DL. Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and beta-cell apoptosis. Diabetes Obes Metab. 2013;15 Suppl 3:71–81.
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